Avapritinib
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- $22 - $6622
- Product name: Avapritinib
- CAS: 1703793-34-3
- MF: C26H27FN10
- MW: 498.56
- EINECS:-0
- MDL Number:MFCD31544325
- Synonyms:CPD1212;(1S)-1-(4-Fluorophenyl)-1-(2-{4-[6-(1-methyl-1H-pyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]-1-piperazinyl}-5-pyrimidinyl)ethanamine;Avapritinib(BLU-285);BLU-285 (Avapritinib);BLU-285;BLU 285;BLU285;CS-2474;BLU-N;(S)-1-(4-fluorophenyl)-1-(2-(4-(6-(1-methyl-1H-pyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl)piperazin-1-yl)pyrimidin-5-yl)ethan-1-amine
69 prices
Selected condition：
Brand
- aablocks
- ACHEMBLOCK
- Apolloscientific
- Arctom
- Biosynth
- Cayman Chemical
- ChemScene
- Crysdot
- DC Chemicals
- Matrix Scientific
Package
- 10mM*1mLinDMSO(Solution)
- 1mg
- 2mg
- 5.00mg
- 10mM(1mLinDMSO)
- 5mg
- 10mM*1mLinDMSO(Solid+Solvent)
- 10mg
- 25.00mg
- 25mg
- 50.00mg
- 50mg
- 100mg
- 250mg
- 1g
- Manufactureraablocks
- Product numberAA01DQ80
- Product description(1S)-1-(4-Fluorophenyl)-1-(2-{4-[6-(1-methyl-1H-pyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]-1-piperazinyl}-5-pyrimidinyl)ethanamine 98%
- Packaging25mg
- Price$119
- Updated2026-05-29
- Buy
- Manufactureraablocks
- Product numberAA01DQ80
- Product description(1S)-1-(4-Fluorophenyl)-1-(2-{4-[6-(1-methyl-1H-pyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]-1-piperazinyl}-5-pyrimidinyl)ethanamine 98%
- Packaging50mg
- Price$191
- Updated2026-05-29
- Buy
- Manufactureraablocks
- Product numberAA01DQ80
- Product description(1S)-1-(4-Fluorophenyl)-1-(2-{4-[6-(1-methyl-1H-pyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]-1-piperazinyl}-5-pyrimidinyl)ethanamine 98%
- Packaging100mg
- Price$317
- Updated2026-05-29
- Buy
- Manufactureraablocks
- Product numberAA01DQ80
- Product description(1S)-1-(4-Fluorophenyl)-1-(2-{4-[6-(1-methyl-1H-pyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]-1-piperazinyl}-5-pyrimidinyl)ethanamine 98%
- Packaging5mg
- Price$47
- Updated2026-05-29
- Buy
- Manufactureraablocks
- Product numberAA01DQ80
- Product description(1S)-1-(4-Fluorophenyl)-1-(2-{4-[6-(1-methyl-1H-pyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]-1-piperazinyl}-5-pyrimidinyl)ethanamine ≥98%
- Packaging2mg
- Price$40
- Updated2026-05-29
- Buy
- Manufactureraablocks
- Product numberAA01DQ80
- Product description(1S)-1-(4-Fluorophenyl)-1-(2-{4-[6-(1-methyl-1H-pyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]-1-piperazinyl}-5-pyrimidinyl)ethanamine 98%
- Packaging1mg
- Price$22
- Updated2026-05-29
- Buy
- Manufactureraablocks
- Product numberAA01DQ80
- Product description(1S)-1-(4-Fluorophenyl)-1-(2-{4-[6-(1-methyl-1H-pyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]-1-piperazinyl}-5-pyrimidinyl)ethanamine 98%
- Packaging250mg
- Price$541
- Updated2026-05-29
- Buy
- ManufacturerACHEMBLOCK
- Product numberQ65617
- Product description(S)-1-(4-fluorophenyl)-1-(2-(4-(6-(1-methyl-1H-pyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl)piperazin-1-yl)pyrimidin-5-yl)ethan-1-amine 98%
- Packaging25MG
- Price$135
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberQ65617
- Product description(S)-1-(4-fluorophenyl)-1-(2-(4-(6-(1-methyl-1H-pyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl)piperazin-1-yl)pyrimidin-5-yl)ethan-1-amine 98%
- Packaging100MG
- Price$345
- Updated2026-05-27
- Buy
- ManufacturerApolloscientific
- Product numberBISN0062
- Product descriptionBLU-285 99%
- Packaging10mg
- Price$479
- Updated2021-12-16
- Buy
- ManufacturerApolloscientific
- Product numberBISN0062
- Product descriptionBLU-285 99%
- Packaging5mg
- Price$319
- Updated2021-12-16
- Buy
- ManufacturerApolloscientific
- Product numberBISN0062
- Product descriptionBLU-285 99%
- Packaging25mg
- Price$841
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberHY-101561
- Product descriptionAvapritinib 99.75%
- Packaging100mg
- Price$713
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberSLK-S8553
- Product descriptionAvapritinib (BLU-285) 99.99%
- Packaging25mg
- Price$751
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberHY-101561R
- Product descriptionAvapritinib (Standard)
- Packaging25mg
- Price$794
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberHY-101561R
- Product descriptionAvapritinib (Standard)
- Packaging50mg
- Price$1188
- Updated2026-05-26
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA01DQ80 | (1S)-1-(4-Fluorophenyl)-1-(2-{4-[6-(1-methyl-1H-pyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]-1-piperazinyl}-5-pyrimidinyl)ethanamine 98% | 25mg | $119 | 2026-05-29 | Buy |
