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ChemicalBook >> CAS DataBase List >> Efavirenz

Efavirenz

Efavirenz price.
  • $25 - $2400
  • Product name: Efavirenz
  • CAS: 154598-52-4
  • MF: C14H9ClF3NO2
  • MW: 315.67
  • EINECS:620-492-6
  • MDL Number:MFCD05662344
  • Synonyms:(S)-6-Chloro-4-(cyclopropylethynyl)-1,4-dihydro-4-(trifluoromethyl) 2H-3,1-benzoxazin-2-one;(4S)-6-chloro-4-(2-cyclopropylethynyl)-4-(trifluoromethyl)-1H-3,1-benzoxazin-2-one;Efavirenz (200 mg);(4S)-6-chloro-4-(2-cyclopropylethynyl)-4-(trifluoroMethyl)-2,4-dihydro-1H-3,1-benzoxazin-2-one;2H-3,1-Benzoxazin-2-one, 6-chloro-4-(2-cyclopropylethynyl)-1,4-dihydro-4-(trifluoroMethyl)-, (4S)-;efavuirenz;Efavirenz solution;(S)-6-CHLORO-4-(CYCLOPROPYLETHYNYL)-4-(TRIFLUOROMETHYL)-1H-BENZO[D][1,3]OXAZIN-2(4H)-ONE
42 prices
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Brand

  • Adipogen Life Sciences
  • AHH
  • AK Scientific
  • ApexBio Technology
  • Axon Medchem
  • Biorbyt Ltd
  • Biosynth Carbosynth
  • Cayman Chemical
  • Chem-Impex
  • ChemScene
  • Chemtos
  • Crysdot
  • CSNpharm
  • DC Chemicals
  • Medical Isotopes, Inc.
  • Sigma-Aldrich
  • TRC
  • Usbiological

Package

  • 5mg
  • 10mg
  • 25mg
  • 50mg
  • 100mg
  • 0.1g
  • 200mg
  • 1ml
  • 2g
  • 5G
  • 10mM(in 1mL DMSO)
  • 250mg
  • 500mg
  • 1g
  • ManufacturerAdipogen Life Sciences
  • Product numberAG-CR1-3751-M050
  • Product descriptionEfavirenz ≥98%(HPLC)
  • Packaging50mg
  • Price$110
  • Updated2021-12-16
  • Buy
  • ManufacturerAHH
  • Product numberAPI-1192
  • Product descriptionEfavirenz 98%
  • Packaging0.1g
  • Price$630
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberJ95133
  • Product descriptionEfavirenz
  • Packaging1g
  • Price$25
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB1119
  • Product descriptionEfavirenz
  • Packaging10mM(in 1mL DMSO)
  • Price$55
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB1119
  • Product descriptionEfavirenz
  • Packaging10mg
  • Price$80
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB1119
  • Product descriptionEfavirenz
  • Packaging25mg
  • Price$189
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB1119
  • Product descriptionEfavirenz
  • Packaging50mg
  • Price$335
  • Updated2021-12-16
  • Buy
  • ManufacturerAxon Medchem
  • Product numberAxon3125
  • Product descriptionEfavirenz-DMP-266|L-743,726 99%
  • Packaging10mg
  • Price$66
  • Updated2021-12-16
  • Buy
  • ManufacturerAxon Medchem
  • Product numberAxon3125
  • Product descriptionEfavirenz-DMP-266|L-743,726 99%
  • Packaging50mg
  • Price$132
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb134784
  • Product descriptionEfavirenz >99%
  • Packaging100mg
  • Price$510
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb134784
  • Product descriptionEfavirenz >99%
  • Packaging250mg
  • Price$765
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb134784
  • Product descriptionEfavirenz >99%
  • Packaging1g
  • Price$1504.5
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFC30275
  • Product description(4S)-6-Chloro-4-(cyclopropylethynyl)-1,4-dihydro-4-(trifluoromethyl)-2H-3,1-benzoxazin-2-one
  • Packaging100mg
  • Price$150
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFC30275
  • Product description(4S)-6-Chloro-4-(cyclopropylethynyl)-1,4-dihydro-4-(trifluoromethyl)-2H-3,1-benzoxazin-2-one
  • Packaging250mg
  • Price$235
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFC30275
  • Product description(4S)-6-Chloro-4-(cyclopropylethynyl)-1,4-dihydro-4-(trifluoromethyl)-2H-3,1-benzoxazin-2-one
  • Packaging500mg
  • Price$360
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFC30275
  • Product description(4S)-6-Chloro-4-(cyclopropylethynyl)-1,4-dihydro-4-(trifluoromethyl)-2H-3,1-benzoxazin-2-one
  • Packaging1g
  • Price$550
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Adipogen Life Sciences AG-CR1-3751-M050 Efavirenz ≥98%(HPLC) 50mg $110 2021-12-16 Buy
AHH API-1192 Efavirenz 98% 0.1g $630 2021-12-16 Buy
AK Scientific J95133 Efavirenz 1g $25 2021-12-16 Buy
ApexBio Technology B1119 Efavirenz 10mM(in 1mL DMSO) $55 2021-12-16 Buy
ApexBio Technology B1119 Efavirenz 10mg $80 2021-12-16 Buy
ApexBio Technology B1119 Efavirenz 25mg $189 2021-12-16 Buy
ApexBio Technology B1119 Efavirenz 50mg $335 2021-12-16 Buy
Axon Medchem Axon3125 Efavirenz-DMP-266|L-743,726 99% 10mg $66 2021-12-16 Buy
Axon Medchem Axon3125 Efavirenz-DMP-266|L-743,726 99% 50mg $132 2021-12-16 Buy
Biorbyt Ltd orb134784 Efavirenz >99% 100mg $510 2021-12-16 Buy
Biorbyt Ltd orb134784 Efavirenz >99% 250mg $765 2021-12-16 Buy
Biorbyt Ltd orb134784 Efavirenz >99% 1g $1504.5 2021-12-16 Buy
Biosynth Carbosynth FC30275 (4S)-6-Chloro-4-(cyclopropylethynyl)-1,4-dihydro-4-(trifluoromethyl)-2H-3,1-benzoxazin-2-one 100mg $150 2021-12-16 Buy
Biosynth Carbosynth FC30275 (4S)-6-Chloro-4-(cyclopropylethynyl)-1,4-dihydro-4-(trifluoromethyl)-2H-3,1-benzoxazin-2-one 250mg $235 2021-12-16 Buy
Biosynth Carbosynth FC30275 (4S)-6-Chloro-4-(cyclopropylethynyl)-1,4-dihydro-4-(trifluoromethyl)-2H-3,1-benzoxazin-2-one 500mg $360 2021-12-16 Buy
Biosynth Carbosynth FC30275 (4S)-6-Chloro-4-(cyclopropylethynyl)-1,4-dihydro-4-(trifluoromethyl)-2H-3,1-benzoxazin-2-one 1g $550 2021-12-16 Buy

