CASPASE INHIBITOR3
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- $52 - $1209.29
- Product name: CASPASE INHIBITOR3
- CAS: 187389-53-3
- MF: C11H18FNO5
- MW: 263.26
- EINECS:
- MDL Number:MFCD07370667
- Synonyms:CASPASE INHIBITOR3;(3S)-3-[[(1,1-Dimethylethoxy)carbonyl]amino]-5-fluoro-4-oxo-pentanoic acid methyl ester;N-Boc-L-aspartic acid 4-methyl ester fluoromethyl ketone;(S)-methyl 3-((tert-butoxycarbonyl)amino)-5-fluoro-4-oxopentanoate;N-BOC-D-FMK;Boc-D-FMK - Boc-Asp(OMe)-fluoromethyl ketone | BAF;Pentanoic acid, 3-[[(1,1-dimethylethoxy)carbonyl]amino]-5-fluoro-4-oxo-, methyl ester, (3S)-;Boc-D-FMK/Boc-Asp(OMe)-fluoromethyl ketone
35 prices
Selected condition：
Brand
- aablocks
- ACHEMBLOCK
- Adipogen Life Sciences
- AK Scientific
- American Custom Chemicals Corporation
- ApexBio Technology
- Arctom
- Axon Medchem
- Cayman Chemical
- ChemScene
- DC Chemicals
- Sigma-Aldrich
- Thermo Scientific Chemicals
- TRC
Package
- 10mM(in 1mL DMSO)
- 1mg
- 10mM*1mLinDMSO(Liquid+Solvent)
- 500μg
- 10mM*1mLinDMSO(Solution)
- 2mg
- 3MG
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- Manufactureraablocks
- Product numberAA007RV4
- Product descriptionMethyl (S)-3-((Tert-Butoxycarbonyl)Amino)-5-Fluoro-4-Oxopentanoate
- Packaging1mg
- Price$52
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA007RV4
- Product descriptionMethyl (S)-3-((Tert-Butoxycarbonyl)Amino)-5-Fluoro-4-Oxopentanoate
- Packaging5mg
- Price$98
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA007RV4
- Product descriptionMethyl (S)-3-((Tert-Butoxycarbonyl)Amino)-5-Fluoro-4-Oxopentanoate
- Packaging10mg
- Price$144
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA007RV4
- Product descriptionMethyl (S)-3-((Tert-Butoxycarbonyl)Amino)-5-Fluoro-4-Oxopentanoate
- Packaging25mg
- Price$271
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA007RV4
- Product descriptionMethyl (S)-3-((Tert-Butoxycarbonyl)Amino)-5-Fluoro-4-Oxopentanoate
- Packaging50mg
- Price$415
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA007RV4
- Product descriptionMethyl (S)-3-((Tert-Butoxycarbonyl)Amino)-5-Fluoro-4-Oxopentanoate
- Packaging100mg
- Price$599
- Updated2026-05-28
- Buy
- ManufacturerACHEMBLOCK
- Product numberY228124
- Product descriptionBoc-Asp(OMe)-fluoromethyl ketone 97.00%
- Packaging50MG
- Price$590
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberY228124
- Product descriptionBoc-Asp(OMe)-fluoromethyl ketone 97.00%
- Packaging10MG
- Price$185
- Updated2026-05-27
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberAG-CP3-0030-M005
- Product descriptionBoc-Asp(OMe)-FMK ≥98%
- Packaging5mg
- Price$320
- Updated2026-05-06
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberAG-CP3-0030-M001
- Product descriptionBoc-Asp(OMe)-FMK ≥98%
- Packaging1mg
- Price$80
- Updated2026-05-06
- Buy
- ManufacturerAK Scientific
- Product number3505AH
- Product descriptionBoc-D-Fmk
- Packaging1mg
- Price$205
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberHCH0066744
- Product descriptionBOC-ASP(OME)-FLUOROMETHYL KETONE 95.00%
- Packaging3MG
- Price$1209.29
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA1904
- Product descriptionBoc-D-FMK
- Packaging10mg
- Price$225
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA1904
- Product descriptionBoc-D-FMK
- Packaging25mg
- Price$500
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA1904
- Product descriptionBoc-D-FMK
- Packaging10mM(in 1mL DMSO)
- Price$145
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberHY-103348
- Product descriptionBoc-Asp(OMe)-fluoromethyl ketone 98.0%
