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ChemicalBook >> CAS DataBase List >> Efinaconazole

Efinaconazole

$14 - $2500
Product name: Efinaconazole
CAS: 164650-44-6
MF: C18H22F2N4O
MW: 348.39
EINECS:813-597-5
MDL Number:MFCD00936406
Synonyms:KP 103 (pharmaceutical);(2R,3R)-2-(2,4-Difluorophenyl)-3-(4-methylenepiperidin-1-yl)-1-(1,2,4-triazol-1-yl)-2-butanol;Efinaconazole(KP 103);(R,R)-2-(2,4-Difluorophenyl)-3-(4-methylenepiperidin-1-yl)-1-(1,2,4-triazol-1-yl)-2-butanol;(αR,βR)-α-(2,4-Difluorophenyl)-β-methyl-4-methylene-α-(1H-1,2,4-triazol-1-ylmethyl)-1-piperidineethanol;1-Piperidineethanol, α-(2,4-difluorophenyl)-β-methyl-4-methylene-α-(1H-1,2,4-triazol-1-ylmethyl)-, (αR,βR)-;Efinaconazole (Jublia);KP 103 USP/EP/BP

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aablocks
ACHEMBLOCK
AK Scientific
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American Custom Chemicals Corporation
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10mg
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10mM(in 1mL DMSO)
10mM*1mLinDMSO(Solid+Solvent)
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Manufactureraablocks
Product numberAA001UXP
Product description(αR,βR)-α-(2,4-Difluorophenyl)-β-methyl-4-methylene-α-(1H-1,2,4-triazol-1-ylmethyl)-1-piperidineethanol 98%
Packaging250mg
Price$68
Updated2026-05-28
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Manufactureraablocks
Product numberAA001UXP
Product description(αR,βR)-α-(2,4-Difluorophenyl)-β-methyl-4-methylene-α-(1H-1,2,4-triazol-1-ylmethyl)-1-piperidineethanol 98%(HPLC)
Packaging1g
Price$152
Updated2026-05-28
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Manufactureraablocks
Product numberAA001UXP
Product description(αR,βR)-α-(2,4-Difluorophenyl)-β-methyl-4-methylene-α-(1H-1,2,4-triazol-1-ylmethyl)-1-piperidineethanol 98%(HPLC)
Packaging5g
Price$456
Updated2026-05-28
Buy

Manufactureraablocks
Product numberAA001UXP
Product description(αR,βR)-α-(2,4-Difluorophenyl)-β-methyl-4-methylene-α-(1H-1,2,4-triazol-1-ylmethyl)-1-piperidineethanol 98%
Packaging10g
Price$807
Updated2026-05-28
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Manufactureraablocks
Product numberAA001UXP
Product description(αR,βR)-α-(2,4-Difluorophenyl)-β-methyl-4-methylene-α-(1H-1,2,4-triazol-1-ylmethyl)-1-piperidineethanol 98%
Packaging25g
Price$1608
Updated2026-05-28
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Manufactureraablocks
Product numberAA001UXP
Product description(αR,βR)-α-(2,4-Difluorophenyl)-β-methyl-4-methylene-α-(1H-1,2,4-triazol-1-ylmethyl)-1-piperidineethanol 98%(HPLC)
Packaging100mg
Price$39
Updated2026-05-28
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Manufactureraablocks
Product numberAA001UXP
Product description(αR,βR)-α-(2,4-Difluorophenyl)-β-methyl-4-methylene-α-(1H-1,2,4-triazol-1-ylmethyl)-1-piperidineethanol 98%(HPLC)
Packaging50mg
Price$32
Updated2026-05-28
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Manufactureraablocks
Product numberAA001UXP
Product description(αR,βR)-α-(2,4-Difluorophenyl)-β-methyl-4-methylene-α-(1H-1,2,4-triazol-1-ylmethyl)-1-piperidineethanol 98%(HPLC)
Packaging25mg
Price$25
Updated2026-05-28
Buy

