DIACYLGLYCEROL KINASE INHIBITOR I
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- $37 - $2500
- Product name: DIACYLGLYCEROL KINASE INHIBITOR I
- CAS: 93076-89-2
- MF: C27H26FN3OS
- MW: 459.58
- EINECS:
- MDL Number:MFCD00055114
- Synonyms:DIACYLGLYCEROL KINASE;DIACYLGLYCEROL KINASE INHIBITOR I;DIACYLGLYCEROL KINASE INHIBITOR I (R59 022);DAGK;DAG KINASE;EC 2.7.1.107;EC: 2.7.1.107;DKI
66 prices
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Brand
- aablocks
- ACHEMBLOCK
- AK Scientific
- American Custom Chemicals Corporation
- ApexBio Technology
- AvaChem
- Biosynth
- Cayman Chemical
- Chemenu
- ChemScene
- DC Chemicals
- Medical Isotopes, Inc.
- Sigma-Aldrich
- Tocris
- TRC
- Usbiological
Package
- 5mg
- 10
- 1mg
- 50
- 10mg
- 25MG
- 50mg
- 100MG
- 250mg
- 1g
- Manufactureraablocks
- Product numberAA00GRR0
- Product description6-(2-(4-((4-Fluorophenyl)(phenyl)methylene)piperidin-1-yl)ethyl)-7-methyl-5H-thiazolo[3,2-a]pyrimidin-5-one ≥98%
- Packaging10mg
- Price$173
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00GRR0
- Product description6-(2-(4-((4-Fluorophenyl)(phenyl)methylene)piperidin-1-yl)ethyl)-7-methyl-5H-thiazolo[3,2-a]pyrimidin-5-one ≥98%
- Packaging50mg
- Price$737
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00GRR0
- Product description6-(2-(4-((4-Fluorophenyl)(phenyl)methylene)piperidin-1-yl)ethyl)-7-methyl-5H-thiazolo[3,2-a]pyrimidin-5-one ≥98%
- Packaging5mg
- Price$99
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00GRR0
- Product description6-(2-(4-((4-Fluorophenyl)(phenyl)methylene)piperidin-1-yl)ethyl)-7-methyl-5H-thiazolo[3,2-a]pyrimidin-5-one ≥98%
- Packaging1mg
- Price$41
- Updated2026-05-28
- Buy
- ManufacturerACHEMBLOCK
- Product numberAD264355
- Product descriptionR 59-022 98%
- Packaging25MG
- Price$300
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberAD264355
- Product descriptionR 59-022 98%
- Packaging100MG
- Price$900
- Updated2026-05-27
- Buy
- ManufacturerAK Scientific
- Product number0350CA
- Product descriptionDiacylglycerol Kinase Inhibitor I
- Packaging50mg
- Price$843
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberKIN0000210
- Product descriptionR-59-022 95.00%
- Packaging50MG
- Price$1138.78
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberKIN0000210
- Product descriptionR-59-022 95.00%
- Packaging1MG
- Price$140.7
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberKIN0000210
- Product descriptionR-59-022 95.00%
- Packaging10MG
- Price$685.21
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB6967
- Product descriptionR59-022
- Packaging5mg
- Price$102
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB6967
- Product descriptionR 59-022
- Packaging5mg
- Price$176
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberB6967
- Product descriptionR 59-022
- Packaging10mg
- Price$306
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberB6967
- Product descriptionR 59-022
- Packaging50mg
- Price$1307
- Updated2026-05-06
- Buy
- ManufacturerAvaChem
- Product number6722
- Product descriptionR-59022 98%
- Packaging5mg
- Price$70
- Updated2026-05-22
- Buy
- ManufacturerAvaChem
- Product number6722
- Product descriptionR-59022 98%
- Packaging25mg
- Price$270
- Updated2026-05-22
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA00GRR0 | 6-(2-(4-((4-Fluorophenyl)(phenyl)methylene)piperidin-1-yl)ethyl)-7-methyl-5H-thiazolo[3,2-a]pyrimidin-5-one ≥98% | 10mg | $173 | 2026-05-28 | Buy |
