MK-1775
|
- $28 - $2395.3
- Product name: MK-1775
- CAS: 955365-80-7
- MF: C27H32N8O2
- MW: 500.6
- EINECS:
- MDL Number:MFCD17215200
- Synonyms:2-allyl-1-(6-(2-hydroxypropan-2-yl)pyridin-2-yl)-6-(4-(4-methylpiperazin-1-yl)phenylamino)-1H-pyrazolo[3,4-d]pyrimidin-3(2H)-one;MK-1775;MK-1775,MK1775;2-allyl-1-(6-(2-hydroxypropan-2-yl)pyridin-2-yl)-6-(4-(4-methylpiperazin-1-yl)phenylamino)-1,2-dihydropyrazolo[3,4-d]pyrimidin-3-one;2-Allyl-1-(6-(2-hydroxypropan-2-yl)pyridin-2-yl)-6-(4-(4-methylpiperazin-1-yl)phenylamino)-1H-pyrazolo[3,4-d]pyrimidin-3(2H)-one MK 1775;MK 1775 2-Allyl-1-(6-(2-hydroxypropan-2-yl)pyridin-2-yl)-6-(4-(4-methylpiperazin-1-yl)phenylamino)-1H-pyrazolo[3,4-d]pyrimidin-3(2H)-one;MK-1775, >=98%;MK-1175
30 prices
Selected condition：
Brand
- AK Scientific
- American Custom Chemicals Corporation
- ApexBio Technology
- Arctom
- Axon Medchem
- Biorbyt Ltd
- Biosynth Carbosynth
- Cayman Chemical
- Chemenu
- ChemScene
- Crysdot
- DC Chemicals
- Medical Isotopes, Inc.
- Usbiological
Package
- 10mg
- 2x25mg
- 50mg
- 250mg
- 1g
- 1unit
- 5MG
- 25mg
- 100mg
- 10mM(in 1mL DMSO)
- ManufacturerAK Scientific
- Product numberSYN5698
- Product descriptionMK-1775
- Packaging50mg
- Price$547
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberSYN5698
- Product descriptionMK-1775
- Packaging100mg
- Price$931
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0006846
- Product descriptionMK-1775 95.00%
- Packaging5MG
- Price$330
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA5755
- Product descriptionMK-1775
- Packaging1unit
- Price$28
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA5755
- Product descriptionMK-1775
- Packaging5mg
- Price$70
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA5755
- Product descriptionMK-1775
- Packaging10mM(in 1mL DMSO)
- Price$100
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA5755
- Product descriptionMK-1775
- Packaging10mg
- Price$110
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA5755
- Product descriptionMK-1775
- Packaging50mg
- Price$330
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA5755
- Product descriptionMK-1775
- Packaging100mg
- Price$550
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberCFN60066
- Product descriptionAdavosertib(MK-1775) ≥98%
- Packaging10mg
- Price$178
- Updated2021-12-16
- Buy
- ManufacturerAxon Medchem
- Product numberAxon1494
- Product descriptionMK1775-AZD1775|Adavosertib 99%
- Packaging2x25mg
- Price$396
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb180811
- Product descriptionMK-1775 >98%
- Packaging100mg
- Price$690.2
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb180811
- Product descriptionMK-1775 >98%
- Packaging250mg
- Price$1283.5
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb180811
- Product descriptionMK-1775 >98%
- Packaging1g
- Price$2395.3
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberBM161385
- Product descriptionMK 1775
- Packaging10mg
- Price$125
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberBM161385
- Product descriptionMK 1775
- Packaging50mg
- Price$437.5
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | SYN5698 | MK-1775 | 50mg | $547 | 2021-12-16 | Buy |
| AK Scientific | SYN5698 | MK-1775 | 100mg | $931 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0006846 | MK-1775 95.00% | 5MG | $330 | 2021-12-16 | Buy |
| ApexBio Technology | A5755 | MK-1775 | 1unit | $28 | 2021-12-16 | Buy |
| ApexBio Technology | A5755 | MK-1775 | 5mg | $70 | 2021-12-16 | Buy |
| ApexBio Technology | A5755 | MK-1775 | 10mM(in 1mL DMSO) | $100 | 2021-12-16 | Buy |
| ApexBio Technology | A5755 | MK-1775 | 10mg | $110 | 2021-12-16 | Buy |
| ApexBio Technology | A5755 | MK-1775 | 50mg | $330 | 2021-12-16 | Buy |
| ApexBio Technology | A5755 | MK-1775 | 100mg | $550 | 2021-12-16 | Buy |
| Arctom | CFN60066 | Adavosertib(MK-1775) ≥98% | 10mg | $178 | 2021-12-16 | Buy |
| Axon Medchem | Axon1494 | MK1775-AZD1775|Adavosertib 99% | 2x25mg | $396 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb180811 | MK-1775 >98% | 100mg | $690.2 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb180811 | MK-1775 >98% | 250mg | $1283.5 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb180811 | MK-1775 >98% | 1g | $2395.3 | 2021-12-16 | Buy |
| Biosynth Carbosynth | BM161385 | MK 1775 | 10mg | $125 | 2021-12-16 | Buy |
| Biosynth Carbosynth | BM161385 | MK 1775 | 50mg | $437.5 | 2021-12-16 | Buy |
Properties
Melting point :179-181°C
Boiling point :723.8±70.0 °C(Predicted)
Density :1.292
storage temp. :-20°C
solubility :Soluble in DMSO (70 mg/ml)
form :solid
pka :13.27±0.29(Predicted)
color :Yellow
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Boiling point :723.8±70.0 °C(Predicted)
Density :1.292
storage temp. :-20°C
solubility :Soluble in DMSO (70 mg/ml)
form :solid
pka :13.27±0.29(Predicted)
color :Yellow
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Safety Information
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| Signal word: | Warning | ||||||||||||||
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Description
MK-1775 is a small molecule inhibitor of the tyrosine kinase WEE1 with potential antineoplastic sensitizing activity. MK-1775 selectively targets and inhibits WEE1, a tyrosine kinase that phosphorylates cyclin-dependent kinase 1 (CDK1, CDC2) to inactivate the CDC2/cyclin B complex. Inhibition of WEE1 activity prevents the phosphorylation of CDC2 and impairs the G2 DNA damage checkpoint. This may lead to apoptosis upon treatment with DNA damaging chemotherapeutic agents. MK-1775 is a type of biological therapy. It is a cancer growth blocker. It stops signals that cancer cells use to divide and grow. MK-1775 has been used in trials studying the treatment of LYMPHOMA, Neoplasms, Ovarian Cancer, Tongue Carcinoma, and Adult Glioblastoma, among others.Related product price
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