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ChemicalBook >> CAS DataBase List >> N-[2-oxo-2-(1,2,3,4-tetrahydronaphthalen-1-ylamino)ethyl]biphenyl-4-carboxamide

N-[2-oxo-2-(1,2,3,4-tetrahydronaphthalen-1-ylamino)ethyl]biphenyl-4-carboxamide

N-[2-oxo-2-(1,2,3,4-tetrahydronaphthalen-1-ylamino)ethyl]biphenyl-4-carboxamide price.
  • $19 - $3991
  • Product name: N-[2-oxo-2-(1,2,3,4-tetrahydronaphthalen-1-ylamino)ethyl]biphenyl-4-carboxamide
  • CAS: 850467-66-2
  • MF: C25H24N2O2
  • MW: 384.47
  • EINECS:-0
  • MDL Number:MFCD15612807
  • Synonyms:N-[2-oxo-2-(1,2,3,4-tetrahydronaphthalen-1-ylamino)ethyl]biphenyl-4-carboxamide;N-[2-oxo-2-(1,2,3,4-tetrahydronaphthalen-1-ylamino)ethyl]-4-phenylbenzamide;CP 43;TAOK inhibitor 43;N-[2-Oxo-2-(1,2,3,4-tetrahydro-1-naphthalenylamino)ethyl]-4-biphenylcarboxamide;N-(2-Oxo-2-((1,2,3,4-tetrahydronaphthalen-1-yl)amino)ethyl)-[1,1'-biphenyl]-4-carboxamide;[1,1'-Biphenyl]-4-carboxamide, N-[2-oxo-2-[(1,2,3,4-tetrahydro-1-naphthalenyl)amino]ethyl]-;CP 43,TAO Kinase inhibitor-1,MAP kinase kinase kinase, MEKK, MAPKKK,CP43,CP-43,inhibit,TAO Kinase inhibitor 1,MAP3K,Inhibitor,TAO Kinase inhibitor1
Price45 Properties Safety Information Description
45 prices
Selected condition：
Brand
  • aablocks
  • ACHEMBLOCK
  • AK Scientific
  • Ambeed
  • Arctom
  • Biosynth
  • Cayman Chemical
  • ChemScene
  • DC Chemicals
  • Matrix Scientific
  • Tocris
  • TRC
Package
  • 10.00mg
  • 25.00mg
  • 50.00mg
  • 10mM*1mLinDMSO(Solid+Solvent)
  • 5g
  • 50
  • 10g
  • 10
  • 25g
  • 1mg
  • 5mg
  • 10mg
  • 25mg
  • 1g
  • 50mg
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  • 10mM*1mLinDMSO(Solution)
  • Manufactureraablocks
  • Product numberAA01ENEN
  • Product descriptionN-(2-Oxo-2-((1,2,3,4-tetrahydronaphthalen-1-yl)amino)ethyl)-[1,1'-biphenyl]-4-carboxamide 99%
  • Packaging1mg
  • Price$19
  • Updated2026-05-30
  • Buy
  • Manufactureraablocks
  • Product numberAA01ENEN
  • Product descriptionN-(2-Oxo-2-((1,2,3,4-tetrahydronaphthalen-1-yl)amino)ethyl)-[1,1'-biphenyl]-4-carboxamide 99%
  • Packaging5mg
  • Price$35
  • Updated2026-05-30
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  • Manufactureraablocks
  • Product numberAA01ENEN
  • Product descriptionN-(2-Oxo-2-((1,2,3,4-tetrahydronaphthalen-1-yl)amino)ethyl)-[1,1'-biphenyl]-4-carboxamide 99%
  • Packaging10mg
  • Price$54
  • Updated2026-05-30
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  • Manufactureraablocks
  • Product numberAA01ENEN
  • Product descriptionN-(2-Oxo-2-((1,2,3,4-tetrahydronaphthalen-1-yl)amino)ethyl)-[1,1'-biphenyl]-4-carboxamide 99%
  • Packaging25mg
  • Price$102
  • Updated2026-05-30
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  • Manufactureraablocks
  • Product numberAA01ENEN
  • Product descriptionN-(2-Oxo-2-((1,2,3,4-tetrahydronaphthalen-1-yl)amino)ethyl)-[1,1'-biphenyl]-4-carboxamide 99%
  • Packaging50mg
  • Price$172
  • Updated2026-05-30
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  • Manufactureraablocks
  • Product numberAA01ENEN
  • Product descriptionN-(2-Oxo-2-((1,2,3,4-tetrahydronaphthalen-1-yl)amino)ethyl)-[1,1'-biphenyl]-4-carboxamide 99%
  • Packaging100mg
  • Price$290
  • Updated2026-05-30
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  • Manufactureraablocks
  • Product numberAA01ENEN
  • Product descriptionN-(2-Oxo-2-((1,2,3,4-tetrahydronaphthalen-1-yl)amino)ethyl)-[1,1'-biphenyl]-4-carboxamide ≥98%(HPLC)
  • Packaging250mg
  • Price$625
  • Updated2026-05-30
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  • Manufactureraablocks
  • Product numberAA01ENEN
  • Product descriptionN-(2-Oxo-2-((1,2,3,4-tetrahydronaphthalen-1-yl)amino)ethyl)-[1,1'-biphenyl]-4-carboxamide ≥98%(HPLC)
  • Packaging1g
  • Price$1685
  • Updated2026-05-30
