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ChemicalBook >> CAS DataBase List >> 3-[3-(4-Methoxyphenyl)-1-oxo-2-propen-1-yl]-4-phenyl-2(1H)-quinolinone

3-[3-(4-Methoxyphenyl)-1-oxo-2-propen-1-yl]-4-phenyl-2(1H)-quinolinone

3-[3-(4-Methoxyphenyl)-1-oxo-2-propen-1-yl]-4-phenyl-2(1H)-quinolinone price.
  • $57 - $1440
  • Product name: 3-[3-(4-Methoxyphenyl)-1-oxo-2-propen-1-yl]-4-phenyl-2(1H)-quinolinone
  • CAS: 1402830-75-4
  • MF: C25H19NO3
  • MW: 381.42
  • EINECS:802-692-7
  • MDL Number:MFCD25977826
  • Synonyms:3-[3-(4-Methoxyphenyl)-1-oxo-2-propen-1-yl]-4-phenyl-2(1H)-quinolinone;3-[3-(4-Methoxyphenyl)-1-oxo-2-propenyl]-4-phenyl-2(1H)-quinolinone;2(1H)-Quinolinone, 3-[3-(4-methoxyphenyl)-1-oxo-2-propen-1-yl]-4-phenyl-;Ceranib-2 >=98% (HPLC);Ceranib-2, 10 mM in DMSO;3-[(2E)-3-(4-Methoxyphenyl)prop-2-enoyl]-4-phenyl-1,2-dihydroquinolin-2-one
Price33 Properties Safety Information Description
33 prices
Selected condition：
Brand
  • aablocks
  • ACHEMBLOCK
  • ApexBio Technology
  • Arctom
  • Biosynth
  • Cayman Chemical
  • ChemScene
  • Sigma-Aldrich
Package
  • 10mM*1mLinDMSO(Solid+Solvent)
  • 5mg
  • 10mg
  • 10mM*1mLinDMSO(Solution)
  • 25mg
  • 50mg
  • 100MG
  • Manufactureraablocks
  • Product numberAA009YBR
  • Product descriptionCeranib-2
  • Packaging5mg
  • Price$58
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA009YBR
  • Product descriptionCeranib-2
  • Packaging10mg
  • Price$92
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA009YBR
  • Product descriptionCeranib-2
  • Packaging25mg
  • Price$172
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA009YBR
  • Product descriptionCeranib-2
  • Packaging50mg
  • Price$271
  • Updated2026-05-28
  • Buy
  • ManufacturerACHEMBLOCK
  • Product numberY225970
  • Product descriptionCeranib-2 97.00%
  • Packaging100MG
  • Price$615
  • Updated2026-05-27
  • Buy
  • ManufacturerACHEMBLOCK
  • Product numberY225970
  • Product descriptionCeranib-2 97.00%
  • Packaging25MG
  • Price$225
  • Updated2026-05-27
  • Buy
  • ManufacturerApexBio Technology
  • Product numberC3649
  • Product descriptionCeranib-2
  • Packaging50mg
  • Price$930
  • Updated2026-05-06
  • Buy
  • ManufacturerApexBio Technology
  • Product numberC3649
  • Product descriptionCeranib-2
  • Packaging25mg
  • Price$527
  • Updated2026-05-06
  • Buy
  • ManufacturerApexBio Technology
  • Product numberC3649
  • Product descriptionCeranib-2
  • Packaging5mg
  • Price$121
  • Updated2026-05-06
  • Buy
  • ManufacturerApexBio Technology
  • Product numberC3649
  • Product descriptionCeranib-2
  • Packaging10mg
  • Price$224
  • Updated2026-05-06
  • Buy
  • ManufacturerArctom
  • Product numberHY-116147
  • Product descriptionCeranib-2 98.92%
  • Packaging5mg
  • Price$57
  • Updated2026-05-26
  • Buy
  • ManufacturerArctom
  • Product numberHY-116147
  • Product descriptionCeranib-2 98.92%
  • Packaging25mg
  • Price$219
  • Updated2026-05-26
  • Buy
  • ManufacturerArctom
  • Product numberHY-116147
  • Product descriptionCeranib-2 98.92%
  • Packaging10mg
  • Price$105
  • Updated2026-05-26
  • Buy
  • ManufacturerArctom
  • Product numberHY-116147
  • Product descriptionCeranib-2 98.92%
  • Packaging10mM*1mLinDMSO(Solid+Solvent)
  • Price$60
  • Updated2026-05-26
  • Buy
  • ManufacturerArctom
  • Product numberHY-116147
  • Product descriptionCeranib-2 98.92%
  • Packaging10mM*1mLinDMSO(Solution)
  • Price$63
  • Updated2026-05-26
  • Buy
  • ManufacturerArctom
  • Product numberHY-116147
  • Product descriptionCeranib-2 98.92%
  • Packaging50mg
  • Price$361
  • Updated2026-05-26
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
aablocks AA009YBR Ceranib-2 5mg $58 2026-05-28 Buy
aablocks AA009YBR Ceranib-2 10mg $92 2026-05-28 Buy
aablocks AA009YBR Ceranib-2 25mg $172 2026-05-28 Buy
aablocks AA009YBR Ceranib-2 50mg $271 2026-05-28 Buy
ACHEMBLOCK Y225970 Ceranib-2 97.00% 100MG $615 2026-05-27 Buy
ACHEMBLOCK Y225970 Ceranib-2 97.00% 25MG $225 2026-05-27 Buy
ApexBio Technology C3649 Ceranib-2 50mg $930 2026-05-06 Buy
ApexBio Technology C3649 Ceranib-2 25mg $527 2026-05-06 Buy
ApexBio Technology C3649 Ceranib-2 5mg $121 2026-05-06 Buy
ApexBio Technology C3649 Ceranib-2 10mg $224 2026-05-06 Buy
Arctom HY-116147 Ceranib-2 98.92% 5mg $57 2026-05-26 Buy
Arctom HY-116147 Ceranib-2 98.92% 25mg $219 2026-05-26 Buy
Arctom HY-116147 Ceranib-2 98.92% 10mg $105 2026-05-26 Buy
Arctom HY-116147 Ceranib-2 98.92% 10mM*1mLinDMSO(Solid+Solvent) $60 2026-05-26 Buy
Arctom HY-116147 Ceranib-2 98.92% 10mM*1mLinDMSO(Solution) $63 2026-05-26 Buy
Arctom HY-116147 Ceranib-2 98.92% 50mg $361 2026-05-26 Buy
Next Last

