KRN 633
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- $8 - $21021
- Product name: KRN 633
- CAS: 286370-15-8
- MF: C20H21ClN4O4
- MW: 416.86
- EINECS:
- MDL Number:MFCD14155620
- Synonyms:KRN 633;N-[2-Chloro-4-[(6,7-dimethoxy-4-quinazolinyl)oxy]phenyl]-N'-propylurea;1-(2-chloro-4-(6,7-diMethoxyquinazolin-4-yloxy)phenyl)-3-propylurea;N-[2-Chloro-4-[(6,7-dimethoxy-4-quinazolinyl)oxy]phenyl]-N'-propylurea KRN633;VEGFR Tyrosine Kinase Inhibitor III, KRN633;KRN 633;KRN-633;CS-463;KRN633; KRN-633; KRN 633
64 prices
Selected condition：
Brand
- aablocks
- ACHEMBLOCK
- AK Scientific
- Ambeed
- American Custom Chemicals Corporation
- ApexBio Technology
- Arctom
- Cayman Chemical
- Chemenu
- ChemScene
- Crysdot
- DC Chemicals
- Medical Isotopes, Inc.
- Sigma-Aldrich
- TRC
Package
- 10mM(in1mLDMSO)
- 1mg
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- 250mg
- 1g
- 1KG
- Manufactureraablocks
- Product numberAA002VU8
- Product description1-{2-Chloro-4-[(6,7-dimethoxyquinazolin-4-yl)oxy]phenyl}-3-propylurea 98%
- Packaging1mg
- Price$8
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA002VU8
- Product description1-{2-Chloro-4-[(6,7-dimethoxyquinazolin-4-yl)oxy]phenyl}-3-propylurea ≥97%
- Packaging5mg
- Price$12
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA002VU8
- Product description1-{2-Chloro-4-[(6,7-dimethoxyquinazolin-4-yl)oxy]phenyl}-3-propylurea 98%
- Packaging10mg
- Price$22
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA002VU8
- Product description1-{2-Chloro-4-[(6,7-dimethoxyquinazolin-4-yl)oxy]phenyl}-3-propylurea ≥97%
- Packaging25mg
- Price$43
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA002VU8
- Product description1-{2-Chloro-4-[(6,7-dimethoxyquinazolin-4-yl)oxy]phenyl}-3-propylurea ≥97%
- Packaging100mg
- Price$136
- Updated2026-05-28
- Buy
- ManufacturerACHEMBLOCK
- Product numberM15307
- Product descriptionKRN 633 98%
- Packaging25MG
- Price$110
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberM15307
- Product descriptionKRN 633 98%
- Packaging100MG
- Price$215
- Updated2026-05-27
- Buy
- ManufacturerAK Scientific
- Product numberX7494
- Product descriptionKRN633
- Packaging10mg
- Price$178
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA263491
- Product descriptionKRN-633 98+%
- Packaging100mg
- Price$201
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA263491
- Product descriptionKRN-633 98+%
- Packaging50mg
- Price$149
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA263491
- Product descriptionKRN-633 98+%
- Packaging1mg
- Price$40
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA263491
- Product descriptionKRN-633 98+%
- Packaging5mg
- Price$68
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA263491
- Product descriptionKRN-633 98+%
- Packaging10mg
- Price$88
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA263491
- Product descriptionKRN-633 98+%
- Packaging250mg
- Price$396
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA263491
- Product descriptionKRN-633 98+%
- Packaging1g
- Price$1032
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberKIN0000143