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  • ManufacturerACHEMBLOCK
  • Product numberY226868
  • Product descriptionTAO Kinase inhibitor 1 97.00%
  • Packaging100MG
  • Price$320
  • Updated2026-05-27
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  • ManufacturerACHEMBLOCK
  • Product numberY226868
  • Product descriptionTAO Kinase inhibitor 1 97.00%
  • Packaging25MG
  • Price$125
  • Updated2026-05-27
  • Buy
  • ManufacturerAK Scientific
  • Product number4995DG
  • Product descriptionN-[2-Oxo-2-(1,2,3,4-tetrahydronaphthalen-1-ylamino)ethyl]-4-phenylbenzamide
  • Packaging1mg
  • Price$133
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA1000438
  • Product descriptionN-(2-Oxo-2-((1,2,3,4-tetrahydronaphthalen-1-yl)amino)ethyl)-[1,1'-biphenyl]-4-carboxamide 99%
  • Packaging10mg
  • Price$149
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA1000438
  • Product descriptionN-(2-Oxo-2-((1,2,3,4-tetrahydronaphthalen-1-yl)amino)ethyl)-[1,1'-biphenyl]-4-carboxamide 99%
  • Packaging5mg
  • Price$84
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA1000438
  • Product descriptionN-(2-Oxo-2-((1,2,3,4-tetrahydronaphthalen-1-yl)amino)ethyl)-[1,1'-biphenyl]-4-carboxamide 99%
  • Packaging25mg
  • Price$326
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA1000438
  • Product descriptionN-(2-Oxo-2-((1,2,3,4-tetrahydronaphthalen-1-yl)amino)ethyl)-[1,1'-biphenyl]-4-carboxamide 99%
  • Packaging50mg
  • Price$605
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA1000438
  • Product descriptionN-(2-Oxo-2-((1,2,3,4-tetrahydronaphthalen-1-yl)amino)ethyl)-[1,1'-biphenyl]-4-carboxamide 99%
  • Packaging100mg
  • Price$1023
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
aablocks AA01ENEN N-(2-Oxo-2-((1,2,3,4-tetrahydronaphthalen-1-yl)amino)ethyl)-[1,1'-biphenyl]-4-carboxamide 99% 1mg $19 2026-05-30 Buy
aablocks AA01ENEN N-(2-Oxo-2-((1,2,3,4-tetrahydronaphthalen-1-yl)amino)ethyl)-[1,1'-biphenyl]-4-carboxamide 99% 5mg $35 2026-05-30 Buy
aablocks AA01ENEN N-(2-Oxo-2-((1,2,3,4-tetrahydronaphthalen-1-yl)amino)ethyl)-[1,1'-biphenyl]-4-carboxamide 99% 10mg $54 2026-05-30 Buy
aablocks AA01ENEN N-(2-Oxo-2-((1,2,3,4-tetrahydronaphthalen-1-yl)amino)ethyl)-[1,1'-biphenyl]-4-carboxamide 99% 25mg $102 2026-05-30 Buy
aablocks AA01ENEN N-(2-Oxo-2-((1,2,3,4-tetrahydronaphthalen-1-yl)amino)ethyl)-[1,1'-biphenyl]-4-carboxamide 99% 50mg $172 2026-05-30 Buy
aablocks AA01ENEN N-(2-Oxo-2-((1,2,3,4-tetrahydronaphthalen-1-yl)amino)ethyl)-[1,1'-biphenyl]-4-carboxamide 99% 100mg $290 2026-05-30 Buy
aablocks AA01ENEN N-(2-Oxo-2-((1,2,3,4-tetrahydronaphthalen-1-yl)amino)ethyl)-[1,1'-biphenyl]-4-carboxamide ≥98%(HPLC) 250mg $625 2026-05-30 Buy
aablocks AA01ENEN N-(2-Oxo-2-((1,2,3,4-tetrahydronaphthalen-1-yl)amino)ethyl)-[1,1'-biphenyl]-4-carboxamide ≥98%(HPLC) 1g $1685 2026-05-30 Buy
ACHEMBLOCK Y226868 TAO Kinase inhibitor 1 97.00% 100MG $320 2026-05-27 Buy
ACHEMBLOCK Y226868 TAO Kinase inhibitor 1 97.00% 25MG $125 2026-05-27 Buy
AK Scientific 4995DG N-[2-Oxo-2-(1,2,3,4-tetrahydronaphthalen-1-ylamino)ethyl]-4-phenylbenzamide 1mg $133 2021-12-16 Buy
Ambeed A1000438 N-(2-Oxo-2-((1,2,3,4-tetrahydronaphthalen-1-yl)amino)ethyl)-[1,1'-biphenyl]-4-carboxamide 99% 10mg $149 2021-12-16 Buy
Ambeed A1000438 N-(2-Oxo-2-((1,2,3,4-tetrahydronaphthalen-1-yl)amino)ethyl)-[1,1'-biphenyl]-4-carboxamide 99% 5mg $84 2021-12-16 Buy
Ambeed A1000438 N-(2-Oxo-2-((1,2,3,4-tetrahydronaphthalen-1-yl)amino)ethyl)-[1,1'-biphenyl]-4-carboxamide 99% 25mg $326 2021-12-16 Buy
Ambeed A1000438 N-(2-Oxo-2-((1,2,3,4-tetrahydronaphthalen-1-yl)amino)ethyl)-[1,1'-biphenyl]-4-carboxamide 99% 50mg $605 2021-12-16 Buy
Ambeed A1000438 N-(2-Oxo-2-((1,2,3,4-tetrahydronaphthalen-1-yl)amino)ethyl)-[1,1'-biphenyl]-4-carboxamide 99% 100mg $1023 2021-12-16 Buy
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Properties

