GSK J4 HCl
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- $12 - $1962
- Product name: GSK J4 HCl
- CAS: 1373423-53-0
- MF: C24H27N5O2
- MW: 417.5
- EINECS:
- MDL Number:MFCD22683852
- Synonyms:GSK J4;N-[2-(2-Pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-pyrimidinyl]-beta-alanine ethyl ester;GSK J4 HCl;N-[2-(2-Pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-pyriMidinyl]-|-alanine ethyl ester;β-Alanine, N-[2-(2-pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-pyrimidinyl]-, ethyl ester, hydrochloride (1:1);Ethyl 3-((6-(4,5-dihydro-1H-benzo[d]azepin-3(2H)-yl)-2-(pyridin-2-yl)pyrimidin-4-yl)amino)propanoate;Ethyl 3-((6-(4,5-dihydro-1H-benzo[d]azepin-3(2H)-yl)-2-(pyridin-2-yl)pyrimidin-4-yl)amino)prop;Histone Lysine Demethylase Inhibitor VIII, GSK-J4
44 prices
Selected condition：
Brand
- aablocks
- ACHEMBLOCK
- ApexBio Technology
- Arctom
- AvaChem
- Axon Medchem
- ChemScene
- Crysdot
- DC Chemicals
- Sigma-Aldrich
- Synthonix
- Tocris
- TRC
Package
- 25mg
- 2x25mg
- 10mM*1mLinDMSO(Solution)
- 50MG
- 10mM*1mLinDMSO
- 1mg
- 5mg
- 10mg
- 50
- 100MG
- 250mg
- 500mg
- 1g
- 10mM*1mLinDMSO(Solid+Solvent)
- Manufactureraablocks
- Product numberAA009C9F
- Product descriptionGsk J4 Hcl 98%
- Packaging1mg
- Price$12
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA009C9F
- Product descriptionGsk J4 Hcl 98%
- Packaging5mg
- Price$28
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA009C9F
- Product descriptionGsk J4 Hcl 98%
- Packaging10mg
- Price$44
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA009C9F
- Product descriptionGsk J4 Hcl 95%
- Packaging250mg
- Price$511
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA009C9F
- Product descriptionGsk J4 Hcl 95%
- Packaging500mg
- Price$773
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA009C9F
- Product descriptionGsk J4 Hcl 95%
- Packaging1g
- Price$1175
- Updated2026-05-28
- Buy
- ManufacturerACHEMBLOCK
- Product numberX212247
- Product descriptionGSK-J4 97%
- Packaging100MG
- Price$340
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberX212247
- Product descriptionGSK-J4 97%
- Packaging50MG
- Price$205
- Updated2026-05-27
- Buy
- ManufacturerApexBio Technology
- Product numberA4190
- Product descriptionGSKJ4HCl
- Packaging10mg
- Price$110
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB5959
- Product descriptionGSK J4 free base
- Packaging10mg
- Price$95
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberA4190
- Product descriptionGSKJ4HCl
- Packaging50mg
- Price$350
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberCFN60290
- Product descriptionGSK-J4 ≥98%
- Packaging10mg
- Price$288
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberHY-15648B
- Product descriptionGSK-J4 99.45%
- Packaging100mg
- Price$665
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberHY-15648B
- Product descriptionGSK-J4 99.45%
- Packaging5mg
- Price$96
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberHY-15648B
- Product descriptionGSK-J4 99.45%
- Packaging10mM*1mLinDMSO(Solid+Solvent)
- Price$100
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberHY-15648B
- Product descriptionGSK-J4 99.45%
- Packaging10mM*1mLinDMSO(Solution)
- Price$106
