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ChemicalBook >> CAS DataBase List >> LY3214996

LY3214996

$43 - $2600
Product name: LY3214996
CAS: 1951483-29-6
MF: C22H27N7O2S
MW: 453.56
EINECS:-0
MDL Number:MFCD31544324
Synonyms:LY3214996;6,6-dimethyl-2-(2-((1-methyl-1H-pyrazol-5-yl)amino)pyrimidin-4-yl)-5-(2-morpholinoethyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrol-4-one;CS-2495;4H-Thieno[2,3-c]pyrrol-4-one, 5,6-dihydro-6,6-dimethyl-2-[2-[(1-methyl-1H-pyrazol-5-yl)amino]-4-pyrimidinyl]-5-[2-(4-morpholinyl)ethyl]-;Temuterkib (LY3214996);LY-3214996,LY 3214996,inhibit,Extracellular signal regulated kinases,Temuterkib,Inhibitor,ERK;LY-3214996 (LY3214996);Temuterkib, 10 mM in DMSO

Price35 Properties Safety Information Description

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aablocks
ACHEMBLOCK
AK Scientific
Apolloscientific
Biorbyt Ltd
Biosynth
Cayman Chemical
ChemScene
DC Chemicals

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Manufactureraablocks
Product numberAA01EAZC
Product description5,6-Dihydro-6,6-dimethyl-2-[2-[(1-methyl-1H-pyrazol-5-yl)amino]-4-pyrimidinyl]-5-[2-(4-morpholinyl)ethyl]-4H-thieno[2,3-c]pyrrol-4-one ≥98%
Packaging1mg
Price$43
Updated2026-05-30
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Manufactureraablocks
Product numberAA01EAZC
Product description5,6-Dihydro-6,6-dimethyl-2-[2-[(1-methyl-1H-pyrazol-5-yl)amino]-4-pyrimidinyl]-5-[2-(4-morpholinyl)ethyl]-4H-thieno[2,3-c]pyrrol-4-one
Packaging2mg
Price$78
Updated2026-05-30
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Manufactureraablocks
Product numberAA01EAZC
Product description5,6-Dihydro-6,6-dimethyl-2-[2-[(1-methyl-1H-pyrazol-5-yl)amino]-4-pyrimidinyl]-5-[2-(4-morpholinyl)ethyl]-4H-thieno[2,3-c]pyrrol-4-one 98%
Packaging5mg
Price$87
Updated2026-05-30
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Manufactureraablocks
Product numberAA01EAZC
Product description5,6-Dihydro-6,6-dimethyl-2-[2-[(1-methyl-1H-pyrazol-5-yl)amino]-4-pyrimidinyl]-5-[2-(4-morpholinyl)ethyl]-4H-thieno[2,3-c]pyrrol-4-one 98%
Packaging10mg
Price$131
Updated2026-05-30
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Manufactureraablocks
Product numberAA01EAZC
Product description5,6-Dihydro-6,6-dimethyl-2-[2-[(1-methyl-1H-pyrazol-5-yl)amino]-4-pyrimidinyl]-5-[2-(4-morpholinyl)ethyl]-4H-thieno[2,3-c]pyrrol-4-one ≥98%
Packaging100mg
Price$573
Updated2026-05-30
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Manufactureraablocks
Product numberAA01EAZC
Product description5,6-Dihydro-6,6-dimethyl-2-[2-[(1-methyl-1H-pyrazol-5-yl)amino]-4-pyrimidinyl]-5-[2-(4-morpholinyl)ethyl]-4H-thieno[2,3-c]pyrrol-4-one ≥98%
Packaging50mg
Price$382
Updated2026-05-30
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Manufactureraablocks
Product numberAA01EAZC
Product description5,6-Dihydro-6,6-dimethyl-2-[2-[(1-methyl-1H-pyrazol-5-yl)amino]-4-pyrimidinyl]-5-[2-(4-morpholinyl)ethyl]-4H-thieno[2,3-c]pyrrol-4-one 98%
Packaging25mg
Price$201
Updated2026-05-30
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ManufacturerACHEMBLOCK
Product numberT97259
Product description6,6-dimethyl-2-(2-(1-methyl-1H-pyrazol-5-ylamino)pyrimidin-4-yl)-5-(2-morpholinoethyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrol-4-one 98%
Packaging5MG
Price$125
Updated2026-05-27
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ManufacturerACHEMBLOCK
Product numberT97259
Product description6,6-dimethyl-2-(2-(1-methyl-1H-pyrazol-5-ylamino)pyrimidin-4-yl)-5-(2-morpholinoethyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrol-4-one 98%
Packaging25MG
Price$440
Updated2026-05-27
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ManufacturerACHEMBLOCK
