LDN-193189
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- $35 - $3306
- Product name: LDN-193189
- CAS: 1062368-24-4
- MF: C25H22N6
- MW: 406.48
- EINECS:
- MDL Number:MFCD17169988
- Synonyms:LDN193189 LDN193189 HCl;4-(6-(4-(piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline;LDN193189(DM3189);4-[6-[4-(1-Piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]quinoline;DM 3189;DM-3189;6-(4-(2-(piperidin-1-yl)ethoxy)phenyl)-3-(pyridin-4-yl)pyrazolo[1,5-a]pyriMidine LDN 193189(DM3189);4-{6-[4-(piperazin-1-yl)phenyl]pyrazolo[
32 prices
Selected condition：
Brand
- AK Scientific
- Ambeed
- American Custom Chemicals Corporation
- ApexBio Technology
- Arctom
- Biosynth Carbosynth
- Cayman Chemical
- Chemenu
- ChemScene
- Crysdot
- DC Chemicals
- Labseeker
- Medical Isotopes, Inc.
- Sigma-Aldrich
- TRC
Package
- 1mg
- 2mg
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- 250mg
- 1g
- 5g
- ManufacturerAK Scientific
- Product numberX7510
- Product descriptionLDN193189
- Packaging1mg
- Price$39
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberX7510
- Product descriptionLDN193189
- Packaging5mg
- Price$84
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberX7510
- Product descriptionLDN193189
- Packaging10mg
- Price$108
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA125436
- Product description4-(6-(4-(Piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline 98+%
- Packaging2mg
- Price$44
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA125436
- Product description4-(6-(4-(Piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline 98+%
- Packaging5mg
- Price$57
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA125436
- Product description4-(6-(4-(Piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline 98+%
- Packaging10mg
- Price$74
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA125436
- Product description4-(6-(4-(Piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline 98+%
- Packaging50mg
- Price$196
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA125436
- Product description4-(6-(4-(Piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline 98+%
- Packaging100mg
- Price$305
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA125436
- Product description4-(6-(4-(Piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline 98+%
- Packaging250mg
- Price$575
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA125436
- Product description4-(6-(4-(Piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline 98+%
- Packaging1g
- Price$1433
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberKIN0002409
- Product descriptionLDN-193189 95.00%
- Packaging5MG
- Price$500.91
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA8324
- Product descriptionLDN-193189
- Packaging5mg
- Price$85
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA8324
- Product descriptionLDN-193189
- Packaging10mg
- Price$160
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA8324
- Product descriptionLDN-193189
- Packaging50mg
- Price$600
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberCFN60077
- Product descriptionLDN193189
- Packaging5mg
- Price$168
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFP43352
- Product descriptionLDN 193189
- Packaging10mg
- Price$125
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | X7510 | LDN193189 | 1mg | $39 | 2021-12-16 | Buy |
| AK Scientific | X7510 | LDN193189 | 5mg | $84 | 2021-12-16 | Buy |
| AK Scientific | X7510 | LDN193189 | 10mg | $108 | 2021-12-16 | Buy |
| Ambeed | A125436 | 4-(6-(4-(Piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline 98+% | 2mg | $44 | 2021-12-16 | Buy |
| Ambeed | A125436 | 4-(6-(4-(Piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline 98+% | 5mg | $57 | 2021-12-16 | Buy |
| Ambeed | A125436 | 4-(6-(4-(Piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline 98+% | 10mg | $74 | 2021-12-16 | Buy |
| Ambeed | A125436 | 4-(6-(4-(Piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline 98+% | 50mg | $196 | 2021-12-16 | Buy |
| Ambeed | A125436 | 4-(6-(4-(Piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline 98+% | 100mg | $305 | 2021-12-16 | Buy |
| Ambeed | A125436 | 4-(6-(4-(Piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline 98+% | 250mg | $575 | 2021-12-16 | Buy |
| Ambeed | A125436 | 4-(6-(4-(Piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline 98+% | 1g | $1433 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | KIN0002409 | LDN-193189 95.00% | 5MG | $500.91 | 2021-12-16 | Buy |
| ApexBio Technology | A8324 | LDN-193189 | 5mg | $85 | 2021-12-16 | Buy |
| ApexBio Technology | A8324 | LDN-193189 | 10mg | $160 | 2021-12-16 | Buy |
| ApexBio Technology | A8324 | LDN-193189 | 50mg | $600 | 2021-12-16 | Buy |
| Arctom | CFN60077 | LDN193189 | 5mg | $168 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FP43352 | LDN 193189 | 10mg | $125 | 2021-12-16 | Buy |
Properties
Density :1.33
storage temp. :Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility :H2O: soluble5mg/mL, clear (warmed)
form :powder
pka :8.79±0.10(Predicted)
color :yellow to orange
InChIKey :XHBVYDAKJHETMP-UHFFFAOYSA-N
storage temp. :Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility :H2O: soluble5mg/mL, clear (warmed)
form :powder
pka :8.79±0.10(Predicted)
color :yellow to orange
InChIKey :XHBVYDAKJHETMP-UHFFFAOYSA-N
Safety Information
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Description
Normal development and tissue repair are controlled in part by SMADs, a family of intracellular proteins that are activated by signaling via serine/threonine kinase receptors of the TGF-β superfamily. LDN-193189 inhibits SMAD1/5/8 phosphorylation by the bone morphogenetic protein (BMP) type I receptors, which are known as activin receptor-like kinases (ALKs), with an IC50 value of 4.9 nM. In in vitro kinase assays, it shows specificity for ALK1, 2, 3, and 6 (IC50s = 0.8, 0.8, 5.3, and 16.7 nM, respectively) over ALK4 and 5 (IC50s = 101 and 350 nM, respectively). LDN-193189 has been used to inhibit BMP type I receptor activity to study the pathogenesis of fibrodysplasia ossificans progressive, a congenital hyperossification disorder, and to examine the role of osteogenesis in prostate tumor metastases in bone.Suppliers and manufacturers
career henan chemical co
![6-(4-(2-(piperidin-1-yl)ethoxy)phenyl)-3-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidine](https://img.chemicalbook.com/ProductImageEN/2020-1/small/4c986cba-27a2-4ffd-a034-04950c3172a5.png)
Capot Chemical Co.,Ltd.
ATK CHEMICAL COMPANY LIMITED
Biochempartner
Hubei Jusheng Technology Co.,Ltd.
BOC Sciences
CONIER CHEM AND PHARMA LIMITED
TargetMol Chemicals Inc.
HANGZHOU CLAP TECHNOLOGY CO.,LTD
Dideu Industries Group Limited
$9.80 /1.79999995231628KG
6-(4-(2-(piperidin-1-yl)ethoxy)phenyl)-3-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidine CAS:1062368-24-4
6-(4-(2-(piperidin-1-yl)ethoxy)phenyl)-3-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidine CAS:1062368-24-4