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ChemicalBook >> CAS DataBase List >> FIIN-3

FIIN-3

FIIN-3 price.
  • $37 - $2220
  • Product name: FIIN-3
  • CAS: 1637735-84-2
  • MF: C34H36Cl2N8O4
  • MW: 691.61
  • EINECS:
  • MDL Number:MFCD28386554
  • Synonyms:FIIN-3;FIN-3;FIIN3; FIIN 3;FIIN3; FIIN 3; FIIN-3;CS-2331;2-Propenamide, N-[4-[[[[(2,6-dichloro-3,5-dimethoxyphenyl)amino]carbonyl][6-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]amino]methyl]phenyl]-;Inhibitor,FIIN 3,FIIN-3,HER1,FIIN3,ErbB-1,Epidermal growth factor receptor,inhibit,Fibroblast growth factor receptor,EGFR,FGFR
Price14 Properties Safety Information Description
14 prices
Selected condition：
Brand
  • AK Scientific
  • Cayman Chemical
  • ChemScene
  • DC Chemicals
  • TRC
Package
  • 1mg
  • 5mg
  • 10mg
  • 25mg
  • 50mg
  • 100mg
  • 250mg
  • 1g
  • ManufacturerAK Scientific
  • Product number7571DW
  • Product descriptionN-[4-[[(2,6-Dichloro-3,5-dimethoxyphenyl)carbamoyl-[6-[4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]amino]methyl]phenyl]prop-2-enamide
  • Packaging1mg
  • Price$139
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number20709
  • Product descriptionFIIN-3 ≥98%
  • Packaging1mg
  • Price$37
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number20709
  • Product descriptionFIIN-3 ≥98%
  • Packaging5mg
  • Price$161
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number20709
  • Product descriptionFIIN-3 ≥98%
  • Packaging10mg
  • Price$283
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number20709
  • Product descriptionFIIN-3 ≥98%
  • Packaging25mg
  • Price$618
  • Updated2024-03-01
  • Buy
  • ManufacturerChemScene
  • Product numberCS-5514
  • Product descriptionFIIN-3 98.13%
  • Packaging1mg
  • Price$108
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-5514
  • Product descriptionFIIN-3 98.13%
  • Packaging5mg
  • Price$264
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-5514
  • Product descriptionFIIN-3 98.13%
  • Packaging10mg
  • Price$420
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-5514
  • Product descriptionFIIN-3 98.13%
  • Packaging50mg
  • Price$1440
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-5514
  • Product descriptionFIIN-3 98.13%
  • Packaging100mg
  • Price$2220
  • Updated2021-12-16
  • Buy
  • ManufacturerDC Chemicals
  • Product numberDC9642
  • Product descriptionFIIN-3 >98%
  • Packaging100mg
  • Price$500
  • Updated2021-12-16
  • Buy
  • ManufacturerDC Chemicals
  • Product numberDC9642
  • Product descriptionFIIN-3 >98%
  • Packaging250mg
  • Price$900
  • Updated2021-12-16
  • Buy
  • ManufacturerDC Chemicals
  • Product numberDC9642
  • Product descriptionFIIN-3 >98%
  • Packaging1g
  • Price$1800
  • Updated2021-12-16
  • Buy
  • ManufacturerTRC
  • Product numberF336510
  • Product descriptionFIIN-​3
  • Packaging1mg
  • Price$145
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 7571DW N-[4-[[(2,6-Dichloro-3,5-dimethoxyphenyl)carbamoyl-[6-[4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]amino]methyl]phenyl]prop-2-enamide 1mg $139 2021-12-16 Buy
Cayman Chemical 20709 FIIN-3 ≥98% 1mg $37 2024-03-01 Buy
Cayman Chemical 20709 FIIN-3 ≥98% 5mg $161 2024-03-01 Buy
Cayman Chemical 20709 FIIN-3 ≥98% 10mg $283 2024-03-01 Buy
Cayman Chemical 20709 FIIN-3 ≥98% 25mg $618 2024-03-01 Buy
ChemScene CS-5514 FIIN-3 98.13% 1mg $108 2021-12-16 Buy
ChemScene CS-5514 FIIN-3 98.13% 5mg $264 2021-12-16 Buy
ChemScene CS-5514 FIIN-3 98.13% 10mg $420 2021-12-16 Buy
ChemScene CS-5514 FIIN-3 98.13% 50mg $1440 2021-12-16 Buy
ChemScene CS-5514 FIIN-3 98.13% 100mg $2220 2021-12-16 Buy
DC Chemicals DC9642 FIIN-3 >98% 100mg $500 2021-12-16 Buy
DC Chemicals DC9642 FIIN-3 >98% 250mg $900 2021-12-16 Buy
DC Chemicals DC9642 FIIN-3 >98% 1g $1800 2021-12-16 Buy
TRC F336510 FIIN-​3 1mg $145 2021-12-16 Buy

Properties

Boiling point :909.4±65.0 °C(Predicted)
Density :1.379±0.06 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :Acetonitrile: sparingly soluble; Methanol: sparingly soluble
form :A crystalline solid
pka :10.78±0.70(Predicted)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

FIIN-3 is an inhibitor of FGF receptors (FGFRs; IC50s = 13, 21, 31, and 35 nM for recombinant FGFR1-4, respectively). It is selective for FGFRs over a panel of 456 kinases at a concentration of 1 μM, however, it does inhibit EGFR (IC50 = 204 nM). FIIN-3 inhibits growth of Ba/F3 cells that are dependent on the kinase activity of wild-type FGFR1-4 as well as gatekeeper mutant FGFR2 and FGFR3 (EC50s = <1-69 nM) and inhibits FGFR-dependent signaling in a concentration-dependent manner in FGFR2TEL/V564M-dependent Ba/F3 cells. FIIN-3 also inhibits growth in a panel of cancer cell lines (EC50s = 1.4-499 nM).

Suppliers and manufacturers

InvivoChem
TargetMol Chemicals Inc.
ShenZhen Trendseen Biological Technology Co.,Ltd.
Wuhan Topule Biopharmaceutical Co., Ltd
Aladdin Scientific Shanghai Boyle Chemical Co., Ltd. Haoyuan Chemexpress Co., Ltd. MedChemexpress LLC HangZhou YuHao Chemical Technology Co., Ltd. Shanghai Lollane Biological Technology Co.,Ltd.