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ChemicalBook >> CAS DataBase List >> Andrographolide

Andrographolide

Andrographolide price.
  • $10 - $640
  • Product name: Andrographolide
  • CAS: 5508-58-7
  • MF: C20H30O5
  • MW: 350.45
  • EINECS:226-852-5
  • MDL Number:MFCD07778082
  • Synonyms:Andrographolide/Andrographis Paniculata P.E.;5-alpha,6-alpha,8a-alpha))-t ;2(3h)-furanone,3-(2-(decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-met ;3-(2-(Decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylene- 1-naphthalenyl)ethylidene)dihydro-4-hydroxy-, (1R-(1-alpha(E(S*)),4a-beta,5- alpha,6-alpha,8a-alpha))-2(3H)-furanone;(3E,4S)-3-[2-[(1R,4aS,5R,6R,8aS)-1,2,3,4,4a,5,6,7,8,8a-Decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylenenaphthalene-1-yl]ethylidene]dihydro-4-hydroxy-2(3H)-furanone;(S)-3-[(E)-2-[[(1R,4aα)-Decahydro-6β-hydroxy-5β-hydroxymethyl-5,8aβ-dimethyl-2-methylenenaphthalen]-1β-yl]ethylidene]dihydro-4-hydroxy-2(3H)-furanone;Andrographolid;Andrographolide (50 mg)
52 prices
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Brand
  • Adipogen Life Sciences
  • AK Scientific
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Arctom
  • AvaChem
  • Biorbyt Ltd
  • Biosynth Carbosynth
  • Cayman Chemical
  • Chemenu
  • Chem-Impex
  • ChemScene
  • Crysdot
  • CSNpharm
  • DC Chemicals
  • JR MediChem
  • Matrix Scientific
  • Medical Isotopes, Inc.
  • Sigma-Aldrich
  • TCI Chemical
  • Tocris
  • TRC
  • Usbiological
Package
  • 5mg
  • 10mg
  • 20mg
  • 25mg
  • 50mg
  • 250mg
  • 500mg
  • 100mg
  • 50
  • 10mM(in 1mL DMSO)
  • 1G
  • 1000mg
  • 5g
  • 10g
  • 25g
  • 50g
  • 100g
  • ManufacturerAdipogen Life Sciences
  • Product numberCDX-A0576-M500
  • Product descriptionAndrographolide ≥98%(HPLC)
  • Packaging500mg
  • Price$94
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberL973
  • Product descriptionAndrographolide
  • Packaging5g
  • Price$41
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberPXT0000076
  • Product descriptionANDROGRAPHIS 95.00%
  • Packaging1G
  • Price$132.3
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberN1855
  • Product descriptionAndrographolide
  • Packaging100mg
  • Price$40
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberN1855
  • Product descriptionAndrographolide
  • Packaging10mM(in 1mL DMSO)
  • Price$50
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberN1855
  • Product descriptionAndrographolide
  • Packaging500mg
  • Price$120
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberCFN98923
  • Product descriptionAndrographolide ≥98%
  • Packaging20mg
  • Price$30
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberSY009509
  • Product description(3E,4S)-3-[2-[(1R,4aS,5R,6R,8aS)-Decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylene-1-napthalenyl]ethylidene]dihydro-4-hydroxy-2(3H)-furanone ≥97%
  • Packaging10mg
  • Price$34.09
  • Updated2021-12-16
  • Buy
  • ManufacturerAvaChem
  • Product number1015
  • Product descriptionAndrographolide
  • Packaging500mg
  • Price$45
  • Updated2021-12-16
  • Buy
  • ManufacturerAvaChem
  • Product number1015
  • Product descriptionAndrographolide
  • Packaging1g
  • Price$75
  • Updated2021-12-16
  • Buy
  • ManufacturerAvaChem
  • Product number1015
  • Product descriptionAndrographolide
  • Packaging10g
  • Price$390
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb545848
  • Product descriptionAndrographolide >98%
  • Packaging100mg
  • Price$125.8
  • Updated2021-12-16
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  • ManufacturerBiorbyt Ltd
  • Product numberorb593737
  • Product descriptionAndrographolide
  • Packaging20mg
  • Price$153
  • Updated2021-12-16
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  • ManufacturerBiorbyt Ltd
  • Product numberorb593737
  • Product descriptionAndrographolide
  • Packaging1000mg
  • Price$221
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb545848
  • Product descriptionAndrographolide >98%
  • Packaging500mg
  • Price$283.9
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFA17902
  • Product descriptionAndrographolide
  • Packaging5G
  • Price$60
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Adipogen Life Sciences CDX-A0576-M500 Andrographolide ≥98%(HPLC) 500mg $94 2021-12-16 Buy
AK Scientific L973 Andrographolide 5g $41 2021-12-16 Buy
American Custom Chemicals Corporation PXT0000076 ANDROGRAPHIS 95.00% 1G $132.3 2021-12-16 Buy
ApexBio Technology N1855 Andrographolide 100mg $40 2021-12-16 Buy
ApexBio Technology N1855 Andrographolide 10mM(in 1mL DMSO) $50 2021-12-16 Buy
ApexBio Technology N1855 Andrographolide 500mg $120 2021-12-16 Buy
Arctom CFN98923 Andrographolide ≥98% 20mg $30 2021-12-16 Buy
Arctom SY009509 (3E,4S)-3-[2-[(1R,4aS,5R,6R,8aS)-Decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylene-1-napthalenyl]ethylidene]dihydro-4-hydroxy-2(3H)-furanone ≥97% 10mg $34.09 2021-12-16 Buy
AvaChem 1015 Andrographolide 500mg $45 2021-12-16 Buy
AvaChem 1015 Andrographolide 1g $75 2021-12-16 Buy
AvaChem 1015 Andrographolide 10g $390 2021-12-16 Buy
Biorbyt Ltd orb545848 Andrographolide >98% 100mg $125.8 2021-12-16 Buy
Biorbyt Ltd orb593737 Andrographolide 20mg $153 2021-12-16 Buy
Biorbyt Ltd orb593737 Andrographolide 1000mg $221 2021-12-16 Buy
Biorbyt Ltd orb545848 Andrographolide >98% 500mg $283.9 2021-12-16 Buy
Biosynth Carbosynth FA17902 Andrographolide 5G $60 2021-12-16 Buy

