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ChemicalBook >> CAS DataBase List >>[2-(4-chlorophenyl)quinolin-4-yl]-(2-piperidyl)methanol

[2-(4-chlorophenyl)quinolin-4-yl]-(2-piperidyl)methanol

[2-(4-chlorophenyl)quinolin-4-yl]-(2-piperidyl)methanol Structure
[2-(4-chlorophenyl)quinolin-4-yl]-(2-piperidyl)methanol structure
CAS No.
5428-80-8
Chemical Name:
[2-(4-chlorophenyl)quinolin-4-yl]-(2-piperidyl)methanol
Synonyms
Vacquinol-1;CS-2185;NSC13316;NSC-13316;NSC 13316;Vacquinol-1（NSC13316）;NSC 13316;NSC13316;NSC-13316;VACQUINOL 1;VACQUINOL1;4-Quinolinemethanol,2-(4-chlorophenyl)-a-2-piperidinyl-;[2-(4-chlorophenyl)quinolin-4-yl]-(2-piperidyl)methanol;4-Quinolinemethanol, 2-(4-chlorophenyl)-α-2-piperidinyl-
CBNumber:
CB51254607
Molecular Formula:
C21H21ClN2O
Molecular Weight:
352.86
MDL Number:
MFCD29918839
MOL File:
5428-80-8.mol
Modify Date:2022-12-30 16:20:48
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[2-(4-chlorophenyl)quinolin-4-yl]-(2-piperidyl)methanol Properties

Melting point 198-199.5 °C
Boiling point 551.4±50.0 °C(Predicted)
Density 1.244±0.06 g/cm3(Predicted)
pka 13.22±0.20(Predicted)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H317-H319
Precautionary statements  P280-P305+P351+P338
HS Code  2933499090

[2-(4-chlorophenyl)quinolin-4-yl]-(2-piperidyl)methanol price More Price(14)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 16321 Vacquinol-1 ≥98% 5428-80-8 1mg $45 2023-01-06 Buy
Cayman Chemical 16321 Vacquinol-1 ≥98% 5428-80-8 5mg $124 2023-01-06 Buy
Cayman Chemical 16321 Vacquinol-1 ≥98% 5428-80-8 10mg $225 2023-01-06 Buy
Cayman Chemical 16321 Vacquinol-1 ≥98% 5428-80-8 25mg $506 2023-01-06 Buy
Usbiological 468532 Vacquinol-1 5428-80-8 1mg $319 2021-12-16 Buy
Product number Packaging Price Buy
16321 1mg $45 Buy
16321 5mg $124 Buy
16321 10mg $225 Buy
16321 25mg $506 Buy
468532 1mg $319 Buy

[2-(4-chlorophenyl)quinolin-4-yl]-(2-piperidyl)methanol Chemical Properties,Uses,Production

Description

Vacquinols are a new class of quinine-derivatives that stimulate death in glioblastoma cells by massive macropinocytotic vacuolization, ATP depletion, and cytoplasmic membrane rupture. A key effector of vacquinols is MAPK kinase 4 (MKK4). Vacquinol-1 is an activator of MKK4-dependent macropinocytotic cell death in glioblastoma cells. It induces ATP depletion in glioblastoma cells (IC50 = 3.14 μM at 1 day) without affecting fibroblasts, embryonic stem cells, or osteosarcoma cells. Vacquinol-1 is orally bioavailable with good brain penetrance and excellent pharmacokinetics. Oral administration of vacquinol-1 (20 mg/kg once daily for five days) substantially impairs the growth of engrafted glioblastoma cell tumors in mice and prolongs survival.

Uses

Vacquinol-1 is in the vacquinol class of quinine derivatives that stimulate death in glioblastoma cells through massive macropinocytotic vacuolization, ATP depletion and eventual cytoplasmic membrane rupture.

[2-(4-chlorophenyl)quinolin-4-yl]-(2-piperidyl)methanol Preparation Products And Raw materials

Raw materials

Preparation Products

[2-(4-chlorophenyl)quinolin-4-yl]-(2-piperidyl)methanol Suppliers

Global( 63)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		21-51619050 ivan@atkchemical.com China 31382 60
career henan chemical co 		+86-0371-86658258 factory@coreychem.com China 29828 58
Henan Alfa Chemical Co., Ltd 		+8618339805032 sale03@alfachem.cn China 14265 58
InvivoChem 		+1-708-3101919 sales@invivochem.net United States 6395 58
ShenZhen Trendseen Biological Technology Co.,Ltd. 		13417589054 trendseenbio@gmail.com China 9991 58
Amadis Chemical Company Limited 		571-89925085 sales@amadischem.com China 132094 58
EnliPharma Technology Co., Ltd 0551-66399836 18955197623 sales@enlipharma.com China 1993 55
AdooQ Bioscience CHINA 025-58849295 info@adooq.cn China 3004 60
Shanghai YuanQi Biotechnology Co., Ltd. +86-2332782371 +86-18120098618 sales@adobechem.com China 3159 50
Shanghai Lollane Biological Technology Co.,Ltd. 021-52996696 15000506266 2311958233@qq.com China 3522 55
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 		60
career henan chemical co 		58
Henan Alfa Chemical Co., Ltd 		58
InvivoChem 		58
ShenZhen Trendseen Biological Technology Co.,Ltd. 		58
Amadis Chemical Company Limited 		58
EnliPharma Technology Co., Ltd 55
AdooQ Bioscience CHINA 60
Shanghai YuanQi Biotechnology Co., Ltd. 50
Shanghai Lollane Biological Technology Co.,Ltd. 55

View Lastest Price from [2-(4-chlorophenyl)quinolin-4-yl]-(2-piperidyl)methanol manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Vacquinol-1 pictures 2020-01-02 Vacquinol-1
5428-80-8
 US $1.00 / KG 1KG Min98% HPLC g/kg/ton Career Henan Chemical Co
  • Vacquinol-1 pictures
  • Vacquinol-1
    5428-80-8
  • US $1.00 / KG
  • Min98% HPLC
  • Career Henan Chemical Co

5428-80-8([2-(4-chlorophenyl)quinolin-4-yl]-(2-piperidyl)methanol)Related Search:

Nintedanib Valspodar Vandetanib Vardenafil hydrochloride trihydrate Vanoxerine dihydrochloride
[2-(4-chlorophenyl)quinolin-4-yl]-(2-piperidyl)methanol 4-Quinolinemethanol,2-(4-chlorophenyl)-a-2-piperidinyl- NSC 13316 NSC 13316;NSC13316;NSC-13316;VACQUINOL 1;VACQUINOL1 NSC13316 NSC-13316 CS-2185 4-Quinolinemethanol, 2-(4-chlorophenyl)-α-2-piperidinyl- Vacquinol-1 Vacquinol-1（NSC13316） 5428-80-8 C21H23Cl3N2O building block