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ChemicalBook >> CAS DataBase List >> Amiodarone hydrochloride

Amiodarone hydrochloride

Amiodarone hydrochloride price.
  • $10.9 - $377
  • Product name: Amiodarone hydrochloride
  • CAS: 19774-82-4
  • MF: C25H29I2NO3.ClH
  • MW: 681.77
  • EINECS:243-293-2
  • MDL Number:MFCD08064189
  • Synonyms:Methanone,(2-butyl-3-benzofuranyl)[4-[2-(diethylaMino)ethoxy]-3,5-diiodophenyl]-,hydrochloride (1:1);AMiodarone hydrochloride API;AMidorone (HCl);Nexterone;AMiodarone iMpurity;(2-Butylbenzofuran-3-yl)(4-(2-(diethylaMino)ethoxy)-3,5-diiodophenyl)Methanone hydrochloride;2-BUTYL-3-BENZOFURANYL 4-[2-(DIETHYLAMINO)ETHOXY]-3,5-DIIODOPHENYL KETONE HYDROCHLORIDE;(2-BUTYL-3-BENZOFURANYL)-[4-[2-(DIETHYLAMINO)ETHOXY]-3,5-DIIODO-PHENYL]-METHANONE HYDROCHLORIDE
16 prices
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Brand

  • Alfa Aesar
  • Cayman Chemical
  • Sigma-Aldrich
  • TCI Chemical

Package

  • 060-1ml
  • 500mg
  • 200mg
  • a0575000
  • 1g
  • 5g
  • 10g
  • 25g
  • ManufacturerAlfa Aesar
  • Product numberJ60456
  • Product descriptionAmiodarone hydrochloride
  • Packaging1g
  • Price$10.9
  • Updated2018-11-13
  • Buy
  • ManufacturerAlfa Aesar
  • Product numberJ60456
  • Product descriptionAmiodarone hydrochloride
  • Packaging5g
  • Price$29.8
  • Updated2018-11-13
  • Buy
  • ManufacturerAlfa Aesar
  • Product numberJ60456
  • Product descriptionAmiodarone hydrochloride
  • Packaging25g
  • Price$118
  • Updated2018-11-13
  • Buy
  • ManufacturerCayman Chemical
  • Product number15213
  • Product descriptionAmiodarone (hydrochloride) ≥98%
  • Packaging10g
  • Price$175
  • Updated2018-11-13
  • Buy
  • ManufacturerCayman Chemical
  • Product number15213
  • Product descriptionAmiodarone (hydrochloride) ≥98%
  • Packaging500mg
  • Price$25
  • Updated2018-11-13
  • Buy
  • ManufacturerCayman Chemical
  • Product number15213
  • Product descriptionAmiodarone (hydrochloride) ≥98%
  • Packaging1g
  • Price$35
  • Updated2018-11-13
  • Buy
  • ManufacturerCayman Chemical
  • Product number15213
  • Product descriptionAmiodarone (hydrochloride) ≥98%
  • Packaging5g
  • Price$98
  • Updated2018-11-13
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  • ManufacturerSigma-Aldrich
  • Product numberA-060
  • Product descriptionAmiodarone hydrochloride solution 1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material
  • Packaging060-1ml
  • Price$99.9
  • Updated2018-11-13
  • Buy
  • ManufacturerSigma-Aldrich
  • Product numberA8423
  • Product descriptionAmiodarone hydrochloride ≥98%
  • Packaging1g
  • Price$59.7
  • Updated2018-11-13
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  • ManufacturerSigma-Aldrich
  • Product numberPHR1164
  • Product descriptionAmiodarone hydrochloride Pharmaceutical Secondary Standard; Certified Reference Material
  • Packaging1g
  • Price$68.5
  • Updated2018-11-13
  • Buy
  • ManufacturerSigma-Aldrich
  • Product numberA0575000
  • Product descriptionAmiodarone hydrochloride European Pharmacopoeia (EP) Reference Standard
  • Packaginga0575000
  • Price$179
  • Updated2018-11-23
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  • ManufacturerSigma-Aldrich
  • Product numberA8423
  • Product descriptionAmiodarone hydrochloride ≥98%
  • Packaging5g
  • Price$229
  • Updated2018-11-13
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  • ManufacturerSigma-Aldrich
  • Product number1027302
  • Product descriptionAmiodarone hydrochloride United States Pharmacopeia (USP) Reference Standard
  • Packaging200mg
  • Price$348
  • Updated2018-11-13
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  • ManufacturerSigma-Aldrich
  • Product numberA8423
  • Product descriptionAmiodarone hydrochloride ≥98%
  • Packaging10g
  • Price$377
  • Updated2018-11-13
  • Buy
  • ManufacturerTCI Chemical
  • Product numberA2530
  • Product descriptionAmiodarone Hydrochloride >98.0%(HPLC)(T)
  • Packaging5g
  • Price$36
  • Updated2018-11-22
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  • ManufacturerTCI Chemical
  • Product numberA2530
  • Product descriptionAmiodarone Hydrochloride >98.0%(HPLC)(T)
  • Packaging1g
  • Price$13
  • Updated2018-11-22
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Alfa Aesar J60456 Amiodarone hydrochloride 1g $10.9 2018-11-13 Buy
Alfa Aesar J60456 Amiodarone hydrochloride 5g $29.8 2018-11-13 Buy
Alfa Aesar J60456 Amiodarone hydrochloride 25g $118 2018-11-13 Buy
Cayman Chemical 15213 Amiodarone (hydrochloride) ≥98% 10g $175 2018-11-13 Buy
Cayman Chemical 15213 Amiodarone (hydrochloride) ≥98% 500mg $25 2018-11-13 Buy
Cayman Chemical 15213 Amiodarone (hydrochloride) ≥98% 1g $35 2018-11-13 Buy
Cayman Chemical 15213 Amiodarone (hydrochloride) ≥98% 5g $98 2018-11-13 Buy
Sigma-Aldrich A-060 Amiodarone hydrochloride solution 1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material 060-1ml $99.9 2018-11-13 Buy
Sigma-Aldrich A8423 Amiodarone hydrochloride ≥98% 1g $59.7 2018-11-13 Buy
Sigma-Aldrich PHR1164 Amiodarone hydrochloride Pharmaceutical Secondary Standard; Certified Reference Material 1g $68.5 2018-11-13 Buy
Sigma-Aldrich A0575000 Amiodarone hydrochloride European Pharmacopoeia (EP) Reference Standard a0575000 $179 2018-11-23 Buy
Sigma-Aldrich A8423 Amiodarone hydrochloride ≥98% 5g $229 2018-11-13 Buy
Sigma-Aldrich 1027302 Amiodarone hydrochloride United States Pharmacopeia (USP) Reference Standard 200mg $348 2018-11-13 Buy
Sigma-Aldrich A8423 Amiodarone hydrochloride ≥98% 10g $377 2018-11-13 Buy
TCI Chemical A2530 Amiodarone Hydrochloride >98.0%(HPLC)(T) 5g $36 2018-11-22 Buy
TCI Chemical A2530 Amiodarone Hydrochloride >98.0%(HPLC)(T) 1g $13 2018-11-22 Buy

