Carfilzomib
|
- $30 - $73856.48
- Product name: Carfilzomib
- CAS: 868540-17-4
- MF: C40H57N5O7
- MW: 719.91
- EINECS:692-054-2
- MDL Number:MFCD11040997
- Synonyms:CarfilzoMib salt;CarfilzoMib/PR 171;PR-171 (CarfilzoMib);(alphaS)-alpha-[(4-Morpholinylacetyl)amino]benzenebutanoyl-L-leucyl-N-[(1S)-3-methyl-1-[[(2R)-2-methyloxiranyl]carbonyl]butyl]-L-phenylalaninamide;Carfilzomib;CarfilzoMib, Free Base, >99%;(S)-4-Methyl-N-((S)-1-((S)-4-Methyl-1-((R)-2- Methyloxiran-2-yl)-1 -oxopentan-2-ylaMino)-1-oxo-3-phenylpropan-2-yl)-2-((S)-2-(2-MorpholinoacetaMido)-4-phenylbutanaMido)pentanaMide;L-Phenylalaninamide, (αS)-α-[[2-(4-morpholinyl)acetyl]amino]benzenebutanoyl-L-leucyl-N-[(1S)-3-methyl-1-[[(2R)-2-methyl-2-oxiranyl]carbonyl]butyl]-
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Brand
- aablocks
- ACHEMBLOCK
- Adipogen Life Sciences
- AK Scientific
- Ambeed
- American Custom Chemicals Corporation
- ApexBio Technology
- Arctom
- AvaChem
- Biorbyt Ltd
- Biosynth
- Cayman Chemical
- Chemenu
- ChemScene
- Crysdot
- DC Chemicals
- Labseeker
- Matrix Scientific
- Medical Isotopes, Inc.
- Tocris
- TRC
Package
- 5mg
- 50
- 1mg
- 10mg
- 20mg
- 25mg
- 50mg
- 100mg
- 100.00mg
- 200mg
- 250mg
- 500mg
- 1g
- 1.00g
- 2g
- 5G
- 10mM*1mLinDMSO
- 10G
- EvaluationSample
- 10mM(in1mLDMSO)
- Manufactureraablocks
- Product numberAA0039HG
- Product description(αS)-α-[[2-(4-Morpholinyl)acetyl]amino]benzenebutanoyl-L-leucyl-N-[(1S)-3-methyl-1-[[(2R)-2-methyl-2-oxiranyl]carbonyl]butyl]-L-phenylalaninamide ≥99%
- Packaging5mg
- Price$42
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0039HG
- Product description(αS)-α-[[2-(4-Morpholinyl)acetyl]amino]benzenebutanoyl-L-leucyl-N-[(1S)-3-methyl-1-[[(2R)-2-methyl-2-oxiranyl]carbonyl]butyl]-L-phenylalaninamide
- Packaging100mg
- Price$172
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0039HG
- Product description(αS)-α-[[2-(4-Morpholinyl)acetyl]amino]benzenebutanoyl-L-leucyl-N-[(1S)-3-methyl-1-[[(2R)-2-methyl-2-oxiranyl]carbonyl]butyl]-L-phenylalaninamide ≥99%
- Packaging10mg
- Price$59
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0039HG
- Product description(αS)-α-[[2-(4-Morpholinyl)acetyl]amino]benzenebutanoyl-L-leucyl-N-[(1S)-3-methyl-1-[[(2R)-2-methyl-2-oxiranyl]carbonyl]butyl]-L-phenylalaninamide ≥98%
- Packaging25mg
- Price$97
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0039HG
- Product description(αS)-α-[[2-(4-Morpholinyl)acetyl]amino]benzenebutanoyl-L-leucyl-N-[(1S)-3-methyl-1-[[(2R)-2-methyl-2-oxiranyl]carbonyl]butyl]-L-phenylalaninamide 95%
- Packaging50mg
- Price$122
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0039HG
- Product description(αS)-α-[[2-(4-Morpholinyl)acetyl]amino]benzenebutanoyl-L-leucyl-N-[(1S)-3-methyl-1-[[(2R)-2-methyl-2-oxiranyl]carbonyl]butyl]-L-phenylalaninamide 95%
- Packaging1g
- Price$744
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0039HG
- Product description(αS)-α-[[2-(4-Morpholinyl)acetyl]amino]benzenebutanoyl-L-leucyl-N-[(1S)-3-methyl-1-[[(2R)-2-methyl-2-oxiranyl]carbonyl]butyl]-L-phenylalaninamide 95%
- Packaging250mg
- Price$300
- Updated2026-05-28
- Buy
- ManufacturerACHEMBLOCK
- Product numberF-4770
- Product descriptionCarfilzomib 98%
- Packaging1G
- Price$650
