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ChemicalBook >> CAS DataBase List >> PD 173074

PD 173074

PD 173074 price.
  • $28 - $1647
  • Product name: PD 173074
  • CAS: 219580-11-7
  • MF: C28H41N7O3
  • MW: 523.67
  • EINECS:
  • MDL Number:MFCD08705327
  • Synonyms:n-[2-[[4-(diethylamino)butyl]amino-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]-n'-(1,1-dimethylethyl)urea;N-[2-[[4-(diethylaMino)butyl]aMino]-6-(3,5-diMethoxyphenyl)pyrido[2,3-d ]pyriMidin-7-yl]-N'-(1,1-diMethylethyl)-;PD173074/PD-173074;1-(tert-butyl)-3-(2-((4-(diethylaMino)butyl)aMino)-6-(3,5-diMethoxyphenyl)pyrido[2,3-d]pyriMidin-7-yl)urea;1-(tert-Butyl)-3-(2-((4-(diethylamino)butyl)amino)-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-;Urea, N-[2-[[4-(diethylaMino)butyl]aMino]-6-(3,5-diMethoxyphenyl)pyrido[2,3-d]pyriMidin-7-yl]-N'-(1,1-diMethylethyl)-;PD176074;N-[2-[[4-(Diethylamino)butyl]amino]-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]-N'-(1,1-dimethylethyl)urea PD 173074
Price38 Properties Safety Information Description
38 prices
Selected condition：
Brand
  • AK Scientific
  • Ambeed
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Arctom
  • Cayman Chemical
  • Chem-Impex
  • ChemScene
  • Crysdot
  • DC Chemicals
  • Labseeker
  • Matrix Scientific
  • Sigma-Aldrich
  • TCI Chemical
  • TRC
Package
  • 1MG
  • 1unit
  • 5mg
  • 10mg
  • 25mg
  • 50mg
  • 100mg
  • 200mg
  • 10mM(in 1mL DMSO)
  • 250mg
  • 1g
  • ManufacturerAK Scientific
  • Product numberX7486
  • Product descriptionPD 173074
  • Packaging1g
  • Price$1491
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA150425
  • Product description1-(tert-Butyl)-3-(2-((4-(diethylamino)butyl)amino)-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl)urea 99+%
  • Packaging5mg
  • Price$45
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA150425
  • Product description1-(tert-Butyl)-3-(2-((4-(diethylamino)butyl)amino)-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl)urea 99+%
  • Packaging10mg
  • Price$58
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA150425
  • Product description1-(tert-Butyl)-3-(2-((4-(diethylamino)butyl)amino)-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl)urea 99+%
  • Packaging50mg
  • Price$105
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA150425
  • Product description1-(tert-Butyl)-3-(2-((4-(diethylamino)butyl)amino)-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl)urea 99+%
  • Packaging100mg
  • Price$136
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA150425
  • Product description1-(tert-Butyl)-3-(2-((4-(diethylamino)butyl)amino)-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl)urea 99+%
  • Packaging250mg
  • Price$262
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA150425
  • Product description1-(tert-Butyl)-3-(2-((4-(diethylamino)butyl)amino)-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl)urea 99+%
  • Packaging1g
  • Price$650
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberKIN0000180
  • Product descriptionPD 173074 95.00%
  • Packaging1MG
  • Price$166.95
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberKIN0000180
  • Product descriptionPD 173074 95.00%
  • Packaging10MG
  • Price$693.92
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA8253
  • Product descriptionPD 173074
  • Packaging1unit
  • Price$28
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA8253
  • Product descriptionPD 173074
  • Packaging10mg
  • Price$50
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA8253
  • Product descriptionPD 173074
  • Packaging10mM(in 1mL DMSO)
  • Price$60
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA8253
  • Product descriptionPD 173074
  • Packaging50mg
  • Price$140
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberCFN60135
  • Product descriptionPD 173074
  • Packaging10mg
  • Price$118
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number13032
  • Product descriptionPD 173074 ≥98%
  • Packaging5mg
  • Price$39
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number13032
  • Product descriptionPD 173074 ≥98%
  • Packaging10mg
  • Price$74
  • Updated2024-03-01
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific X7486 PD 173074 1g $1491 2021-12-16 Buy
Ambeed A150425 1-(tert-Butyl)-3-(2-((4-(diethylamino)butyl)amino)-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl)urea 99+% 5mg $45 2021-12-16 Buy
Ambeed A150425 1-(tert-Butyl)-3-(2-((4-(diethylamino)butyl)amino)-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl)urea 99+% 10mg $58 2021-12-16 Buy
Ambeed A150425 1-(tert-Butyl)-3-(2-((4-(diethylamino)butyl)amino)-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl)urea 99+% 50mg $105 2021-12-16 Buy
Ambeed A150425 1-(tert-Butyl)-3-(2-((4-(diethylamino)butyl)amino)-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl)urea 99+% 100mg $136 2021-12-16 Buy
Ambeed A150425 1-(tert-Butyl)-3-(2-((4-(diethylamino)butyl)amino)-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl)urea 99+% 250mg $262 2021-12-16 Buy
Ambeed A150425 1-(tert-Butyl)-3-(2-((4-(diethylamino)butyl)amino)-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl)urea 99+% 1g $650 2021-12-16 Buy
American Custom Chemicals Corporation KIN0000180 PD 173074 95.00% 1MG $166.95 2021-12-16 Buy
American Custom Chemicals Corporation KIN0000180 PD 173074 95.00% 10MG $693.92 2021-12-16 Buy
ApexBio Technology A8253 PD 173074 1unit $28 2021-12-16 Buy
ApexBio Technology A8253 PD 173074 10mg $50 2021-12-16 Buy
ApexBio Technology A8253 PD 173074 10mM(in 1mL DMSO) $60 2021-12-16 Buy
ApexBio Technology A8253 PD 173074 50mg $140 2021-12-16 Buy
Arctom CFN60135 PD 173074 10mg $118 2021-12-16 Buy
Cayman Chemical 13032 PD 173074 ≥98% 5mg $39 2024-03-01 Buy
Cayman Chemical 13032 PD 173074 ≥98% 10mg $74 2024-03-01 Buy
Next Last

