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[2-(4-chlorophenyl)quinolin-4-yl]-(2-piperidyl)methanol

CAS No.
5428-80-8
Chemical Name:
[2-(4-chlorophenyl)quinolin-4-yl]-(2-piperidyl)methanol
Synonyms
Vacquinol-1;CS-2185;NSC13316;NSC-13316;NSC 13316;Vacquinol-1(NSC13316);NSC 13316;NSC13316;NSC-13316;VACQUINOL 1;VACQUINOL1;4-Quinolinemethanol,2-(4-chlorophenyl)-a-2-piperidinyl-;[2-(4-chlorophenyl)quinolin-4-yl]-(2-piperidyl)methanol;4-Quinolinemethanol, 2-(4-chlorophenyl)-α-2-piperidinyl-
CBNumber:
CB51254607
Molecular Formula:
C21H21ClN2O
Molecular Weight:
352.86
MDL Number:
MFCD29918839
MOL File:
5428-80-8.mol
Last updated:2023-06-08 09:02:17

[2-(4-chlorophenyl)quinolin-4-yl]-(2-piperidyl)methanol Properties

Melting point 198-199.5 °C
Boiling point 551.4±50.0 °C(Predicted)
Density 1.244±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMF: 10 mg/ml; DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml; DMSO: 1 mg/ml; Ethanol: 0.25 mg/ml
form A crystalline solid
pka 13.22±0.20(Predicted)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H317-H319
Precautionary statements  P280-P305+P351+P338
HS Code  2933499090
NFPA 704
0
2 0

[2-(4-chlorophenyl)quinolin-4-yl]-(2-piperidyl)methanol price More Price(14)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 16321 Vacquinol-1 ≥98% 5428-80-8 1mg $51 2024-03-01 Buy
Cayman Chemical 16321 Vacquinol-1 ≥98% 5428-80-8 5mg $140 2024-03-01 Buy
Cayman Chemical 16321 Vacquinol-1 ≥98% 5428-80-8 10mg $253 2024-03-01 Buy
Cayman Chemical 16321 Vacquinol-1 ≥98% 5428-80-8 25mg $569 2024-03-01 Buy
Usbiological 468532 Vacquinol-1 5428-80-8 1mg $319 2021-12-16 Buy
Product number Packaging Price Buy
16321 1mg $51 Buy
16321 5mg $140 Buy
16321 10mg $253 Buy
16321 25mg $569 Buy
468532 1mg $319 Buy

[2-(4-chlorophenyl)quinolin-4-yl]-(2-piperidyl)methanol Chemical Properties,Uses,Production

Description

Vacquinols are a new class of quinine-derivatives that stimulate death in glioblastoma cells by massive macropinocytotic vacuolization, ATP depletion, and cytoplasmic membrane rupture. A key effector of vacquinols is MAPK kinase 4 (MKK4). Vacquinol-1 is an activator of MKK4-dependent macropinocytotic cell death in glioblastoma cells. It induces ATP depletion in glioblastoma cells (IC50 = 3.14 μM at 1 day) without affecting fibroblasts, embryonic stem cells, or osteosarcoma cells. Vacquinol-1 is orally bioavailable with good brain penetrance and excellent pharmacokinetics. Oral administration of vacquinol-1 (20 mg/kg once daily for five days) substantially impairs the growth of engrafted glioblastoma cell tumors in mice and prolongs survival.

Uses

Vacquinol-1 is in the vacquinol class of quinine derivatives that stimulate death in glioblastoma cells through massive macropinocytotic vacuolization, ATP depletion and eventual cytoplasmic membrane rupture.

[2-(4-chlorophenyl)quinolin-4-yl]-(2-piperidyl)methanol Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 67)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795 ivan@atkchemical.com China 32480 60
career henan chemical co
+86-0371-86658258 15093356674; factory@coreychem.com China 29827 58
Zhejiang J&C Biological Technology Co.,Limited
+1-2135480471 +1-2135480471 sales@sarms4muscle.com China 10523 58
InvivoChem
+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6393 58
TargetMol Chemicals Inc.
+1-781-999-5354 support@targetmol.com United States 19973 58
ShenZhen Trendseen Biological Technology Co.,Ltd.
13417589054 trendseenbio@gmail.com China 11681 58
Wuhan Topule Biopharmaceutical Co., Ltd
+8618327326525 masar@topule.com China 8475 58
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd
+86-18341751992 +86-15382112998 757984502@qq.com China 892 58
Shanghai Acmec Biochemical Technology Co., Ltd.
+undefined18621343501 product@acmec-e.com China 33349 58
Amadis Chemical Company Limited
571-89925085 sales@amadischem.com China 132020 58

View Lastest Price from [2-(4-chlorophenyl)quinolin-4-yl]-(2-piperidyl)methanol manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Vacquinol-1 pictures 2020-01-02 Vacquinol-1
5428-80-8
US $1.00 / KG 1KG Min98% HPLC g/kg/ton Career Henan Chemical Co
  • Vacquinol-1 pictures
  • Vacquinol-1
    5428-80-8
  • US $1.00 / KG
  • Min98% HPLC
  • Career Henan Chemical Co

5428-80-8([2-(4-chlorophenyl)quinolin-4-yl]-(2-piperidyl)methanol)Related Search:

[2-(4-chlorophenyl)quinolin-4-yl]-(2-piperidyl)methanol 4-Quinolinemethanol,2-(4-chlorophenyl)-a-2-piperidinyl- NSC 13316 NSC 13316;NSC13316;NSC-13316;VACQUINOL 1;VACQUINOL1 NSC13316 NSC-13316 CS-2185 4-Quinolinemethanol, 2-(4-chlorophenyl)-α-2-piperidinyl- Vacquinol-1 Vacquinol-1(NSC13316) 5428-80-8 C21H23Cl3N2O building block