- Updated2026-05-26
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA009C9F | Gsk J4 Hcl 98% | 1mg | $12 | 2026-05-28 | Buy |
| aablocks | AA009C9F | Gsk J4 Hcl 98% | 5mg | $28 | 2026-05-28 | Buy |
| aablocks | AA009C9F | Gsk J4 Hcl 98% | 10mg | $44 | 2026-05-28 | Buy |
| aablocks | AA009C9F | Gsk J4 Hcl 95% | 250mg | $511 | 2026-05-28 | Buy |
| aablocks | AA009C9F | Gsk J4 Hcl 95% | 500mg | $773 | 2026-05-28 | Buy |
| aablocks | AA009C9F | Gsk J4 Hcl 95% | 1g | $1175 | 2026-05-28 | Buy |
| ACHEMBLOCK | X212247 | GSK-J4 97% | 100MG | $340 | 2026-05-27 | Buy |
| ACHEMBLOCK | X212247 | GSK-J4 97% | 50MG | $205 | 2026-05-27 | Buy |
| ApexBio Technology | A4190 | GSKJ4HCl | 10mg | $110 | 2021-12-16 | Buy |
| ApexBio Technology | B5959 | GSK J4 free base | 10mg | $95 | 2026-05-06 | Buy |
| ApexBio Technology | A4190 | GSKJ4HCl | 50mg | $350 | 2021-12-16 | Buy |
| Arctom | CFN60290 | GSK-J4 ≥98% | 10mg | $288 | 2021-12-16 | Buy |
| Arctom | HY-15648B | GSK-J4 99.45% | 100mg | $665 | 2026-05-26 | Buy |
| Arctom | HY-15648B | GSK-J4 99.45% | 5mg | $96 | 2026-05-26 | Buy |
| Arctom | HY-15648B | GSK-J4 99.45% | 10mM*1mLinDMSO(Solid+Solvent) | $100 | 2026-05-26 | Buy |
| Arctom | HY-15648B | GSK-J4 99.45% | 10mM*1mLinDMSO(Solution) | $106 | 2026-05-26 | Buy |
Properties
Boiling point :581.2±50.0 °C(Predicted)
Density :1.216±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: soluble20mg/mL, clear
pka :5.95±0.10(Predicted)
form :Tan semi-solid
color :white to beige
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
InChI :1S/C24H27N5O2/c1-2-31-23(30)10-14-26-21-17-22(28-24(27-21)20-9-5-6-13-25-20)29-15-11-18-7-3-4-8-19(18)12-16-29/h3-9,13,17H,2,10-12,14-16H2,1H3,(H,26,27,28)
InChIKey :WBKCKEHGXNWYMO-UHFFFAOYSA-N
SMILES :O=C(OCC)CCNC1=CC(N2CCC(C=CC=C3)=C3CC2)=NC(C4=CC=CC=N4)=N1
Density :1.216±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: soluble20mg/mL, clear
pka :5.95±0.10(Predicted)
form :Tan semi-solid
color :white to beige
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
InChI :1S/C24H27N5O2/c1-2-31-23(30)10-14-26-21-17-22(28-24(27-21)20-9-5-6-13-25-20)29-15-11-18-7-3-4-8-19(18)12-16-29/h3-9,13,17H,2,10-12,14-16H2,1H3,(H,26,27,28)
InChIKey :WBKCKEHGXNWYMO-UHFFFAOYSA-N
SMILES :O=C(OCC)CCNC1=CC(N2CCC(C=CC=C3)=C3CC2)=NC(C4=CC=CC=N4)=N1
Safety Information
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| Signal word: | Warning | ||||||||||||||||||||||||||||
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Description
GSK-J4 (1373423-53-0) is a histone demethylase JMJD3/UTX inhibitor. Inhibits demethylation of histone H3K27. Reduces LPS-induced proinflammatory cytokine production in primary human macrophages (IC50 = 9 μM for the inhibition of TNFα release). Cell permeable, ethyl ester of GSK J1 (cat.# 10-1393).1 GSK-J4 rescues newborn pups from embryonic lethality in BRAF knockin mice which recapitulate major features of RASopathies.2Related product price
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![ethyl 3-[[2-pyridin-2-yl-6-(1,2,4,5-tetrahydro-3-benzazepin-3-yl)pyrimidin-4-yl]amino]propanoate](https://img.chemicalbook.com/ProductImageEN/2019-12/small/6071f2ba-f93d-486f-9cdb-74f52151c90f.png){kind=small}