Properties

Melting point: :154-158°C
Flash point: :9℃
storage temp.  :2-8°C
solubility  :Soluble in chloroform, methanol.
pka :pKa (25°C) 6.56 ±0.06
form  :neat
λmax :242nm(MeOH)(lit.)
Merck  :14,482
CAS DataBase Reference :19774-82-4(CAS DataBase Reference)

Safety Information

Symbol(GHS):
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H225 Highly Flammable liquid and vapour Flammable liquids Category 2 Danger P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H303 May be harmfulif swallowed Acute toxicity,oral Category 5 P312
H312 Harmful in contact with skin Acute toxicity,dermal Category 4 Warning P280,P302+P352, P312, P322, P363,P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H332 Harmful if inhaled Acute toxicity,inhalation Category 4 Warning P261, P271, P304+P340, P312
H361 Suspected of damaging fertility or the unborn child Reproductive toxicity Category 2 Warning P201, P202, P281, P308+P313, P405,P501
H362 May cause harm to breast-fed children Reproductive toxicity, effects on or via lactation Additional category P201, P260, P263, P264, P270,P308+P313
H370 Causes damage to organs Specific target organ toxicity, single exposure Category 1 Danger P260, P264, P270, P307+P311, P321,P405, P501
H373 May cause damage to organs through prolonged or repeated exposure Specific target organ toxicity, repeated exposure Category 2 Warning P260, P314, P501
Precautionary statements:
P201 Obtain special instructions before use.
P202 Do not handle until all safety precautions have been read and understood.
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P263 Avoid contact during pregnancy/while nursing.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P311 Call a POISON CENTER or doctor/physician.
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P308+P313 IF exposed or concerned: Get medical advice/attention.
P405 Store locked up.
P501 Dispose of contents/container to..…

Description

Amiodarone is a class III antiarrhythmic agent, in that it prolongs both cardiac action potential and refractoriness by blocking potassium currents. It inhibits the voltage-gated potassium channel hERG, also known as KCNH2, with an IC50 value of 1 μM. In addition, amiodarone binds with high affinity to the sigma-1 opioid receptor, 3-β-hydroxysteroid Δ8Δ7 isomerase, and C-8 sterol isomerase (Kis = 1, 25, and 62 nM, respectively) and inhibits human thyroid hormone receptors α and β (IC50s = 0.6, 0.65 μM, respectively). It also inhibits the cytochrome P450 (CYP) isoforms CYP2C8 and CYP3A4 in vitro at low micromolar concentrations.

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