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ChemicalBook >> CAS DataBase List >> AMG 925

AMG 925

$36 - $2237
Product name: AMG 925
CAS: 1401033-86-0
MF: C26H29N7O2
MW: 471.56
EINECS:
MDL Number:MFCD28155269
Synonyms:AMG 925;1-[7,8-Dihydro-2-[[9-(trans-4-methylcyclohexyl)-9H-pyrido[4',3':4,5]pyrrolo[2,3-d]pyrimidin-2-yl]amino]-1,6-naphthyridin-6(5H)-yl]-2-hydroxyethanone;2-Hydroxy-1-(2-((9-((1r,4r)-4-methylcyclohexyl)-9H-pyrido[4',3':4,5]pyrrolo[2,3-d]pyrimidin-2-;Ethanone, 1-[7,8-dihydro-2-[[9-(trans-4-methylcyclohexyl)-9H-pyrido[4',3':4,5]pyrrolo[2,3-d]pyrimidin-2-yl]amino]-1,6-naphthyridin-6(5H)-yl]-2-hydroxy-;AMG 925;AMG925;AMG-925;CS-1594;2-Hydroxy-1-(2-((9-((1r,4r)-4-methylcyclohexyl)-9H-pyrido[4',3':4,5]pyrrolo[2,3-d]pyrimidin-2-yl)amino)-7,8-dihydro-1,6-naphthyridin-6(5H)-yl)ethanone;AMG925; AMG-925; AMG 925; FLX925; FLX-925; FLX 925.

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aablocks
ACHEMBLOCK
AK Scientific
ApexBio Technology
Arctom
Biosynth
Cayman Chemical
ChemScene
Crysdot
DC Chemicals
Matrix Scientific
TRC
Usbiological

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1mg
2mg
5.00mg
5mg
10.00mg
10mg
25mg
50mg
100mg
250mg
10mM*1mLinDMSO
200mg
1g

Manufactureraablocks
Product numberAA001BYF
Product description1-[7,8-Dihydro-2-[[9-(trans-4-methylcyclohexyl)-9H-pyrido[4',3':4,5]pyrrolo[2,3-d]pyrimidin-2-yl]amino]-1,6-naphthyridin-6(5H)-yl]-2-hydroxyethanone ≥95%
Packaging1mg
Price$36
Updated2026-05-28
Buy

Manufactureraablocks
Product numberAA001BYF
Product description1-[7,8-Dihydro-2-[[9-(trans-4-methylcyclohexyl)-9H-pyrido[4',3':4,5]pyrrolo[2,3-d]pyrimidin-2-yl]amino]-1,6-naphthyridin-6(5H)-yl]-2-hydroxyethanone
Packaging2mg
Price$55
Updated2026-05-28
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Manufactureraablocks
Product numberAA001BYF
Product description1-[7,8-Dihydro-2-[[9-(trans-4-methylcyclohexyl)-9H-pyrido[4',3':4,5]pyrrolo[2,3-d]pyrimidin-2-yl]amino]-1,6-naphthyridin-6(5H)-yl]-2-hydroxyethanone
Packaging5mg
Price$75
Updated2026-05-28
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Manufactureraablocks
Product numberAA001BYF
Product description1-[7,8-Dihydro-2-[[9-(trans-4-methylcyclohexyl)-9H-pyrido[4',3':4,5]pyrrolo[2,3-d]pyrimidin-2-yl]amino]-1,6-naphthyridin-6(5H)-yl]-2-hydroxyethanone
Packaging10mg
Price$98
Updated2026-05-28
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Manufactureraablocks
Product numberAA001BYF
Product description1-[7,8-Dihydro-2-[[9-(trans-4-methylcyclohexyl)-9H-pyrido[4',3':4,5]pyrrolo[2,3-d]pyrimidin-2-yl]amino]-1,6-naphthyridin-6(5H)-yl]-2-hydroxyethanone
Packaging25mg
Price$159
Updated2026-05-28
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Manufactureraablocks
Product numberAA001BYF
Product description1-[7,8-Dihydro-2-[[9-(trans-4-methylcyclohexyl)-9H-pyrido[4',3':4,5]pyrrolo[2,3-d]pyrimidin-2-yl]amino]-1,6-naphthyridin-6(5H)-yl]-2-hydroxyethanone
Packaging50mg
Price$251
Updated2026-05-28
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ManufacturerACHEMBLOCK
Product numberM15296
Product descriptionAMG-925 98%
Packaging25MG
Price$205
Updated2026-05-27
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ManufacturerACHEMBLOCK
Product numberM15296
Product descriptionAMG-925 98%
Packaging50MG
Price$345
Updated2026-05-27
Buy

ManufacturerAK Scientific
Product numberSYN5735
Product descriptionAMG-925
Packaging100mg
Price$2237
Updated2021-12-16
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ManufacturerApexBio Technology
Product numberB3277
Product descriptionAMG 925
Packaging100mg
Price$701
Updated2026-05-06
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ManufacturerApexBio Technology
Product numberB3277
Product descriptionAMG 925
Packaging25mg
Price$311
Updated2026-05-06
Buy

ManufacturerApexBio Technology
Product numberB3277
Product descriptionAMG 925
Packaging5mg
Price$103
Updated2026-05-06
Buy

ManufacturerArctom
Product numberHY-15889
Product descriptionAMG925 99.02%
Packaging5mg
Price$119
Updated2026-05-26
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ManufacturerArctom
Product numberHY-15889
Product descriptionAMG925 99.02%
Packaging10mg
Price$168
Updated2026-05-26
Buy

