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ChemicalBook >> CAS DataBase List >> 3-METHYLADENINE

3-METHYLADENINE

3-METHYLADENINE price.
  • $20 - $1890
  • Product name: 3-METHYLADENINE
  • CAS: 5142-23-4
  • MF: C6H7N5
  • MW: 149.15
  • EINECS:225-908-6
  • MDL Number:MFCD00010531
  • Synonyms:3H-Purin-6-amine, 3-methyl-;3-methyl-3h-purin-6-amin ;3-Methyl-3H-purin-6-amine;3-methyl-adenin ;Adenine, 3-methyl-;3-METHYLADENINE;3-methyl-3H-adenine ;6-AMINO-3-METHYLPURINE
46 prices
Selected condition:

Brand

  • Adipogen Life Sciences
  • AHH
  • AK Scientific
  • Alfa Aesar
  • ApexBio Technology
  • Apolloscientific
  • Arctom
  • AvaChem
  • Biorbyt Ltd
  • Cayman Chemical
  • Chemenu
  • ChemScene
  • Crysdot
  • CSNpharm
  • DC Chemicals
  • Medical Isotopes, Inc.
  • Sigma-Aldrich
  • SynQuest Laboratories
  • TCI Chemical
  • Tocris
  • TRC
  • Usbiological

Package

  • 20mg
  • 25mg
  • 10mg
  • 50
  • 10mM(in 1mL DMSO)
  • 50mg
  • 100mg
  • 200mg
  • 250mg
  • 0.5g
  • 500mg
  • 1000mg
  • 1g
  • 5g
  • 10g
  • ManufacturerAdipogen Life Sciences
  • Product numberCDX-M0203-M025
  • Product description3-Methyladenine ≥98%(HPLC)
  • Packaging25mg
  • Price$41
  • Updated2021-12-16
  • Buy
  • ManufacturerAHH
  • Product numberMT-17316
  • Product description3-Methyladenine 98%
  • Packaging0.5g
  • Price$298
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberX5709
  • Product description3-Methyladenine
  • Packaging25mg
  • Price$33
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberJ11161
  • Product descriptionAutophagy Inhibitor, 3-MA
  • Packaging100mg
  • Price$95
  • Updated2021-12-16
  • Buy
  • ManufacturerAlfa Aesar
  • Product numberJ64813
  • Product descriptionAutophagy Inhibitor, 3-MA
  • Packaging25mg
  • Price$66.3
  • Updated2023-06-20
  • Buy
  • ManufacturerAlfa Aesar
  • Product numberJ64813
  • Product descriptionAutophagy Inhibitor, 3-MA
  • Packaging50mg
  • Price$111
  • Updated2023-06-20
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA8353
  • Product description3-Methyladenine
  • Packaging50mg
  • Price$50
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA8353
  • Product description3-Methyladenine
  • Packaging10mM(in 1mL DMSO)
  • Price$50
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA8353
  • Product description3-Methyladenine
  • Packaging200mg
  • Price$120
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA8353
  • Product description3-Methyladenine
  • Packaging500mg
  • Price$240
  • Updated2021-12-16
  • Buy
  • ManufacturerApolloscientific
  • Product numberOR470734
  • Product description3-Methyladenine
  • Packaging10mg
  • Price$27
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS016753
  • Product description3-Methyl-3H-purin-6-amine ≥98%
  • Packaging50mg
  • Price$20
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS016753
  • Product description3-Methyl-3H-purin-6-amine ≥98%
  • Packaging100mg
  • Price$25
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS016753
  • Product description3-Methyl-3H-purin-6-amine ≥98%
  • Packaging250mg
  • Price$34
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberCFN60037
  • Product description3-Methyladenine ≥98%
  • Packaging20mg
  • Price$50
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS016753
  • Product description3-Methyl-3H-purin-6-amine ≥98%
  • Packaging1g
  • Price$60
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Adipogen Life Sciences CDX-M0203-M025 3-Methyladenine ≥98%(HPLC) 25mg $41 2021-12-16 Buy
AHH MT-17316 3-Methyladenine 98% 0.5g $298 2021-12-16 Buy
AK Scientific X5709 3-Methyladenine 25mg $33 2021-12-16 Buy
AK Scientific J11161 Autophagy Inhibitor, 3-MA 100mg $95 2021-12-16 Buy
Alfa Aesar J64813 Autophagy Inhibitor, 3-MA 25mg $66.3 2023-06-20 Buy
Alfa Aesar J64813 Autophagy Inhibitor, 3-MA 50mg $111 2023-06-20 Buy
ApexBio Technology A8353 3-Methyladenine 50mg $50 2021-12-16 Buy
ApexBio Technology A8353 3-Methyladenine 10mM(in 1mL DMSO) $50 2021-12-16 Buy
ApexBio Technology A8353 3-Methyladenine 200mg $120 2021-12-16 Buy
ApexBio Technology A8353 3-Methyladenine 500mg $240 2021-12-16 Buy
Apolloscientific OR470734 3-Methyladenine 10mg $27 2021-12-16 Buy
Arctom AS016753 3-Methyl-3H-purin-6-amine ≥98% 50mg $20 2021-12-16 Buy
Arctom AS016753 3-Methyl-3H-purin-6-amine ≥98% 100mg $25 2021-12-16 Buy
Arctom AS016753 3-Methyl-3H-purin-6-amine ≥98% 250mg $34 2021-12-16 Buy
Arctom CFN60037 3-Methyladenine ≥98% 20mg $50 2021-12-16 Buy
Arctom AS016753 3-Methyl-3H-purin-6-amine ≥98% 1g $60 2021-12-16 Buy

Properties

Melting point :~300 °C (dec.)(lit.)
Boiling point :240℃
Density :1.60
refractive index :1.8070 (estimate)
Flash point :99℃
storage temp. :Keep in dark place,Sealed in dry,Room Temperature
solubility :Soluble in DMSO (up to 3 mg/ml), or in DMF (up to 10 mg/ml).
pka :6.77±0.20(Predicted)
form :Powder
color :White
BRN :146087
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or DMF may be stored at -20° for up to 3 months.

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
Precautionary statements:
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313 IF SKIN irritation occurs: Get medical advice/attention.
P337+P313 IF eye irritation persists: Get medical advice/attention.
P403 Store in a well-ventilated place.

Description

Autophagy is a multi-step process that involves the degradation and digestion of intracellular components by the lysosome. This process allows cells to efficiently mobilize and recycle cellular constituents, and also prevents the accumulation of damaged organelles, misfolded proteins, and invading microorganisms. mTOR, whose activation is controlled by phosphoinositide 3-kinase (PI3K), is a key regulator of autophagy. 3-Methyladenine (3-MA) is a specific inhibitor of PI3K activity and one of the most widely used inhibitors of the initial phase of the autophagic process: the sequestering of cytoplasmic material by the lysosome. At 5 mM, 3-MA inhibits protein degradation in rat hepatocytes by 65%. 3-MA has been shown to block class I, class II, and class III PI3Ks, including some downstream targets, and to suppress the invasion of highly metastatic human fibrosarcoma HT1080 cells at 10 mM.

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