(Z,E)-5-(4-ETHYLBENZYLIDINE)-2-THIOXOTHIAZOLIDIN-4-ONE
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- $45 - $1654.1
- Product name: (Z,E)-5-(4-ETHYLBENZYLIDINE)-2-THIOXOTHIAZOLIDIN-4-ONE
- CAS: 403811-55-2
- MF: C12H11NOS2
- MW: 249.35
- EINECS:
- MDL Number:MFCD00758517
- Synonyms:(5E)-5-[(4-ethylphenyl)methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one;c-Myc Inhibitor;ZINC01085340;(Z,E)-5-(4-ETHYLBENZYLIDINE)-2-THIOXOTHIAZOLIDIN-4-ONE;10058-F4;5-[(4-Ethylphenyl)methylene]-2-thioxo-4-thiazolidinone;(5E)-5-(4-ethylbenzylidene)-2-mercapto-1,3-thiazol-4(5H)-one;Albb-009118
33 prices
Selected condition：
Brand
- Adipogen Life Sciences
- AK Scientific
- American Custom Chemicals Corporation
- ApexBio Technology
- Arctom
- Axon Medchem
- Biorbyt Ltd
- Cayman Chemical
- ChemBridge Corporation
- Crysdot
- DC Chemicals
- Matrix Scientific
- Medical Isotopes, Inc.
- Sigma-Aldrich
- TCI Chemical
- TRC
- Usbiological
Package
- 10mg
- 20mg
- 50mg
- 100mg
- 250mg
- 1000mg
- 5mg
- 25mg
- 500mg
- 0.5G
- 1g
- 10mM(in 1mL DMSO)
- ManufacturerAdipogen Life Sciences
- Product numberCDX-E0533-M025
- Product description5-[(4-Ethylphenyl)methylene]-2-thioxo-4-thiazolidinone ≥95%(NMR)
- Packaging25mg
- Price$141
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberZ6200
- Product description(E)-5-(4-Ethylbenzylidene)-2-thioxothiazolidin-4-one
- Packaging500mg
- Price$152
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberZ6200
- Product description(E)-5-(4-Ethylbenzylidene)-2-thioxothiazolidin-4-one
- Packaging1g
- Price$207
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberINB0004449
- Product description10058-F4 95.00%
- Packaging0.5G
- Price$605
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA1169
- Product description10058-F4
- Packaging5mg
- Price$45
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA1169
- Product description10058-F4
- Packaging10mM(in 1mL DMSO)
- Price$55
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA1169
- Product description10058-F4
- Packaging10mg
- Price$70
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA1169
- Product description10058-F4
- Packaging50mg
- Price$220
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberCFN60158
- Product description10058-F4 ≥98%
- Packaging20mg
- Price$288
- Updated2021-12-16
- Buy
- ManufacturerAxon Medchem
- Product numberAxon2222
- Product description10058-F4 99%
- Packaging50mg
- Price$308
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb545908
- Product description10058-F4 >98%
- Packaging5mg
- Price$154.7
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb545908
- Product description10058-F4 >98%
- Packaging25mg
- Price$389.3
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb181392
- Product description10058-F4 >98%
- Packaging100mg
- Price$606.9
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb181392
- Product description10058-F4 >98%
- Packaging250mg
- Price$765
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb181392
- Product description10058-F4 >98%
- Packaging1000mg
- Price$1654.1
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number15929
- Product description10058-F4 ≥95%
- Packaging5mg
- Price$62
- Updated2024-03-01
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Adipogen Life Sciences | CDX-E0533-M025 | 5-[(4-Ethylphenyl)methylene]-2-thioxo-4-thiazolidinone ≥95%(NMR) | 25mg | $141 | 2021-12-16 | Buy |
| AK Scientific | Z6200 | (E)-5-(4-Ethylbenzylidene)-2-thioxothiazolidin-4-one | 500mg | $152 | 2021-12-16 | Buy |
| AK Scientific | Z6200 | (E)-5-(4-Ethylbenzylidene)-2-thioxothiazolidin-4-one | 1g | $207 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0004449 | 10058-F4 95.00% | 0.5G | $605 | 2021-12-16 | Buy |
| ApexBio Technology | A1169 | 10058-F4 | 5mg | $45 | 2021-12-16 | Buy |
| ApexBio Technology | A1169 | 10058-F4 | 10mM(in 1mL DMSO) | $55 | 2021-12-16 | Buy |
| ApexBio Technology | A1169 | 10058-F4 | 10mg | $70 | 2021-12-16 | Buy |
| ApexBio Technology | A1169 | 10058-F4 | 50mg | $220 | 2021-12-16 | Buy |
| Arctom | CFN60158 | 10058-F4 ≥98% | 20mg | $288 | 2021-12-16 | Buy |
| Axon Medchem | Axon2222 | 10058-F4 99% | 50mg | $308 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb545908 | 10058-F4 >98% | 5mg | $154.7 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb545908 | 10058-F4 >98% | 25mg | $389.3 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb181392 | 10058-F4 >98% | 100mg | $606.9 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb181392 | 10058-F4 >98% | 250mg | $765 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb181392 | 10058-F4 >98% | 1000mg | $1654.1 | 2021-12-16 | Buy |
| Cayman Chemical | 15929 | 10058-F4 ≥95% | 5mg | $62 | 2024-03-01 | Buy |
Properties
Density :1.33±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: >10mg/mL
form :Yellow solid
pka :7.72±0.30(Predicted)
color :yellow
Water Solubility :Soluble in DMSO. Soluble in water at concentrations less than 2mg/ml
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
InChI :1S/C12H11NOS2/c1-2-8-3-5-9(6-4-8)7-10-11(14)13-12(15)16-10/h3-7H,2H2,1H3,(H,13,14,15)/b10-7+
InChIKey :SVXDHPADAXBMFB-JXMROGBWSA-N
SMILES :CCc1ccc(cc1)\C=C2\SC(=S)NC2=O
storage temp. :2-8°C
solubility :DMSO: >10mg/mL
form :Yellow solid
pka :7.72±0.30(Predicted)
color :yellow
Water Solubility :Soluble in DMSO. Soluble in water at concentrations less than 2mg/ml
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
InChI :1S/C12H11NOS2/c1-2-8-3-5-9(6-4-8)7-10-11(14)13-12(15)16-10/h3-7H,2H2,1H3,(H,13,14,15)/b10-7+
InChIKey :SVXDHPADAXBMFB-JXMROGBWSA-N
SMILES :CCc1ccc(cc1)\C=C2\SC(=S)NC2=O
Safety Information
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| Signal word: | Warning | |||||||||||||||||||||
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Description
The Myc proto-oncogenes interact with Max to form a dimer that regulates gene transcription. The protein c-Myc, in particular, promotes gene expression relevant to cell growth and thus drives cancer. 10058-F4 is a cell-permeable thiazolidinone that inhibits the dimerization of c-Myc and Max at 64 μM, preventing c-Myc-dependent gene expression and cell proliferation. It induces cell cycle arrest, apoptosis, and myeloid differentiation at 100 μM in human acute myeloid leukemia cells. 10058-F4 is rapidly metabolized in mice when given intravenously, limiting its effects on tumors in vivo. In addition to c-Myc, 10058-F4 inhibits the nuclear Myc protein, N-Myc, at 50 μM, inducing arrest, apoptosis, and differentiation in neuroblastoma cells overexpressing the gene for N-Myc. This compound can be used to delineate novel actions of Myc proteins, especially those related to lipid and glucose metabolism.More related product prices
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