LDN-193189
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- $29 - $3791
- Product name: LDN-193189
- CAS: 1062368-24-4
- MF: C25H22N6
- MW: 406.48
- EINECS:
- MDL Number:MFCD17169988
- Synonyms:LDN193189 LDN193189 HCl;4-(6-(4-(piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline;LDN193189(DM3189);4-[6-[4-(1-Piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]quinoline;DM 3189;DM-3189;6-(4-(2-(piperidin-1-yl)ethoxy)phenyl)-3-(pyridin-4-yl)pyrazolo[1,5-a]pyriMidine LDN 193189(DM3189);4-{6-[4-(piperazin-1-yl)phenyl]pyrazolo[
72 prices
Selected condition：
Brand
- aablocks
- AccelPharmtech
- ACHEMBLOCK
- AK Scientific
- Ambeed
- American Custom Chemicals Corporation
- ApexBio Technology
- Arctom
- Biosynth
- Cayman Chemical
- Chemenu
- ChemScene
- Crysdot
- DC Chemicals
- Labseeker
- Matrix Scientific
- Medical Isotopes, Inc.
- Sigma-Aldrich
- TRC
- Usbiological
Package
- 2mg
- 5mg
- 1mg
- 10mM*1mLinDMSO
- 10mg
- 10.00mg
- 25MG
- 50mg
- 50.00mg
- 100.00mg
- 100mg
- 250mg
- 500mg
- 1G
- 2G
- 5g
- 25 mg
- Manufactureraablocks
- Product numberAA008TEI
- Product descriptionQuinoline, 4-[6-[4-(1-piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]- 98%
- Packaging5mg
- Price$29
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA008TEI
- Product descriptionQuinoline, 4-[6-[4-(1-piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]- 98%
- Packaging10mg
- Price$47
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA008TEI
- Product descriptionQuinoline, 4-[6-[4-(1-piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]- 98%
- Packaging50mg
- Price$128
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA008TEI
- Product descriptionQuinoline, 4-[6-[4-(1-piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]- 98%
- Packaging100mg
- Price$204
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA008TEI
- Product descriptionQuinoline, 4-[6-[4-(1-piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]- 99%(HPLC)
- Packaging250mg
- Price$486
- Updated2026-05-28
- Buy
- ManufacturerAccelPharmtech
- Product numberWW1382
- Product description4-(6-(4-(piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline 98%+
- Packaging2G
- Price$1860
- Updated2026-05-21
- Buy
- ManufacturerACHEMBLOCK
- Product number10240
- Product descriptionLDN-193189 98%
- Packaging1G
- Price$1250
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product number10240
- Product descriptionLDN-193189 98%
- Packaging100MG
- Price$240
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product number10240
- Product descriptionLDN-193189 98%
- Packaging25MG
- Price$110
- Updated2026-05-27
- Buy
- ManufacturerAK Scientific
- Product numberX7510
- Product descriptionLDN193189
- Packaging5mg
- Price$84
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberX7510
- Product descriptionLDN193189
- Packaging1mg
- Price$39
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberX7510
- Product descriptionLDN193189
- Packaging10mg
- Price$108
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA125436
- Product description4-(6-(4-(Piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline 98+%
- Packaging50mg
- Price$196
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA125436
- Product description4-(6-(4-(Piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline 98+%
- Packaging2mg
- Price$44
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA125436
- Product description4-(6-(4-(Piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline 98+%
- Packaging5mg
- Price$57
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA125436
- Product description4-(6-(4-(Piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline 98+%
- Packaging10mg
- Price$74
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA008TEI | Quinoline, 4-[6-[4-(1-piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]- 98% | 5mg | $29 | 2026-05-28 | Buy |
