[2-(4-chlorophenyl)quinolin-4-yl]-(2-piperidyl)methanol
![[2-(4-chlorophenyl)quinolin-4-yl]-(2-piperidyl)methanol price.](/CAS/GIF/5428-80-8.gif)
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- $51 - $1450
- Product name: [2-(4-chlorophenyl)quinolin-4-yl]-(2-piperidyl)methanol
- CAS: 5428-80-8
- MF: C21H21ClN2O
- MW: 352.86
- EINECS:
- MDL Number:MFCD29918839
- Synonyms:[2-(4-chlorophenyl)quinolin-4-yl]-(2-piperidyl)methanol;4-Quinolinemethanol,2-(4-chlorophenyl)-a-2-piperidinyl-;NSC 13316;NSC 13316;NSC13316;NSC-13316;VACQUINOL 1;VACQUINOL1;NSC13316;NSC-13316;CS-2185;4-Quinolinemethanol, 2-(4-chlorophenyl)-α-2-piperidinyl-
14 prices
Selected condition：
Brand
- AK Scientific
- ApexBio Technology
- Apolloscientific
- Cayman Chemical
- DC Chemicals
- TRC
- Usbiological
Package
- 1mg
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- 250mg
- ManufacturerAK Scientific
- Product number5589BA
- Product description(2-(4-Chlorophenyl)quinolin-4-yl)(piperidin-2-yl)methanol
- Packaging5mg
- Price$357
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB6159
- Product descriptionVacquinol-1
- Packaging5mg
- Price$146
- Updated2021-12-16
- Buy
- ManufacturerApolloscientific
- Product numberBISN0246
- Product description(2-(4-Chlorophenyl)quinolin-4-yl)(piperidin-2-yl)methanol
- Packaging5mg
- Price$131
- Updated2021-12-16
- Buy
- ManufacturerApolloscientific
- Product numberBISN0246
- Product description(2-(4-Chlorophenyl)quinolin-4-yl)(piperidin-2-yl)methanol
- Packaging10mg
- Price$167
- Updated2021-12-16
- Buy
- ManufacturerApolloscientific
- Product numberBISN0246
- Product description(2-(4-Chlorophenyl)quinolin-4-yl)(piperidin-2-yl)methanol
- Packaging25mg
- Price$283
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number16321
- Product descriptionVacquinol-1 ≥98%
- Packaging1mg
- Price$51
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number16321
- Product descriptionVacquinol-1 ≥98%
- Packaging5mg
- Price$140
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number16321
- Product descriptionVacquinol-1 ≥98%
- Packaging10mg
- Price$253
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number16321
- Product descriptionVacquinol-1 ≥98%
- Packaging25mg
- Price$569
- Updated2024-03-01
- Buy
- ManufacturerDC Chemicals
- Product numberDC8473
- Product descriptionVacquinol-1 >98%
- Packaging50mg
- Price$450
- Updated2021-12-16
- Buy
- ManufacturerDC Chemicals
- Product numberDC8473
- Product descriptionVacquinol-1 >98%
- Packaging100mg
- Price$800
- Updated2021-12-16
- Buy
- ManufacturerDC Chemicals
- Product numberDC8473
- Product descriptionVacquinol-1 >98%
- Packaging250mg
- Price$1450
- Updated2021-12-16
- Buy
- ManufacturerTRC
- Product numberV075000
- Product descriptionVacquinol-1
- Packaging1mg
- Price$55
- Updated2021-12-16
- Buy
- ManufacturerUsbiological
- Product number468532
- Product descriptionVacquinol-1
- Packaging1mg
- Price$319
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | 5589BA | (2-(4-Chlorophenyl)quinolin-4-yl)(piperidin-2-yl)methanol | 5mg | $357 | 2021-12-16 | Buy |
| ApexBio Technology | B6159 | Vacquinol-1 | 5mg | $146 | 2021-12-16 | Buy |
| Apolloscientific | BISN0246 | (2-(4-Chlorophenyl)quinolin-4-yl)(piperidin-2-yl)methanol | 5mg | $131 | 2021-12-16 | Buy |
| Apolloscientific | BISN0246 | (2-(4-Chlorophenyl)quinolin-4-yl)(piperidin-2-yl)methanol | 10mg | $167 | 2021-12-16 | Buy |
| Apolloscientific | BISN0246 | (2-(4-Chlorophenyl)quinolin-4-yl)(piperidin-2-yl)methanol | 25mg | $283 | 2021-12-16 | Buy |
| Cayman Chemical | 16321 | Vacquinol-1 ≥98% | 1mg | $51 | 2024-03-01 | Buy |
| Cayman Chemical | 16321 | Vacquinol-1 ≥98% | 5mg | $140 | 2024-03-01 | Buy |
| Cayman Chemical | 16321 | Vacquinol-1 ≥98% | 10mg | $253 | 2024-03-01 | Buy |
| Cayman Chemical | 16321 | Vacquinol-1 ≥98% | 25mg | $569 | 2024-03-01 | Buy |
| DC Chemicals | DC8473 | Vacquinol-1 >98% | 50mg | $450 | 2021-12-16 | Buy |
| DC Chemicals | DC8473 | Vacquinol-1 >98% | 100mg | $800 | 2021-12-16 | Buy |
| DC Chemicals | DC8473 | Vacquinol-1 >98% | 250mg | $1450 | 2021-12-16 | Buy |
| TRC | V075000 | Vacquinol-1 | 1mg | $55 | 2021-12-16 | Buy |
| Usbiological | 468532 | Vacquinol-1 | 1mg | $319 | 2021-12-16 | Buy |
Properties
Melting point :198-199.5 °C
Boiling point :551.4±50.0 °C(Predicted)
Density :1.244±0.06 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMF: 10 mg/ml; DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml; DMSO: 1 mg/ml; Ethanol: 0.25 mg/ml
form :A crystalline solid
pka :13.22±0.20(Predicted)
Boiling point :551.4±50.0 °C(Predicted)
Density :1.244±0.06 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMF: 10 mg/ml; DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml; DMSO: 1 mg/ml; Ethanol: 0.25 mg/ml
form :A crystalline solid
pka :13.22±0.20(Predicted)
Safety Information
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| Signal word: | Warning | |||||||||||||||||||||
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Description
Vacquinols are a new class of quinine-derivatives that stimulate death in glioblastoma cells by massive macropinocytotic vacuolization, ATP depletion, and cytoplasmic membrane rupture. A key effector of vacquinols is MAPK kinase 4 (MKK4). Vacquinol-1 is an activator of MKK4-dependent macropinocytotic cell death in glioblastoma cells. It induces ATP depletion in glioblastoma cells (IC50 = 3.14 μM at 1 day) without affecting fibroblasts, embryonic stem cells, or osteosarcoma cells. Vacquinol-1 is orally bioavailable with good brain penetrance and excellent pharmacokinetics. Oral administration of vacquinol-1 (20 mg/kg once daily for five days) substantially impairs the growth of engrafted glioblastoma cell tumors in mice and prolongs survival.Related product price
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