AZ 628
|
- $25 - $2841
- Product name: AZ 628
- CAS: 878739-06-1
- MF: C27H25N5O2
- MW: 451.52
- EINECS:
- MDL Number:MFCD17392577
- Synonyms:3-(1-Cyano-1-methylethyl)-N-[3-[(3,4-dihydro-3-methyl-4-oxo-6-quinazolinyl)amino]-4-methylphenyl]benzamide;AZ-628;AZ628/AZ-628;AZD628;3-(2-cyanopropan-2-yl)-N-(4-methyl-3-(3-methyl-4-oxo-3,4-dihydroquinazolin-6-ylamino)phenyl)benzamide;AZ628, >=99%;3-(2-Cyanopropan-2-yl)-N-(4-methyl-3-((3-methyl-4-oxo-3,4-dihydroquinazolin-6-yl)amino)phenyl)ben;Benzamide, 3-(1-cyano-1-methylethyl)-N-[3-[(3,4-dihydro-3-methyl-4-oxo-6-quinazolinyl)amino]-4-methylphenyl]-
71 prices
Selected condition：
Brand
- aablocks
- ACHEMBLOCK
- AK Scientific
- American Custom Chemicals Corporation
- ApexBio Technology
- Apolloscientific
- Arctom
- Axon Medchem
- Biorbyt Ltd
- Biosynth
- Cayman Chemical
- ChemScene
- Crysdot
- DC Chemicals
- Matrix Scientific
- Sigma-Aldrich
- Tocris
- TRC
- Usbiological
Package
- 2.5mg
- 250.00mg
- 1g
- 2mg
- 10mM*1mLinDMSO(Solution)
- 10mM*1mLinDMSO(Solid+Solvent)
- 1000mg
- 50
- 10
- 1.00g
- 10mM(in 1mL DMSO)
- 1mg
- 10mM(in1mLDMSO)
- 5mg
- 10mg
- 25mg
- 50mg
- 250mg
- 10mM(1mLinDMSO)
- 100mg
- Manufactureraablocks
- Product numberAA00GTYC
- Product description3-(2-Cyanopropan-2-yl)-N-(4-methyl-3-((3-methyl-4-oxo-3,4-dihydroquinazolin-6-yl)amino)phenyl)benzamide 98%
- Packaging1mg
- Price$26
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00GTYC
- Product description3-(2-Cyanopropan-2-yl)-N-(4-methyl-3-((3-methyl-4-oxo-3,4-dihydroquinazolin-6-yl)amino)phenyl)benzamide 98%
- Packaging5mg
- Price$45
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00GTYC
- Product description3-(2-Cyanopropan-2-yl)-N-(4-methyl-3-((3-methyl-4-oxo-3,4-dihydroquinazolin-6-yl)amino)phenyl)benzamide 98%
- Packaging10mg
- Price$70
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00GTYC
- Product description3-(2-Cyanopropan-2-yl)-N-(4-methyl-3-((3-methyl-4-oxo-3,4-dihydroquinazolin-6-yl)amino)phenyl)benzamide 98%
- Packaging25mg
- Price$140
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00GTYC
- Product description3-(2-Cyanopropan-2-yl)-N-(4-methyl-3-((3-methyl-4-oxo-3,4-dihydroquinazolin-6-yl)amino)phenyl)benzamide 98%
- Packaging50mg
- Price$223
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00GTYC
- Product description3-(2-Cyanopropan-2-yl)-N-(4-methyl-3-((3-methyl-4-oxo-3,4-dihydroquinazolin-6-yl)amino)phenyl)benzamide 98
- Packaging100mg
- Price$319
- Updated2026-05-28
- Buy
- ManufacturerACHEMBLOCK
- Product numberY228749
- Product descriptionAZ 628 97.00%
- Packaging100MG
- Price$445
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberY228749
- Product descriptionAZ 628 97.00%
- Packaging25MG
- Price$215
- Updated2026-05-27
- Buy
- ManufacturerAK Scientific
- Product numberY0332
- Product descriptionAZ628
- Packaging1mg
- Price$25
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberCHM0388678
- Product description3-(2-CYANOPROPAN-2-YL)-N-(4-METHYL-3-((3-METHYL-4-OXO-3,4-DIHYDROQUINAZOLIN-6-YL)AMINO)PHENYL)BENZAMIDE 95.00%
- Packaging5MG
- Price$502.88
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA8371
- Product descriptionAZ 628
- Packaging50mg
- Price$360
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberA8371
- Product descriptionAZ 628
- Packaging5mg
- Price$70
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberA8371
- Product descriptionAZ628
- Packaging10mM(in 1mL DMSO)
- Price$77
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA8371
- Product descriptionAZ 628
- Packaging10mM(in1mLDMSO)
- Price$77
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberA8371
- Product descriptionAZ 628
- Packaging10mg
- Price$110
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberA8371
- Product descriptionAZ 628
- Packaging25mg
- Price$220
- Updated2026-05-06
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA00GTYC | 3-(2-Cyanopropan-2-yl)-N-(4-methyl-3-((3-methyl-4-oxo-3,4-dihydroquinazolin-6-yl)amino)phenyl)benzamide 98% | 1mg | $26 | 2026-05-28 | Buy |
