LY-364947
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- $45 - $18700
- Product name: LY-364947
- CAS: 396129-53-6
- MF: C17H12N4
- MW: 272.3
- EINECS:
- MDL Number:MFCD00800758
- Synonyms:LY 364947 4-[3-(2-Pyridinyl)-1H-pyrazol-4-yl]quinoline;LY-364947, 396129-53-6;Transforming Growth Factor-β Type I Receptor Kinase Inhibitor;LY-364947;LY-364947, >=98%;LY364947;HTS466284; LY-364947;TGF-β RI Kinase Inhibitor ;[3-(Pyridin-2-yl)-4-(4-quinonyl)]-1H-pyrazole
38 prices
Selected condition：
Brand
- AK Scientific
- American Custom Chemicals Corporation
- ApexBio Technology
- Arctom
- Biorbyt Ltd
- Cayman Chemical
- Chemenu
- ChemScene
- Crysdot
- DC Chemicals
- Matrix Scientific
- Medical Isotopes, Inc.
- Sigma-Aldrich
- SynQuest Laboratories
- Tocris
- TRC
- Usbiological
Package
- 616451-5MG
- 5mg
- 10mg
- 25mg
- 10
- 1mg
- 616451-5UNMG
- 1
- 50mg
- 100mg
- 250mg
- 1G
- 5G
- 10G
- 10mM(in 1mL DMSO)
- ManufacturerAK Scientific
- Product numberX5937
- Product description4-[3-(2-Pyridinyl)-1H-pyrazol-4-yl]-quinoline
- Packaging250mg
- Price$110
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberKIN0000011
- Product description4-(3-PYRIDIN-2-YL-1H-PYRAZOL-4-YL)QUINOLINE 95.00%
- Packaging1G
- Price$685.19
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberKIN0000011
- Product description4-(3-PYRIDIN-2-YL-1H-PYRAZOL-4-YL)QUINOLINE 95.00%
- Packaging5G
- Price$1166.97
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberKIN0000011
- Product description4-(3-PYRIDIN-2-YL-1H-PYRAZOL-4-YL)QUINOLINE 95.00%
- Packaging10G
- Price$1740.95
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB2287
- Product descriptionLY364947
- Packaging10mg
- Price$77
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB2287
- Product descriptionLY364947
- Packaging10mM(in 1mL DMSO)
- Price$81
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB2287
- Product descriptionLY364947
- Packaging25mg
- Price$189
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB2287
- Product descriptionLY364947
- Packaging50mg
- Price$259
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberCFN60332
- Product descriptionLY364947
- Packaging10mg
- Price$138
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb180875
- Product descriptionLY364947 >98%
- Packaging100mg
- Price$615.4
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb180875
- Product descriptionLY364947 >98%
- Packaging250mg
- Price$1060.8
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb180875
- Product descriptionLY364947 >98%
- Packaging1g
- Price$1949.9
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number13341
- Product descriptionLY364947 ≥98%
- Packaging5mg
- Price$92
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number13341
- Product descriptionLY364947 ≥98%
- Packaging10mg
- Price$174
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number13341
- Product descriptionLY364947 ≥98%
- Packaging25mg
- Price$404
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number13341
- Product descriptionLY364947 ≥98%
- Packaging50mg
- Price$719
- Updated2024-03-01
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | X5937 | 4-[3-(2-Pyridinyl)-1H-pyrazol-4-yl]-quinoline | 250mg | $110 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | KIN0000011 | 4-(3-PYRIDIN-2-YL-1H-PYRAZOL-4-YL)QUINOLINE 95.00% | 1G | $685.19 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | KIN0000011 | 4-(3-PYRIDIN-2-YL-1H-PYRAZOL-4-YL)QUINOLINE 95.00% | 5G | $1166.97 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | KIN0000011 | 4-(3-PYRIDIN-2-YL-1H-PYRAZOL-4-YL)QUINOLINE 95.00% | 10G | $1740.95 | 2021-12-16 | Buy |
| ApexBio Technology | B2287 | LY364947 | 10mg | $77 | 2021-12-16 | Buy |
| ApexBio Technology | B2287 | LY364947 | 10mM(in 1mL DMSO) | $81 | 2021-12-16 | Buy |
| ApexBio Technology | B2287 | LY364947 | 25mg | $189 | 2021-12-16 | Buy |
| ApexBio Technology | B2287 | LY364947 | 50mg | $259 | 2021-12-16 | Buy |
| Arctom | CFN60332 | LY364947 | 10mg | $138 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb180875 | LY364947 >98% | 100mg | $615.4 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb180875 | LY364947 >98% | 250mg | $1060.8 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb180875 | LY364947 >98% | 1g | $1949.9 | 2021-12-16 | Buy |
| Cayman Chemical | 13341 | LY364947 ≥98% | 5mg | $92 | 2024-03-01 | Buy |
| Cayman Chemical | 13341 | LY364947 ≥98% | 10mg | $174 | 2024-03-01 | Buy |
| Cayman Chemical | 13341 | LY364947 ≥98% | 25mg | $404 | 2024-03-01 | Buy |
| Cayman Chemical | 13341 | LY364947 ≥98% | 50mg | $719 | 2024-03-01 | Buy |
Properties
Melting point :>230℃ (dec.)
Boiling point :490.8±45.0 °C(Predicted)
Density :1.283±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: soluble2mg/mL, clear
pka :8.94±0.50(Predicted)
form :powder
color :white to beige
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
InChIKey :IBCXZJCWDGCXQT-UHFFFAOYSA-N
Boiling point :490.8±45.0 °C(Predicted)
Density :1.283±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: soluble2mg/mL, clear
pka :8.94±0.50(Predicted)
form :powder
color :white to beige
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
InChIKey :IBCXZJCWDGCXQT-UHFFFAOYSA-N
Safety Information
| Symbol(GHS): |
 
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| Signal word: | Danger | ||||||||||||||||||||||||||||||||||||||||||
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Description
Transforming growth factor-β (TGF-β) signals through a cell surface heteromeric complex involving type I (TGF-β RI) and type II (TGF-β RII) receptors. Downstream signal transduction is mediated by the TGF-β RI kinase domain through the phosphorylation of Smad proteins. LY364947 is a selective inhibitor of TGF-β RI (TGFR-I, TβR-I, ALK-5), with an IC50 value of 59 nM. LY364947 less effectively inhibits TGF-β RII (IC50 = 400 nM), p38 MAPK (IC50 = 740 nM), and mixed-lineage kinase 7 (MLK7; IC50 = 1,400 nM). It inhibits TGF-β-induced cell growth (IC50 = 89 nM) in NIH 3T3 mouse fibroblasts and TGF-β-directed Smad phosphorylation, synthesis of fibronectin, PAI-1 and uPA protein, and matrigel invasion in MDA-MB-231 cells.More related product prices
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