Product numberT97259
Product description6,6-dimethyl-2-(2-(1-methyl-1H-pyrazol-5-ylamino)pyrimidin-4-yl)-5-(2-morpholinoethyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrol-4-one 98%
Packaging100MG
Price$945
Updated2026-05-27
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ManufacturerAK Scientific
Product number5975EG
Product descriptionCID121408882
Packaging5mg
Price$357
Updated2021-12-16
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ManufacturerApolloscientific
Product numberBISN0168
Product descriptionLY3214996
Packaging1mg
Price$52
Updated2026-06-04
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ManufacturerBiorbyt Ltd
Product numberorb1225789
Product descriptionLY-3214996 >98%(HPLC)
Packaging2mg
Price$140
Updated2026-05-06
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ManufacturerBiorbyt Ltd
Product numberorb1225789
Product descriptionLY-3214996 >98%(HPLC)
Packaging5mg
Price$190
Updated2026-05-06
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ManufacturerBiorbyt Ltd
Product numberorb1225789
Product descriptionLY-3214996 >98%(HPLC)
Packaging25mg
Price$580
Updated2026-05-06
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ManufacturerBiorbyt Ltd
Product numberorb1225789
Product descriptionLY-3214996 >98%(HPLC)
Packaging10mg
Price$280
Updated2026-05-06
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Manufacturer	Product number	Product description	Packaging	Price	Updated	Buy
aablocks	AA01EAZC	5,6-Dihydro-6,6-dimethyl-2-[2-[(1-methyl-1H-pyrazol-5-yl)amino]-4-pyrimidinyl]-5-[2-(4-morpholinyl)ethyl]-4H-thieno[2,3-c]pyrrol-4-one ≥98%	1mg	$43	2026-05-30	Buy
aablocks	AA01EAZC	5,6-Dihydro-6,6-dimethyl-2-[2-[(1-methyl-1H-pyrazol-5-yl)amino]-4-pyrimidinyl]-5-[2-(4-morpholinyl)ethyl]-4H-thieno[2,3-c]pyrrol-4-one	2mg	$78	2026-05-30	Buy
aablocks	AA01EAZC	5,6-Dihydro-6,6-dimethyl-2-[2-[(1-methyl-1H-pyrazol-5-yl)amino]-4-pyrimidinyl]-5-[2-(4-morpholinyl)ethyl]-4H-thieno[2,3-c]pyrrol-4-one 98%	5mg	$87	2026-05-30	Buy
aablocks	AA01EAZC	5,6-Dihydro-6,6-dimethyl-2-[2-[(1-methyl-1H-pyrazol-5-yl)amino]-4-pyrimidinyl]-5-[2-(4-morpholinyl)ethyl]-4H-thieno[2,3-c]pyrrol-4-one 98%	10mg	$131	2026-05-30	Buy
aablocks	AA01EAZC	5,6-Dihydro-6,6-dimethyl-2-[2-[(1-methyl-1H-pyrazol-5-yl)amino]-4-pyrimidinyl]-5-[2-(4-morpholinyl)ethyl]-4H-thieno[2,3-c]pyrrol-4-one ≥98%	100mg	$573	2026-05-30	Buy
aablocks	AA01EAZC	5,6-Dihydro-6,6-dimethyl-2-[2-[(1-methyl-1H-pyrazol-5-yl)amino]-4-pyrimidinyl]-5-[2-(4-morpholinyl)ethyl]-4H-thieno[2,3-c]pyrrol-4-one ≥98%	50mg	$382	2026-05-30	Buy
aablocks	AA01EAZC	5,6-Dihydro-6,6-dimethyl-2-[2-[(1-methyl-1H-pyrazol-5-yl)amino]-4-pyrimidinyl]-5-[2-(4-morpholinyl)ethyl]-4H-thieno[2,3-c]pyrrol-4-one 98%	25mg	$201	2026-05-30	Buy
ACHEMBLOCK	T97259	6,6-dimethyl-2-(2-(1-methyl-1H-pyrazol-5-ylamino)pyrimidin-4-yl)-5-(2-morpholinoethyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrol-4-one 98%	5MG	$125	2026-05-27	Buy
ACHEMBLOCK	T97259	6,6-dimethyl-2-(2-(1-methyl-1H-pyrazol-5-ylamino)pyrimidin-4-yl)-5-(2-morpholinoethyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrol-4-one 98%	25MG	$440	2026-05-27	Buy
ACHEMBLOCK	T97259	6,6-dimethyl-2-(2-(1-methyl-1H-pyrazol-5-ylamino)pyrimidin-4-yl)-5-(2-morpholinoethyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrol-4-one 98%	100MG	$945	2026-05-27	Buy
AK Scientific	5975EG	CID121408882	5mg	$357	2021-12-16	Buy
Apolloscientific	BISN0168	LY3214996	1mg	$52	2026-06-04	Buy
Biorbyt Ltd	orb1225789	LY-3214996 >98%(HPLC)	2mg	$140	2026-05-06	Buy
Biorbyt Ltd	orb1225789	LY-3214996 >98%(HPLC)	5mg	$190	2026-05-06	Buy
Biorbyt Ltd	orb1225789	LY-3214996 >98%(HPLC)	25mg	$580	2026-05-06	Buy
Biorbyt Ltd	orb1225789	LY-3214996 >98%(HPLC)	10mg	$280	2026-05-06	Buy

