GDC-0623
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- $41 - $3960
- Product name: GDC-0623
- CAS: 1168091-68-6
- MF: C16H14FIN4O3
- MW: 456.21
- EINECS:604-604-1
- MDL Number:MFCD25976760
- Synonyms:RG 7421;5-(2-Fluoro-4-iodophenylamino)imidazo[1,5-a]pyridine-6-carboxylic acid N-(2-hydroxyethoxy)amide;GDC-0623 (5-((2-Fluoro-4-Iodophenyl)amino)-N-(2-Hydroxyethoxy)imidazo[1,5-a]pyridine-6-Carboxamide);5-(2-Fluoro-4-iodophenylamino)imidazo[1,5-a]pyridine-6-carboxylic acid N-(2-hydroxyethoxy)amide RG 7421 GDC-0623;GDC-0623;MEK inhibitor 1;G-868;5-((2-FLUORO-4-IODOPHENYL)AMINO)-N-(2-HYDROXYETHOXY)IMIDAZO[1,5-A]PYRIDINE-6-CARBOXAMIDE
52 prices
Selected condition：
Brand
- ACHEMBLOCK
- AK Scientific
- ApexBio Technology
- Apolloscientific
- Arctom
- Biorbyt Ltd
- Biosynth
- Cayman Chemical
- Chemenu
- Crysdot
- DC Chemicals
- Usbiological
Package
- 1mg
- 2mg
- 5mg
- 10mM*1mLinDMSO(Solution)
- 10mg
- 25mg
- 10mM*1mLinDMSO(Solid+Solvent)
- 50mg
- 250mg
- 1G
- 10mM(in1mLDMSO)
- 10mM(1mLinDMSO)
- 100MG
- ManufacturerACHEMBLOCK
- Product numberL13965
- Product descriptionGDC-0623 98%
- Packaging100MG
- Price$605
- Updated2026-05-25
- Buy
- ManufacturerACHEMBLOCK
- Product numberL13965
- Product descriptionGDC-0623 98%
- Packaging100MG
- Price$605
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberL13965
- Product descriptionGDC-0623 98%
- Packaging1G
- Price$3960
- Updated2026-05-25
- Buy
- ManufacturerACHEMBLOCK
- Product numberL13965
- Product descriptionGDC-0623 98%
- Packaging1G
- Price$3960
- Updated2026-05-27
- Buy
- ManufacturerAK Scientific
- Product number9855DD
- Product descriptionGdc-0623
- Packaging10mg
- Price$313
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB1135
- Product descriptionGDC-0623
- Packaging25mg
- Price$383
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberB1135
- Product descriptionGDC-0623
- Packaging5mg
- Price$124
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB1135
- Product descriptionGDC-0623
- Packaging5mg
- Price$136
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberB1135
- Product descriptionGDC-0623
- Packaging10mM(in1mLDMSO)
- Price$143
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberB1135
- Product descriptionGDC-0623
- Packaging100mg
- Price$768
- Updated2026-05-06
- Buy
- ManufacturerApolloscientific
- Product numberBISN0174
- Product descriptionGDC-0623
- Packaging50mg
- Price$756
- Updated2021-12-16
- Buy
- ManufacturerApolloscientific
- Product numberBISN0174
- Product descriptionGDC-0623
- Packaging5mg
- Price$189
- Updated2021-12-16
- Buy
- ManufacturerApolloscientific
- Product numberBISN0174
- Product descriptionGDC-0623
- Packaging10mg
- Price$291
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberSLK-S7553
- Product descriptionGDC-0623 99.28%
- Packaging10mM(1mLinDMSO)
- Price$235
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberHY-15610
- Product descriptionGDC-0623 98.74%
- Packaging10mg
- Price$238
