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ChemicalBook >> CAS DataBase List >> GSK 2334470

GSK 2334470

$54 - $1900
Product name: GSK 2334470
CAS: 1227911-45-6
MF: C25H34N8O
MW: 462.59
EINECS:
MDL Number:MFCD21608525
Synonyms:GSK 2334470;1S,4R)-3-(6-(3-aMino-1H-indazol-6-yl)-2-(MethylaMino)pyriMidin-4-yl)-N-cyclohexyl-4-MethylcyclohexanecarboxaMide;(3S,6R)-1-[6-(3-Amino-1H-indazol-6-yl)-2-(methylamino)-4-pyrimidinyl]-N-cyclohexyl-6-methyl-3-piperidinecarboxamide;3-Piperidinecarboxamide, 1-[6-(3-amino-1H-indazol-6-yl)-2-(methylamino)-4-pyrimidinyl]-N-cyclohexyl-6-methyl-, (3S,6R)-;(3S,6R)-1-[6-(3-Amino-1H-indazol-6-yl)-2-(methylamino)-4-pyrimidinyl]-N-cyclohexyl-6-methyl-3-piperidinecarboxamide GSK 2334470;GSK2334470;GSK 2334470;GSK-2334470;((3S,6R)-1-(6-(3-amino-1H-indazol-6-yl)-2-(methylamino)pyrimidin-4-yl)-6-methylpiperidin-3-yl)(piperidin-1-yl)methanone;1S,4R)-3-(6-(3-AMINO-1H-INDAZOL-6-YL)-2-(METHYLAMINO)PYRIMIDIN-4-YL)-N-CYCLOHEXYL-4-METHYLCYCLOHEXAN

Price47 Properties Safety Information Description

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aablocks
ACHEMBLOCK
AK Scientific
ApexBio Technology
Arctom
AvaChem
Axon Medchem
Biosynth
Cayman Chemical
Chemenu
ChemScene
Crysdot
DC Chemicals
Sigma-Aldrich
Tocris
TRC
Usbiological

Package

2x5mg
10mM*1mLinDMSO(Solution)
10mM*1mLinDMSO(Solid+Solvent)
250mg
50
10
1g
5mg
10mM(in1mLDMSO)
10mg
25mg
50mg
100MG
10mM(in 1mL DMSO)

Manufactureraablocks
Product numberAA009C98
Product description(3S,6R)-1-[6-(3-Amino-1H-indazol-6-yl)-2-(methylamino)-4-pyrimidinyl]-N-cyclohexyl-6-methyl-3-piperidinecarboxamide 99%
Packaging5mg
Price$54
Updated2026-05-28
Buy

Manufactureraablocks
Product numberAA009C98
Product description(3S,6R)-1-[6-(3-Amino-1H-indazol-6-yl)-2-(methylamino)-4-pyrimidinyl]-N-cyclohexyl-6-methyl-3-piperidinecarboxamide 99
Packaging10mg
Price$84
Updated2026-05-28
Buy

Manufactureraablocks
Product numberAA009C98
Product description(3S,6R)-1-[6-(3-Amino-1H-indazol-6-yl)-2-(methylamino)-4-pyrimidinyl]-N-cyclohexyl-6-methyl-3-piperidinecarboxamide 99
Packaging25mg
Price$139
Updated2026-05-28
Buy

ManufacturerACHEMBLOCK
Product numberT101754
Product description((3S,6R)-1-(6-(3-amino-1H-indazol-6-yl)-2-(methylamino)pyrimidin-4-yl)-6-methylpiperidin-3-yl)(piperidin-1-yl)methanone 98%
Packaging25MG
Price$175
Updated2026-05-27
Buy

ManufacturerACHEMBLOCK
Product numberT101754
Product description((3S,6R)-1-(6-(3-amino-1H-indazol-6-yl)-2-(methylamino)pyrimidin-4-yl)-6-methylpiperidin-3-yl)(piperidin-1-yl)methanone 98%
Packaging100MG
Price$525
Updated2026-05-27
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ManufacturerAK Scientific
Product number2445AH
Product descriptionGSK2334470
Packaging100mg
Price$848
Updated2021-12-16
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ManufacturerApexBio Technology
Product numberB2174
Product descriptionGSK2334470
Packaging50mg
Price$330
Updated2026-05-06
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ManufacturerApexBio Technology
Product numberB2174
Product descriptionGSK2334470
Packaging25mg
Price$212
Updated2026-05-06
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ManufacturerApexBio Technology
Product numberB2174
Product descriptionGSK2334470
Packaging10mM(in1mLDMSO)
Price$110
Updated2026-05-06
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ManufacturerApexBio Technology
Product numberB2174
Product descriptionGSK2334470
Packaging10mM(in 1mL DMSO)
Price$130
Updated2021-12-16
Buy

ManufacturerApexBio Technology
Product numberB2174
Product descriptionGSK2334470
Packaging10mg
Price$107
Updated2026-05-06
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ManufacturerArctom
Product numberHY-14981
Product descriptionGSK2334470 99.79%
Packaging10mg
Price$95
Updated2026-05-26
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ManufacturerArctom
Product numberHY-14981
Product descriptionGSK2334470 99.79%
Packaging10mM*1mLinDMSO(Solid+Solvent)
Price$58
Updated2026-05-26
Buy

