MIRA-1
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- $52 - $763
- Product name: MIRA-1
- CAS: 72835-26-8
- MF: C8H9NO4
- MW: 183.16
- EINECS:-0
- MDL Number:MFCD12828765
- Synonyms:MIRA-1;1-[(1-Oxopropoxy)methyl]-1H-pyrrole-2,5-dione;NSC 19630;1H-Pyrrole-2,5-dione, 1-[(1-oxopropoxy)methyl]-;Ethyl 2,5-Dioxo-2,5-dihydropyrrole-1-acetate;1-[(1-Oxopropoxy)methyl]-1H-pyrrole-2;5-dihydro-1H-pyrrol-1-yl)methyl propionate;p53 Activator VIII
14 prices
Selected condition：
Brand
- AK Scientific
- Ambeed
- American Custom Chemicals Corporation
- ApexBio Technology
- Cayman Chemical
- Sigma-Aldrich
- Tocris
- TRC
- Usbiological
Package
- 10
- 5MG
- 10mg
- 50mg
- 100mg
- 250mg
- 1g
- ManufacturerAK Scientific
- Product number3962CB
- Product description1h-Pyrrole-2,5-dione,1-[(1-oxopropoxy)methyl]-
- Packaging10mg
- Price$197
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA1208571
- Product description(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)methylpropionate 97%
- Packaging100mg
- Price$52
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA1208571
- Product description(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)methylpropionate 97%
- Packaging250mg
- Price$87
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA1208571
- Product description(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)methylpropionate 97%
- Packaging1g
- Price$208
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0008055
- Product descriptionMIRA-1 95.00%
- Packaging5MG
- Price$496.93
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4479
- Product descriptionMIRA-1
- Packaging10mg
- Price$182
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4479
- Product descriptionMIRA-1
- Packaging50mg
- Price$763
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number14858
- Product descriptionMIRA-1 ≥98%
- Packaging10mg
- Price$106
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number14858
- Product descriptionMIRA-1 ≥98%
- Packaging50mg
- Price$440
- Updated2024-03-01
- Buy
- ManufacturerSigma-Aldrich
- Product number681647
- Product descriptionWRN Helicase Inhibitor, NSC 19630 - CAS 72835-26-8 - Calbiochem
- Packaging5MG
- Price$144
- Updated2024-03-01
- Buy
- ManufacturerTocris
- Product number3362
- Product descriptionMIRA-1
- Packaging10
- Price$119
- Updated2021-12-16
- Buy
- ManufacturerTRC
- Product numberN900430
- Product descriptionMIRA-1
- Packaging10mg
- Price$60
- Updated2021-12-16
- Buy
- ManufacturerTRC
- Product numberN900430
- Product descriptionMIRA-1
- Packaging50mg
- Price$320
- Updated2021-12-16
- Buy
- ManufacturerUsbiological
- Product number255822
- Product descriptionMIRA-1
- Packaging10mg
- Price$366
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | 3962CB | 1h-Pyrrole-2,5-dione,1-[(1-oxopropoxy)methyl]- | 10mg | $197 | 2021-12-16 | Buy |
| Ambeed | A1208571 | (2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)methylpropionate 97% | 100mg | $52 | 2021-12-16 | Buy |
| Ambeed | A1208571 | (2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)methylpropionate 97% | 250mg | $87 | 2021-12-16 | Buy |
| Ambeed | A1208571 | (2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)methylpropionate 97% | 1g | $208 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0008055 | MIRA-1 95.00% | 5MG | $496.93 | 2021-12-16 | Buy |
| ApexBio Technology | A4479 | MIRA-1 | 10mg | $182 | 2021-12-16 | Buy |
| ApexBio Technology | A4479 | MIRA-1 | 50mg | $763 | 2021-12-16 | Buy |
| Cayman Chemical | 14858 | MIRA-1 ≥98% | 10mg | $106 | 2024-03-01 | Buy |
| Cayman Chemical | 14858 | MIRA-1 ≥98% | 50mg | $440 | 2024-03-01 | Buy |
| Sigma-Aldrich | 681647 | WRN Helicase Inhibitor, NSC 19630 - CAS 72835-26-8 - Calbiochem | 5MG | $144 | 2024-03-01 | Buy |
| Tocris | 3362 | MIRA-1 | 10 | $119 | 2021-12-16 | Buy |
| TRC | N900430 | MIRA-1 | 10mg | $60 | 2021-12-16 | Buy |
| TRC | N900430 | MIRA-1 | 50mg | $320 | 2021-12-16 | Buy |
| Usbiological | 255822 | MIRA-1 | 10mg | $366 | 2021-12-16 | Buy |
Properties
Melting point :44 °C
Boiling point :298.2±23.0 °C(Predicted)
Density :1.307±0.06 g/cm3(Predicted)
storage temp. :Store at +4°C
solubility :Soluble to 100 mM in DMSO and to 100 mM in ethanol
form :Powder
pka :-2.79±0.20(Predicted)
Boiling point :298.2±23.0 °C(Predicted)
Density :1.307±0.06 g/cm3(Predicted)
storage temp. :Store at +4°C
solubility :Soluble to 100 mM in DMSO and to 100 mM in ethanol
form :Powder
pka :-2.79±0.20(Predicted)
Safety Information
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Description
MIRA-1 is a maleimide-derived small molecule that reactivates the tumor suppressor function of mutant p53, inducing apoptosis in several human solid tumor cell lines carrying tetracycline-regulated mutant p53 (IC50 = 10 μM in vitro). Treatment of tumor cells with MIRA-1 induces p21, MDM2 and PUMA in a mutant p53-dependent manner. At a concentration of 5-10 mg/kg, MIRA-1, alone or in combination with dexamethasone , arrested tumor growth in a mouse xenograft model of multiple myeloma.Suppliers and manufacturers
TargetMol Chemicals Inc.
Aladdin Scientific
3B Pharmachem (Wuhan) International Co.,Ltd.
VDM Biochemicals
Shanghai Raise Chemical Technology Co.,Ltd
Bide Pharmatech Ltd.
EMMX Biotechnology LLC
Henan Weituxi Chemical Technology Co., Ltd.
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
MedBioPharmaceutical Technology Inc