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ChemicalBook >> CAS DataBase List >> 7-Ethyl-10-hydroxycamptothecin

7-Ethyl-10-hydroxycamptothecin

7-Ethyl-10-hydroxycamptothecin price.
  • $13 - $4420
  • Product name: 7-Ethyl-10-hydroxycamptothecin
  • CAS: 86639-52-3
  • MF: C22H20N2O5
  • MW: 392.4
  • EINECS:643-093-9
  • MDL Number:MFCD06762720
  • Synonyms:7-10-hydroxycamptothecin;(4S)-4,9-Dihydroxy-4,11-diethyl-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione;(4S)-4,9-Dihydroxy-4α,11-diethyl-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14-dione;EHCPT;7-Ethyl-10-hydroxy-CPT (Camptothecine), SN-38;10-Hydroxycamptothecin acetate salt ,99%;Irinotecan Related Compound B (10 mg) ((S)-4,11-diethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione);SN 38(7-Ethyl-10-hydroxycaMptothecin)
Price62 Properties Safety Information Description
62 prices
Selected condition：
Brand
  • Abosyn
  • AccelPharmtech
  • AHH
  • AK Scientific
  • Ambeed
  • ApexBio Technology
  • Arctom
  • AstaTech
  • AvaChem
  • Biorbyt Ltd
  • Biosynth Carbosynth
  • BroadPharm
  • Cayman Chemical
  • Chem-Impex
  • ChemScene
  • Crysdot
  • DC Chemicals
  • Medical Isotopes, Inc.
  • Oakwood
  • Sigma-Aldrich
  • SynChem
  • TCI Chemical
  • TRC
  • Usbiological
Package
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  • 500mg
  • 0.5g
  • 1G
  • 5g
  • 10g
  • 25g
  • 100G
  • 250G
  • 10mM(in 1mL DMSO)
  • ManufacturerAbosyn
  • Product number61-3255
  • Product description(S)-4,11-diethyl-4,8-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione 95+%
  • Packaging10g
  • Price$675
  • Updated2021-12-16
  • Buy
  • ManufacturerAbosyn
  • Product number61-3255
  • Product description(S)-4,11-diethyl-4,8-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione 95+%
  • Packaging25g
  • Price$1305
  • Updated2021-12-16
  • Buy
  • ManufacturerAccelPharmtech
  • Product numberAT5299
  • Product description7-ethyl-10-hydroxycamptothecin 99.00%
  • Packaging1G
  • Price$130
  • Updated2021-12-16
  • Buy
  • ManufacturerAccelPharmtech
  • Product numberAT5299
  • Product description7-ethyl-10-hydroxycamptothecin 99.00%
  • Packaging25G
  • Price$710
  • Updated2021-12-16
  • Buy
  • ManufacturerAccelPharmtech
  • Product numberAT5299
  • Product description7-ethyl-10-hydroxycamptothecin 99.00%
  • Packaging100G
  • Price$2010
  • Updated2021-12-16
  • Buy
  • ManufacturerAccelPharmtech
  • Product numberAT5299
  • Product description7-ethyl-10-hydroxycamptothecin 99.00%
  • Packaging250G
  • Price$4420
  • Updated2021-12-16
  • Buy
  • ManufacturerAHH
  • Product numberAPI-1296
  • Product description7-Ethyl-10-hydroxycamptothecin 98%
  • Packaging1g
  • Price$610
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberJ90015
  • Product descriptionSN-38
  • Packaging1g
  • Price$74
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA366170
  • Product description(S)-4,11-Diethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione 98+%
  • Packaging100mg
  • Price$20
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA366170
  • Product description(S)-4,11-Diethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione 98+%
  • Packaging50mg
  • Price$20
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA366170
  • Product description(S)-4,11-Diethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione 98+%
  • Packaging250mg
  • Price$74
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA366170
  • Product description(S)-4,11-Diethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione 98+%
  • Packaging1g
  • Price$292
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA366170
  • Product description(S)-4,11-Diethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione 98+%
  • Packaging5g
  • Price$511
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA366170
  • Product description(S)-4,11-Diethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione 98+%
  • Packaging10g
  • Price$1092
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA366170
  • Product description(S)-4,11-Diethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione 98+%
  • Packaging25g
  • Price$1092
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberN2133
  • Product description7-Ethyl-10-hydroxycamptothecin
  • Packaging20mg
  • Price$35
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Abosyn 61-3255 (S)-4,11-diethyl-4,8-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione 95+% 10g $675 2021-12-16 Buy
Abosyn 61-3255 (S)-4,11-diethyl-4,8-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione 95+% 25g $1305 2021-12-16 Buy
AccelPharmtech AT5299 7-ethyl-10-hydroxycamptothecin 99.00% 1G $130 2021-12-16 Buy
AccelPharmtech AT5299 7-ethyl-10-hydroxycamptothecin 99.00% 25G $710 2021-12-16 Buy
AccelPharmtech AT5299 7-ethyl-10-hydroxycamptothecin 99.00% 100G $2010 2021-12-16 Buy
AccelPharmtech AT5299 7-ethyl-10-hydroxycamptothecin 99.00% 250G $4420 2021-12-16 Buy
AHH API-1296 7-Ethyl-10-hydroxycamptothecin 98% 1g $610 2021-12-16 Buy
AK Scientific J90015 SN-38 1g $74 2021-12-16 Buy
Ambeed A366170 (S)-4,11-Diethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione 98+% 100mg $20 2021-12-16 Buy
Ambeed A366170 (S)-4,11-Diethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione 98+% 50mg $20 2021-12-16 Buy
Ambeed A366170 (S)-4,11-Diethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione 98+% 250mg $74 2021-12-16 Buy
Ambeed A366170 (S)-4,11-Diethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione 98+% 1g $292 2021-12-16 Buy
Ambeed A366170 (S)-4,11-Diethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione 98+% 5g $511 2021-12-16 Buy
Ambeed A366170 (S)-4,11-Diethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione 98+% 10g $1092 2021-12-16 Buy
Ambeed A366170 (S)-4,11-Diethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione 98+% 25g $1092 2021-12-16 Buy
ApexBio Technology N2133 7-Ethyl-10-hydroxycamptothecin 20mg $35 2021-12-16 Buy
Next Last

