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ChemicalBook >> CAS DataBase List >> BAY-41-8543

BAY-41-8543

$35 - $1740
Product name: BAY-41-8543
CAS: 256498-66-5
MF: C21H21FN8O
MW: 420.44
EINECS:
MDL Number:MFCD18382081
Synonyms:BAY-41-8543;BAY-41-8543 Exclusive;BAY 41-8543 (BAY 418543);2-[1-[(2-Fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl]-5-(4-morpholinyl)-4,6-pyrimidinediamine;4,6-Pyrimidinediamine, 2-[1-[(2-fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl]-5-(4-morpholinyl)-;BAY 418543,vascular,systemic,antiplatelet,vasodilator,soluble,pulmonary,orally,nitric,beds,cardiovascular,BAY 41 8543,Guanylate Cyclase,Inhibitor,sGC,BAY 41-8543,oxide,inhibit;2-[1-[(2-fluorophenyl)methyl]pyrazolo[3,4-b]pyridin-3-yl]-5-morpholin-4-ylpyrimidine-4,6-diamine;2-(1-(2-fluorobenzyl)-1h-pyrazolo[3,4-b]pyridin-3-yl)-5-morpholinopyrimidine-4,6-diamine

Price16 Properties Safety Information Description

16 prices

Selected condition：

Brand

AK Scientific
ApexBio Technology
Cayman Chemical
Chemenu
ChemScene
Crysdot
Sigma-Aldrich
Tocris
TRC

Package

5mg
10
1mg
50
10mg
25mg
50mg
100mg

ManufacturerAK Scientific
Product number4490CR
Product descriptionBAY 41-8543
Packaging5mg
Price$410
Updated2021-12-16
Buy

ManufacturerAK Scientific
Product number4490CR
Product descriptionBAY 41-8543
Packaging25mg
Price$1305
Updated2021-12-16
Buy

ManufacturerApexBio Technology
Product numberC3639
Product descriptionBAY 41-8543
Packaging10mg
Price$348
Updated2021-12-16
Buy

ManufacturerApexBio Technology
Product numberC3639
Product descriptionBAY 41-8543
Packaging50mg
Price$1464
Updated2021-12-16
Buy

ManufacturerCayman Chemical
Product number10011131
Product descriptionBAY 41-8543 ≥98%
Packaging1mg
Price$35
Updated2024-03-01
Buy

ManufacturerCayman Chemical
Product number10011131
Product descriptionBAY 41-8543 ≥98%
Packaging5mg
Price$114
Updated2024-03-01
Buy

ManufacturerCayman Chemical
Product number10011131
Product descriptionBAY 41-8543 ≥98%
Packaging10mg
Price$210
Updated2024-03-01
Buy

ManufacturerCayman Chemical
Product number10011131
Product descriptionBAY 41-8543 ≥98%
Packaging25mg
Price$481
Updated2024-03-01
Buy

ManufacturerChemenu
Product numberCM332231
Product description2-[1-[(2-fluorophenyl)methyl]pyrazolo[3,4-b]pyridin-3-yl]-5-morpholin-4-ylpyrimidine-4,6-diamine 95%+
Packaging100mg
Price$1740
Updated2021-12-16
Buy

ManufacturerChemScene
Product numberCS-0054690
Product descriptionBAY 41-8543
Packaging100mg
Price$1160
Updated2021-12-16
Buy

ManufacturerCrysdot
Product numberCD11157932
Product descriptionBAY 41-8543 97%
Packaging100mg
Price$1420
Updated2021-12-16
Buy

ManufacturerSigma-Aldrich
Product numberSML2727
Product descriptionBAY 41-8543 ≥98% (HPLC)
Packaging5MG
Price$101.65
Updated2025-07-31
Buy

ManufacturerSigma-Aldrich
Product numberSML2727
Product descriptionBAY 41-8543 ≥98% (HPLC)
Packaging25MG
Price$433
Updated2025-07-31
Buy

ManufacturerTocris
Product number5708
Product descriptionBAY 41-8543 ≥98%(HPLC)
Packaging10
Price$229
Updated2021-12-16
Buy

ManufacturerTocris
Product number5708
Product descriptionBAY 41-8543 ≥98%(HPLC)
Packaging50
Price$963
Updated2021-12-16
Buy

ManufacturerTRC
Product numberB127610
Product descriptionBAY 41-8543
Packaging5mg
Price$440
Updated2021-12-16
Buy

