ChemicalBook >> CAS DataBase List >>[2-(4-chlorophenyl)quinolin-4-yl]-(2-piperidyl)methanol


Chemical Name:
Vacquinol-1;CS-2185;NSC13316;NSC-13316;NSC 13316;Vacquinol-1(NSC13316);NSC 13316;NSC13316;NSC-13316;VACQUINOL 1;VACQUINOL1;4-Quinolinemethanol,2-(4-chlorophenyl)-a-2-piperidinyl-;[2-(4-chlorophenyl)quinolin-4-yl]-(2-piperidyl)methanol;4-Quinolinemethanol, 2-(4-chlorophenyl)-α-2-piperidinyl-
Molecular Formula:
Molecular Weight:
MDL Number:
MOL File:
Modify Date:2022-12-30 16:20:48

[2-(4-chlorophenyl)quinolin-4-yl]-(2-piperidyl)methanol Properties

Melting point 198-199.5 °C
Boiling point 551.4±50.0 °C(Predicted)
Density 1.244±0.06 g/cm3(Predicted)
pka 13.22±0.20(Predicted)


Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
Signal word  Warning
Hazard statements  H317-H319
Precautionary statements  P280-P305+P351+P338
HS Code  2933499090

[2-(4-chlorophenyl)quinolin-4-yl]-(2-piperidyl)methanol price More Price(14)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 16321 Vacquinol-1 ≥98% 5428-80-8 1mg $45 2023-01-06 Buy
Cayman Chemical 16321 Vacquinol-1 ≥98% 5428-80-8 5mg $124 2023-01-06 Buy
Cayman Chemical 16321 Vacquinol-1 ≥98% 5428-80-8 10mg $225 2023-01-06 Buy
Cayman Chemical 16321 Vacquinol-1 ≥98% 5428-80-8 25mg $506 2023-01-06 Buy
Usbiological 468532 Vacquinol-1 5428-80-8 1mg $319 2021-12-16 Buy
Product number Packaging Price Buy
16321 1mg $45 Buy
16321 5mg $124 Buy
16321 10mg $225 Buy
16321 25mg $506 Buy
468532 1mg $319 Buy

[2-(4-chlorophenyl)quinolin-4-yl]-(2-piperidyl)methanol Chemical Properties,Uses,Production


Vacquinols are a new class of quinine-derivatives that stimulate death in glioblastoma cells by massive macropinocytotic vacuolization, ATP depletion, and cytoplasmic membrane rupture. A key effector of vacquinols is MAPK kinase 4 (MKK4). Vacquinol-1 is an activator of MKK4-dependent macropinocytotic cell death in glioblastoma cells. It induces ATP depletion in glioblastoma cells (IC50 = 3.14 μM at 1 day) without affecting fibroblasts, embryonic stem cells, or osteosarcoma cells. Vacquinol-1 is orally bioavailable with good brain penetrance and excellent pharmacokinetics. Oral administration of vacquinol-1 (20 mg/kg once daily for five days) substantially impairs the growth of engrafted glioblastoma cell tumors in mice and prolongs survival.


Vacquinol-1 is in the vacquinol class of quinine derivatives that stimulate death in glioblastoma cells through massive macropinocytotic vacuolization, ATP depletion and eventual cytoplasmic membrane rupture.

[2-(4-chlorophenyl)quinolin-4-yl]-(2-piperidyl)methanol Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 63)Suppliers
Supplier Tel Email Country ProdList Advantage
21-51619050 China 31382 60
career henan chemical co
+86-0371-86658258 China 29828 58
Henan Alfa Chemical Co., Ltd
+8618339805032 China 14265 58
+1-708-3101919 United States 6395 58
ShenZhen Trendseen Biological Technology Co.,Ltd.
13417589054 China 9991 58
Amadis Chemical Company Limited
571-89925085 China 132094 58
EnliPharma Technology Co., Ltd 0551-66399836 18955197623 China 1993 55
AdooQ Bioscience CHINA 025-58849295 China 3004 60
Shanghai YuanQi Biotechnology Co., Ltd. +86-2332782371 +86-18120098618 China 3159 50
Shanghai Lollane Biological Technology Co.,Ltd. 021-52996696 15000506266 China 3522 55

View Lastest Price from [2-(4-chlorophenyl)quinolin-4-yl]-(2-piperidyl)methanol manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Vacquinol-1 pictures 2020-01-02 Vacquinol-1
US $1.00 / KG 1KG Min98% HPLC g/kg/ton Career Henan Chemical Co
  • Vacquinol-1 pictures
  • Vacquinol-1
  • US $1.00 / KG
  • Min98% HPLC
  • Career Henan Chemical Co

5428-80-8([2-(4-chlorophenyl)quinolin-4-yl]-(2-piperidyl)methanol)Related Search:

[2-(4-chlorophenyl)quinolin-4-yl]-(2-piperidyl)methanol 4-Quinolinemethanol,2-(4-chlorophenyl)-a-2-piperidinyl- NSC 13316 NSC 13316;NSC13316;NSC-13316;VACQUINOL 1;VACQUINOL1 NSC13316 NSC-13316 CS-2185 4-Quinolinemethanol, 2-(4-chlorophenyl)-α-2-piperidinyl- Vacquinol-1 Vacquinol-1(NSC13316) 5428-80-8 C21H23Cl3N2O building block