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberF-4770
- Product descriptionCarfilzomib 98%
- Packaging25MG
- Price$55
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberF-4770
- Product descriptionCarfilzomib 98%
- Packaging100MG
- Price$160
- Updated2026-05-27
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberAG-CR1-3669-M005
- Product descriptionCarfilzomib [PR-171] ≥98%(HPLC)
- Packaging5mg
- Price$50
- Updated2026-05-06
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberAG-CR1-3669-M001
- Product descriptionCarfilzomib [PR-171] ≥98%(HPLC)
- Packaging1mg
- Price$30
- Updated2026-05-06
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberAG-CR1-3669-M025
- Product descriptionCarfilzomib [PR-171] ≥98%(HPLC)
- Packaging25mg
- Price$90
- Updated2026-05-06
- Buy
- ManufacturerAK Scientific
- Product numberY0441
- Product descriptionCarfilzomib
- Packaging10mg
- Price$84
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA101004
- Product description(S)-4-methyl-N-((S)-1-(((S)-4-methyl-1-((R)-2-methyloxiran-2-yl)-1-oxopentan-2-yl)amino)-1-oxo-3-phenylpropan-2-yl)-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamide 98+%
- Packaging50mg
- Price$114
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA101004
- Product description(S)-4-methyl-N-((S)-1-(((S)-4-methyl-1-((R)-2-methyloxiran-2-yl)-1-oxopentan-2-yl)amino)-1-oxo-3-phenylpropan-2-yl)-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamide 98+%
- Packaging10mg
- Price$57
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA0039HG | (αS)-α-[[2-(4-Morpholinyl)acetyl]amino]benzenebutanoyl-L-leucyl-N-[(1S)-3-methyl-1-[[(2R)-2-methyl-2-oxiranyl]carbonyl]butyl]-L-phenylalaninamide ≥99% | 5mg | $42 | 2026-05-28 | Buy |
| aablocks | AA0039HG | (αS)-α-[[2-(4-Morpholinyl)acetyl]amino]benzenebutanoyl-L-leucyl-N-[(1S)-3-methyl-1-[[(2R)-2-methyl-2-oxiranyl]carbonyl]butyl]-L-phenylalaninamide | 100mg | $172 | 2026-05-28 | Buy |
| aablocks | AA0039HG | (αS)-α-[[2-(4-Morpholinyl)acetyl]amino]benzenebutanoyl-L-leucyl-N-[(1S)-3-methyl-1-[[(2R)-2-methyl-2-oxiranyl]carbonyl]butyl]-L-phenylalaninamide ≥99% | 10mg | $59 | 2026-05-28 | Buy |
| aablocks | AA0039HG | (αS)-α-[[2-(4-Morpholinyl)acetyl]amino]benzenebutanoyl-L-leucyl-N-[(1S)-3-methyl-1-[[(2R)-2-methyl-2-oxiranyl]carbonyl]butyl]-L-phenylalaninamide ≥98% | 25mg | $97 | 2026-05-28 | Buy |
| aablocks | AA0039HG | (αS)-α-[[2-(4-Morpholinyl)acetyl]amino]benzenebutanoyl-L-leucyl-N-[(1S)-3-methyl-1-[[(2R)-2-methyl-2-oxiranyl]carbonyl]butyl]-L-phenylalaninamide 95% | 50mg | $122 | 2026-05-28 | Buy |
| aablocks | AA0039HG | (αS)-α-[[2-(4-Morpholinyl)acetyl]amino]benzenebutanoyl-L-leucyl-N-[(1S)-3-methyl-1-[[(2R)-2-methyl-2-oxiranyl]carbonyl]butyl]-L-phenylalaninamide 95% | 1g | $744 | 2026-05-28 | Buy |
| aablocks | AA0039HG | (αS)-α-[[2-(4-Morpholinyl)acetyl]amino]benzenebutanoyl-L-leucyl-N-[(1S)-3-methyl-1-[[(2R)-2-methyl-2-oxiranyl]carbonyl]butyl]-L-phenylalaninamide 95% | 250mg | $300 | 2026-05-28 | Buy |
| ACHEMBLOCK | F-4770 | Carfilzomib 98% | 1G | $650 | 2026-05-27 | Buy |
| ACHEMBLOCK | F-4770 | Carfilzomib 98% | 25MG | $55 | 2026-05-27 | Buy |
| ACHEMBLOCK | F-4770 | Carfilzomib 98% | 100MG | $160 | 2026-05-27 | Buy |
| Adipogen Life Sciences | AG-CR1-3669-M005 | Carfilzomib [PR-171] ≥98%(HPLC) | 5mg | $50 | 2026-05-06 | Buy |
