(2R)-1-[[5-[(Z)-[5-[[(2,6-Dichlorophenyl)methyl]sulfonyl]-1,2-dihydro-2-oxo-3H-indol-3-ylidene]methyl]-2,4-dimethyl-1H-pyrrol-3-yl]carbonyl]-2-(1-pyrrolidinylmethyl)pyrrolidine
![(2R)-1-[[5-[(Z)-[5-[[(2,6-Dichlorophenyl)methyl]sulfonyl]-1,2-dihydro-2-oxo-3H-indol-3-ylidene]methyl]-2,4-dimethyl-1H-pyrrol-3-yl]carbonyl]-2-(1-pyrrolidinylmethyl)pyrrolidine price.](/CAS/GIF/477575-56-7.gif)
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- $30 - $3411
- Product name: (2R)-1-[[5-[(Z)-[5-[[(2,6-Dichlorophenyl)methyl]sulfonyl]-1,2-dihydro-2-oxo-3H-indol-3-ylidene]methyl]-2,4-dimethyl-1H-pyrrol-3-yl]carbonyl]-2-(1-pyrrolidinylmethyl)pyrrolidine
- CAS: 477575-56-7
- MF: C32H34Cl2N4O4S
- MW: 641.61
- EINECS:
- MDL Number:MFCD07772270
- Synonyms:PHA 665752;(2R)-1-[[5-[(Z)-[5-[[(2,6-DICHLOROPHENYL)METHYL]SULFONYL]-1,2-DIHYDRO-2-OXO-3H-INDOL-3-YLIDENE]METHYL]-2,4-DIMETHYL-1H-PYRROL-3-YL]CARBONYL]-2-(1-PYRROLIDINYLMETHYL)PYRROLIDINE PHA 665752;PHA-665752/PHA665752;(R,Z)-5-(2,6-dichlorobenzylsulfonyl)-3-((3,5-dimethyl-4-(2-(pyrrolidin-1-ylmethyl)pyrrolidine-1-carbonyl)-1H-pyrrol-2-yl)methylene)indolin-2-one;PHA 665752 (2R)-1-[[5-[(Z)-[5-[[(2,6-Dichlorophenyl)methyl]sulfonyl]-1,2-dihydro-2-oxo-3H-indol-3-ylidene]methyl]-2,4-dimethyl-1H-pyrrol-3-yl]carbonyl]-2-(1-pyrrolidinylmethyl)pyrrolidine;(R,Z)-5-((2,6-Dichlorobenzyl)sulfonyl)-3-((3,5-dimethyl-4-(2-(pyrrolidin-1-ylmethyl)pyrrolidin;(2R)-1-[[5-[(Z)-[5-[[(2,6-DICHLOROPHENYL)METHYL]SULFONYL]-1,2-DIHYDRO-2-OXO-3H-INDOL-3-YLIDENE]METHYL]-2,4-DIMETHYL-1H-PYRROL-3-YL]CARBONYL]-2-(1-PYRROLIDINYLMETHYL)PYRROLIDINE USP/EP/BP;2H-Indol-2-one, 5-[[(2,6-dichlorophenyl)methyl]sulfonyl]-3-[[3,5-dimethyl-4-[[(2R)-2-(1-pyrrolidinylmethyl)-1-pyrrolidinyl]carbonyl]-1H-pyrrol-2-yl]methylene]-1,3-dihydro-, (3Z)-
56 prices
Selected condition：
Brand
- aablocks
- ACHEMBLOCK
- AK Scientific
- American Custom Chemicals Corporation
- ApexBio Technology
- Arctom
- Biorbyt Ltd
- Biosynth
- Cayman Chemical
- ChemScene
- DC Chemicals
- Medical Isotopes, Inc.
