Carbonic Anhydrase IX/XII Inhibitor II(U-104)
|
- $48 - $2491
- Product name: Carbonic Anhydrase IX/XII Inhibitor II(U-104)
- CAS: 178606-66-1
- MF: C13H12FN3O3S
- MW: 309.32
- EINECS:
- MDL Number:MFCD00159265
- Synonyms:NSC 213841;Carbonic Anhydrase IX/XII Inhibitor II(U-104);U-104;MST-104 ;4-[[[(4-Fluorophenyl)amino]carbonyl]amino]benzenesulfonamide;U104/NSC 213841/MST104;U-104;NSC 213841;U 104;4-[[[(4-Fluorophenyl)aMino]carbonyl]aMino]-benzenesulfonaMide, NSC 213841
37 prices
Selected condition：
Brand
- AK Scientific
- Ambeed
- American Custom Chemicals Corporation
- ApexBio Technology
- Biorbyt Ltd
- Cayman Chemical
- ChemScene
- Crysdot
- CSNpharm
- DC Chemicals
- Sigma-Aldrich
- Tocris
- TRC
- Usbiological
Package
- 10μg
- 10
- 250mg
- 500mg
- 25μL
- 100μL
- 50
- 5mg
- 10mg
- 25mg
- 1g
- 50mg
- 100mg
- 10mM(in 1mL DMSO)
- ManufacturerAK Scientific
- Product numberX5935
- Product descriptionU-104
- Packaging5mg
- Price$116
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberX5935
- Product descriptionU-104
- Packaging10mg
- Price$130
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberX5935
- Product descriptionU-104
- Packaging25mg
- Price$211
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA112487
- Product descriptionU-104 98+%
- Packaging5mg
- Price$104
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA112487
- Product descriptionU-104 98+%
- Packaging10mg
- Price$134
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA112487
- Product descriptionU-104 98+%
- Packaging50mg
- Price$226
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA112487
- Product descriptionU-104 98+%
- Packaging100mg
- Price$293
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA112487
- Product descriptionU-104 98+%
- Packaging1g
- Price$2491
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0014180
- Product descriptionU-104 99.00%
- Packaging5MG
- Price$174.9
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4358
- Product descriptionU-104
- Packaging10mg
- Price$50
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4358
- Product descriptionU-104
- Packaging10mM(in 1mL DMSO)
- Price$50
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4358
- Product descriptionU-104
- Packaging25mg
- Price$105
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4358
- Product descriptionU-104
- Packaging50mg
- Price$190
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb600662
- Product descriptionDNAJA4
- Packaging10μg
- Price$290.7
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb600661
- Product descriptionDNAJA4
- Packaging10μg
- Price$290.7
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number16717
- Product descriptionU-104 ≥98%
- Packaging5mg
- Price$48
- Updated2024-03-01
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | X5935 | U-104 | 5mg | $116 | 2021-12-16 | Buy |
| AK Scientific | X5935 | U-104 | 10mg | $130 | 2021-12-16 | Buy |
| AK Scientific | X5935 | U-104 | 25mg | $211 | 2021-12-16 | Buy |
| Ambeed | A112487 | U-104 98+% | 5mg | $104 | 2021-12-16 | Buy |
| Ambeed | A112487 | U-104 98+% | 10mg | $134 | 2021-12-16 | Buy |
| Ambeed | A112487 | U-104 98+% | 50mg | $226 | 2021-12-16 | Buy |
| Ambeed | A112487 | U-104 98+% | 100mg | $293 | 2021-12-16 | Buy |
| Ambeed | A112487 | U-104 98+% | 1g | $2491 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0014180 | U-104 99.00% | 5MG | $174.9 | 2021-12-16 | Buy |
| ApexBio Technology | A4358 | U-104 | 10mg | $50 | 2021-12-16 | Buy |
| ApexBio Technology | A4358 | U-104 | 10mM(in 1mL DMSO) | $50 | 2021-12-16 | Buy |
| ApexBio Technology | A4358 | U-104 | 25mg | $105 | 2021-12-16 | Buy |
| ApexBio Technology | A4358 | U-104 | 50mg | $190 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb600662 | DNAJA4 | 10μg | $290.7 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb600661 | DNAJA4 | 10μg | $290.7 | 2021-12-16 | Buy |
| Cayman Chemical | 16717 | U-104 ≥98% | 5mg | $48 | 2024-03-01 | Buy |
Properties
Melting point :242-243℃
Density :1.523±0.06 g/cm3 (20 ºC 760 Torr)
storage temp. :2-8°C
solubility :DMSO: >15mg/mL
form :powder
pka :9.94±0.12(Predicted)
color :white to beige
Density :1.523±0.06 g/cm3 (20 ºC 760 Torr)
storage temp. :2-8°C
solubility :DMSO: >15mg/mL
form :powder
pka :9.94±0.12(Predicted)
color :white to beige
Safety Information
| Symbol(GHS): |
|
|||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal word: | Warning | |||||||||||||||||||||||||||||||||||
| Hazard statements: |
|
|||||||||||||||||||||||||||||||||||
| Precautionary statements: |
|
Description
Carbonic anhydrases are zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide to form bicarbonate ion plus a proton. Carbonic anhydrases IX (CAIX) and CAXII are hypoxia and HIF-1-inducible proteins located in cellular transmembranes that regulate intra- and extracellular pH under hypoxic conditions and promote tumor cell survival and invasion in hypoxic microenvironments. U-104 is a ureido-sulfonamide inhibitor of transmembrane CAIX (Ki = 45.1 nM) and CAXII (Ki = 4.5 nM). It demonstrates reduced affinity for the cytosolic isoforms, CAI and CAII (Kis = 5.08 and 9.64 μM, respectively). U-104 associates with CAIX/CAXII only under hypoxic conditions in vivo, reducing extracellular acidity and resulting in significant inhibition of tumor growth and metastasis in experimental models.More related product prices
Crenolanib 779353-01-4 Erlotinib hydrochloride Tozasertib Gefitinib AZD-4547Related product price
- Crenolanib
$45-5045 - 779353-01-4
$28-3728.1 - Erlotinib hydrochloride
$5-3498.6