Properties

Melting point :229-232 °C (lit.)
Boiling point :557.3±50.0 °C(Predicted)
alpha :-126 º (c=1.5,HAc)
Density :d421 1.2317
storage temp. :2-8°C
solubility :Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 8 mg/ml).
pka :12.36±0.20(Predicted)
form :Off-white solid
color :Off-white
optical activity :[α]20/D 126°, c = 1.5 in acetic acid
λmax :223nm(MeOH)(lit.)
Merck :14,633
BRN :42762
Stability :Stable for 2 years from date of purchsae as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
InChIKey :BOJKULTULYSRAS-QPSYGYIJSA-N
LogP :0.424 (est)
CAS DataBase Reference :5508-58-7

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H332 Harmful if inhaled Acute toxicity,inhalation Category 4 Warning GHS hazard pictograms P261, P271, P304+P340, P312
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Andrographolide is the bitter principle, a colorless and neutral crystalline substance. It is the major labdane diterpenoid isolated from Andrographis paniculate. It exhibits antiviral, anti-inflammatory, and anticancer activities. The underlying mechanism is the inhibition of the mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) signaling (specifically p38 MAPK/ERK1/2) pathway and downstream transcription factors such as nuclear factor kappa B (NF-κB) and nuclear factor of activated T cells (NFAT). Andrographolide is also confirmed with chemopreventive effects against and the inhibitory effects on cancer cell growth in breast, colon, epidermoid, gastric, liver, leukemia, myeloma, peripheral blood lymphocytes, and prostate cancers.

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