- Sigma-Aldrich
- Tocris
- TRC
- Usbiological
Package
- 250mg
- 10mM*1mLinDMSO(Solution)
- 10mM(1mLinDMSO)
- 10
- 50
- 1g
- 10mM*1mLinDMSO
- 1000mg
- 10mM*1mLinDMSO(Solid+Solvent)
- 1mg
- EvaluationSample
- 5mg
- 10mg
- 25mg
- 100mg
- 10mM(in1mLDMSO)
- 50mg
- Manufactureraablocks
- Product numberAA00DB4G
- Product descriptionPHA-665752 99%
- Packaging1mg
- Price$35
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00DB4G
- Product descriptionPHA-665752 99%
- Packaging5mg
- Price$44
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00DB4G
- Product descriptionPHA-665752 99%
- Packaging10mg
- Price$67
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00DB4G
- Product descriptionPHA-665752 99%
- Packaging25mg
- Price$134
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00DB4G
- Product descriptionPHA-665752 99%
- Packaging50mg
- Price$212
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00DB4G
- Product descriptionPHA-665752 99
- Packaging100mg
- Price$410
- Updated2026-05-28
- Buy
- ManufacturerACHEMBLOCK
- Product numberU102928
- Product descriptionPHA665752 98.00%
- Packaging25MG
- Price$225
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberU102928
- Product descriptionPHA665752 98.00%
- Packaging100MG
- Price$580
- Updated2026-05-27
- Buy
- ManufacturerAK Scientific
- Product number2650AH
- Product description(3Z)-5-[(2,6-Dichlorophenyl)methylsulfonyl]-3-[[3,5-dimethyl-4-[(2R)-2-(pyrrolidin-1-ylmethyl)pyrrolidine-1-carbonyl]-1H-pyrrol-2-yl]methylidene]-1H-indol-2-one
- Packaging1mg
- Price$101
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberKIN0000322
- Product descriptionPHA-665752 95.00%
- Packaging10MG
- Price$811.34
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberKIN0000322
- Product descriptionPHA-665752 95.00%
- Packaging50MG
- Price$1703.92
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA2307
- Product descriptionPHA-665752
- Packaging100mg
- Price$570
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberA2307
- Product descriptionPHA-665752
- Packaging10mg
- Price$80
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberA2307
- Product descriptionPHA-665752
- PackagingEvaluationSample
- Price$30
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberA2307
- Product descriptionPHA-665752
- Packaging10mM(in1mLDMSO)
- Price$90
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberA2307
- Product descriptionPHA-665752
- Packaging50mg
- Price$330
- Updated2026-05-06
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA00DB4G | PHA-665752 99% | 1mg | $35 | 2026-05-28 | Buy |
| aablocks | AA00DB4G | PHA-665752 99% | 5mg | $44 | 2026-05-28 | Buy |
| aablocks | AA00DB4G | PHA-665752 99% | 10mg | $67 | 2026-05-28 | Buy |
| aablocks | AA00DB4G | PHA-665752 99% | 25mg | $134 | 2026-05-28 | Buy |
| aablocks | AA00DB4G | PHA-665752 99% | 50mg | $212 | 2026-05-28 | Buy |
| aablocks | AA00DB4G | PHA-665752 99 | 100mg | $410 | 2026-05-28 | Buy |
| ACHEMBLOCK | U102928 | PHA665752 98.00% | 25MG | $225 | 2026-05-27 | Buy |
| ACHEMBLOCK | U102928 | PHA665752 98.00% | 100MG | $580 | 2026-05-27 | Buy |
