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ChemicalBook >> CAS DataBase List >> GNE 7915

GNE 7915

GNE 7915 price.
  • $60 - $2541.5
  • Product name: GNE 7915
  • CAS: 1351761-44-8
  • MF: C19H21F4N5O3
  • MW: 443.4
  • EINECS:
  • MDL Number:MFCD25977005
  • Synonyms:GNE 7915;[4-[[4-(Ethylamino)-5-(trifluoromethyl)-2-pyrimidinyl]amino]-2-fluoro-5-methoxyphenyl]-4-morpholinylmethanone;GNE-7915, >=98%;(4-((4-(Ethylamino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)-2-fluoro-5-methoxyphenyl)(morphol;(4-((4-(ethylamino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)-2-fluoro-5-methoxyphenyl)(morpholino)methanone;CS-1279;GNE7915; GNE 7915;Methanone, [4-[[4-(ethylamino)-5-(trifluoromethyl)-2-pyrimidinyl]amino]-2-fluoro-5-methoxyphenyl]-4-morpholinyl-
Price53 Properties Safety Information Description
53 prices
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Brand
  • ACHEMBLOCK
  • Acrotein
  • Activate Scientific
  • AK Scientific
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Arctom
  • Axon Medchem
  • Biorbyt Ltd
  • Cayman Chemical
  • Crysdot
  • DC Chemicals
  • Matrix Scientific
  • Synthonix
  • TRC
  • Usbiological
Package
  • 50mg
  • 200mg
  • 1000mg
  • 10mM(in1mLDMSO)
  • 50.00mg
  • 100MG
  • 100.00mg
  • 10mM*1mLinDMSO
  • 5MG
  • 10.00mg
  • 10mg
  • 25mg
  • 250MG
  • 1G
  • 0.25g
  • 10mM(in 1mL DMSO)
  • ManufacturerACHEMBLOCK
  • Product numberT101912
  • Product description(4-(4-(ethylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-2-fluoro-5-methoxyphenyl)(morpholino)methanone 98%
  • Packaging100MG
  • Price$105
  • Updated2026-05-25
  • Buy
  • ManufacturerACHEMBLOCK
  • Product numberT101912
  • Product description(4-(4-(ethylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-2-fluoro-5-methoxyphenyl)(morpholino)methanone 98%
  • Packaging250MG
  • Price$245
  • Updated2026-05-25
  • Buy
  • ManufacturerACHEMBLOCK
  • Product numberT101912
  • Product description(4-(4-(ethylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-2-fluoro-5-methoxyphenyl)(morpholino)methanone 98%
  • Packaging1G
  • Price$935
  • Updated2026-05-25
  • Buy
  • ManufacturerAcrotein
  • Product numberdm-2712
  • Product descriptionGNE7915 97%
  • Packaging0.25g
  • Price$788.34
  • Updated2026-05-25
  • Buy
  • ManufacturerAcrotein
  • Product numberDM-2712
  • Product descriptionGNE7915 97%
  • Packaging100mg
  • Price$385
  • Updated2021-12-16
  • Buy
  • ManufacturerAcrotein
  • Product numberdm-2712
  • Product descriptionGNE7915 97%
  • Packaging100mg
  • Price$385
  • Updated2026-05-25
  • Buy
  • ManufacturerAcrotein
  • Product numberdm-2712
  • Product descriptionGNE7915 97%
  • Packaging25mg
  • Price$165
  • Updated2026-05-25
  • Buy
  • ManufacturerActivate Scientific
  • Product numberAS106813
  • Product descriptionGNE7915 97%
  • Packaging100mg
  • Price$515
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberSYN5761
  • Product descriptionGNE-7915
  • Packaging10mg
  • Price$160
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberINB0004720
  • Product description[4-[[4-(ETHYLAMINO)-5-(TRIFLUOROMETHYL)-2-PYRIMIDINYL]AMINO]-2-FLUORO-5-METHOXYPHENYL]-4-MORPHOLINYL-METHANONE 95.00%
  • Packaging5MG
  • Price$497.78
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB3605
  • Product descriptionGNE-7915
  • Packaging100mg
  • Price$470
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB3605
  • Product descriptionGNE-7915
  • Packaging100mg
  • Price$517
  • Updated2026-05-06
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB3605
  • Product descriptionGNE-7915
  • Packaging25mg
  • Price$198
  • Updated2026-05-06
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB3605
  • Product descriptionGNE-7915
  • Packaging25mg
  • Price$200
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB3605
  • Product descriptionGNE-7915
  • Packaging10mM(in 1mL DMSO)
  • Price$112
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB3605
  • Product descriptionGNE-7915
  • Packaging5mg
  • Price$60
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
ACHEMBLOCK T101912 (4-(4-(ethylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-2-fluoro-5-methoxyphenyl)(morpholino)methanone 98% 100MG $105 2026-05-25 Buy
ACHEMBLOCK T101912 (4-(4-(ethylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-2-fluoro-5-methoxyphenyl)(morpholino)methanone 98% 250MG $245 2026-05-25 Buy
ACHEMBLOCK T101912 (4-(4-(ethylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-2-fluoro-5-methoxyphenyl)(morpholino)methanone 98% 1G $935 2026-05-25 Buy
Acrotein dm-2712 GNE7915 97% 0.25g $788.34 2026-05-25 Buy
Acrotein DM-2712 GNE7915 97% 100mg $385 2021-12-16 Buy
Acrotein dm-2712 GNE7915 97% 100mg $385 2026-05-25 Buy
Acrotein dm-2712 GNE7915 97% 25mg $165 2026-05-25 Buy
Activate Scientific AS106813 GNE7915 97% 100mg $515 2021-12-16 Buy
AK Scientific SYN5761 GNE-7915 10mg $160 2021-12-16 Buy
American Custom Chemicals Corporation INB0004720 [4-[[4-(ETHYLAMINO)-5-(TRIFLUOROMETHYL)-2-PYRIMIDINYL]AMINO]-2-FLUORO-5-METHOXYPHENYL]-4-MORPHOLINYL-METHANONE 95.00% 5MG $497.78 2021-12-16 Buy
ApexBio Technology B3605 GNE-7915 100mg $470 2021-12-16 Buy
ApexBio Technology B3605 GNE-7915 100mg $517 2026-05-06 Buy
ApexBio Technology B3605 GNE-7915 25mg $198 2026-05-06 Buy
ApexBio Technology B3605 GNE-7915 25mg $200 2021-12-16 Buy
ApexBio Technology B3605 GNE-7915 10mM(in 1mL DMSO) $112 2021-12-16 Buy
ApexBio Technology B3605 GNE-7915 5mg $60 2021-12-16 Buy
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Properties