Properties

Melting point :82-85°C
Density :1.163
storage temp. :2-8°C
solubility :DMSO: 21 mg/mL
form :solid
pka :10.12±0.43(Predicted)
color :yellow
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/protective clothing/eye protection/face protection.

Description

The fibroblast growth factor receptors (FGFRs) are cell surface receptors with intrinsic tyrosine kinase activity, which is necessary for receptor activation and signal propagation. PD 173074 is a potent and selective inhibitor of FGFR tyrosine kinase activity, blocking autophosphorylation of FGFR1 with an IC50 value of 21.5 nM. For comparison, it weakly inhibits PDGFR and c-Src (IC50 = 17.6 and 19.8 μM, respectively) and has no effect on EGFR, InsR, MEK, or PKC. PD 173074 also prevents signaling, at nanomolar levels, through FGFR2-5. Inhibition of FGFR signaling using PD 173074, impairs angiogenesis as well as self-renewal of stem cells via ERK1/2 activation.

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Suppliers and manufacturers

career henan chemical co
PD 173074
$1.00 /1KG
PD 173074 CAS:219580-11-7
Capot Chemical Co.,Ltd.
Hangzhou FandaChem Co.,Ltd.
ATK CHEMICAL COMPANY LIMITED
Zhejiang ZETian Fine Chemicals Co. LTD
BOC Sciences
Chongqing Chemdad Co., Ltd
CONIER CHEM AND PHARMA LIMITED
TargetMol Chemicals Inc.
Finetech Industry Limited