CAY10621
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- $31 - $3224
- Product name: CAY10621
- CAS: 120005-55-2
- MF: C26H45NO4
- MW: 435.64
- EINECS:
- MDL Number:MFCD18428021
- Synonyms:CAY10621;2,2-Dimethyl-4S-(1-oxo-2-hexadecyn-1-yl)-1,1-dimethylethyl ester-3-oxazolidinecarboxylic acid;SKI 5C;SPHK1 Inhibitor 5C;YGBSGZPIDCXNEH-QFIPXVFZSA-N;3-Oxazolidinecarboxylic acid, 2,2-dimethyl-4-(1-oxo-2-hexadecyn-1-yl)-, 1,1-dimethylethyl ester, (4S)-;CAY10621 (SKI 5C);CAY10621 (SKI 5C), SPHK 1 inhibitor
20 prices
Selected condition：
Brand
- aablocks
- AK Scientific
- American Custom Chemicals Corporation
- Arctom
- Biosynth
- Cayman Chemical
- Sigma-Aldrich
- TRC
Package
- 2.5mg
- 1mg(22.95mM*100??LinMethylacetate)(Solvent)
- 1mg
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- Manufactureraablocks
- Product numberAA000Q03
- Product descriptionCAY10621 ≥98%
- Packaging1mg
- Price$31
- Updated2026-05-25
- Buy
- Manufactureraablocks
- Product numberAA000Q03
- Product descriptionCAY10621 ≥98%
- Packaging5mg
- Price$129
- Updated2026-05-25
- Buy
- Manufactureraablocks
- Product numberAA000Q03
- Product descriptionCAY10621 ≥98%
- Packaging10mg
- Price$228
- Updated2026-05-25
- Buy
- Manufactureraablocks
- Product numberAA000Q03
- Product descriptionCAY10621 ≥98%
- Packaging25mg
- Price$493
- Updated2026-05-25
- Buy
- ManufacturerAK Scientific
- Product number1329AH
- Product description2,2-Dimethyl-4S-(1-oxo-2-hexadecyn-1-yl)-1,1-dimethylethylester-3-oxazolidinecarboxylicacid
- Packaging5mg
- Price$228
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product number1329AH
- Product description2,2-Dimethyl-4S-(1-oxo-2-hexadecyn-1-yl)-1,1-dimethylethylester-3-oxazolidinecarboxylicacid
- Packaging25mg
- Price$596
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberCCH0005902
- Product description2,2-DIMETHYL-4S-(1-OXO-2-HEXADECYN-1-YL)-1,1-DIMETHYLETHYL ESTER-3-OXAZOLIDINECARBOXYLIC ACID 95.00%
- Packaging1MG
- Price$131.25
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberCCH0005902
- Product description2,2-DIMETHYL-4S-(1-OXO-2-HEXADECYN-1-YL)-1,1-DIMETHYLETHYL ESTER-3-OXAZOLIDINECARBOXYLIC ACID 95.00%
- Packaging5MG
- Price$498.86
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberHY-117563
- Product descriptionCAY10621 99.3%
- Packaging1mg(22.95mM*100??LinMethylacetate)(Solvent)
- Price$62
- Updated2026-05-26
- Buy
- ManufacturerBiosynth
- Product numberVEA00555
- Product descriptionSKI 5C
- Packaging10mg
- Price$772.4
- Updated2026-06-05
- Buy
- ManufacturerBiosynth
- Product numberVEA00555
- Product descriptionSKI 5C
- Packaging25mg
- Price$1448.5
- Updated2026-06-05
- Buy
- ManufacturerBiosynth
- Product numberVEA00555
- Product descriptionSKI 5C
- Packaging50mg
- Price$2014.5
- Updated2026-06-05
- Buy
- ManufacturerBiosynth
- Product numberVEA00555
- Product descriptionSKI 5C
- Packaging100mg
- Price$3224
- Updated2026-06-05
- Buy
- ManufacturerCayman Chemical
- Product number13371
- Product descriptionCAY10621 ≥98%
- Packaging25mg
- Price$493
- Updated2026-04-30
- Buy
- ManufacturerCayman Chemical
- Product number13371
- Product descriptionCAY10621 ≥98%
- Packaging1mg
- Price$31
- Updated2026-04-30
- Buy
- ManufacturerCayman Chemical
- Product number13371
- Product descriptionCAY10621 ≥98%
- Packaging10mg
- Price$228
- Updated2026-04-30