| aablocks | AA00GRR0 | 6-(2-(4-((4-Fluorophenyl)(phenyl)methylene)piperidin-1-yl)ethyl)-7-methyl-5H-thiazolo[3,2-a]pyrimidin-5-one ≥98% | 50mg | $737 | 2026-05-28 | Buy |
| aablocks | AA00GRR0 | 6-(2-(4-((4-Fluorophenyl)(phenyl)methylene)piperidin-1-yl)ethyl)-7-methyl-5H-thiazolo[3,2-a]pyrimidin-5-one ≥98% | 5mg | $99 | 2026-05-28 | Buy |
| aablocks | AA00GRR0 | 6-(2-(4-((4-Fluorophenyl)(phenyl)methylene)piperidin-1-yl)ethyl)-7-methyl-5H-thiazolo[3,2-a]pyrimidin-5-one ≥98% | 1mg | $41 | 2026-05-28 | Buy |
| ACHEMBLOCK | AD264355 | R 59-022 98% | 25MG | $300 | 2026-05-27 | Buy |
| ACHEMBLOCK | AD264355 | R 59-022 98% | 100MG | $900 | 2026-05-27 | Buy |
| AK Scientific | 0350CA | Diacylglycerol Kinase Inhibitor I | 50mg | $843 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | KIN0000210 | R-59-022 95.00% | 50MG | $1138.78 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | KIN0000210 | R-59-022 95.00% | 1MG | $140.7 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | KIN0000210 | R-59-022 95.00% | 10MG | $685.21 | 2021-12-16 | Buy |
| ApexBio Technology | B6967 | R59-022 | 5mg | $102 | 2021-12-16 | Buy |
| ApexBio Technology | B6967 | R 59-022 | 5mg | $176 | 2026-05-06 | Buy |
| ApexBio Technology | B6967 | R 59-022 | 10mg | $306 | 2026-05-06 | Buy |
| ApexBio Technology | B6967 | R 59-022 | 50mg | $1307 | 2026-05-06 | Buy |
| AvaChem | 6722 | R-59022 98% | 5mg | $70 | 2026-05-22 | Buy |
| AvaChem | 6722 | R-59022 98% | 25mg | $270 | 2026-05-22 | Buy |
Properties
Boiling point :619.8±65.0 °C(Predicted)
Density :1.26±0.1 g/cm3(Predicted)
storage temp. :-20°C
solubility :0.1 M HCl: slightly soluble
form :solid
pka :7.76±0.20(Predicted)
color :pale yellow
biological source :synthetic (organic)
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
InChI :1S/C27H26FN3OS/c1-19-24(26(32)31-17-18-33-27(31)29-19)13-16-30-14-11-22(12-15-30)25(20-5-3-2-4-6-20)21-7-9-23(28)10-8-21/h2-10,17-18H,11-16H2,1H3
InChIKey :MFVJXLPANKSLLD-UHFFFAOYSA-N
SMILES :Fc1ccc(cc1)C(=C3CCN(CC3)CCc4[c]([n]5c([s]cc5)nc4C)=O)c2ccccc2
Density :1.26±0.1 g/cm3(Predicted)
storage temp. :-20°C
solubility :0.1 M HCl: slightly soluble
form :solid
pka :7.76±0.20(Predicted)
color :pale yellow
biological source :synthetic (organic)
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
InChI :1S/C27H26FN3OS/c1-19-24(26(32)31-17-18-33-27(31)29-19)13-16-30-14-11-22(12-15-30)25(20-5-3-2-4-6-20)21-7-9-23(28)10-8-21/h2-10,17-18H,11-16H2,1H3
InChIKey :MFVJXLPANKSLLD-UHFFFAOYSA-N
SMILES :Fc1ccc(cc1)C(=C3CCN(CC3)CCc4[c]([n]5c([s]cc5)nc4C)=O)c2ccccc2
Safety Information
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Description
Diacylglycerol (DAG) kinases (DGKs) phosphorylate DAG to give phosphatidic acid (PA), reducing signaling through DAG and increasing signaling through PA. R-59-022 is an inhibitor of DGK (IC50 = 2.8 μM). This results in increased DAG-dependent PKC activity and potentiates aggregation of thrombin-stimulated platelets. R-59-022 also blocks vascular contraction induced by the thromboxane analog U-46619 . At 10 μM, R-59-022 induces apoptosis in glioblastoma cells without being toxic to non-cancerous cells. It inhibits DGK-θ in vitro at concentrations below 1 μM and blocks DGK-θ activity in vivo. R-59-022 also inhibits A. thaliana DGK2 (IC50 = 50 μM) and suppresses root growth but does not affect DGK7 at 50 μM.Related product price
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