- Product descriptionKRN 633 95.00%
- Packaging1KG
- Price$21021
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA002VU8 | 1-{2-Chloro-4-[(6,7-dimethoxyquinazolin-4-yl)oxy]phenyl}-3-propylurea 98% | 1mg | $8 | 2026-05-28 | Buy |
| aablocks | AA002VU8 | 1-{2-Chloro-4-[(6,7-dimethoxyquinazolin-4-yl)oxy]phenyl}-3-propylurea ≥97% | 5mg | $12 | 2026-05-28 | Buy |
| aablocks | AA002VU8 | 1-{2-Chloro-4-[(6,7-dimethoxyquinazolin-4-yl)oxy]phenyl}-3-propylurea 98% | 10mg | $22 | 2026-05-28 | Buy |
| aablocks | AA002VU8 | 1-{2-Chloro-4-[(6,7-dimethoxyquinazolin-4-yl)oxy]phenyl}-3-propylurea ≥97% | 25mg | $43 | 2026-05-28 | Buy |
| aablocks | AA002VU8 | 1-{2-Chloro-4-[(6,7-dimethoxyquinazolin-4-yl)oxy]phenyl}-3-propylurea ≥97% | 100mg | $136 | 2026-05-28 | Buy |
| ACHEMBLOCK | M15307 | KRN 633 98% | 25MG | $110 | 2026-05-27 | Buy |
| ACHEMBLOCK | M15307 | KRN 633 98% | 100MG | $215 | 2026-05-27 | Buy |
| AK Scientific | X7494 | KRN633 | 10mg | $178 | 2021-12-16 | Buy |
| Ambeed | A263491 | KRN-633 98+% | 100mg | $201 | 2021-12-16 | Buy |
| Ambeed | A263491 | KRN-633 98+% | 50mg | $149 | 2021-12-16 | Buy |
| Ambeed | A263491 | KRN-633 98+% | 1mg | $40 | 2021-12-16 | Buy |
| Ambeed | A263491 | KRN-633 98+% | 5mg | $68 | 2021-12-16 | Buy |
| Ambeed | A263491 | KRN-633 98+% | 10mg | $88 | 2021-12-16 | Buy |
| Ambeed | A263491 | KRN-633 98+% | 250mg | $396 | 2021-12-16 | Buy |
| Ambeed | A263491 | KRN-633 98+% | 1g | $1032 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | KIN0000143 | KRN 633 95.00% | 1KG | $21021 | 2021-12-16 | Buy |
Properties
Melting point :231-232°C
Boiling point :545.6±50.0 °C(Predicted)
Density :1.321
storage temp. :-20°C
solubility :DMSO: soluble3mg/mL, clear (warmed)
pka :13.08±0.70(Predicted)
form :powder
color :white to beige
InChI :1S/C20H21ClN4O4/c1-4-7-22-20(26)25-15-6-5-12(8-14(15)21)29-19-13-9-17(27-2)18(28-3)10-16(13)23-11-24-19/h5-6,8-11H,4,7H2,1-3H3,(H2,22,25,26)
InChIKey :VPBYZLCHOKSGRX-UHFFFAOYSA-N
Boiling point :545.6±50.0 °C(Predicted)
Density :1.321
storage temp. :-20°C
solubility :DMSO: soluble3mg/mL, clear (warmed)
pka :13.08±0.70(Predicted)
form :powder
color :white to beige
InChI :1S/C20H21ClN4O4/c1-4-7-22-20(26)25-15-6-5-12(8-14(15)21)29-19-13-9-17(27-2)18(28-3)10-16(13)23-11-24-19/h5-6,8-11H,4,7H2,1-3H3,(H2,22,25,26)
InChIKey :VPBYZLCHOKSGRX-UHFFFAOYSA-N
Safety Information
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| Signal word: | Warning | ||||||||||||||
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Description
KRN 633 is an ATP-competitive inhibitor of VEGFR kinase activity (IC50s = 170, 160, and 125 nM for VEGFR1, 2, and 3, respectively). At higher concentrations KRN 633 inhibits PDGFR-α and c-KIT with IC50 values of 0.97 and 4.3 μM, respectively, and is inactive towards a panel of 17 additional kinases. KRN 633 suppresses VEGF-dependent activation of MAPK and cell proliferation and demonstrates antitumor and antiangiogenic activity by inhibiting vessel formation and vascular permeability in human tumor xenograft models.More related product prices
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