| aablocks | AA00GTYC | 3-(2-Cyanopropan-2-yl)-N-(4-methyl-3-((3-methyl-4-oxo-3,4-dihydroquinazolin-6-yl)amino)phenyl)benzamide 98% | 5mg | $45 | 2026-05-28 | Buy |
| aablocks | AA00GTYC | 3-(2-Cyanopropan-2-yl)-N-(4-methyl-3-((3-methyl-4-oxo-3,4-dihydroquinazolin-6-yl)amino)phenyl)benzamide 98% | 10mg | $70 | 2026-05-28 | Buy |
| aablocks | AA00GTYC | 3-(2-Cyanopropan-2-yl)-N-(4-methyl-3-((3-methyl-4-oxo-3,4-dihydroquinazolin-6-yl)amino)phenyl)benzamide 98% | 25mg | $140 | 2026-05-28 | Buy |
| aablocks | AA00GTYC | 3-(2-Cyanopropan-2-yl)-N-(4-methyl-3-((3-methyl-4-oxo-3,4-dihydroquinazolin-6-yl)amino)phenyl)benzamide 98% | 50mg | $223 | 2026-05-28 | Buy |
| aablocks | AA00GTYC | 3-(2-Cyanopropan-2-yl)-N-(4-methyl-3-((3-methyl-4-oxo-3,4-dihydroquinazolin-6-yl)amino)phenyl)benzamide 98 | 100mg | $319 | 2026-05-28 | Buy |
| ACHEMBLOCK | Y228749 | AZ 628 97.00% | 100MG | $445 | 2026-05-27 | Buy |
| ACHEMBLOCK | Y228749 | AZ 628 97.00% | 25MG | $215 | 2026-05-27 | Buy |
| AK Scientific | Y0332 | AZ628 | 1mg | $25 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | CHM0388678 | 3-(2-CYANOPROPAN-2-YL)-N-(4-METHYL-3-((3-METHYL-4-OXO-3,4-DIHYDROQUINAZOLIN-6-YL)AMINO)PHENYL)BENZAMIDE 95.00% | 5MG | $502.88 | 2021-12-16 | Buy |
| ApexBio Technology | A8371 | AZ 628 | 50mg | $360 | 2026-05-06 | Buy |
| ApexBio Technology | A8371 | AZ 628 | 5mg | $70 | 2026-05-06 | Buy |
| ApexBio Technology | A8371 | AZ628 | 10mM(in 1mL DMSO) | $77 | 2021-12-16 | Buy |
| ApexBio Technology | A8371 | AZ 628 | 10mM(in1mLDMSO) | $77 | 2026-05-06 | Buy |
| ApexBio Technology | A8371 | AZ 628 | 10mg | $110 | 2026-05-06 | Buy |
| ApexBio Technology | A8371 | AZ 628 | 25mg | $220 | 2026-05-06 | Buy |
Properties
Density :1.21±0.1 g/cm3(Predicted)
storage temp. :-20°C
solubility :DMSO: soluble10mg/mL, clear
form :powder
pka :12.92±0.70(Predicted)
color :white to beige
InChI :1S/C27H25N5O2/c1-17-8-9-21(31-25(33)18-6-5-7-19(12-18)27(2,3)15-28)14-24(17)30-20-10-11-23-22(13-20)26(34)32(4)16-29-23/h5-14,16,30H,1-4H3,(H,31,33)
InChIKey :ZGBGPEDJXCYQPH-UHFFFAOYSA-N
SMILES :[n]1([c](c2c(nc1)ccc(c2)Nc3c(ccc(c3)NC(=O)c4cc(ccc4)C(C)(C)C#N)C)=O)C
storage temp. :-20°C
solubility :DMSO: soluble10mg/mL, clear
form :powder
pka :12.92±0.70(Predicted)
color :white to beige
InChI :1S/C27H25N5O2/c1-17-8-9-21(31-25(33)18-6-5-7-19(12-18)27(2,3)15-28)14-24(17)30-20-10-11-23-22(13-20)26(34)32(4)16-29-23/h5-14,16,30H,1-4H3,(H,31,33)
InChIKey :ZGBGPEDJXCYQPH-UHFFFAOYSA-N
SMILES :[n]1([c](c2c(nc1)ccc(c2)Nc3c(ccc(c3)NC(=O)c4cc(ccc4)C(C)(C)C#N)C)=O)C
Safety Information
| Symbol(GHS): |
|
|||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal word: | Danger | |||||||||||||||||||||||||||||||||||
| Hazard statements: |
|
|||||||||||||||||||||||||||||||||||
| Precautionary statements: |
|
Description
The Raf kinases activate cellular pathways that lead to cell proliferation and can contribute to certain types of cancer. Mutations in the kinase B-Raf are involved in a wide range of cancers. In particular, the mutation B-RafV600E occurs in melanomas and other types of cancer but is poorly targeted by many inhibitors of wild type B-Raf. AZ 628 is a quinazilinone that inhibits several Raf kinases, including B-Raf, B-RafV600E, and c-Raf-1 (IC50s = 105, 34, and 29 nM in in vitro kinase assays). It also prevents activation of several tyrosine kinases, including VEGFR2, DDR2, Lyn, Flt1, and FMS. In colon and melanoma cell lines carrying B-RafV600E mutations, AZ 628 is reported to inhibit anchorage-dependent and -independent growth, induce cell cycle arrest, and cause apoptosis.Related product price
-
GDC-0879
$34-2872 -
871700-17-3
$28-4391.1 -
Tozasertib
$11-1840
Suppliers and manufacturers
Shanghai Boyle Chemical Co., Ltd.
Chembest Research Laboratories Limited
Jinan Trio PharmaTech Co., Ltd.
Shanghai civi chemical technology co.,Ltd
NCE Biomedical Co.,Ltd.
Haoyuan Chemexpress Co., Ltd.
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Guangzhou Isun Pharmaceutical Co., Ltd
AdooQ BioScience, LLC
CEG Chemical Science&Technology Co., Ltd.