ML-184
|
- $26 - $2237
- Product name: ML-184
- CAS: 794572-10-4
- MF: C25H34N4O3S
- MW: 470.63
- EINECS:
- MDL Number:MFCD06367291
- Synonyms:ML-184;3-[[4-(2,3-Dimethylphenyl)-1-piperazinyl]carbonyl]-N,N-dimethyl-4-(1-pyrrolidinyl)benzenesulfonamide;3-[4-(2,3-dimethylphenyl)piperazine-1-carbonyl]-N,N-dimethyl-4-pyrrolidin-1-ylbenzenesulfonamide;3-[4-(2,3-dimethylphenyl)piperazine-1-carbonyl]-N,N-dimethyl-4-(pyrrolidin-1-yl)benzene-1-sulfonamide;Benzenesulfonamide, 3-[[4-(2,3-dimethylphenyl)-1-piperazinyl]carbonyl]-N,N-dimethyl-4-(1-pyrrolidinyl)-;CID2440433;ML184,ML-184,inhibit,CID 2440433,ML 184,G protein-coupled receptor 55,CID-2440433,Inhibitor,GPR55;ML-184, 10 mM in DMSO
10 prices
Selected condition：
Brand
- AK Scientific
- Cayman Chemical
- Sigma-Aldrich
- Tocris
Package
- 1mg
- 10
- 500μg
- 5mg
- 50
- 10mg
- 25MG
- 100mg
- 25 mg
- ManufacturerAK Scientific
- Product numberSYN5297
- Product descriptionML184
- Packaging100mg
- Price$2237
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number17641
- Product descriptionML-184 ≥98%
- Packaging1mg
- Price$26
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number17641
- Product descriptionML-184 ≥98%
- Packaging500μg
- Price$39
- Updated2023-01-06
- Buy
- ManufacturerCayman Chemical
- Product number17641
- Product descriptionML-184 ≥98%
- Packaging5mg
- Price$90
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number17641
- Product descriptionML-184 ≥98%
- Packaging10mg
- Price$167
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number17641
- Product descriptionML-184 ≥98%
- Packaging25 mg
- Price$351
- Updated2024-03-01
- Buy
- ManufacturerSigma-Aldrich
- Product numberSML2884
- Product descriptionML184 ≥98% (HPLC)
- Packaging5MG
- Price$78.18
- Updated2025-07-31
- Buy
- ManufacturerSigma-Aldrich
- Product numberSML2884
- Product descriptionML184 ≥98% (HPLC)
- Packaging25MG
- Price$333
- Updated2025-07-31
- Buy
- ManufacturerTocris
- Product number6668
- Product descriptionML184 ≥98%(HPLC)
- Packaging10
- Price$182
- Updated2021-12-16
- Buy
- ManufacturerTocris
- Product number6668
- Product descriptionML184 ≥98%(HPLC)
- Packaging50
- Price$767
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | SYN5297 | ML184 | 100mg | $2237 | 2021-12-16 | Buy |
| Cayman Chemical | 17641 | ML-184 ≥98% | 1mg | $26 | 2024-03-01 | Buy |
| Cayman Chemical | 17641 | ML-184 ≥98% | 500μg | $39 | 2023-01-06 | Buy |
| Cayman Chemical | 17641 | ML-184 ≥98% | 5mg | $90 | 2024-03-01 | Buy |
| Cayman Chemical | 17641 | ML-184 ≥98% | 10mg | $167 | 2024-03-01 | Buy |
| Cayman Chemical | 17641 | ML-184 ≥98% | 25 mg | $351 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML2884 | ML184 ≥98% (HPLC) | 5MG | $78.18 | 2025-07-31 | Buy |
| Sigma-Aldrich | SML2884 | ML184 ≥98% (HPLC) | 25MG | $333 | 2025-07-31 | Buy |
| Tocris | 6668 | ML184 ≥98%(HPLC) | 10 | $182 | 2021-12-16 | Buy |
| Tocris | 6668 | ML184 ≥98%(HPLC) | 50 | $767 | 2021-12-16 | Buy |
Properties
storage temp. :Store at -20°C
solubility :DMF: 30 mg/ml; DMF:PBS (pH 7.2) (1:4): 0.2 mg/ml; DMSO: 20 mg/ml; Ethanol: 1 mg/ml
form :A crystalline solid
color :White to off-white
InChI :InChI=1S/C25H34N4O3S/c1-19-8-7-9-23(20(19)2)28-14-16-29(17-15-28)25(30)22-18-21(33(31,32)26(3)4)10-11-24(22)27-12-5-6-13-27/h7-11,18H,5-6,12-17H2,1-4H3
InChIKey :VRSJAHQGJHDACS-UHFFFAOYSA-N
SMILES :C1(S(N(C)C)(=O)=O)=CC=C(N2CCCC2)C(C(N2CCN(C3=CC=CC(C)=C3C)CC2)=O)=C1
solubility :DMF: 30 mg/ml; DMF:PBS (pH 7.2) (1:4): 0.2 mg/ml; DMSO: 20 mg/ml; Ethanol: 1 mg/ml
form :A crystalline solid
color :White to off-white
InChI :InChI=1S/C25H34N4O3S/c1-19-8-7-9-23(20(19)2)28-14-16-29(17-15-28)25(30)22-18-21(33(31,32)26(3)4)10-11-24(22)27-12-5-6-13-27/h7-11,18H,5-6,12-17H2,1-4H3
InChIKey :VRSJAHQGJHDACS-UHFFFAOYSA-N
SMILES :C1(S(N(C)C)(=O)=O)=CC=C(N2CCCC2)C(C(N2CCN(C3=CC=CC(C)=C3C)CC2)=O)=C1
Safety Information
| Symbol(GHS): | ||||||||
|---|---|---|---|---|---|---|---|---|
| Signal word: | ||||||||
| Hazard statements: |
|
|||||||
| Precautionary statements: |
|
Description
GPR55 is a G protein-coupled receptor that is weakly activated by some cannabinoids (CBs) at nM concentrations but displays a 5- to 10-fold greater stimulation in response to 1 μM lysophosphatidylinositol (LPI). ML-184 is a potent synthetic agonist of GPR55 (EC50 = 0.26 μM). It does not act at the related kynurenic acid receptor GPR35 and is a weak antagonist of CB1 and CB2 (IC50s = 21.8 and 15.1 μM, respectively). Like LPI, ML-184 induces phosphorylation of ERK1/2 and translocation of PKCβII to the plasma membrane by activating GPR55.Suppliers and manufacturers
TargetMol Chemicals Inc.
Wuhan Topule Biopharmaceutical Co., Ltd
LEAPCHEM CO., LTD.
Aladdin Scientific
ShangHai ChuanQian Chemcial Technique Centre
Shanghai Lollane Biological Technology Co.,Ltd.
Shanghai EFE Biological Technology Co., Ltd.
Shanghai YuanYe Biotechnology Co., Ltd.
Shanghai Chaolan Chemical Technology Center
Beijing Solarbio Science & Tecnology Co., Ltd.