Manufactureraablocks
Product numberAA001UXP
Product description(αR,βR)-α-(2,4-Difluorophenyl)-β-methyl-4-methylene-α-(1H-1,2,4-triazol-1-ylmethyl)-1-piperidineethanol 98%(HPLC)
Packaging10mg
Price$22
Updated2026-05-28
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Manufactureraablocks
Product numberAA001UXP
Product description(αR,βR)-α-(2,4-Difluorophenyl)-β-methyl-4-methylene-α-(1H-1,2,4-triazol-1-ylmethyl)-1-piperidineethanol 98%(HPLC)
Packaging5mg
Price$18
Updated2026-05-28
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ManufacturerACHEMBLOCK
Product numberX203752
Product descriptionEfinaconazole 95%
Packaging1G
Price$160
Updated2026-05-27
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ManufacturerACHEMBLOCK
Product numberX203752
Product descriptionEfinaconazole 95%
Packaging5G
Price$475
Updated2026-05-27
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ManufacturerAK Scientific
Product number2856AH
Product descriptionEfinaconazole
Packaging25mg
Price$96
Updated2021-12-16
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ManufacturerAmbeed
Product numberA162236
Product descriptionEfinaconazole 98+%
Packaging5g
Price$410
Updated2021-12-16
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ManufacturerAmbeed
Product numberA162236
Product descriptionEfinaconazole 98+%
Packaging1g
Price$136
Updated2021-12-16
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ManufacturerAmbeed
Product numberA162236
Product descriptionEfinaconazole 98+%
Packaging5mg
Price$14
Updated2021-12-16
Buy

Manufacturer	Product number	Product description	Packaging	Price	Updated	Buy
aablocks	AA001UXP	(αR,βR)-α-(2,4-Difluorophenyl)-β-methyl-4-methylene-α-(1H-1,2,4-triazol-1-ylmethyl)-1-piperidineethanol 98%	250mg	$68	2026-05-28	Buy
aablocks	AA001UXP	(αR,βR)-α-(2,4-Difluorophenyl)-β-methyl-4-methylene-α-(1H-1,2,4-triazol-1-ylmethyl)-1-piperidineethanol 98%(HPLC)	1g	$152	2026-05-28	Buy
aablocks	AA001UXP	(αR,βR)-α-(2,4-Difluorophenyl)-β-methyl-4-methylene-α-(1H-1,2,4-triazol-1-ylmethyl)-1-piperidineethanol 98%(HPLC)	5g	$456	2026-05-28	Buy
aablocks	AA001UXP	(αR,βR)-α-(2,4-Difluorophenyl)-β-methyl-4-methylene-α-(1H-1,2,4-triazol-1-ylmethyl)-1-piperidineethanol 98%	10g	$807	2026-05-28	Buy
aablocks	AA001UXP	(αR,βR)-α-(2,4-Difluorophenyl)-β-methyl-4-methylene-α-(1H-1,2,4-triazol-1-ylmethyl)-1-piperidineethanol 98%	25g	$1608	2026-05-28	Buy
aablocks	AA001UXP	(αR,βR)-α-(2,4-Difluorophenyl)-β-methyl-4-methylene-α-(1H-1,2,4-triazol-1-ylmethyl)-1-piperidineethanol 98%(HPLC)	100mg	$39	2026-05-28	Buy
aablocks	AA001UXP	(αR,βR)-α-(2,4-Difluorophenyl)-β-methyl-4-methylene-α-(1H-1,2,4-triazol-1-ylmethyl)-1-piperidineethanol 98%(HPLC)	50mg	$32	2026-05-28	Buy
aablocks	AA001UXP	(αR,βR)-α-(2,4-Difluorophenyl)-β-methyl-4-methylene-α-(1H-1,2,4-triazol-1-ylmethyl)-1-piperidineethanol 98%(HPLC)	25mg	$25	2026-05-28	Buy
aablocks	AA001UXP	(αR,βR)-α-(2,4-Difluorophenyl)-β-methyl-4-methylene-α-(1H-1,2,4-triazol-1-ylmethyl)-1-piperidineethanol 98%(HPLC)	10mg	$22	2026-05-28	Buy
aablocks	AA001UXP	(αR,βR)-α-(2,4-Difluorophenyl)-β-methyl-4-methylene-α-(1H-1,2,4-triazol-1-ylmethyl)-1-piperidineethanol 98%(HPLC)	5mg	$18	2026-05-28	Buy
ACHEMBLOCK	X203752	Efinaconazole 95%	1G	$160	2026-05-27	Buy
ACHEMBLOCK	X203752	Efinaconazole 95%	5G	$475	2026-05-27	Buy
AK Scientific	2856AH	Efinaconazole	25mg	$96	2021-12-16	Buy
Ambeed	A162236	Efinaconazole 98+%	5g	$410	2021-12-16	Buy
Ambeed	A162236	Efinaconazole 98+%	1g	$136	2021-12-16	Buy
Ambeed	A162236	Efinaconazole 98+%	5mg	$14	2021-12-16	Buy