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA000Q03 | CAY10621 ≥98% | 1mg | $31 | 2026-05-25 | Buy |
| aablocks | AA000Q03 | CAY10621 ≥98% | 5mg | $129 | 2026-05-25 | Buy |
| aablocks | AA000Q03 | CAY10621 ≥98% | 10mg | $228 | 2026-05-25 | Buy |
| aablocks | AA000Q03 | CAY10621 ≥98% | 25mg | $493 | 2026-05-25 | Buy |
| AK Scientific | 1329AH | 2,2-Dimethyl-4S-(1-oxo-2-hexadecyn-1-yl)-1,1-dimethylethylester-3-oxazolidinecarboxylicacid | 5mg | $228 | 2021-12-16 | Buy |
| AK Scientific | 1329AH | 2,2-Dimethyl-4S-(1-oxo-2-hexadecyn-1-yl)-1,1-dimethylethylester-3-oxazolidinecarboxylicacid | 25mg | $596 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | CCH0005902 | 2,2-DIMETHYL-4S-(1-OXO-2-HEXADECYN-1-YL)-1,1-DIMETHYLETHYL ESTER-3-OXAZOLIDINECARBOXYLIC ACID 95.00% | 1MG | $131.25 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | CCH0005902 | 2,2-DIMETHYL-4S-(1-OXO-2-HEXADECYN-1-YL)-1,1-DIMETHYLETHYL ESTER-3-OXAZOLIDINECARBOXYLIC ACID 95.00% | 5MG | $498.86 | 2021-12-16 | Buy |
| Arctom | HY-117563 | CAY10621 99.3% | 1mg(22.95mM*100??LinMethylacetate)(Solvent) | $62 | 2026-05-26 | Buy |
| Biosynth | VEA00555 | SKI 5C | 10mg | $772.4 | 2026-06-05 | Buy |
| Biosynth | VEA00555 | SKI 5C | 25mg | $1448.5 | 2026-06-05 | Buy |
| Biosynth | VEA00555 | SKI 5C | 50mg | $2014.5 | 2026-06-05 | Buy |
| Biosynth | VEA00555 | SKI 5C | 100mg | $3224 | 2026-06-05 | Buy |
| Cayman Chemical | 13371 | CAY10621 ≥98% | 25mg | $493 | 2026-04-30 | Buy |
| Cayman Chemical | 13371 | CAY10621 ≥98% | 1mg | $31 | 2026-04-30 | Buy |
| Cayman Chemical | 13371 | CAY10621 ≥98% | 10mg | $228 | 2026-04-30 | Buy |
Properties
Boiling point :519.0±60.0 °C(Predicted)
Density :0.985±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMF: 3 mg/ml; DMSO: 2 mg/ml; Ethanol: 2.5 mg/ml
form :oil
pka :-3.98±0.60(Predicted)
color :colorless to light brown
InChI :1S/C26H45NO4/c1-7-8-9-10-11-12-13-14-15-16-17-18-19-20-23(28)22-21-30-26(5,6)27(22)24(29)31-25(2,3)4/h22H,7-18,21H2,1-6H3/t22-/m0/s1
InChIKey :YGBSGZPIDCXNEH-QFIPXVFZSA-N
SMILES :CCCCCCCCCCCCCC#CC(=O)[C@@H]1COC(C)(C)N1C(=O)OC(C)(C)C
Density :0.985±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMF: 3 mg/ml; DMSO: 2 mg/ml; Ethanol: 2.5 mg/ml
form :oil
pka :-3.98±0.60(Predicted)
color :colorless to light brown
InChI :1S/C26H45NO4/c1-7-8-9-10-11-12-13-14-15-16-17-18-19-20-23(28)22-21-30-26(5,6)27(22)24(29)31-25(2,3)4/h22H,7-18,21H2,1-6H3/t22-/m0/s1
InChIKey :YGBSGZPIDCXNEH-QFIPXVFZSA-N
SMILES :CCCCCCCCCCCCCC#CC(=O)[C@@H]1COC(C)(C)N1C(=O)OC(C)(C)C
Safety Information
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Description
The sphingosine kinases (SPHK) phosphorylate sphingosine, producing the important lipid mediator sphingosine-1-phosphate (S1P). The two known kinases, SPHK 1 and SPHK 2, have different developmental and tissue expression patterns, suggesting that they have distinct physiological functions. Notably, SPHK 1 is overexpressed in several forms of cancer and inhibition of SPHK 1 inhibits tumor growth. CAY10621 is a selective inhibitor of SPHK 1, both in vitro (IC50 = 3.3 μM) and in U937 cells overexpressing human SPHK 1 (70% inhibition at 5 μM). It has no inhibitory effect on SPHK 2 either in vitro or in cells. Similarly, CAY10621 does not reduce the activity of protein kinase C (PKC) except at very high concentration (>75 μM).More related product prices
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