Welcome to chemicalbook!
010-86108875
RFQ
Try our best to find the right business for you.
Do not miss inquiry messages Please log in to view all inquiry messages.

Welcome back!

ChemicalBook >> CAS DataBase List >> Wortmannin-Rapamycin Conjugate

Wortmannin-Rapamycin Conjugate

Wortmannin-Rapamycin Conjugate price.
  • $152 - $1439
  • Product name: Wortmannin-Rapamycin Conjugate
  • CAS: 1067892-47-0
  • MF: C88H131N3O23
  • MW: 1598.99
  • EINECS:
  • MDL Number:
  • Synonyms:Wortmannin-Rapamycin Conjugate;ATASUAOFUAOSAN-NVEIXTJJSA-N;Rapamycin, 42-[8-[(1E,4S,4aR,5R,6aS,7S,9aR)-5-(acetyloxy)-1-[[[3-(dimethylamino)propyl]methylamino]methylene]-1,2,4,4a,5,6,6a,7,8,9,9a,10-dodecahydro-11-hydroxy-4-(methoxymethyl)-4a,6a-dimethyl-2,10-dioxocyclopenta[5,6]naphtho[1,2-c]pyran-7-yl] octanedioate]
13 prices
Selected condition:
Brand
  • aablocks
  • AK Scientific
  • Cayman Chemical
  • ChemScene
Package
  • 500μg
  • 1mg
  • 5mg
  • 500??g
  • Manufactureraablocks
  • Product numberAA008SQ0
  • Product descriptionWortmannin-Rapamycin Conjugate ≥98%
  • Packaging5mg
  • Price$1325
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA008SQ0
  • Product descriptionWortmannin-Rapamycin Conjugate ≥98%
  • Packaging1mg
  • Price$317
  • Updated2026-05-28
  • Buy
  • ManufacturerAK Scientific
  • Product number1384EN
  • Product description8-O-[(1S,3Ar,6E,9S,9aR,10R,11aS)-10-acetyloxy-6-[[3-(dimethylamino)propyl-methylamino]methylidene]-5-hydroxy-9-(methoxymethyl)-9a,11a-dimethyl-4,7-dioxo-2,3,3a,9,10,11-hexahydro-1H-indeno[4,5-h]isochromen-1-yl]1-O-[(1R,2R,4S)-4-[(2R)-2-[(1R,9S,12S,15R,16Z,18R,19R,21R,23S,24Z,26Z,28Z,30S,32S,35R)-1,18-dihydroxy-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-2,3,10,14,20-pentaoxo-11,36-dioxa-4-azatricyclo[30.3.1.04,9]hexatriaconta-16,24,26,28-tetraen-12-yl]propyl]-2-methoxycyclohexyl]octanedioate
  • Packaging5mg
  • Price$1439
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number13671
  • Product descriptionWortmannin-Rapamycin Conjugate ≥98%
  • Packaging5mg
  • Price$1204
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number13671
  • Product descriptionWortmannin-Rapamycin Conjugate ≥98%
  • Packaging500μg
  • Price$152
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number13671
  • Product descriptionWortmannin-Rapamycin Conjugate ≥98%
  • Packaging500μg
  • Price$168
  • Updated2026-04-30
  • Buy
  • ManufacturerCayman Chemical
  • Product number13671
  • Product descriptionWortmannin-Rapamycin Conjugate ≥98%
  • Packaging1mg
  • Price$288
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number13671
  • Product descriptionWortmannin-Rapamycin Conjugate ≥98%
  • Packaging1mg
  • Price$317
  • Updated2026-04-30
  • Buy
  • ManufacturerCayman Chemical
  • Product number13671
  • Product descriptionWortmannin-Rapamycin Conjugate ≥98%
  • Packaging5mg
  • Price$1325
  • Updated2026-04-30
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0146636
  • Product descriptionWortmannin-Rapamycin Conjugate 1
  • Packaging500??g
  • Price$362
  • Updated2026-06-04
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0146636