Manufacturer	Product number	Product description	Packaging	Price	Updated	Buy
AK Scientific	4490CR	BAY 41-8543	5mg	$410	2021-12-16	Buy
AK Scientific	4490CR	BAY 41-8543	25mg	$1305	2021-12-16	Buy
ApexBio Technology	C3639	BAY 41-8543	10mg	$348	2021-12-16	Buy
ApexBio Technology	C3639	BAY 41-8543	50mg	$1464	2021-12-16	Buy
Cayman Chemical	10011131	BAY 41-8543 ≥98%	1mg	$35	2024-03-01	Buy
Cayman Chemical	10011131	BAY 41-8543 ≥98%	5mg	$114	2024-03-01	Buy
Cayman Chemical	10011131	BAY 41-8543 ≥98%	10mg	$210	2024-03-01	Buy
Cayman Chemical	10011131	BAY 41-8543 ≥98%	25mg	$481	2024-03-01	Buy
Chemenu	CM332231	2-[1-[(2-fluorophenyl)methyl]pyrazolo[3,4-b]pyridin-3-yl]-5-morpholin-4-ylpyrimidine-4,6-diamine 95%+	100mg	$1740	2021-12-16	Buy
ChemScene	CS-0054690	BAY 41-8543	100mg	$1160	2021-12-16	Buy
Crysdot	CD11157932	BAY 41-8543 97%	100mg	$1420	2021-12-16	Buy
Sigma-Aldrich	SML2727	BAY 41-8543 ≥98% (HPLC)	5MG	$101.65	2025-07-31	Buy
Sigma-Aldrich	SML2727	BAY 41-8543 ≥98% (HPLC)	25MG	$433	2025-07-31	Buy
Tocris	5708	BAY 41-8543 ≥98%(HPLC)	10	$229	2021-12-16	Buy
Tocris	5708	BAY 41-8543 ≥98%(HPLC)	50	$963	2021-12-16	Buy
TRC	B127610	BAY 41-8543	5mg	$440	2021-12-16	Buy

Properties

Boiling point :599.7±50.0 °C(Predicted)
Density :1.55±0.1 g/cm3(Predicted)
solubility :DMF: 3 mg/ml; DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml
form :A crystalline solid
pka :5.18±0.10(Predicted)
color :White to off-white

Safety Information

Symbol(GHS):

Signal word:

Warning

Hazard statements:

Code	Hazard statements	Hazard class	Category	Signal word	P-Codes
H302	Harmful if swallowed	Acute toxicity,oral	Category 4	Warning	P264, P270, P301+P312, P330, P501
H315	Causes skin irritation	Skin corrosion/irritation	Category 2	Warning	P264, P280, P302+P352, P321,P332+P313, P362
H319	Causes serious eye irritation	Serious eye damage/eye irritation	Category 2A	Warning	P264, P280, P305+P351+P338,P337+P313P
H335	May cause respiratory irritation	Specific target organ toxicity, single exposure;Respiratory tract irritation	Category 3	Warning

Precautionary statements:

P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Soluble guanylate cyclase (sGC) is the primary cellular receptor for nitric oxide (NO). NO binds and activates a heme group in sGC, initiating the conversion of GTP to the second messenger cyclic GMP (cGMP). BAY-41-8543 is a heme-dependent stimulator of sGC, increasing the activity of recombinant sGC dose-dependently up to 92-fold. Surprisingly, NO donors synergize with BAY-41-8543 in stimulating recombinant sGC. BAY-41-8543 relaxes vessels and inhibits platelet aggregation in vitro at nM concentrations. In vivo, BAY-41-8543 decreases blood pressure dose-dependently, prolongs bleeding time, and reduces thrombosis. Inhalation of microparticles containing BAY-41-8543 increases pulmonary vasodilation without changing mean arterial pressure suggesting that agonists of sGC may be efficacious in treating pulmonary hypertension.

Suppliers and manufacturers

TargetMol Chemicals Inc.

Career Henan Chemica Co

InvivoChem

Aceschem Inc.

Aladdin Scientific

Suzhou ARTK Medchem Co., Ltd.

NANJING YINGWEN BIOTECHNOLOGY CO LTD

Amadis Chemical Company Limited Nanjing Chemlin Chemical Co., Ltd Shanghai XingMo Biotechnology Co., Ltd.

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