Boiling point :673.2±54.0 °C(Predicted)
Density :1.22±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMSO: 100 mM; Ethanol: 20 mM
form :A solid
pka :13.08±0.46(Predicted)
color :White to off-white

Safety Information

Symbol(GHS): Exclamation Mark (GHS07)
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Compound 43 TAO kinase inhibitor is an ATP-competitive inhibitor of the thousand-and-one amino acid kinases TAOK1 and TAOK2 (IC50s = 11 and 15 nM, respectively). It is selective for TAOK1 and TAOK2 over 62 kinases in a panel, but does inhibit TAOK3 by 87% and seven additional kinases by 21-52%. Compound 43 TAO kinase inhibitor inhibits proliferation of SK-BR-3, BT-549, and MCF-7 cells by 94, 82, and 46%, respectively, at a concentration of 10 μM. It reduces tau phosphorylation by TAOK2 at residues S262/S356 and S202/T205/S208 when used at concentrations ranging from 5 to 60 μM in a kinase assay and at residues S202/T205/S208 when used at concentrations of 5, 10, and 30 μM in HEK293 cells. Compound 43 TAO kinase inhibitor reduces tau phosphorylation of residues T123 and T427, which are phosphorylated by TAOK1 and TAOK2 in vitro and have been identified in tangles in Alzheimer’s disease brain tissue. It also reduces tau phosphorylation in cortical neurons in a transgenic mouse model of tauopathy and in induced pluripotent stem cell-derived neurons from patients with frontotemporal lobar degeneration.

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