Latanoprost (free acid)-d4

$44 - $1940
Product name: Latanoprost (free acid)-d4
CAS: 1224443-47-3
MF: C23H30D4O5
MW: 394.537707112
EINECS:
MDL Number:
Synonyms:Latanoprost (free acid)-d4;HNPFPERDNWXAGS-GPPKKVIBSA-N;Latanoprost Acid-d4;[2H4]-Latanoprost Acid;Latanoprost EP Impurity H-d4 (Latanoprost USP Related Compound E-d4)

Price6 Properties Safety Information Description

6 prices

Selected condition：

Brand

AK Scientific
Cayman Chemical
TRC

Package

50μg
100μg
500μg
1mg
10mg

ManufacturerAK Scientific
Product number1202EL
Product description(Z)-3,3,4,4-Tetradeuterio-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl]hept-5-enoicacid
Packaging1mg
Price$770
Updated2021-12-16
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ManufacturerCayman Chemical
Product number316811
Product descriptionLatanoprost (free acid)-d4 ≥99% deuterated forms (d1-d4)
Packaging50μg
Price$44
Updated2024-03-01
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ManufacturerCayman Chemical
Product number316811
Product descriptionLatanoprost (free acid)-d4 ≥99% deuterated forms (d1-d4)
Packaging100μg
Price$84
Updated2024-03-01
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ManufacturerCayman Chemical
Product number316811
Product descriptionLatanoprost (free acid)-d4 ≥99% deuterated forms (d1-d4)
Packaging500μg
Price$341
Updated2024-03-01
Buy

ManufacturerCayman Chemical
Product number316811
Product descriptionLatanoprost (free acid)-d4 ≥99% deuterated forms (d1-d4)
Packaging1mg
Price$603
Updated2024-03-01
Buy

ManufacturerTRC
Product numberL177312
Product descriptionLatanoprostAcid-d4
Packaging10mg
Price$1940
Updated2021-12-16
Buy

Manufacturer	Product number	Product description	Packaging	Price	Updated	Buy
AK Scientific	1202EL	(Z)-3,3,4,4-Tetradeuterio-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl]hept-5-enoicacid	1mg	$770	2021-12-16	Buy
Cayman Chemical	316811	Latanoprost (free acid)-d4 ≥99% deuterated forms (d1-d4)	50μg	$44	2024-03-01	Buy
Cayman Chemical	316811	Latanoprost (free acid)-d4 ≥99% deuterated forms (d1-d4)	100μg	$84	2024-03-01	Buy
Cayman Chemical	316811	Latanoprost (free acid)-d4 ≥99% deuterated forms (d1-d4)	500μg	$341	2024-03-01	Buy
Cayman Chemical	316811	Latanoprost (free acid)-d4 ≥99% deuterated forms (d1-d4)	1mg	$603	2024-03-01	Buy
TRC	L177312	LatanoprostAcid-d4	10mg	$1940	2021-12-16	Buy

Properties

storage temp. :Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility :Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
form :Oil to Gel
color :Colorless.

Safety Information

Symbol(GHS):

Signal word:

Danger

Hazard statements:

Code	Hazard statements	Hazard class	Category	Signal word	P-Codes
H225	Highly Flammable liquid and vapour	Flammable liquids	Category 2	Danger	P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H319	Causes serious eye irritation	Serious eye damage/eye irritation	Category 2A	Warning	P264, P280, P305+P351+P338,P337+P313P
H336	May cause drowsiness or dizziness	Specific target organ toxicity,single exposure; Narcotic effects	Category 3	Warning	P261, P271, P304+P340, P312,P403+P233, P405, P501

Precautionary statements:

P210	Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P240	Ground/bond container and receiving equipment.
P241	Use explosion-proof electrical/ventilating/lighting/…/equipment.
P242	Use only non-sparking tools.
P243	Take precautionary measures against static discharge.
P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P264	Wash hands thoroughly after handling.
P264	Wash skin thouroughly after handling.
P271	Use only outdoors or in a well-ventilated area.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304+P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P337+P313	IF eye irritation persists: Get medical advice/attention.
P370+P378	In case of fire: Use … for extinction.
P403+P233	Store in a well-ventilated place. Keep container tightly closed.
P403+P235	Store in a well-ventilated place. Keep cool.
P405	Store locked up.
P501	Dispose of contents/container to..…

Description

Latanoprost (free acid)-d4 (Lat-FA-d4) contains four deuterium atoms at the 3, 3, 4, and 4 positions. It is intended for use as an internal standard for the quantification of Lat-FA by GC- or LC-mass spectrometry. Latanoprost is an F-series prostaglandin (PG) analog which has been approved for use as an ocular hypotensive drug. It is the isopropyl ester of a PGF2α analog containing an aromatic group (17-phenyl) in the ω-chain. As an isopropyl ester, latanoprost acts as a prodrug which is converted to Lat-FA by endogenous esterase enzymes. Lat-FA is a potent FP receptor agonist with an EC50 value of 3.6 nM for human FP receptors, which is twice the potency of PGF2α and more than 200 times more potent latanoprost. The efficacy of PG analog esters for the treatment of glaucoma correlates closely with the FP receptor binding affinity of the free acid. However, Lat-FA is more irritating and less effective than the prodrug latanoprost when applied directly to the eyes of human glaucoma patients.

Suppliers and manufacturers

Shanghai EFE Biological Technology Co., Ltd. Hangzhou Synstar pharmaceutical Technology CO.,Ltd ChemeGen(Shanghai) Biotechnology Co.,Ltd. Hubei Qingbei Yunyan Pharmaceutical Technology Co., Ltd Henan Vcommend Consultrading Co., Ltd.

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