| aablocks | AA008TEI | Quinoline, 4-[6-[4-(1-piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]- 98% | 10mg | $47 | 2026-05-28 | Buy |
| aablocks | AA008TEI | Quinoline, 4-[6-[4-(1-piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]- 98% | 50mg | $128 | 2026-05-28 | Buy |
| aablocks | AA008TEI | Quinoline, 4-[6-[4-(1-piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]- 98% | 100mg | $204 | 2026-05-28 | Buy |
| aablocks | AA008TEI | Quinoline, 4-[6-[4-(1-piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]- 99%(HPLC) | 250mg | $486 | 2026-05-28 | Buy |
| AccelPharmtech | WW1382 | 4-(6-(4-(piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline 98%+ | 2G | $1860 | 2026-05-21 | Buy |
| ACHEMBLOCK | 10240 | LDN-193189 98% | 1G | $1250 | 2026-05-27 | Buy |
| ACHEMBLOCK | 10240 | LDN-193189 98% | 100MG | $240 | 2026-05-27 | Buy |
| ACHEMBLOCK | 10240 | LDN-193189 98% | 25MG | $110 | 2026-05-27 | Buy |
| AK Scientific | X7510 | LDN193189 | 5mg | $84 | 2021-12-16 | Buy |
| AK Scientific | X7510 | LDN193189 | 1mg | $39 | 2021-12-16 | Buy |
| AK Scientific | X7510 | LDN193189 | 10mg | $108 | 2021-12-16 | Buy |
| Ambeed | A125436 | 4-(6-(4-(Piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline 98+% | 50mg | $196 | 2021-12-16 | Buy |
| Ambeed | A125436 | 4-(6-(4-(Piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline 98+% | 2mg | $44 | 2021-12-16 | Buy |
| Ambeed | A125436 | 4-(6-(4-(Piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline 98+% | 5mg | $57 | 2021-12-16 | Buy |
| Ambeed | A125436 | 4-(6-(4-(Piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline 98+% | 10mg | $74 | 2021-12-16 | Buy |
Properties
Density :1.33
storage temp. :Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility :H2O: soluble5mg/mL, clear (warmed)
form :powder
pka :8.79±0.10(Predicted)
color :yellow to orange
Water Solubility :H2O: 5mg/mL, clear (warmed)
InChI :1S/C25H22N6.ClH/c1-2-4-24-22(3-1)21(9-10-27-24)23-16-29-31-17-19(15-28-25(23)31)18-5-7-20(8-6-18)30-13-11-26-12-14-30;/h1-10,15-17,26H,11-14H2;1H
InChIKey :XHBVYDAKJHETMP-UHFFFAOYSA-N
SMILES :C(C=N1)(C2=CC=C(N3CCNCC3)C=C2)=CN4C1=C(C5=CC=NC6=C5C=CC=C6)C=N4.Cl
storage temp. :Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility :H2O: soluble5mg/mL, clear (warmed)
form :powder
pka :8.79±0.10(Predicted)
color :yellow to orange
Water Solubility :H2O: 5mg/mL, clear (warmed)
InChI :1S/C25H22N6.ClH/c1-2-4-24-22(3-1)21(9-10-27-24)23-16-29-31-17-19(15-28-25(23)31)18-5-7-20(8-6-18)30-13-11-26-12-14-30;/h1-10,15-17,26H,11-14H2;1H
InChIKey :XHBVYDAKJHETMP-UHFFFAOYSA-N
SMILES :C(C=N1)(C2=CC=C(N3CCNCC3)C=C2)=CN4C1=C(C5=CC=NC6=C5C=CC=C6)C=N4.Cl
Safety Information
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Description
Normal development and tissue repair are controlled in part by SMADs, a family of intracellular proteins that are activated by signaling via serine/threonine kinase receptors of the TGF-β superfamily. LDN-193189 inhibits SMAD1/5/8 phosphorylation by the bone morphogenetic protein (BMP) type I receptors, which are known as activin receptor-like kinases (ALKs), with an IC50 value of 4.9 nM. In in vitro kinase assays, it shows specificity for ALK1, 2, 3, and 6 (IC50s = 0.8, 0.8, 5.3, and 16.7 nM, respectively) over ALK4 and 5 (IC50s = 101 and 350 nM, respectively). LDN-193189 has been used to inhibit BMP type I receptor activity to study the pathogenesis of fibrodysplasia ossificans progressive, a congenital hyperossification disorder, and to examine the role of osteogenesis in prostate tumor metastases in bone.Suppliers and manufacturers
Shanghai Boyle Chemical Co., Ltd.
J & K SCIENTIFIC LTD.
Chembest Research Laboratories Limited
JinYan Chemicals(ShangHai) Co.,Ltd.
Shangchem Co., Ltd.
Jinan Trio PharmaTech Co., Ltd.
NCE Biomedical Co.,Ltd.
Haoyuan Chemexpress Co., Ltd.
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Moltt Biocem Co., Ltd.