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ChemicalBook >> CAS DataBase List >> N-(dibenzo[b,d]furan-3-yl)-5-nitrofuran-2-carboxamide

N-(dibenzo[b,d]furan-3-yl)-5-nitrofuran-2-carboxamide

N-(dibenzo[b,d]furan-3-yl)-5-nitrofuran-2-carboxamide price.
  • $32 - $1190
  • Product name: N-(dibenzo[b,d]furan-3-yl)-5-nitrofuran-2-carboxamide
  • CAS: 329198-87-0
  • MF: C17H10N2O5
  • MW: 322.27
  • EINECS:-0
  • MDL Number:
  • Synonyms:N-(dibenzo[b,d]furan-3-yl)-5-nitrofuran-2-carboxamide;C-178;N-(3-Dibenzofuranyl)-5-nitro-2-furancarboxamide;2-Furancarboxamide, N-3-dibenzofuranyl-5-nitro-;MITA,inhibit,Inhibitor,STING,MPYS,C178,ERIS,C-178,C 178,Stimulator of Interferon Genes,TMEM173
15 prices
Selected condition:
Brand
  • AK Scientific
  • Cayman Chemical
  • ChemScene
  • DC Chemicals
  • Sigma-Aldrich
  • TRC
Package
  • 5mg
  • 10mg
  • 25mg
  • 50mg
  • 100mg
  • 250mg
  • 1g
  • ManufacturerAK Scientific
  • Product number3619CJ
  • Product descriptionSTINGinhibitorC-178
  • Packaging10mg
  • Price$164
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product number3619CJ
  • Product descriptionSTINGinhibitorC-178
  • Packaging5mg
  • Price$133
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number25860
  • Product descriptionC-178
  • Packaging5mg
  • Price$32
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number25860
  • Product descriptionC-178
  • Packaging10mg
  • Price$61
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number25860
  • Product descriptionC-178
  • Packaging25mg
  • Price$139
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number25860
  • Product descriptionC-178
  • Packaging50mg
  • Price$230
  • Updated2024-03-01
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0087693
  • Product descriptionC-178 99.90%
  • Packaging5mg
  • Price$100
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0087693
  • Product descriptionC-178 99.90%
  • Packaging10mg
  • Price$150
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0087693
  • Product descriptionC-178 99.90%
  • Packaging25mg
  • Price$295
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0087693
  • Product descriptionC-178 99.90%
  • Packaging50mg
  • Price$450
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0087693
  • Product descriptionC-178 99.90%
  • Packaging100mg
  • Price$650
  • Updated2021-12-16
  • Buy
  • ManufacturerDC Chemicals
  • Product numberDC10959
  • Product descriptionSTINGinhibitorC-178 >98%
  • Packaging250mg
  • Price$700
  • Updated2021-12-16
  • Buy
  • ManufacturerSigma-Aldrich
  • Product numberSML3098
  • Product descriptionC-178 ≥98% (HPLC)
  • Packaging25MG
  • Price$359
  • Updated2024-03-01
  • Buy
  • ManufacturerSigma-Aldrich
  • Product numberSML3098
  • Product descriptionC-178 ≥98% (HPLC)
  • Packaging5MG
  • Price$89
  • Updated2024-03-01
  • Buy
  • ManufacturerTRC
  • Product numberD417535
  • Product descriptionN-​(3-​Dibenzofuranyl)-​5-​nitro-2-​furancarboxamide
  • Packaging1g
  • Price$1190
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 3619CJ STINGinhibitorC-178 10mg $164 2021-12-16 Buy
AK Scientific 3619CJ STINGinhibitorC-178 5mg $133 2021-12-16 Buy
Cayman Chemical 25860 C-178 5mg $32 2024-03-01 Buy
Cayman Chemical 25860 C-178 10mg $61 2024-03-01 Buy
Cayman Chemical 25860 C-178 25mg $139 2024-03-01 Buy
Cayman Chemical 25860 C-178 50mg $230 2024-03-01 Buy
ChemScene CS-0087693 C-178 99.90% 5mg $100 2021-12-16 Buy
ChemScene CS-0087693 C-178 99.90% 10mg $150 2021-12-16 Buy
ChemScene CS-0087693 C-178 99.90% 25mg $295 2021-12-16 Buy
ChemScene CS-0087693 C-178 99.90% 50mg $450 2021-12-16 Buy
ChemScene CS-0087693 C-178 99.90% 100mg $650 2021-12-16 Buy
DC Chemicals DC10959 STINGinhibitorC-178 >98% 250mg $700 2021-12-16 Buy
Sigma-Aldrich SML3098 C-178 ≥98% (HPLC) 25MG $359 2024-03-01 Buy
Sigma-Aldrich SML3098 C-178 ≥98% (HPLC) 5MG $89 2024-03-01 Buy
TRC D417535 N-​(3-​Dibenzofuranyl)-​5-​nitro-2-​furancarboxamide 1g $1190 2021-12-16 Buy

Properties

Melting point :>225°C (dec.)
Boiling point :448.3±35.0 °C(Predicted)
Density :1.506±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :Soluble in DMSO (up to 25 mg/ml)
form :solid
pka :11.35±0.43(Predicted)
color :Orange
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

C-178 is a covalent inhibitor of stimulator of interferon genes (STING). It binds to Cys91 on STING to block its palmitoylation and prevents recruitment and phosphorylation of TBK1 in HEK293T cells. C-178 (0.01-1.25 μM) selectively reduces STING-, but not RIG-I- or TBK1-, mediated IFN-β reporter activity in HEK293 cells. It also prevents increases in Ifnb1 expression in bone marrow-derived macrophages (BMDMs) induced by cyclic di-GMP , double-stranded DNA, and LPS when used at a concentration of 0.5 μM.

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