Cdk4/6 Inhibitor IV
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- $43 - $2800
- Product name: Cdk4/6 Inhibitor IV
- CAS: 359886-84-3
- MF: C27H32N6O
- MW: 456.58
- EINECS:
- MDL Number:MFCD06407771
- Synonyms:Cdk4/6 Inhibitor IV;Cyclohexanol, 4-[[6-(ethylamino)-2-[[1-(phenylmethyl)-1H-indol-5-yl]amino]-4-pyrimidinyl]amino]-,trans-;CGP-82996 (Synonyms: CINK4);GP-82996
10 prices
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Brand
- AK Scientific
- American Custom Chemicals Corporation
- ApexBio Technology
- Cayman Chemical
- DC Chemicals
- Sigma-Aldrich
- TRC
Package
- 1mg
- 5MG
- 10mg
- 250mg
- 1g
- 25 mg
- ManufacturerAK Scientific
- Product number1686DC
- Product description4-[[6-(Ethylamino)-2-[[1-(phenylmethyl)-5-indolyl]amino]-4-pyrimidinyl]amino]-1-cyclohexanol
- Packaging10mg
- Price$444
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0014175
- Product descriptionTRANS-4-((6-(ETHYLAMINO)-2-((1-(PHENYLMETHYL)-1H-INDOL-5-YL)AMINO)-4-PYRIMIDINYL)AMINO)-CYCLOHEXANOL 95.00%
- Packaging5MG
- Price$505.12
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberC3995
- Product descriptionCdk4/6InhibitorIV
- Packaging10mg
- Price$354
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number17974
- Product descriptionCdk4/6 Inhibitor IV ≥98%
- Packaging1mg
- Price$43
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number17974
- Product descriptionCdk4/6 Inhibitor IV ≥98%
- Packaging5mg
- Price$167
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number17974
- Product descriptionCdk4/6 Inhibitor IV ≥98%
- Packaging10mg
- Price$311
- Updated2024-03-01
- Buy
- ManufacturerDC Chemicals
- Product numberDC8596
- Product descriptionCdk4/6InhibitorIV >98%
- Packaging250mg
- Price$1400
- Updated2021-12-16
- Buy
- ManufacturerDC Chemicals
- Product numberDC8596
- Product descriptionCdk4/6InhibitorIV >98%
- Packaging1g
- Price$2800
- Updated2021-12-16
- Buy
- ManufacturerSigma-Aldrich
- Product numberSML1352
- Product descriptionCINK4 ≥95% (HPLC)
- Packaging25 mg
- Price$323
- Updated2025-07-31
- Buy
- ManufacturerTRC
- Product numberC228135
- Product descriptionCdk4/6InhibitorIV
- Packaging10mg
- Price$275
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | 1686DC | 4-[[6-(Ethylamino)-2-[[1-(phenylmethyl)-5-indolyl]amino]-4-pyrimidinyl]amino]-1-cyclohexanol | 10mg | $444 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0014175 | TRANS-4-((6-(ETHYLAMINO)-2-((1-(PHENYLMETHYL)-1H-INDOL-5-YL)AMINO)-4-PYRIMIDINYL)AMINO)-CYCLOHEXANOL 95.00% | 5MG | $505.12 | 2021-12-16 | Buy |
| ApexBio Technology | C3995 | Cdk4/6InhibitorIV | 10mg | $354 | 2021-12-16 | Buy |
| Cayman Chemical | 17974 | Cdk4/6 Inhibitor IV ≥98% | 1mg | $43 | 2024-03-01 | Buy |
| Cayman Chemical | 17974 | Cdk4/6 Inhibitor IV ≥98% | 5mg | $167 | 2024-03-01 | Buy |
| Cayman Chemical | 17974 | Cdk4/6 Inhibitor IV ≥98% | 10mg | $311 | 2024-03-01 | Buy |
| DC Chemicals | DC8596 | Cdk4/6InhibitorIV >98% | 250mg | $1400 | 2021-12-16 | Buy |
| DC Chemicals | DC8596 | Cdk4/6InhibitorIV >98% | 1g | $2800 | 2021-12-16 | Buy |
| Sigma-Aldrich | SML1352 | CINK4 ≥95% (HPLC) | 25 mg | $323 | 2025-07-31 | Buy |
| TRC | C228135 | Cdk4/6InhibitorIV | 10mg | $275 | 2021-12-16 | Buy |
Properties
Boiling point :755.4±70.0 °C(Predicted)
Density :1.28±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :≤1mg/ml in ethanol;30mg/ml in DMSO;20mg/ml in dimethyl formamide
form :crystalline solid
pka :15.05±0.40(Predicted)
color :white to light brown
InChIKey :YVXCDLCJCIDFHE-AFARHQOCSA-N
SMILES :O[C@@H]1CC[C@@H](NC2=CC(NCC)=NC(NC3=CC=C(N(CC4=CC=CC=C4)C=C5)C5=C3)=N2)CC1
Density :1.28±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :≤1mg/ml in ethanol;30mg/ml in DMSO;20mg/ml in dimethyl formamide
form :crystalline solid
pka :15.05±0.40(Predicted)
color :white to light brown
InChIKey :YVXCDLCJCIDFHE-AFARHQOCSA-N
SMILES :O[C@@H]1CC[C@@H](NC2=CC(NCC)=NC(NC3=CC=C(N(CC4=CC=CC=C4)C=C5)C5=C3)=N2)CC1
Safety Information
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Description
Cdk4/6 inhibitor IV is a cell-permeable triaminopyrimidine that reversibly blocks Cdk4/cyclin D1 and Cdk6/cyclin D1 activity with IC50 values of 1.5 and 5.6 μM, respectively. It demonstrates potent selectivity for Cdk4/6 over Cdk5/p35, v-abl, c-met, IGF-1R, insulin receptor, Cdk2/cyclin A, Cdk2/cyclin E, Cdk4/cyclin D2, Cdk6/cyclin D2, and Cdk1/cyclin B (IC50s = > 10-100 μM). At 5-10 μM, this compound blocks retinoblastoma protein phosphorylation at Ser780 and Ser795, inducing cell cycle arrest in the G1 phase and apoptosis in asynchronous cell lines. In mice bearing human HCT116 colon carcinoma xenografts, 30 mg/kg, i.p. Cdk/6 inhibitor IV suppressed tumor growth after 29 days of treatment.Suppliers and manufacturers
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MedBioPharmaceutical Technology Inc