ManufacturerArctom
Product numberHY-15889
Product descriptionAMG925 99.02%
Packaging1mg
Price$46
Updated2026-05-26
Buy

ManufacturerArctom
Product numberHY-15889
Product descriptionAMG925 99.02%
Packaging25mg
Price$308
Updated2026-05-26
Buy

Manufacturer	Product number	Product description	Packaging	Price	Updated	Buy
aablocks	AA001BYF	1-[7,8-Dihydro-2-[[9-(trans-4-methylcyclohexyl)-9H-pyrido[4',3':4,5]pyrrolo[2,3-d]pyrimidin-2-yl]amino]-1,6-naphthyridin-6(5H)-yl]-2-hydroxyethanone ≥95%	1mg	$36	2026-05-28	Buy
aablocks	AA001BYF	1-[7,8-Dihydro-2-[[9-(trans-4-methylcyclohexyl)-9H-pyrido[4',3':4,5]pyrrolo[2,3-d]pyrimidin-2-yl]amino]-1,6-naphthyridin-6(5H)-yl]-2-hydroxyethanone	2mg	$55	2026-05-28	Buy
aablocks	AA001BYF	1-[7,8-Dihydro-2-[[9-(trans-4-methylcyclohexyl)-9H-pyrido[4',3':4,5]pyrrolo[2,3-d]pyrimidin-2-yl]amino]-1,6-naphthyridin-6(5H)-yl]-2-hydroxyethanone	5mg	$75	2026-05-28	Buy
aablocks	AA001BYF	1-[7,8-Dihydro-2-[[9-(trans-4-methylcyclohexyl)-9H-pyrido[4',3':4,5]pyrrolo[2,3-d]pyrimidin-2-yl]amino]-1,6-naphthyridin-6(5H)-yl]-2-hydroxyethanone	10mg	$98	2026-05-28	Buy
aablocks	AA001BYF	1-[7,8-Dihydro-2-[[9-(trans-4-methylcyclohexyl)-9H-pyrido[4',3':4,5]pyrrolo[2,3-d]pyrimidin-2-yl]amino]-1,6-naphthyridin-6(5H)-yl]-2-hydroxyethanone	25mg	$159	2026-05-28	Buy
aablocks	AA001BYF	1-[7,8-Dihydro-2-[[9-(trans-4-methylcyclohexyl)-9H-pyrido[4',3':4,5]pyrrolo[2,3-d]pyrimidin-2-yl]amino]-1,6-naphthyridin-6(5H)-yl]-2-hydroxyethanone	50mg	$251	2026-05-28	Buy
ACHEMBLOCK	M15296	AMG-925 98%	25MG	$205	2026-05-27	Buy
ACHEMBLOCK	M15296	AMG-925 98%	50MG	$345	2026-05-27	Buy
AK Scientific	SYN5735	AMG-925	100mg	$2237	2021-12-16	Buy
ApexBio Technology	B3277	AMG 925	100mg	$701	2026-05-06	Buy
ApexBio Technology	B3277	AMG 925	25mg	$311	2026-05-06	Buy
ApexBio Technology	B3277	AMG 925	5mg	$103	2026-05-06	Buy
Arctom	HY-15889	AMG925 99.02%	5mg	$119	2026-05-26	Buy
Arctom	HY-15889	AMG925 99.02%	10mg	$168	2026-05-26	Buy
Arctom	HY-15889	AMG925 99.02%	1mg	$46	2026-05-26	Buy
Arctom	HY-15889	AMG925 99.02%	25mg	$308	2026-05-26	Buy

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Properties

Melting point :213-215 °C
Boiling point :712.3±70.0 °C(Predicted)
Density :1.48±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :insoluble in DMSO; insoluble in H2O; insoluble in EtOH
form :solid
pka :13.41±0.10(Predicted)
color :Light yellow to yellow

Safety Information

Symbol(GHS):

Signal word:

Hazard statements:

Code	Hazard statements	Hazard class	Category	Signal word	Pictogram	P-Codes

Precautionary statements:

Description

AMG 925 is a dual inhibitor of FMS-related tyrosine kinase 3 (FLT3) and cyclin-dependent kinase 4 (Cdk4; IC₅₀s = 1 and 3 nM, respectively). It is selective for FLT3 and Cdk4 over Cdk1 (IC₅₀ = 2.22 μM). AMG 925 also binds to FLT3^ITD, FLT3^D835Y, FLT3^D835H, FLT3^K663Q, and FLT3^N841I (K_ds = 1-4 nM). It inhibits proliferation of MOLM-13, COLO 205, and U937 cancer cells (IC₅₀s = 19, 55, and 52 nM, respectively). AMG 925 (50, 75, and 150 mg/kg) reduces intratumor levels of pSTAT5 and pRb and inhibits tumor growth in a MOLM-13 acute myeloid leukemia (AML) mouse xenograft model.

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Suppliers and manufacturers

TargetMol Chemicals Inc.

$30.00
AMG 925 CAS:1401033-86-0

BOC Sciences

TargetMol Chemicals Inc.

Aladdin Scientific

Amadis Chemical Company Limited WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd. Dalian Meilun Biotech Co., Ltd. Shanghai Topbiochem Technology Co., Ltd Hangzhou J&H Chemical Co., Ltd. Shanghai EFE Biological Technology Co., Ltd.

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AMG 925

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