Properties

Melting point :217 °C
Boiling point :810.3±65.0 °C(Predicted)
Density :1.51±0.1 g/cm3(Predicted)
refractive index :21.5 ° (C=0.2, THF)
storage temp. :2-8°C
solubility :DMSO: soluble1mg/mL
form :powder
pka :9.13±0.40(Predicted)
color :Off-white
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
InChIKey :FJHBVJOVLFPMQE-QFIPXVFZSA-N
CAS DataBase Reference :86639-52-3(CAS DataBase Reference)

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H372 Causes damage to organs through prolonged or repeated exposure Specific target organ toxicity, repeated exposure Category 1 Danger GHS hazard pictograms P260, P264, P270, P314, P501
Precautionary statements:
P202 Do not handle until all safety precautions have been read and understood.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P308+P313 IF exposed or concerned: Get medical advice/attention.

Description

SN-38 is the active metabolite of irinotecan , a derivative of the alkaloid camptothecin , and acts as a potent inhibitor of DNA topoisomerase I. It is formed by the hydrolysis of irinotecan by carboxylesterases and metabolized through glucuronidation by UDP glucuronosyl transferase 1A1. SN-38 is a more potent topopisomerase I inhibitor and more cytotoxic to HT-29 colon cancer cells (IC50 = 8.8 nM) compared to irinotecan (IC50 > 100 nM).

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Suppliers and manufacturers

Henan Fengda Chemical Co., Ltd
7-Ethyl-10-hydroxycamptothecin
$1.00 /100KG
7-Ethyl-10-hydroxycamptothecin CAS:86639-52-3
Xilinglab Co., Ltd.
Capot Chemical Co.,Ltd.
Shanghai Daken Advanced Materials Co.,Ltd
Beijing Cooperate Pharmaceutical Co.,Ltd
Henan Tianfu Chemical Co.,Ltd.
Nanjing ChemLin Chemical Industry Co., Ltd.
Nanjing Finetech Chemical Co., Ltd.
ATK CHEMICAL COMPANY LIMITED
Shanghai Zheyan Biotech Co., Ltd.