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberHY-15610
- Product descriptionGDC-0623 98.74%
- Packaging50mg
- Price$447
- Updated2026-05-26
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| ACHEMBLOCK | L13965 | GDC-0623 98% | 100MG | $605 | 2026-05-25 | Buy |
| ACHEMBLOCK | L13965 | GDC-0623 98% | 100MG | $605 | 2026-05-27 | Buy |
| ACHEMBLOCK | L13965 | GDC-0623 98% | 1G | $3960 | 2026-05-25 | Buy |
| ACHEMBLOCK | L13965 | GDC-0623 98% | 1G | $3960 | 2026-05-27 | Buy |
| AK Scientific | 9855DD | Gdc-0623 | 10mg | $313 | 2021-12-16 | Buy |
| ApexBio Technology | B1135 | GDC-0623 | 25mg | $383 | 2026-05-06 | Buy |
| ApexBio Technology | B1135 | GDC-0623 | 5mg | $124 | 2021-12-16 | Buy |
| ApexBio Technology | B1135 | GDC-0623 | 5mg | $136 | 2026-05-06 | Buy |
| ApexBio Technology | B1135 | GDC-0623 | 10mM(in1mLDMSO) | $143 | 2026-05-06 | Buy |
| ApexBio Technology | B1135 | GDC-0623 | 100mg | $768 | 2026-05-06 | Buy |
| Apolloscientific | BISN0174 | GDC-0623 | 50mg | $756 | 2021-12-16 | Buy |
| Apolloscientific | BISN0174 | GDC-0623 | 5mg | $189 | 2021-12-16 | Buy |
| Apolloscientific | BISN0174 | GDC-0623 | 10mg | $291 | 2021-12-16 | Buy |
| Arctom | SLK-S7553 | GDC-0623 99.28% | 10mM(1mLinDMSO) | $235 | 2026-05-26 | Buy |
| Arctom | HY-15610 | GDC-0623 98.74% | 10mg | $238 | 2026-05-26 | Buy |
| Arctom | HY-15610 | GDC-0623 98.74% | 50mg | $447 | 2026-05-26 | Buy |
Properties
Density :1.81±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :insoluble in H2O; ≥16.85 mg/mL in DMSO; ≥2.69 mg/mL in EtOH with ultrasonic
form :solid
pka :14.17±0.10(Predicted)
color :Light yellow to gray
InChI :InChI=1S/C16H14FIN4O3/c17-13-7-10(18)1-4-14(13)20-15-12(16(24)21-25-6-5-23)3-2-11-8-19-9-22(11)15/h1-4,7-9,20,23H,5-6H2,(H,21,24)
InChIKey :RFWVETIZUQEJEF-UHFFFAOYSA-N
SMILES :C12=CN=CN1C(NC1=CC=C(I)C=C1F)=C(C(NOCCO)=O)C=C2
storage temp. :Store at -20°C
solubility :insoluble in H2O; ≥16.85 mg/mL in DMSO; ≥2.69 mg/mL in EtOH with ultrasonic
form :solid
pka :14.17±0.10(Predicted)
color :Light yellow to gray
InChI :InChI=1S/C16H14FIN4O3/c17-13-7-10(18)1-4-14(13)20-15-12(16(24)21-25-6-5-23)3-2-11-8-19-9-22(11)15/h1-4,7-9,20,23H,5-6H2,(H,21,24)
InChIKey :RFWVETIZUQEJEF-UHFFFAOYSA-N
SMILES :C12=CN=CN1C(NC1=CC=C(I)C=C1F)=C(C(NOCCO)=O)C=C2
Safety Information
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| Signal word: | Warning | |||||||||||||||||||||||||||||||||||
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Description
GDC-0623 is a potent, ATP-uncompetitive inhibitor of MEK1 (Ki = 0.13 nM in the presence of ATP). It inhibits the proliferation of A375 BRAF(V600E) and HCT116 KRAS(G13D)-mutant cancer cell lines with EC50 values of 7 and 42 nM, respectively. GDC-0623 inhibits ERK and BIM phosphorylation resulting in upregulation and stabilization of pro-apoptotic BIM protein in KRAS mutant and wild-type HCT116 cells and in KRAS mutant GW620 cells.Related product price
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