| AK Scientific | 2650AH | (3Z)-5-[(2,6-Dichlorophenyl)methylsulfonyl]-3-[[3,5-dimethyl-4-[(2R)-2-(pyrrolidin-1-ylmethyl)pyrrolidine-1-carbonyl]-1H-pyrrol-2-yl]methylidene]-1H-indol-2-one | 1mg | $101 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | KIN0000322 | PHA-665752 95.00% | 10MG | $811.34 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | KIN0000322 | PHA-665752 95.00% | 50MG | $1703.92 | 2021-12-16 | Buy |
| ApexBio Technology | A2307 | PHA-665752 | 100mg | $570 | 2026-05-06 | Buy |
| ApexBio Technology | A2307 | PHA-665752 | 10mg | $80 | 2026-05-06 | Buy |
| ApexBio Technology | A2307 | PHA-665752 | EvaluationSample | $30 | 2026-05-06 | Buy |
| ApexBio Technology | A2307 | PHA-665752 | 10mM(in1mLDMSO) | $90 | 2026-05-06 | Buy |
| ApexBio Technology | A2307 | PHA-665752 | 50mg | $330 | 2026-05-06 | Buy |
Properties
Boiling point :890.2±65.0 °C(Predicted)
Density :1.404
storage temp. :Sealed in dry,2-8°C
solubility :DMSO: ≥20mg/mL
pka :11.39±0.20(Predicted)
form :powder
color :light yellow to light brown
optical activity :[α]/D +50 to +70°, c = 0.2 in methanol
InChIKey :MKHQWLQMOSOUEQ-SCLITUASSA-N
SMILES :O.Cc1[nH]c(\C=C2/C(=O)Nc3ccc(cc23)S(=O)(=O)Cc4c(Cl)cccc4Cl)c(C)c1C(=O)N5CCC[C@@H]5CN6CCCC6
Density :1.404
storage temp. :Sealed in dry,2-8°C
solubility :DMSO: ≥20mg/mL
pka :11.39±0.20(Predicted)
form :powder
color :light yellow to light brown
optical activity :[α]/D +50 to +70°, c = 0.2 in methanol
InChIKey :MKHQWLQMOSOUEQ-SCLITUASSA-N
SMILES :O.Cc1[nH]c(\C=C2/C(=O)Nc3ccc(cc23)S(=O)(=O)Cc4c(Cl)cccc4Cl)c(C)c1C(=O)N5CCC[C@@H]5CN6CCCC6
Safety Information
| Symbol(GHS): | ||||||||
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| Signal word: | ||||||||
| Hazard statements: |
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| Precautionary statements: |
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Description
The c-Met receptor tyrosine kinase and its ligand, hepatocyte growth factor, have been implicated in the development and progression of several human cancers. PHA 665752 is an ATP-competitive, active-site inhibitor of the catalytic activity of c-Met kinase (Ki = 4 nM; IC50 = 9 nM). It exhibits >50-fold selectivity for c-Met over a panel of tyrosine and serine/threonine kinases. PHA 665752 can inhibit c-Met phosphorylation, as well as cell proliferation and cell motility, of various tumor cells (IC50s = 18-50 nM). It also inhibits signal transduction downstream of c-Met, interfering with the activation of Gab-1 adaptor protein, ERK1/2, Akt, STAT3, PLC-γ, and focal adhesion kinase in multiple tumor cell lines. In a gastric carcinoma xenograft model, 25 mg/kg PHA-665752 was shown to reduce tumor growth in mice by inhibiting c-Met activation.More related product prices
Olaparib Crizotinib 2-[(2R)-2-Methylpyrrolidin-2-yl]-1H-benimidazole-4- carboxamide SU 11274 905854-02-6 Bortezomib PHA-848125Related product price
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Olaparib
$11-2994.75 -
Crizotinib
$5-1963.5 -
2-[(2R)-2-Methylpyrrolidin-2-yl]-1H-benimidazole-4-
carboxamide
$10-4644
Suppliers and manufacturers
Shanghai Boyle Chemical Co., Ltd.
3B Pharmachem (Wuhan) International Co.,Ltd.
Chembest Research Laboratories Limited
JinYan Chemicals(ShangHai) Co.,Ltd.
China DongFan Chemical Co.,LTD
Jinan Trio PharmaTech Co., Ltd.
BOC Sciences
Dalian Meilun Biotech Co., Ltd.
Shanghai civi chemical technology co.,Ltd
Beijing HuaMeiHuLiBiological Chemical