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ChemicalBook >> CAS DataBase List >> Costunolide

Costunolide

Costunolide price.
  • $29 - $980
  • Product name: Costunolide
  • CAS: 553-21-9
  • MF: C15H20O2
  • MW: 232.32
  • EINECS:
  • MDL Number:MFCD00210262
  • Synonyms:(3AS,6E,10E,11AR)-3A,4,5,8,9,11A-HEXAHYDRO-6,10-DIMETHYL-3-METHYLENE-CYCLODECA[B]FURAN-2(3H)-ONE;COSTUNOLIDE;(e,e)-6-alpha-hydroxygermacra-1(10),4,11(13)-trien-12-oicacidgamma-lactone ;germacra-1(10),4,11(13)-trien-12-oicacid,6-alpha-hydroxy-,gamma-lactone,(e, ;Cyclodeca[b]furan-2(3H)-one, 3a,4,5,8,9,11a-hexahydro-6,10-dimethyl-3- methylene-, [3aS-(3aR*,6E,10E,11aS*)]-;CUSTUNOLIDE;Cyclodeca[b]furan-2(3H)-one,3a,4,5,8,9,11a-;hexahydro-6,10-dimethyl-3-methylene-,(3aS,6E,10E,11aR)-
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  • AK Scientific
  • Ambeed
  • ApexBio Technology
  • Arctom
  • AvaChem
  • Biorbyt Ltd
  • Biosynth Carbosynth
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  • Chem-Impex
  • ChemScene
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  • CSNpharm
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  • 10
  • 1g
  • 5g
  • ManufacturerAK Scientific
  • Product numberV1471
  • Product descriptionCostunolide
  • Packaging5mg
  • Price$72
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberV1471
  • Product descriptionCostunolide
  • Packaging10mg
  • Price$108
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberV1471
  • Product descriptionCostunolide
  • Packaging25mg
  • Price$219
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA496529
  • Product descriptionCostunolide 98+%
  • Packaging5mg
  • Price$33
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA496529
  • Product descriptionCostunolide 98+%
  • Packaging10mg
  • Price$43
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA496529
  • Product descriptionCostunolide 98+%
  • Packaging100mg
  • Price$101
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA496529
  • Product descriptionCostunolide 98+%
  • Packaging250mg
  • Price$200
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA496529
  • Product descriptionCostunolide 98+%
  • Packaging1g
  • Price$482
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA3327
  • Product descriptionCostunolide
  • Packaging10mg
  • Price$84
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS023163
  • Product descriptionCostunolide ≥98%
  • Packaging5mg
  • Price$33
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberCFN98928
  • Product descriptionCostunolide ≥98%
  • Packaging20mg
  • Price$40
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS023163
  • Product descriptionCostunolide ≥98%
  • Packaging10mg
  • Price$43
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberSY067309
  • Product descriptionCostunolide,98%,fromAuckiandialappaDecne.
  • Packaging10mg
  • Price$68.18
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS023163
  • Product descriptionCostunolide ≥98%
  • Packaging100mg
  • Price$100
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS023163
  • Product descriptionCostunolide ≥98%
  • Packaging250mg
  • Price$198
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS023163
  • Product descriptionCostunolide ≥98%
  • Packaging1g
  • Price$477
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific V1471 Costunolide 5mg $72 2021-12-16 Buy
AK Scientific V1471 Costunolide 10mg $108 2021-12-16 Buy
AK Scientific V1471 Costunolide 25mg $219 2021-12-16 Buy
Ambeed A496529 Costunolide 98+% 5mg $33 2021-12-16 Buy
Ambeed A496529 Costunolide 98+% 10mg $43 2021-12-16 Buy
Ambeed A496529 Costunolide 98+% 100mg $101 2021-12-16 Buy
Ambeed A496529 Costunolide 98+% 250mg $200 2021-12-16 Buy
Ambeed A496529 Costunolide 98+% 1g $482 2021-12-16 Buy
ApexBio Technology A3327 Costunolide 10mg $84 2021-12-16 Buy
Arctom AS023163 Costunolide ≥98% 5mg $33 2021-12-16 Buy
Arctom CFN98928 Costunolide ≥98% 20mg $40 2021-12-16 Buy
Arctom AS023163 Costunolide ≥98% 10mg $43 2021-12-16 Buy
Arctom SY067309 Costunolide,98%,fromAuckiandialappaDecne. 10mg $68.18 2021-12-16 Buy
Arctom AS023163 Costunolide ≥98% 100mg $100 2021-12-16 Buy
Arctom AS023163 Costunolide ≥98% 250mg $198 2021-12-16 Buy
Arctom AS023163 Costunolide ≥98% 1g $477 2021-12-16 Buy

Properties

Melting point :106-107 °C
Boiling point :385.4±42.0 °C(Predicted)
Density :1.03±0.1 g/cm3(Predicted)
storage temp. :-20°C
solubility :DMSO: soluble10mg/mL (clear solution)
form :powder
color :white to beige
InChIKey :HRYLQFBHBWLLLL-GRFSRWIASA-N
LogP :4.049 (est)
CAS DataBase Reference :553-21-9(CAS DataBase Reference)
NIST Chemistry Reference :Germacra-1(10),4,11(13)-trien-12-oic acid, 6«alpha»-hydroxy-, «gamma»-lactone, (e,e)-(553-21-9)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H317 May cause an allergic skin reaction Sensitisation, Skin Category 1 Warning GHS hazard pictograms P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
Precautionary statements:
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352 IF ON SKIN: wash with plenty of soap and water.

Description

Costunolide is a sesquiterpene lactone that is found naturally in certain plant extracts and in alternative medicine oils. It reduces growth (EC50 = 3-35 μM) and induces apoptosis in assorted cancer cell lines. Costunolide inhibits the activation of Akt (15 μM) in endometriotic epithelial cells and STAT3 activation in THP-1 cells (EC50 = 10 μM). It also inhibits telomerase activity in NALM-6 cells.

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