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Properties

Melting point :192-195°C
Boiling point :512.2±60.0 °C(Predicted)
Density :1.26±0.1 g/cm3(Predicted)
storage temp. :-20°C
solubility :Chloroform (Slightly), Methanol (Slightly)
pka :12.11±0.29(Predicted)
form :powder
color :white to beige
optical activity :[α]/D -85 to -95°, c = 1 in chloroform
InChI :InChI=1/C18H22F2N4O/c1-13-5-7-23(8-6-13)14(2)18(25,10-24-12-21-11-22-24)16-4-3-15(19)9-17(16)20/h3-4,9,11-12,14,25H,1,5-8,10H2,2H3/t14-,18-/s3
InChIKey :NFEZZTICAUWDHU-GKGMEZMPNA-N
SMILES :N1([C@H](C)[C@@](C2=CC=C(F)C=C2F)(CN2C=NC=N2)O)CCC(=C)CC1 |&1:1,3,r|

Safety Information

Symbol(GHS):

Signal word:

Warning

Hazard statements:

Code	Hazard statements	Hazard class	Category	Signal word	Pictogram	P-Codes
H361	Suspected of damaging fertility or the unborn child	Reproductive toxicity	Category 2	Warning		P201, P202, P281, P308+P313, P405,P501

Precautionary statements:

P201	Obtain special instructions before use.
P308+P313	IF exposed or concerned: Get medical advice/attention.

Description

In October 2013, efinaconazole (also known as KP-103) was approved in Canada as a 10% topical solution for the treatment of onychomycosis. Like other azole antifungal agents, efinaconazole acts by disrupting fungal cell membranes through inhibition of sterol 14α-demethylase, an enzyme involved in the biosynthesis of ergosterol, which is a key component of the fungal cell membrane. Efinaconazole has potent antifungal activity against clinical isolates of dermatophytes, including Trichophyton mentagrophyes (MIC₈₀ =0.125 μg/mL) and Trichophyton rubrum (MIC₈₀ =0.25 μg/mL), as well as against Candida and Malassezia species. Unlike other antifungal agents, efinaconazole retains activity in the presence of keratin, indicating that more unbound drug is available at the site of action. Efinaconazole is efficacious in guinea-pig models of fungal infection. Efinaconazole is prepared by reaction of an epoxide intermediate with 4-methylenepiperidine.

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Suppliers and manufacturers

Anhui Dexinjia Biopharm Co., Ltd

$150.00
Efinaconazole CAS:164650-44-6

Firsky International Trade (Wuhan) Co., Ltd

$30.00
KP 103 CAS:164650-44-6

Zhengzhou Anbu Chem Co.,Ltd

KP 103 CAS:164650-44-6

Anhui Ruihan Technology Co., Ltd

$30.00
KP 103 CAS:164650-44-6

Cangzhou Kangrui Pharma Tech Co. Ltd.,

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ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

$2.00
Efinaconazole CAS:164650-44-6

Hefei Lbao Physical & Chemical Science Co.,Ltd

KP 103 CAS:164650-44-6

Sinoway Industrial co., ltd.

Efinaconazole CAS:164650-44-6

Jinan Qinmu Fine Chemical Co.,Ltd.

Guangzhou TongYi biochemistry technology Co.,LTD

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Efinaconazole

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