| Adipogen Life Sciences | AG-CR1-3669-M001 | Carfilzomib [PR-171] ≥98%(HPLC) | 1mg | $30 | 2026-05-06 | Buy |
| Adipogen Life Sciences | AG-CR1-3669-M025 | Carfilzomib [PR-171] ≥98%(HPLC) | 25mg | $90 | 2026-05-06 | Buy |
| AK Scientific | Y0441 | Carfilzomib | 10mg | $84 | 2021-12-16 | Buy |
| Ambeed | A101004 | (S)-4-methyl-N-((S)-1-(((S)-4-methyl-1-((R)-2-methyloxiran-2-yl)-1-oxopentan-2-yl)amino)-1-oxo-3-phenylpropan-2-yl)-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamide 98+% | 50mg | $114 | 2021-12-16 | Buy |
| Ambeed | A101004 | (S)-4-methyl-N-((S)-1-(((S)-4-methyl-1-((R)-2-methyloxiran-2-yl)-1-oxopentan-2-yl)amino)-1-oxo-3-phenylpropan-2-yl)-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamide 98+% | 10mg | $57 | 2021-12-16 | Buy |
Properties
Melting point :204 - 208°C
Boiling point :975.6±65.0 °C(Predicted)
Density :1.161
Flash point :543.8℃
storage temp. :-20°
solubility :Soluble in DMSO (up to 80 mg/ml) or in Ethanol (up to 25 mg/ml).
form :solid
pka :13.17±0.46(Predicted)
color :White
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 week.
InChIKey :BLMPQMFVWMYDKT-KWQOZBPPNA-N
SMILES :C([C@@]1(OC1)C)(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)CN1CCOCC1)CCC1C=CC=CC=1)CC1C=CC=CC=1 |&1:1,6,14,18,26,r|
CAS DataBase Reference :868540-17-4
Boiling point :975.6±65.0 °C(Predicted)
Density :1.161
Flash point :543.8℃
storage temp. :-20°
solubility :Soluble in DMSO (up to 80 mg/ml) or in Ethanol (up to 25 mg/ml).
form :solid
pka :13.17±0.46(Predicted)
color :White
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 week.
InChIKey :BLMPQMFVWMYDKT-KWQOZBPPNA-N
SMILES :C([C@@]1(OC1)C)(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)CN1CCOCC1)CCC1C=CC=CC=1)CC1C=CC=CC=1 |&1:1,6,14,18,26,r|
CAS DataBase Reference :868540-17-4
Safety Information
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Description
Carfilzomib is an irreversible proteasome inhibitor and antineoplastic agent.The mechanism of action of carfilzomib is as a Proteasome Inhibitor, Carfilzomib irreversibly binds to and inhibits the chymotrypsin-like activity of the 20S catalytic core subunit of the proteasome, a protease complex responsible for degrading a large variety of cellular proteins. Inhibition of proteasome-mediated proteolysis results in an accumulation of polyubiquinated proteins, which may lead to cell cycle arrest, induction of apoptosis, and inhibition of tumor growth.Carfilzomib is used in treatment of refractory multiple myeloma. Carfilzomib is associated with a low rate of serum enzyme elevations during treatment and has been implicated to rare instances of clinically apparent, acute liver injury some of which have been fatal.
Carfilzomib is a second-generation, irreversible, peptide epoxyketone class proteasome inhibitor that targets the chymotrypsin-like β5 subunit of the constitutive 20S proteasome (IC50 = 5.2 nM) and the β5i subunit of the immunoproteasome 20Si (LMP7; IC50 = 14 nM) with minimal cross reactivity to other proteases. It can induce cell cycle arrest and apoptosis in human cancer cell lines including multiple myeloma, lymphoma, and various solid tumors (IC50s = 2.4-20 nM).
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