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Properties

Boiling point :711.5±70.0 °C(Predicted)
Density :1.43±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMSO:23.5(Max Conc. mg/mL);51.81(Max Conc. mM)
Ethanol:16.0(Max Conc. mg/mL);35.28(Max Conc. mM) form :A crystalline solid
pka :6.58±0.10(Predicted)
color :White to yellow
InChI :InChI=1S/C22H27N7O2S/c1-22(2)19-15(20(30)29(22)9-8-28-10-12-31-13-11-28)14-17(32-19)16-4-6-23-21(25-16)26-18-5-7-24-27(18)3/h4-7,14H,8-13H2,1-3H3,(H,23,25,26)
InChIKey :JNPRPMBJODOFEC-UHFFFAOYSA-N
SMILES :N1(CCN2CCOCC2)C(=O)C2C=C(C3C=CN=C(NC4N(C)N=CC=4)N=3)SC=2C1(C)C

Safety Information

Symbol(GHS):

Signal word:

Warning

Hazard statements:

Code	Hazard statements	Hazard class	Category	Signal word	P-Codes
H315	Causes skin irritation	Skin corrosion/irritation	Category 2	Warning	P264, P280, P302+P352, P321,P332+P313, P362
H319	Causes serious eye irritation	Serious eye damage/eye irritation	Category 2A	Warning	P264, P280, P305+P351+P338,P337+P313P
H335	May cause respiratory irritation	Specific target organ toxicity, single exposure;Respiratory tract irritation	Category 3	Warning

Precautionary statements:

P301+P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352	IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

LY3214996 is an inhibitor of ERK1 and ERK2 (IC₅₀ = 5 nM for both). It inhibits cell proliferation of tumor cells in vitro, including those expressing B-RAF, N-Ras, or K-Ras mutations. LY3214996 inhibits tumor growth in B-RAF or N-Ras mutant melanoma, B-RAF or K-Ras mutant colorectal, lung, and pancreatic cancer mouse xenograft models, as well as patient-derived xenograft (PDX) mouse models.

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Suppliers and manufacturers

Suzhou Chenrui Biotechnology Co. LTD BOC Sciences MedChemexpress LLC Shanghai Macklin Biochemical Co.,Ltd. Shanghai YuanQi Biotechnology Co., Ltd. Shanghai Lollane Biological Technology Co.,Ltd. Shanghai EFE Biological Technology Co., Ltd. Shanghai YuanYe Biotechnology Co., Ltd. ShangHai Biochempartner Co.,Ltd Shanghai Chaolan Chemical Technology Center

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LY3214996

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