1,1-Dimethylethyl-N-[(4-chlorophenyl)methyl]-N-[(5-nitro-2-thienyl)methyl])glycinate
![1,1-Dimethylethyl-N-[(4-chlorophenyl)methyl]-N-[(5-nitro-2-thienyl)methyl])glycinate price.](/CAS/GIF/1216744-19-2.gif)
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- $12 - $1440
- Product name: 1,1-Dimethylethyl-N-[(4-chlorophenyl)methyl]-N-[(5-nitro-2-thienyl)methyl])glycinate
- CAS: 1216744-19-2
- MF: C18H21ClN2O4S
- MW: 396.89
- EINECS:
- MDL Number:MFCD12912412
- Synonyms:1,1-Dimethylethyl-N-[(4-chlorophenyl)methyl]-N-[(5-nitro-2-thienyl)methyl])glycinate;GSK 4112;SR6452;GSK4112,SR6452;tert-Butyl2-((4-chlorobenzyl)((5-nitrothiophen-2-yl)methyl)amino)acetate;SR6452; SR-6452; SR 6452;tert-butyl N-(4-chlorobenzyl)-N-((5-nitrothiophen-2-yl)methyl)glycinate;SK4112
60 prices
Selected condition：
Brand
- aablocks
- ACHEMBLOCK
- AK Scientific
- Ambeed
- American Custom Chemicals Corporation
- ApexBio Technology
- Biorbyt Ltd
- Biosynth
- Cayman Chemical
- ChemScene
- Crysdot
- DC Chemicals
- Sigma-Aldrich
- Tocris
- TRC
- Usbiological
Package
- 5mg
- 50
- 1mg
- 25MG
- 10mM*1mLinDMSO
- 10mg
- 10
- 50mg
- 100mg
- 200mg
- 1mlx10mM(inDMSO)
- 250mg
- 1G
- 10 mg
- 10mM(in 1mL DMSO)
- 10mM(in1mLDMSO)
- Manufactureraablocks
- Product numberAA009CFD
- Product descriptiontert-butyl 2-((4-chlorobenzyl)((5-nitrothiophen-2-yl)methyl)amino)acetate 99%
- Packaging50mg
- Price$85
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA009CFD
- Product descriptiontert-butyl 2-((4-chlorobenzyl)((5-nitrothiophen-2-yl)methyl)amino)acetate ≥98%(HPLC)
- Packaging100mg
- Price$159
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA009CFD
- Product descriptiontert-butyl 2-((4-chlorobenzyl)((5-nitrothiophen-2-yl)methyl)amino)acetate 99%
- Packaging10mg
- Price$27
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA009CFD
- Product descriptiontert-butyl 2-((4-chlorobenzyl)((5-nitrothiophen-2-yl)methyl)amino)acetate 99%
- Packaging5mg
- Price$21
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA009CFD
- Product descriptiontert-butyl 2-((4-chlorobenzyl)((5-nitrothiophen-2-yl)methyl)amino)acetate 99%
- Packaging1mg
- Price$12
- Updated2026-05-28
- Buy
- ManufacturerACHEMBLOCK
- Product numberQ65757
- Product descriptiontert-butyl N-(4-chlorobenzyl)-N-((5-nitrothiophen-2-yl)methyl)glycinate 98%
- Packaging100MG
- Price$230
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberQ65757
- Product descriptiontert-butyl N-(4-chlorobenzyl)-N-((5-nitrothiophen-2-yl)methyl)glycinate 98%
- Packaging25MG
- Price$90
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberQ65757
- Product descriptiontert-butyl N-(4-chlorobenzyl)-N-((5-nitrothiophen-2-yl)methyl)glycinate 98%
- Packaging5MG
- Price$30
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberQ65757
- Product descriptiontert-butyl N-(4-chlorobenzyl)-N-((5-nitrothiophen-2-yl)methyl)glycinate 98%
- Packaging1G
- Price$730
- Updated2026-05-27
- Buy
- ManufacturerAK Scientific
- Product number4685DH
- Product descriptionTert-butyl2-[(4-chlorophenyl)methyl-[(5-nitrothiophen-2-yl)methyl]amino]acetate
- Packaging50mg
- Price$661
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA820682
- Product descriptionGSK4112 98+%
- Packaging1g
- Price$608
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA820682
- Product descriptionGSK4112 98+%
- Packaging50mg
- Price$101
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA820682
- Product descriptionGSK4112 98+%
- Packaging100mg
- Price$131
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA820682
- Product descriptionGSK4112 98+%
- Packaging1mg
- Price$25
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA820682
- Product descriptionGSK4112 98+%
- Packaging5mg
- Price$42
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA820682
- Product descriptionGSK4112 98+%
- Packaging10mg
- Price$60