ManufacturerArctom
Product numberHY-14981
Product descriptionGSK2334470 99.79%
Packaging5mg
Price$60
Updated2026-05-26
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ManufacturerArctom
Product numberHY-14981
Product descriptionGSK2334470 99.79%
Packaging10mM*1mLinDMSO(Solution)
Price$61
Updated2026-05-26
Buy

ManufacturerArctom
Product numberCFN60273
Product descriptionGSK2334470
Packaging10mg
Price$208
Updated2021-12-16
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Manufacturer	Product number	Product description	Packaging	Price	Updated	Buy
aablocks	AA009C98	(3S,6R)-1-[6-(3-Amino-1H-indazol-6-yl)-2-(methylamino)-4-pyrimidinyl]-N-cyclohexyl-6-methyl-3-piperidinecarboxamide 99%	5mg	$54	2026-05-28	Buy
aablocks	AA009C98	(3S,6R)-1-[6-(3-Amino-1H-indazol-6-yl)-2-(methylamino)-4-pyrimidinyl]-N-cyclohexyl-6-methyl-3-piperidinecarboxamide 99	10mg	$84	2026-05-28	Buy
aablocks	AA009C98	(3S,6R)-1-[6-(3-Amino-1H-indazol-6-yl)-2-(methylamino)-4-pyrimidinyl]-N-cyclohexyl-6-methyl-3-piperidinecarboxamide 99	25mg	$139	2026-05-28	Buy
ACHEMBLOCK	T101754	((3S,6R)-1-(6-(3-amino-1H-indazol-6-yl)-2-(methylamino)pyrimidin-4-yl)-6-methylpiperidin-3-yl)(piperidin-1-yl)methanone 98%	25MG	$175	2026-05-27	Buy
ACHEMBLOCK	T101754	((3S,6R)-1-(6-(3-amino-1H-indazol-6-yl)-2-(methylamino)pyrimidin-4-yl)-6-methylpiperidin-3-yl)(piperidin-1-yl)methanone 98%	100MG	$525	2026-05-27	Buy
AK Scientific	2445AH	GSK2334470	100mg	$848	2021-12-16	Buy
ApexBio Technology	B2174	GSK2334470	50mg	$330	2026-05-06	Buy
ApexBio Technology	B2174	GSK2334470	25mg	$212	2026-05-06	Buy
ApexBio Technology	B2174	GSK2334470	10mM(in1mLDMSO)	$110	2026-05-06	Buy
ApexBio Technology	B2174	GSK2334470	10mM(in 1mL DMSO)	$130	2021-12-16	Buy
ApexBio Technology	B2174	GSK2334470	10mg	$107	2026-05-06	Buy
Arctom	HY-14981	GSK2334470 99.79%	10mg	$95	2026-05-26	Buy
Arctom	HY-14981	GSK2334470 99.79%	10mM*1mLinDMSO(Solid+Solvent)	$58	2026-05-26	Buy
Arctom	HY-14981	GSK2334470 99.79%	5mg	$60	2026-05-26	Buy
Arctom	HY-14981	GSK2334470 99.79%	10mM*1mLinDMSO(Solution)	$61	2026-05-26	Buy
Arctom	CFN60273	GSK2334470	10mg	$208	2021-12-16	Buy

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Properties

Density :1.30±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: ≥10mg/mL
pka :12.84±0.40(Predicted)
form :powder
color :white to light brown
Stability :Stable for 1 year as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
InChIKey :QLPHOXTXAKOFMU-WBVHZDCISA-N
SMILES :N1(C2C=C(C3=CC4=C(C=C3)C(N)=NN4)N=C(NC)N=2)[C@H](C)CC[C@H](C(NC2CCCCC2)=O)C1

Safety Information

Symbol(GHS):

Signal word:

Hazard statements:

Code	Hazard statements	Hazard class	Category	Signal word	Pictogram	P-Codes

Precautionary statements:

Description

3-Phosphoinositide-dependent protein kinase 1 (PDK1) is a serine-threonine kinase that plays an important role in growth factor signaling by phosphorylating and activating a group of kinases, including protein kinase (PK)B, PKA, and certain isoforms of PKC. GSK2334470 is an inhibitor of PDK1 (IC50 = ~10 nM) that even at 100-fold higher concentrations does not affect the activity of 93 other protein kinases, including that of 13 closely related AGC kinase family members. In HEK293 cells, 30 nM - 1 μM GSK2334470 suppresses T-loop phosphorylation and activation of SGK, S6K1, and RSK, as well as the activation of Akt.

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Suppliers and manufacturers

Chengdu Lanqingting Biotech Company Limited Shanghai Boyle Chemical Co., Ltd. Chembest Research Laboratories Limited Jinan Trio PharmaTech Co., Ltd. Dalian Meilun Biotech Co., Ltd. Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. Haoyuan Chemexpress Co., Ltd. Shanghai Aladdin Bio-Chem Technology Co.,LTD MedChemexpress LLC AdooQ BioScience, LLC

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GSK 2334470

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