JZL 184
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- $44 - $2395.3
- Product name: JZL 184
- CAS: 1101854-58-3
- MF: C27H24N2O9
- MW: 520.49
- EINECS:
- MDL Number:
- Synonyms:4-Nitrophenyl 4-[bis(1,3-benzodioxol-5-yl)(hydroxy)Methyl]-1-piperidinecarboxylate;4-[Bis(1,3-benzodioxol-5-yl)hydroxymethyl]-1-piperidinecarboxylic acid 4-nitrophenyl ester;1-Piperidinecarboxylic acid, 4-[bis(1,3-benzodioxol-5-yl)hydroxymethyl]-, 4-nitrophenyl ester;4-[Bis(1,3-benzodioxol-5-yl)hydroxymethyl]-1-piperidinecarboxylic acid 4-nitrophenyl ester JZL 184;JZL 184;JZL 184 JZL184 JZL-184;MAGL Inhibitor III, JZL184 - CAS 1101854-58-3 - Calbiochem;JZL-184; JZL 184
24 prices
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Brand
- AK Scientific
- American Custom Chemicals Corporation
- Biorbyt Ltd
- Cayman Chemical
- Chemenu
- ChemScene
- Crysdot
- DC Chemicals
- Sigma-Aldrich
- TCI Chemical
- Tocris
- TRC
Package
- 50
- 5MG
- 10mg
- 25mg
- 50mg
- 100mg
- 250mg
- 10
- 1g
- ManufacturerAK Scientific
- Product number2493AH
- Product description4-Nitrophenyl-4-(dibenzo(d)(1,3)dioxol-5-yl(hydroxy)methyl)piperidine-1-carboxylate
- Packaging10mg
- Price$181
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberCCH0005936
- Product description4-NITROPHENYL-4-(DIBENZO(D)(1,3)DIOXOL-5-YL(HYDROXY)METHYL)PIPERIDINE-1-CARBOXYLATE 95.00%
- Packaging5MG
- Price$151.8
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb146267
- Product descriptionJZL184 >98%
- Packaging100mg
- Price$912.9
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb146267
- Product descriptionJZL184 >98%
- Packaging250mg
- Price$1504.5
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb146267
- Product descriptionJZL184 >98%
- Packaging1g
- Price$2395.3
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number13158
- Product descriptionJZL 184 ≥97%
- Packaging5mg
- Price$44
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number13158
- Product descriptionJZL 184 ≥97%
- Packaging10mg
- Price$74
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number13158
- Product descriptionJZL 184 ≥97%
- Packaging50mg
- Price$299
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number13158
- Product descriptionJZL 184 ≥97%
- Packaging100mg
- Price$553
- Updated2024-03-01
- Buy
- ManufacturerChemenu
- Product numberCM161296
- Product description4-nitrophenyl4-(bis(benzo[d][1,3]dioxol-5-yl)(hydroxy)methyl)piperidine-1-carboxylate 98%
- Packaging100mg
- Price$561
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-3373
- Product descriptionJZL184 98.20%
- Packaging10mg
- Price$66
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-3373
- Product descriptionJZL184 98.20%
- Packaging50mg
- Price$264
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-3373
- Product descriptionJZL184 98.20%
- Packaging100mg
- Price$480
- Updated2021-12-16
- Buy
- ManufacturerCrysdot
- Product numberCD31004578
- Product descriptionJZL184 98+%
- Packaging25mg
- Price$100
- Updated2021-12-16
- Buy
- ManufacturerCrysdot
- Product numberCD31004578
- Product descriptionJZL184 98+%
- Packaging100mg
- Price$400
- Updated2021-12-16
- Buy
- ManufacturerDC Chemicals
- Product numberDC5143
- Product descriptionJZL184 >98%
- Packaging100mg
- Price$600