Properties

Melting point :139-141°C
Boiling point :340.6±42.0 °C(Predicted)
alpha :D20 -84.7° (c = 0.005 g/ml in CH3Cl); D25 -94.1° (c = 0.300 in methanol)
Density :1.53±0.1 g/cm3(Predicted)
Flash point :2℃
storage temp. :-20°C
solubility :DMSO: soluble15mg/mL, clear
pka :10.2(at 25℃)
form :powder or crystals
color :white to beige
optical activity :[α]/D -90 to -100°, c = 1 in methanol
Water Solubility :8mg/L(temperature not stated)
λmax :247nm(MeOH)(lit.)
Merck :14,3521
BCS Class :4
EPA Substance Registry System :2H-3,1-Benzoxazin-2-one, 6-chloro-4-(2-cyclopropylethynyl)-1,4-dihydro-4-(trifluoromethyl)-, (4S)- (154598-52-4)

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictogramsGHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H360 May damage fertility or the unborn child Reproductive toxicity Category 1A, 1B Danger GHS hazard pictograms
H410 Very toxic to aquatic life with long lasting effects Hazardous to the aquatic environment, long-term hazard Category 1 Warning GHS hazard pictograms P273, P391, P501
Precautionary statements:
P202 Do not handle until all safety precautions have been read and understood.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P273 Avoid release to the environment.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P308+P313 IF exposed or concerned: Get medical advice/attention.

Description

Non-nucleoside reverse transcriptase inhibitors (NNRTIs) are highly specific and potent allosteric inhibitors of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase. Efavirenz is an NNRTI that prevents RNA plus-strand initiation with an IC50 value of 17 nM. Efavirenz also inhibits the late stages of HIV-1 replication by interfering with HIV-1 Gag-Pol polyprotein processing. It has been used in combination therapy with drugs directed at the treatment of opportunistic infections such as HIV and cancer.

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