  • Product descriptionWortmannin-Rapamycin Conjugate 1
  • Packaging500??g
  • Price$362
  • Updated2026-06-04
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0146636
  • Product descriptionWortmannin-Rapamycin Conjugate 1
  • Packaging1mg
  • Price$687
  • Updated2026-06-04
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0146636
  • Product descriptionWortmannin-Rapamycin Conjugate 1
  • Packaging1mg
  • Price$687
  • Updated2026-06-04
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
aablocks AA008SQ0 Wortmannin-Rapamycin Conjugate ≥98% 5mg $1325 2026-05-28 Buy
aablocks AA008SQ0 Wortmannin-Rapamycin Conjugate ≥98% 1mg $317 2026-05-28 Buy
AK Scientific 1384EN 8-O-[(1S,3Ar,6E,9S,9aR,10R,11aS)-10-acetyloxy-6-[[3-(dimethylamino)propyl-methylamino]methylidene]-5-hydroxy-9-(methoxymethyl)-9a,11a-dimethyl-4,7-dioxo-2,3,3a,9,10,11-hexahydro-1H-indeno[4,5-h]isochromen-1-yl]1-O-[(1R,2R,4S)-4-[(2R)-2-[(1R,9S,12S,15R,16Z,18R,19R,21R,23S,24Z,26Z,28Z,30S,32S,35R)-1,18-dihydroxy-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-2,3,10,14,20-pentaoxo-11,36-dioxa-4-azatricyclo[30.3.1.04,9]hexatriaconta-16,24,26,28-tetraen-12-yl]propyl]-2-methoxycyclohexyl]octanedioate 5mg $1439 2021-12-16 Buy
Cayman Chemical 13671 Wortmannin-Rapamycin Conjugate ≥98% 5mg $1204 2024-03-01 Buy
Cayman Chemical 13671 Wortmannin-Rapamycin Conjugate ≥98% 500μg $152 2024-03-01 Buy
Cayman Chemical 13671 Wortmannin-Rapamycin Conjugate ≥98% 500μg $168 2026-04-30 Buy
Cayman Chemical 13671 Wortmannin-Rapamycin Conjugate ≥98% 1mg $288 2024-03-01 Buy
Cayman Chemical 13671 Wortmannin-Rapamycin Conjugate ≥98% 1mg $317 2026-04-30 Buy
Cayman Chemical 13671 Wortmannin-Rapamycin Conjugate ≥98% 5mg $1325 2026-04-30 Buy
ChemScene CS-0146636 Wortmannin-Rapamycin Conjugate 1 500??g $362 2026-06-04 Buy
ChemScene CS-0146636 Wortmannin-Rapamycin Conjugate 1 500??g $362 2026-06-04 Buy
ChemScene CS-0146636 Wortmannin-Rapamycin Conjugate 1 1mg $687 2026-06-04 Buy
ChemScene CS-0146636 Wortmannin-Rapamycin Conjugate 1 1mg $687 2026-06-04 Buy

Properties

storage temp. :Store at -20°C
solubility :DMF: 30 mg/ml; DMSO: 20 mg/ml; Ethanol: 5 mg/ml
form :A crystalline solid

Safety Information

Symbol(GHS):
Signal word:
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
Precautionary statements:

Description

Phosphoinositide 3-kinase (PI3K) and mammalian target of rapamycin (mTOR) act synergistically in promoting cancer. Wortmannin is a potent inhibitor of PI3K enzymes, while rapamycin blocks mTOR Complex 1 TORC1. Wortmannin-rapamycin conjugate consists of analogs of 17-hydroxy wortmannin and rapamycin conjugated via a prodrug linker. Hydrolysis of the prodrug linker in vivo releases the inhibitors. The wortmannin-rapamycin conjugate inhibits the growth of HT-29 colon tumors and A498 renal tumors in mice better than rapamycin alone. Also, the conjugate, when given in combination with the VEGF-blocker bevacizumab, produces substantial regression of larger A498 tumors. Finally, the wortmannin-rapamycin conjugate is tolerated better than an equivalent mixture of the inhibitors.