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | 2493AH | 4-Nitrophenyl-4-(dibenzo(d)(1,3)dioxol-5-yl(hydroxy)methyl)piperidine-1-carboxylate | 10mg | $181 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | CCH0005936 | 4-NITROPHENYL-4-(DIBENZO(D)(1,3)DIOXOL-5-YL(HYDROXY)METHYL)PIPERIDINE-1-CARBOXYLATE 95.00% | 5MG | $151.8 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb146267 | JZL184 >98% | 100mg | $912.9 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb146267 | JZL184 >98% | 250mg | $1504.5 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb146267 | JZL184 >98% | 1g | $2395.3 | 2021-12-16 | Buy |
| Cayman Chemical | 13158 | JZL 184 ≥97% | 5mg | $44 | 2024-03-01 | Buy |
| Cayman Chemical | 13158 | JZL 184 ≥97% | 10mg | $74 | 2024-03-01 | Buy |
| Cayman Chemical | 13158 | JZL 184 ≥97% | 50mg | $299 | 2024-03-01 | Buy |
| Cayman Chemical | 13158 | JZL 184 ≥97% | 100mg | $553 | 2024-03-01 | Buy |
| Chemenu | CM161296 | 4-nitrophenyl4-(bis(benzo[d][1,3]dioxol-5-yl)(hydroxy)methyl)piperidine-1-carboxylate 98% | 100mg | $561 | 2021-12-16 | Buy |
| ChemScene | CS-3373 | JZL184 98.20% | 10mg | $66 | 2021-12-16 | Buy |
| ChemScene | CS-3373 | JZL184 98.20% | 50mg | $264 | 2021-12-16 | Buy |
| ChemScene | CS-3373 | JZL184 98.20% | 100mg | $480 | 2021-12-16 | Buy |
| Crysdot | CD31004578 | JZL184 98+% | 25mg | $100 | 2021-12-16 | Buy |
| Crysdot | CD31004578 | JZL184 98+% | 100mg | $400 | 2021-12-16 | Buy |
| DC Chemicals | DC5143 | JZL184 >98% | 100mg | $600 | 2021-12-16 | Buy |
Properties
Melting point :116-120°C
Boiling point :706.4±60.0 °C(Predicted)
Density :1.467±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :Soluble in DMSO (up to 25 mg/ml).
form :White to off-white solid
pka :13.32±0.29(Predicted)
color :light yellow to yellow-green
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months
InChIKey :SEGYOKHGGFKMCX-UHFFFAOYSA-N
SMILES :N1(C(OC2=CC=C([N+]([O-])=O)C=C2)=O)CCC(C(C2=CC=C3OCOC3=C2)(C2=CC=C3OCOC3=C2)O)CC1
CAS DataBase Reference :1101854-58-3
Boiling point :706.4±60.0 °C(Predicted)
Density :1.467±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :Soluble in DMSO (up to 25 mg/ml).
form :White to off-white solid
pka :13.32±0.29(Predicted)
color :light yellow to yellow-green
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months
InChIKey :SEGYOKHGGFKMCX-UHFFFAOYSA-N
SMILES :N1(C(OC2=CC=C([N+]([O-])=O)C=C2)=O)CCC(C(C2=CC=C3OCOC3=C2)(C2=CC=C3OCOC3=C2)O)CC1
CAS DataBase Reference :1101854-58-3
Safety Information
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| Signal word: | Danger | ||||||||||||||
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Description
Endocannabinoids such as 2-arachidonoyl glycerol (2-AG) and arachidonoyl ethanolamide (AEA) are biologically active lipids that are involved in a number of synaptic processes including activation of cannabinoid receptors. Monoacylglycerol lipase (MAGL) is a serine hydrolase responsible for the hydrolysis of 2-AG to arachidonic acid and glycerol, thus terminating its biological function. JZL 184 is a potent and selective inhibitor of monoacylglycerol lipase (MAGL) that displays IC50 values of 8 nM and 4 μM for inhibition of MAGL and fatty acid amide hydrolase in mouse brain membranes, respectively. When administered to mice at 16 mg/kg, intraperitoneally, JZL 184 reduces MAGL activity by 85%, elevates brain 2-AG levels by 8-fold, and elicits analgesic activity in a variety of pain assays that qualitatively mimics direct central cannabinoid (CB1) agonists.Related product price
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