L-Leucyl-L-Leucine methyl ester (hydrochloride)
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- $32 - $133
- Product name: L-Leucyl-L-Leucine methyl ester (hydrochloride)
- CAS: 6491-83-4
- MF: C13H27ClN2O3
- MW: 294.81808
- EINECS:
- MDL Number:MFCD00155477
- Synonyms:L-Leucyl-L-Leucine methyl ester (hydrochloride);methyl (2S)-2-[(2S)-2-amino-4-methylpentanamido]-4-methylpentanoate hydrochloride;Leu-Leu-ome hydrochloride;H-Leu-leu-OMe hydrochloride;L-Leucine, L-leucyl-, methyl ester, monohydrochloride;L-Leucyl-L-Leucine methyl ester;lymphocytes,leukocytes,monocytes,pathway,LLeucylLLeucine methyl ester hydrochloride,LLOMe,inhibit,polymorphonuclear,stress,Leu-Leu methyl ester,cytotoxic,Inhibitor,L Leucyl L Leucine methyl ester hydrochloride,Endogenous Metabolite,endolysosomal
5 prices
Selected condition：
Brand
- AK Scientific
- Cayman Chemical
- TRC
Package
- 100mg
- 250mg
- 1g
- ManufacturerAK Scientific
- Product number0116CW
- Product descriptionMethylleucylleucinatehydrochloride
- Packaging100mg
- Price$133
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number16008
- Product descriptionL-Leucyl-L-Leucine methyl ester (hydrochloride) ≥95%
- Packaging100mg
- Price$32
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number16008
- Product descriptionL-Leucyl-L-Leucine methyl ester (hydrochloride) ≥95%
- Packaging250mg
- Price$53
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number16008
- Product descriptionL-Leucyl-L-Leucine methyl ester (hydrochloride) ≥95%
- Packaging1g
- Price$78
- Updated2024-03-01
- Buy
- ManufacturerTRC
- Product numberL330805
- Product descriptionH-Leu-leu-OMehydrochloride
- Packaging1g
- Price$50
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | 0116CW | Methylleucylleucinatehydrochloride | 100mg | $133 | 2021-12-16 | Buy |
| Cayman Chemical | 16008 | L-Leucyl-L-Leucine methyl ester (hydrochloride) ≥95% | 100mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 16008 | L-Leucyl-L-Leucine methyl ester (hydrochloride) ≥95% | 250mg | $53 | 2024-03-01 | Buy |
| Cayman Chemical | 16008 | L-Leucyl-L-Leucine methyl ester (hydrochloride) ≥95% | 1g | $78 | 2024-03-01 | Buy |
| TRC | L330805 | H-Leu-leu-OMehydrochloride | 1g | $50 | 2021-12-16 | Buy |
Properties
Melting point :177-181°C
storage temp. :Hygroscopic, Refrigerator, under inert atmosphere
solubility :DMSO (Slightly), Water (Slightly)
form :Solid
color :White to Off-White
Stability :Hygroscopic
storage temp. :Hygroscopic, Refrigerator, under inert atmosphere
solubility :DMSO (Slightly), Water (Slightly)
form :Solid
color :White to Off-White
Stability :Hygroscopic
Safety Information
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Description
L-Leucyl-L-Leucine methyl ester (LLME) is a lysosomal condensation product that has been reported to be cytotoxic towards natural killer cells and CD4+ and CD8+ T lymphocytes without affecting helper T cells and B cells. It has also been shown to induce death of monocytes, polymorphonuclear leukocytes, and myeloid tumor cells. Upon entry into cells via receptor-mediated endocytosis, LLME undergoes a condensation process catalyzed by dipeptidyl peptidase I (DPPI) in lysosomes. This condensation leads to lysosomal rupture and DNA fragmentation in DPPI-expressing immune cells such as cytotoxic T cells and natural killer cells.Related product price
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