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA009CFD | tert-butyl 2-((4-chlorobenzyl)((5-nitrothiophen-2-yl)methyl)amino)acetate 99% | 50mg | $85 | 2026-05-28 | Buy |
| aablocks | AA009CFD | tert-butyl 2-((4-chlorobenzyl)((5-nitrothiophen-2-yl)methyl)amino)acetate ≥98%(HPLC) | 100mg | $159 | 2026-05-28 | Buy |
| aablocks | AA009CFD | tert-butyl 2-((4-chlorobenzyl)((5-nitrothiophen-2-yl)methyl)amino)acetate 99% | 10mg | $27 | 2026-05-28 | Buy |
| aablocks | AA009CFD | tert-butyl 2-((4-chlorobenzyl)((5-nitrothiophen-2-yl)methyl)amino)acetate 99% | 5mg | $21 | 2026-05-28 | Buy |
| aablocks | AA009CFD | tert-butyl 2-((4-chlorobenzyl)((5-nitrothiophen-2-yl)methyl)amino)acetate 99% | 1mg | $12 | 2026-05-28 | Buy |
| ACHEMBLOCK | Q65757 | tert-butyl N-(4-chlorobenzyl)-N-((5-nitrothiophen-2-yl)methyl)glycinate 98% | 100MG | $230 | 2026-05-27 | Buy |
| ACHEMBLOCK | Q65757 | tert-butyl N-(4-chlorobenzyl)-N-((5-nitrothiophen-2-yl)methyl)glycinate 98% | 25MG | $90 | 2026-05-27 | Buy |
| ACHEMBLOCK | Q65757 | tert-butyl N-(4-chlorobenzyl)-N-((5-nitrothiophen-2-yl)methyl)glycinate 98% | 5MG | $30 | 2026-05-27 | Buy |
| ACHEMBLOCK | Q65757 | tert-butyl N-(4-chlorobenzyl)-N-((5-nitrothiophen-2-yl)methyl)glycinate 98% | 1G | $730 | 2026-05-27 | Buy |
| AK Scientific | 4685DH | Tert-butyl2-[(4-chlorophenyl)methyl-[(5-nitrothiophen-2-yl)methyl]amino]acetate | 50mg | $661 | 2021-12-16 | Buy |
| Ambeed | A820682 | GSK4112 98+% | 1g | $608 | 2021-12-16 | Buy |
| Ambeed | A820682 | GSK4112 98+% | 50mg | $101 | 2021-12-16 | Buy |
| Ambeed | A820682 | GSK4112 98+% | 100mg | $131 | 2021-12-16 | Buy |
| Ambeed | A820682 | GSK4112 98+% | 1mg | $25 | 2021-12-16 | Buy |
| Ambeed | A820682 | GSK4112 98+% | 5mg | $42 | 2021-12-16 | Buy |
| Ambeed | A820682 | GSK4112 98+% | 10mg | $60 | 2021-12-16 | Buy |
Properties
Melting point :95 - 96°C
Boiling point :486.7±45.0 °C(Predicted)
Density :1.296±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :Chloroform (Slightly), Methanol (Slightly, Heated)
pka :3.87±0.50(Predicted)
form :powder
color :off-white to tan
InChI :1S/C18H21ClN2O4S/c1-18(2,3)25-17(22)12-20(10-13-4-6-14(19)7-5-13)11-15-8-9-16(26-15)21(23)24/h4-9H,10-12H2,1-3H3
InChIKey :WYSLOKHVFKLWOU-UHFFFAOYSA-N
SMILES :CC(C)(C)OC(=O)CN(Cc1ccc(Cl)cc1)Cc2ccc(s2)[N+]([O-])=O
Boiling point :486.7±45.0 °C(Predicted)
Density :1.296±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :Chloroform (Slightly), Methanol (Slightly, Heated)
pka :3.87±0.50(Predicted)
form :powder
color :off-white to tan
InChI :1S/C18H21ClN2O4S/c1-18(2,3)25-17(22)12-20(10-13-4-6-14(19)7-5-13)11-15-8-9-16(26-15)21(23)24/h4-9H,10-12H2,1-3H3
InChIKey :WYSLOKHVFKLWOU-UHFFFAOYSA-N
SMILES :CC(C)(C)OC(=O)CN(Cc1ccc(Cl)cc1)Cc2ccc(s2)[N+]([O-])=O
Safety Information
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| Signal word: | Danger | |||||||||||||||||||||
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Description
REV-ERBα is a nuclear hormone receptor with roles in circadian rhythm, adipogenesis, lipid metabolism, and inflammation. It binds porphoryin heme and in response to fluctuations in heme levels in cells it recruits corepressors such as NCoR and HDAC3 to repress the transcription of key genes involved in metabolic and circadian pathways. GSK4112 is a synthetic agonist for REV-ERBα (EC50 = 0.4 μM) that was designed to mimic the action of heme. At 10 μM, GSK4112 can reset the circadian rhythm in a phasic manner by inhibiting expression of the circadian target gene bmal1 and reduce glucose output by 30% in mouse primary hepatocytes by repressing the expression of several gluconeogenic genes. GSK4112 has been used to investigate the function of REV-ERBα in the coordination of circadian rhythm and metabolism in rat ovaries.More related product prices
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