Melting point :143 - 144°C
Boiling point :629.9±65.0 °C(Predicted)
Density :1.404±0.06 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :Chloroform (Slightly), DMSO (Slightly)
form :solid
pka :2.80±0.10(Predicted)
color :Off-white to light yellow
InChI :InChI=1S/C19H21F4N5O3/c1-3-24-16-12(19(21,22)23)10-25-18(27-16)26-14-9-13(20)11(8-15(14)30-2)17(29)28-4-6-31-7-5-28/h8-10H,3-7H2,1-2H3,(H2,24,25,26,27)
InChIKey :XCFLWTZSJYBCPF-UHFFFAOYSA-N
SMILES :C(C1=CC(OC)=C(NC2=NC=C(C(F)(F)F)C(NCC)=N2)C=C1F)(N1CCOCC1)=O
CAS DataBase Reference :1351761-44-8

Safety Information

Symbol(GHS): Exclamation Mark (GHS07)
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Leucine-rich repeat kinase 2 (LRRK2) is an enzyme that interacts with parkin, a ligase that is part of the ubiquitin-proteasome system that mediates the targeting of proteins for degradation. Loss of function of the parkin protein leads to dopaminergic cell death. The development of Parkinson's disease has been strongly associated with mutations in the LRRK2 gene that lead to increased kinase activity. GNE-7915 is a selective, brain-penetrable LRRK2 inhibitor (Kis = 2 and 18.7 nM in biochemical and cell-based assays, respectively). It inhibits LRRK2 Ser1292 autophosphorylation in BAC transgenic mice expressing human LRRK2 protein with the G2019S Parkinson’s disease mutation with an IC50 value of 20 nM in vivo.

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Suppliers and manufacturers

career henan chemical co
GNE 7915
$1.00 /1g
GNE 7915 CAS:1351761-44-8
TargetMol Chemicals Inc.
GNE-7915
$56.00 /10mg
GNE-7915 CAS:1351761-44-8
ATK CHEMICAL COMPANY LIMITED
BOC Sciences
Shanghai Gubang New Materail Technology Co. LTD
HANGZHOU CLAP TECHNOLOGY CO.,LTD
Dideu Industries Group Limited
InvivoChem
Nantong HI-FUTURE Biology Co., Ltd.
Chemtour Biotech Co., Ltd