GSK-2126458
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- $49 - $8373.75
- Product name: GSK-2126458
- CAS: 1086062-66-9
- MF: C25H17F2N5O3S
- MW: 505.5
- EINECS:629-873-1
- MDL Number:MFCD16038929
- Synonyms:GSK2126458;GSK-2126458;GSK2126458; GSK-2126458;2,4-Difluoro-N-[2-methoxy-5-[4-(4-pyridazinyl)-6-quinolinyl]-3-pyridinyl]benzenesulfonamide;HYR-582;GSK212;2,4-Difluoro-N-[2-Methoxy-5-[4-(pyridazin-4-yl)quinolin-6-yl]pyridin-3-yl]benzenesulfonaMide;OMipalisib
35 prices
Selected condition：
Brand
- Adipogen Life Sciences
- AK Scientific
- American Custom Chemicals Corporation
- ApexBio Technology
- Arctom
- Axon Medchem
- Biorbyt Ltd
- Biosynth Carbosynth
- Cayman Chemical
- Chemenu
- ChemScene
- Crysdot
- DC Chemicals
- Labseeker
- Matrix Scientific
- Sigma-Aldrich
- Tocris
- TRC
Package
- 50
- 1mg
- 5mg
- 10mg
- 25MG
- 2x25mg
- 10mM(in 1mL DMSO)
- 50mg
- 100mg
- 250mg
- 1000mg
- 1g
- ManufacturerAdipogen Life Sciences
- Product numberSYN-1126-M001
- Product descriptionGSK2126458 ≥95%
- Packaging1mg
- Price$157
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberSYN1126
- Product descriptionGSK2126458
- Packaging10mg
- Price$370
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberHCH0106597
- Product description2,4-DIFLUORO-N-[2-METHOXY-5-[4-(4-PYRIDAZINYL)-6-QUINOLINYL]-3-PYRIDINYL]BENZENESULFONAMIDE 99.00%
- Packaging10MG
- Price$6641.25
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberHCH0106597
- Product description2,4-DIFLUORO-N-[2-METHOXY-5-[4-(4-PYRIDAZINYL)-6-QUINOLINYL]-3-PYRIDINYL]BENZENESULFONAMIDE 99.00%
- Packaging25MG
- Price$8373.75
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA8556
- Product descriptionGSK2126458
- Packaging5mg
- Price$120
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA8556
- Product descriptionGSK2126458
- Packaging10mM(in 1mL DMSO)
- Price$130
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA8556
- Product descriptionGSK2126458
- Packaging10mg
- Price$150
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA8556
- Product descriptionGSK2126458
- Packaging50mg
- Price$420
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberCFN60257
- Product descriptionOmipalisib(GSK2126458)
- Packaging10mg
- Price$378
- Updated2021-12-16
- Buy
- ManufacturerAxon Medchem
- Product numberAxon1596
- Product descriptionGSK2126458-Omipalisib 99%
- Packaging2x25mg
- Price$506
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb181012
- Product descriptionOmipalisib (GSK-458) >98%
- Packaging100mg
- Price$690.2
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb181012
- Product descriptionOmipalisib (GSK-458) >98%
- Packaging250mg
- Price$1356.6
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb181012
- Product descriptionOmipalisib (GSK-458) >98%
- Packaging1000mg
- Price$2691.1
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFD43337
- Product descriptionGSK 2126458
- Packaging10mg
- Price$165
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFD43337
- Product descriptionGSK 2126458
- Packaging50mg
- Price$577.5
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number17377
- Product descriptionGSK2126458 ≥98%
- Packaging1mg
- Price$49
- Updated2024-03-01
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Adipogen Life Sciences | SYN-1126-M001 | GSK2126458 ≥95% | 1mg | $157 | 2021-12-16 | Buy |
| AK Scientific | SYN1126 | GSK2126458 | 10mg | $370 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | HCH0106597 | 2,4-DIFLUORO-N-[2-METHOXY-5-[4-(4-PYRIDAZINYL)-6-QUINOLINYL]-3-PYRIDINYL]BENZENESULFONAMIDE 99.00% | 10MG | $6641.25 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | HCH0106597 | 2,4-DIFLUORO-N-[2-METHOXY-5-[4-(4-PYRIDAZINYL)-6-QUINOLINYL]-3-PYRIDINYL]BENZENESULFONAMIDE 99.00% | 25MG | $8373.75 | 2021-12-16 | Buy |
| ApexBio Technology | A8556 | GSK2126458 | 5mg | $120 | 2021-12-16 | Buy |
| ApexBio Technology | A8556 | GSK2126458 | 10mM(in 1mL DMSO) | $130 | 2021-12-16 | Buy |
| ApexBio Technology | A8556 | GSK2126458 | 10mg | $150 | 2021-12-16 | Buy |
| ApexBio Technology | A8556 | GSK2126458 | 50mg | $420 | 2021-12-16 | Buy |
| Arctom | CFN60257 | Omipalisib(GSK2126458) | 10mg | $378 | 2021-12-16 | Buy |
| Axon Medchem | Axon1596 | GSK2126458-Omipalisib 99% | 2x25mg | $506 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb181012 | Omipalisib (GSK-458) >98% | 100mg | $690.2 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb181012 | Omipalisib (GSK-458) >98% | 250mg | $1356.6 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb181012 | Omipalisib (GSK-458) >98% | 1000mg | $2691.1 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FD43337 | GSK 2126458 | 10mg | $165 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FD43337 | GSK 2126458 | 50mg | $577.5 | 2021-12-16 | Buy |
| Cayman Chemical | 17377 | GSK2126458 ≥98% | 1mg | $49 | 2024-03-01 | Buy |
Properties
Melting point :187-189℃
Boiling point :715.6±70.0 °C(Predicted)
Density :1.45
storage temp. :Refrigerator
solubility :Chloroform (Slightly), DMSO (Slightly), Methanol (Very Slightly, Heated)
form :Solid
pka :6.23±0.40(Predicted)
color :White to Pale Yellow
Boiling point :715.6±70.0 °C(Predicted)
Density :1.45
storage temp. :Refrigerator
solubility :Chloroform (Slightly), DMSO (Slightly), Methanol (Very Slightly, Heated)
form :Solid
pka :6.23±0.40(Predicted)
color :White to Pale Yellow
Safety Information
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| Signal word: | Danger | |||||||||||||||||||||
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Description
GSK2126458 is a potent inhibitor of phosphoinositide 3-kinase isoforms (Kis = 19, 130, 24, and 60 pM for p110α, β, δ, and γ, respectively). It also inhibits mTOR in both mTORC1 and mTORC2 (Kis = 180 and 300 nM, respectively), as well as several common mutant forms of p110α. GSK2126458 is orally bioavailable, displays favorable pharmacokinetics, and shows efficacy in tumor growth models. GSK2126458 positively combines with inhibitors of discoidin domain receptor 1 (DDR1) inhibitor DDR1-IN-1 to suppress the growth of SNU-1040 colorectal cancer cells.More related product prices
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