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ChemicalBook >> CAS DataBase List >> GM 1489

GM 1489

GM 1489 price.
  • $73 - $341
  • Product name: GM 1489
  • CAS: 171347-75-4
  • MF: C27H33N3O4
  • MW: 463.57
  • EINECS:
  • MDL Number:
  • Synonyms:Hexanoic acid, 3-[[[(1S)-1-(1H-indol-3-ylmethyl)-2-oxo-2-[[(1S)-1-phenylethyl]amino]ethyl]amino]carbonyl]-5-methyl-, (3R)-;(3R)-3-[[[(1S)-1-(1H-indol-3-ylmethyl)-2-oxo-2-[[(1S)-1-phenylethyl]amino]ethyl]amino]carbonyl]-5-methyl-hexanoicacid
2 prices
Selected condition:
Brand
  • Cayman Chemical
Package
  • 1mg
  • 5mg
  • ManufacturerCayman Chemical
  • Product number24313
  • Product descriptionGM 1489 ≥98%
  • Packaging1mg
  • Price$73
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number24313
  • Product descriptionGM 1489 ≥98%
  • Packaging5mg
  • Price$341
  • Updated2024-03-01
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Cayman Chemical 24313 GM 1489 ≥98% 1mg $73 2024-03-01 Buy
Cayman Chemical 24313 GM 1489 ≥98% 5mg $341 2024-03-01 Buy

Properties

Boiling point :795.4±60.0 °C(Predicted)
Density :1.203±0.06 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMF: 50 mg/ml; DMSO: 50 mg/ml; Ethanol: 20 mg/ml; PBS (pH 7.2): 0.2 mg/ml
form :A crystalline solid
pka :4.71±0.10(Predicted)

Safety Information

Symbol(GHS):
Signal word:
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
Precautionary statements:

Description

GM 1489 is a broad-spectrum inhibitor of matrix metalloproteinases (MMPs) with Ki values of 0.002, 0.1, 0.5, 0.2, and 20 μM for MMP-1, MMP-8, MMP-2, MMP-9, and MMP-3, respectively. It reduces 5-aza-2''-deoxycytidine-induced increases in MMP-1, MMP-2, MMP-3, MMP-7, MMP-9, and MMP-14 expression as well as cell invasion in AsPC-1, BxPC-3, Hs766T, MiaPaCa2, and PANC-1 cancer cells. Topical administration of GM 1489 (100 μg) inhibits increases in ear thickness and epidermal hyperplasia induced by phorbol 12-myristate 13-acetate (TPA; ) and phorbol dibutyrate (PdiBu) in mice.