Properties

Melting point :228-230 °C(Solvent: Ethanol)
Boiling point :629.248±55.00 °C(Press: 760.00 Torr)(predicted)
Density :1.245±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
storage temp. :-20°C
solubility :DMSO: soluble20mg/mL, clear
form :powder
pka :10.189±0.70(predicted)
color :white to beige

Safety Information

Symbol(GHS): Exclamation Mark (GHS07)
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
H413 May cause long lasting harmful effects to aquatic life Hazardous to the aquatic environment, long-term hazard Category 4
Precautionary statements:
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P330 Rinse mouth.
P501 Dispose of contents/container to..…

Description

Ceramidase catalyzes the hydrolysis of the N-acyl linkage between the fatty acid and sphingosine base in ceramide to produce sphingosine and a free fatty acid. It plays a critical role in regulating cell fate and its inhibition in both malignant and non-cancerous cells leads to apoptosis. Ceranib-2 is a non-lipid inhibitor of cellular ceramidase activity that demonstates an IC50 of 28 μM in a cell-based assay. At 3.125 μM, Ceranib-2 increased the accumulation of endogenous ceramide species by 109% compared to controls and dose-dependently decreased intracellular levels of sphingosine and sphingosine-1-phosphate. Ceranib-2 inhibited cell proliferation of SKOV3 ovarian cancer cells with an IC50 value of 0.71 μM and had additive effects on cell proliferation when combined with paclitaxel. In vivo, Ceranib-2 at 20-50 mg/kg supresses tumor growth in a syngeneic tumor model without noticeable toxicity.

Suppliers and manufacturers

TargetMol Chemicals Inc.
Ceranib-2
$47.00
Ceranib-2 CAS:1402830-75-4
DKMbiochem.Co. Ltd BOC Sciences Shanghai EFE Biological Technology Co., Ltd. Shanghai YuanYe Biotechnology Co., Ltd. BOC Sciences ChemeGen(Shanghai) Biotechnology Co.,Ltd. MedBioPharmaceutical Technology Inc Energy Chemical Beijing Jin Ming Biotechnology Co., Ltd.