Methyl (4-bromobenzoyl)-L-cysteinate
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- $346 - $1700
- Product name: Methyl (4-bromobenzoyl)-L-cysteinate
- CAS: 1947408-74-3
- MF: C11H12BrNO3S
- MW: 318.19
- EINECS:
- MDL Number:
- Synonyms:Methyl (4-bromobenzoyl)-L-cysteinate;pharmacophore,inhibit,Cysteine thiol probe,products,enone-based,chromophore,thiol-based,electrophilic,Inhibitor,l-cystine,Natural;L-Cysteine, N-(4-bromobenzoyl)-, methyl ester
2 prices
Selected condition：
Brand
- DC Chemicals
- Sigma-Aldrich
Package
- 100mg
- 003
- ManufacturerDC Chemicals
- Product number012836
- Product descriptionCysteinethiolprobe
- Packaging003
- Price$1700
- Updated2021-12-16
- Buy
- ManufacturerSigma-Aldrich
- Product number907243
- Product descriptionMethyl (4-bromobenzoyl)-L-cysteinate ≥95%
- Packaging100mg
- Price$346
- Updated2023-06-20
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| DC Chemicals | 012836 | Cysteinethiolprobe | 003 | $1700 | 2021-12-16 | Buy |
| Sigma-Aldrich | 907243 | Methyl (4-bromobenzoyl)-L-cysteinate ≥95% | 100mg | $346 | 2023-06-20 | Buy |
Properties
Boiling point :465.2±45.0 °C(Predicted)
Density :1.491±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: 250 mg/mL (785.69 mM)
pka :9.05±0.10(Predicted)
Density :1.491±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: 250 mg/mL (785.69 mM)
pka :9.05±0.10(Predicted)
Safety Information
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Description
Methyl (4-bromobenzoyl)-L-cysteinate is a chemoselective thiol probe for detection of electrophilic metabolites. As it is often difficult to isolate low-abundance natural products from extracts, metabolities with bioactivity or therapeutic potential may be missed. Castro-Falcón, et al developed a reactivity-guided approach using thiolate probes to discover electrophilic natural products - a cysteine-based probe and thiophenol-based probe. Both consist of- A chemoselective reagent for covalent reactivity with a pharmacophore,
- A conspicuous UV/VIS or mass spectrometric (MS) tag,
- A linker between the tag and reagent. Methyl (4-bromobenzoyl)-L-cysteinate contains a bromine MS tag and phenyl bromide UV tag that was demonstrated to chemoselectively label enone-, β-lactam-, and β-lactone-based natural products.
Complementarily, a thiophenol probe (cat# 125237) with a chlorine MS tag and phenyl chloride UV tag labeled epoxide-based natural products. These probes can be used in diverse extracts (bacterial, fungal, plant) to chemically faciliate access to high-value metabolites.
Suppliers and manufacturers
Zhejiang J&C Biological Technology Co.,Limited
TargetMol Chemicals Inc.
Sigma-Aldrich
ShangHai Biochempartner Co.,Ltd
Luan lingxi Chemical Products Co., Ltd
DC Chemicals
Changzhou Xuanye Technology Co., Ltd
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Shanghai hongqu biomedical technology co. LTD
Chunchuang (Wuhan) Technology Co., Ltd