CASPASE INHIBITOR3
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- $62 - $1209.29
- Product name: CASPASE INHIBITOR3
- CAS: 187389-53-3
- MF: C11H18FNO5
- MW: 263.26
- EINECS:
- MDL Number:MFCD07370667
- Synonyms:CASPASE INHIBITOR3;(3S)-3-[[(1,1-Dimethylethoxy)carbonyl]amino]-5-fluoro-4-oxo-pentanoic acid methyl ester;N-Boc-L-aspartic acid 4-methyl ester fluoromethyl ketone;(S)-methyl 3-((tert-butoxycarbonyl)amino)-5-fluoro-4-oxopentanoate;N-BOC-D-FMK;Boc-D-FMK - Boc-Asp(OMe)-fluoromethyl ketone | BAF;Pentanoic acid, 3-[[(1,1-dimethylethoxy)carbonyl]amino]-5-fluoro-4-oxo-, methyl ester, (3S)-;Boc-D-FMK/Boc-Asp(OMe)-fluoromethyl ketone
13 prices
Selected condition：
Brand
- Adipogen Life Sciences
- AK Scientific
- Alfa Aesar
- American Custom Chemicals Corporation
- ApexBio Technology
- Axon Medchem
- Cayman Chemical
- Sigma-Aldrich
- TRC
Package
- 1mg
- 2mg
- 10mg
- 25mg
- 500μg
- 3MG
- 5mg
- 10mM(in 1mL DMSO)
- ManufacturerAdipogen Life Sciences
- Product numberAG-CP3-0030-M001
- Product descriptionBoc-Asp(OMe)-FMK ≥98%
- Packaging1mg
- Price$80
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product number3505AH
- Product descriptionBoc-D-Fmk
- Packaging1mg
- Price$205
- Updated2021-12-16
- Buy
- ManufacturerAlfa Aesar
- Product numberJ65812
- Product descriptionN-Boc-L-aspartic acid 4-methyl ester fluoromethyl ketone
- Packaging5mg
- Price$463.65
- Updated2024-03-01
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberHCH0066744
- Product descriptionBOC-ASP(OME)-FLUOROMETHYL KETONE 95.00%
- Packaging3MG
- Price$1209.29
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA1904
- Product descriptionBoc-D-FMK
- Packaging10mM(in 1mL DMSO)
- Price$145
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA1904
- Product descriptionBoc-D-FMK
- Packaging10mg
- Price$225
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA1904
- Product descriptionBoc-D-FMK
- Packaging25mg
- Price$500
- Updated2021-12-16
- Buy
- ManufacturerAxon Medchem
- Product numberAxon2158
- Product descriptionBoc-D-FMK-Boc-Asp(OMe)-fluoromethylketone|BAF 98%
- Packaging2mg
- Price$121
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number16118
- Product descriptionBoc-D-FMK ≥95%
- Packaging500μg
- Price$62
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number16118
- Product descriptionBoc-D-FMK ≥95%
- Packaging1mg
- Price$96
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number16118
- Product descriptionBoc-D-FMK ≥95%
- Packaging5mg
- Price$388
- Updated2024-03-01
- Buy
- ManufacturerSigma-Aldrich
- Product numberB2682
- Product descriptionBoc-Asp(OMe)-fluoromethyl ketone ≥90% (TLC), solid
- Packaging3mg
- Price$1020
- Updated2024-03-01
- Buy
- ManufacturerTRC
- Product numberB646230
- Product descriptionBoc-D-FMK
- Packaging10mg
- Price$655
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Adipogen Life Sciences | AG-CP3-0030-M001 | Boc-Asp(OMe)-FMK ≥98% | 1mg | $80 | 2021-12-16 | Buy |
| AK Scientific | 3505AH | Boc-D-Fmk | 1mg | $205 | 2021-12-16 | Buy |
| Alfa Aesar | J65812 | N-Boc-L-aspartic acid 4-methyl ester fluoromethyl ketone | 5mg | $463.65 | 2024-03-01 | Buy |
| American Custom Chemicals Corporation | HCH0066744 | BOC-ASP(OME)-FLUOROMETHYL KETONE 95.00% | 3MG | $1209.29 | 2021-12-16 | Buy |
| ApexBio Technology | A1904 | Boc-D-FMK | 10mM(in 1mL DMSO) | $145 | 2021-12-16 | Buy |
| ApexBio Technology | A1904 | Boc-D-FMK | 10mg | $225 | 2021-12-16 | Buy |
| ApexBio Technology | A1904 | Boc-D-FMK | 25mg | $500 | 2021-12-16 | Buy |
| Axon Medchem | Axon2158 | Boc-D-FMK-Boc-Asp(OMe)-fluoromethylketone|BAF 98% | 2mg | $121 | 2021-12-16 | Buy |
| Cayman Chemical | 16118 | Boc-D-FMK ≥95% | 500μg | $62 | 2024-03-01 | Buy |
| Cayman Chemical | 16118 | Boc-D-FMK ≥95% | 1mg | $96 | 2024-03-01 | Buy |
| Cayman Chemical | 16118 | Boc-D-FMK ≥95% | 5mg | $388 | 2024-03-01 | Buy |
| Sigma-Aldrich | B2682 | Boc-Asp(OMe)-fluoromethyl ketone ≥90% (TLC), solid | 3mg | $1020 | 2024-03-01 | Buy |
| TRC | B646230 | Boc-D-FMK | 10mg | $655 | 2021-12-16 | Buy |
Properties
Boiling point :383.5±37.0 °C(Predicted)
Density :1.150±0.06 g/cm3 (20 ºC 760 Torr)
storage temp. :-20°C
solubility :Soluble in dry DMSO or DMF at approximately 20mM. Store stock solutions at -20°C.
pka :10.12±0.46(Predicted)
form :Powder
color :Off-white
Density :1.150±0.06 g/cm3 (20 ºC 760 Torr)
storage temp. :-20°C
solubility :Soluble in dry DMSO or DMF at approximately 20mM. Store stock solutions at -20°C.
pka :10.12±0.46(Predicted)
form :Powder
color :Off-white
Safety Information
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Description
Boc-D-FMK is a cell-permeable, irreversible pan-caspase inhibitor. Also known as Boc-D(OMe)-FMK, this compound contains a methyl ester group, which facilitates uptake by cells and subsequently is removed by cytoplasmic esterases, leaving the functional inhibitor. Boc-D-FMK blocks apoptosis stimulated by TNF-α in neutrophils (IC50 = 39 μM), by bile duct ligation in hepatocytes, and by TNF-α in renal endothelial cells. The FMK pharmacophore is known to interact with non-caspase cysteine proteases, presumably explaining why Boc-D-FMK also inhibits cathepsins H and L.Related product price
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