- Packaging10mg
- Price$181
- Updated2026-05-26
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA007RV4 | Methyl (S)-3-((Tert-Butoxycarbonyl)Amino)-5-Fluoro-4-Oxopentanoate | 1mg | $52 | 2026-05-28 | Buy |
| aablocks | AA007RV4 | Methyl (S)-3-((Tert-Butoxycarbonyl)Amino)-5-Fluoro-4-Oxopentanoate | 5mg | $98 | 2026-05-28 | Buy |
| aablocks | AA007RV4 | Methyl (S)-3-((Tert-Butoxycarbonyl)Amino)-5-Fluoro-4-Oxopentanoate | 10mg | $144 | 2026-05-28 | Buy |
| aablocks | AA007RV4 | Methyl (S)-3-((Tert-Butoxycarbonyl)Amino)-5-Fluoro-4-Oxopentanoate | 25mg | $271 | 2026-05-28 | Buy |
| aablocks | AA007RV4 | Methyl (S)-3-((Tert-Butoxycarbonyl)Amino)-5-Fluoro-4-Oxopentanoate | 50mg | $415 | 2026-05-28 | Buy |
| aablocks | AA007RV4 | Methyl (S)-3-((Tert-Butoxycarbonyl)Amino)-5-Fluoro-4-Oxopentanoate | 100mg | $599 | 2026-05-28 | Buy |
| ACHEMBLOCK | Y228124 | Boc-Asp(OMe)-fluoromethyl ketone 97.00% | 50MG | $590 | 2026-05-27 | Buy |
| ACHEMBLOCK | Y228124 | Boc-Asp(OMe)-fluoromethyl ketone 97.00% | 10MG | $185 | 2026-05-27 | Buy |
| Adipogen Life Sciences | AG-CP3-0030-M005 | Boc-Asp(OMe)-FMK ≥98% | 5mg | $320 | 2026-05-06 | Buy |
| Adipogen Life Sciences | AG-CP3-0030-M001 | Boc-Asp(OMe)-FMK ≥98% | 1mg | $80 | 2026-05-06 | Buy |
| AK Scientific | 3505AH | Boc-D-Fmk | 1mg | $205 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | HCH0066744 | BOC-ASP(OME)-FLUOROMETHYL KETONE 95.00% | 3MG | $1209.29 | 2021-12-16 | Buy |
| ApexBio Technology | A1904 | Boc-D-FMK | 10mg | $225 | 2021-12-16 | Buy |
| ApexBio Technology | A1904 | Boc-D-FMK | 25mg | $500 | 2021-12-16 | Buy |
| ApexBio Technology | A1904 | Boc-D-FMK | 10mM(in 1mL DMSO) | $145 | 2021-12-16 | Buy |
| Arctom | HY-103348 | Boc-Asp(OMe)-fluoromethyl ketone 98.0% | 10mg | $181 | 2026-05-26 | Buy |
Properties
Boiling point :383.5±37.0 °C(Predicted)
Density :1.150±0.06 g/cm3 (20 ºC 760 Torr)
storage temp. :-20°C
solubility :Soluble in dry DMSO or DMF at approximately 20mM. Store stock solutions at -20°C.
pka :10.12±0.46(Predicted)
form :Powder
color :Off-white
InChI :InChI=1S/C11H18FNO5/c1-11(2,3)18-10(16)13-7(8(14)6-12)5-9(15)17-4/h7H,5-6H2,1-4H3,(H,13,16)/t7-/m0/s1
InChIKey :MXOOUCRHWJYCAL-ZETCQYMHSA-N
SMILES :C(OC)(=O)C[C@H](NC(OC(C)(C)C)=O)C(=O)CF
Density :1.150±0.06 g/cm3 (20 ºC 760 Torr)
storage temp. :-20°C
solubility :Soluble in dry DMSO or DMF at approximately 20mM. Store stock solutions at -20°C.
pka :10.12±0.46(Predicted)
form :Powder
color :Off-white
InChI :InChI=1S/C11H18FNO5/c1-11(2,3)18-10(16)13-7(8(14)6-12)5-9(15)17-4/h7H,5-6H2,1-4H3,(H,13,16)/t7-/m0/s1
InChIKey :MXOOUCRHWJYCAL-ZETCQYMHSA-N
SMILES :C(OC)(=O)C[C@H](NC(OC(C)(C)C)=O)C(=O)CF
Safety Information
| Symbol(GHS): |
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| Signal word: | Warning | ||||||||||||||
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Description
Boc-D-FMK is a cell-permeable, irreversible pan-caspase inhibitor. Also known as Boc-D(OMe)-FMK, this compound contains a methyl ester group, which facilitates uptake by cells and subsequently is removed by cytoplasmic esterases, leaving the functional inhibitor. Boc-D-FMK blocks apoptosis stimulated by TNF-α in neutrophils (IC50 = 39 μM), by bile duct ligation in hepatocytes, and by TNF-α in renal endothelial cells. The FMK pharmacophore is known to interact with non-caspase cysteine proteases, presumably explaining why Boc-D-FMK also inhibits cathepsins H and L.Related product price
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Sigma-Aldrich
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