| aablocks | AA01DQ80 | (1S)-1-(4-Fluorophenyl)-1-(2-{4-[6-(1-methyl-1H-pyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]-1-piperazinyl}-5-pyrimidinyl)ethanamine 98% | 50mg | $191 | 2026-05-29 | Buy |
| aablocks | AA01DQ80 | (1S)-1-(4-Fluorophenyl)-1-(2-{4-[6-(1-methyl-1H-pyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]-1-piperazinyl}-5-pyrimidinyl)ethanamine 98% | 100mg | $317 | 2026-05-29 | Buy |
| aablocks | AA01DQ80 | (1S)-1-(4-Fluorophenyl)-1-(2-{4-[6-(1-methyl-1H-pyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]-1-piperazinyl}-5-pyrimidinyl)ethanamine 98% | 5mg | $47 | 2026-05-29 | Buy |
| aablocks | AA01DQ80 | (1S)-1-(4-Fluorophenyl)-1-(2-{4-[6-(1-methyl-1H-pyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]-1-piperazinyl}-5-pyrimidinyl)ethanamine ≥98% | 2mg | $40 | 2026-05-29 | Buy |
| aablocks | AA01DQ80 | (1S)-1-(4-Fluorophenyl)-1-(2-{4-[6-(1-methyl-1H-pyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]-1-piperazinyl}-5-pyrimidinyl)ethanamine 98% | 1mg | $22 | 2026-05-29 | Buy |
| aablocks | AA01DQ80 | (1S)-1-(4-Fluorophenyl)-1-(2-{4-[6-(1-methyl-1H-pyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]-1-piperazinyl}-5-pyrimidinyl)ethanamine 98% | 250mg | $541 | 2026-05-29 | Buy |
| ACHEMBLOCK | Q65617 | (S)-1-(4-fluorophenyl)-1-(2-(4-(6-(1-methyl-1H-pyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl)piperazin-1-yl)pyrimidin-5-yl)ethan-1-amine 98% | 25MG | $135 | 2026-05-27 | Buy |
| ACHEMBLOCK | Q65617 | (S)-1-(4-fluorophenyl)-1-(2-(4-(6-(1-methyl-1H-pyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl)piperazin-1-yl)pyrimidin-5-yl)ethan-1-amine 98% | 100MG | $345 | 2026-05-27 | Buy |
| Apolloscientific | BISN0062 | BLU-285 99% | 10mg | $479 | 2021-12-16 | Buy |
| Apolloscientific | BISN0062 | BLU-285 99% | 5mg | $319 | 2021-12-16 | Buy |
| Apolloscientific | BISN0062 | BLU-285 99% | 25mg | $841 | 2021-12-16 | Buy |
| Arctom | HY-101561 | Avapritinib 99.75% | 100mg | $713 | 2026-05-26 | Buy |
| Arctom | SLK-S8553 | Avapritinib (BLU-285) 99.99% | 25mg | $751 | 2026-05-26 | Buy |
| Arctom | HY-101561R | Avapritinib (Standard) | 25mg | $794 | 2026-05-26 | Buy |
| Arctom | HY-101561R | Avapritinib (Standard) | 50mg | $1188 | 2026-05-26 | Buy |
Properties
Density :1.42±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMSO:83.11(Max Conc. mg/mL);166.7(Max Conc. mM)
form :A crystalline solid
pka :6.96±0.10(Predicted)
color :White to light yellow
InChIKey :DWYRIWUZIJHQKQ-JKXWNSIXNA-N
SMILES :C1N(C2N=CC([C@@](N)(C3C=CC(F)=CC=3)C)=CN=2)CCN(C2C3=CC(C4C=NN(C)C=4)=CN3N=CN=2)C1 |&1:6,r|
CAS DataBase Reference :1703793-34-3
storage temp. :Store at -20°C
solubility :DMSO:83.11(Max Conc. mg/mL);166.7(Max Conc. mM)
form :A crystalline solid
pka :6.96±0.10(Predicted)
color :White to light yellow
InChIKey :DWYRIWUZIJHQKQ-JKXWNSIXNA-N
SMILES :C1N(C2N=CC([C@@](N)(C3C=CC(F)=CC=3)C)=CN=2)CCN(C2C3=CC(C4C=NN(C)C=4)=CN3N=CN=2)C1 |&1:6,r|
CAS DataBase Reference :1703793-34-3
Safety Information
| Symbol(GHS): |
 
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| Signal word: | Warning | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Hazard statements: |
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| Precautionary statements: |
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Description
BLU-285 is a dual inhibitor of KIT receptor and platelet-derived growth factor receptor α (PDGFRα) tyrosine kinases with activating loop mutations (IC50s = 0.27 and 0.24 nM for KITD816V and PDGFRαD842V, respectively). It is >150-fold selective for KITD816V and PDGFRαD842V over a kinase panel at a concentration of 3 μM. BLU-285 also has activity against a panel of KIT and PDGFRα loop mutants identified in patients with gastrointestinal stromal tumors (GISTs; IC50s = <100 nM). It inhibits growth of cancer cell lines containing wild-type and mutant KIT and PDGFRα, demonstrating increased potency in cell lines expressing KIT and PDGFRα with activating loop mutations. BLU-285 (0.3-30 mg/kg) reduces tumor volume in a P815 KITD814Y mastocytoma allograft mouse model and a GIST patient-derived mouse xenograft model in a dose-dependent manner. Formulations containing BLU-285 have been used to treat KIT- and PDGFRα-driven malignancies.More related product prices
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Suppliers and manufacturers
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Avapritinib
CAS:1703793-34-3
