OSI-420
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- $59 - $2772
- Product name: OSI-420
- CAS: 183321-86-0
- MF: C21H21N3O4
- MW: 379.41
- EINECS:
- MDL Number:MFCD09841129
- Synonyms:CP 373420;OSI-420 (free base);Erlotinib O-DesMethyl Metabolite;Erlotinib iMpurity H;Desmethyl Erlotinib (CP-473420, OSI-420);6-O-Desmethyl Erlotinib 1;2-((4-((3-ethynylphenyl)amino)-7-(2-methoxyethoxy)quinazolin-6-yl)oxy)ethan-1-ol;2-((4-((3-Ethynylphenyl)amino)-7-(2-methoxyethoxy)quinazolin-6-yl)oxy)ethanol
33 prices
Selected condition：
Brand
- aablocks
- American Custom Chemicals Corporation
- ApexBio Technology
- Axon Medchem
- Biosynth
- Cayman Chemical
- ChemScene
- Crysdot
- TRC
- Usbiological
Package
- 1mg
- 2mg
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- 200mg
- Manufactureraablocks
- Product numberAA0027F3
- Product description2-((4-((3-Ethynylphenyl)amino)-7-(2-methoxyethoxy)quinazolin-6-yl)oxy)ethanol
- Packaging1mg
- Price$59
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0027F3
- Product description2-((4-((3-Ethynylphenyl)amino)-7-(2-methoxyethoxy)quinazolin-6-yl)oxy)ethanol
- Packaging2mg
- Price$76
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0027F3
- Product description2-((4-((3-Ethynylphenyl)amino)-7-(2-methoxyethoxy)quinazolin-6-yl)oxy)ethanol
- Packaging5mg
- Price$114
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0027F3
- Product description2-((4-((3-Ethynylphenyl)amino)-7-(2-methoxyethoxy)quinazolin-6-yl)oxy)ethanol
- Packaging10mg
- Price$179
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0027F3
- Product description2-((4-((3-Ethynylphenyl)amino)-7-(2-methoxyethoxy)quinazolin-6-yl)oxy)ethanol
- Packaging25mg
- Price$300
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0027F3
- Product description2-((4-((3-Ethynylphenyl)amino)-7-(2-methoxyethoxy)quinazolin-6-yl)oxy)ethanol
- Packaging50mg
- Price$439
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0027F3
- Product description2-((4-((3-Ethynylphenyl)amino)-7-(2-methoxyethoxy)quinazolin-6-yl)oxy)ethanol
- Packaging100mg
- Price$626
- Updated2026-05-28
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberCHM0152394
- Product description2-(4-(3-ETHYNYLPHENYLAMINO)-7-(2-METHOXYETHOXY)QUINAZOLIN-6-YLOXY)ETHANOL 95.00%
- Packaging1MG
- Price$818.61
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberCHM0152394
- Product description2-(4-(3-ETHYNYLPHENYLAMINO)-7-(2-METHOXYETHOXY)QUINAZOLIN-6-YLOXY)ETHANOL 95.00%
- Packaging10MG
- Price$2728.69
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB1495
- Product descriptionOSI-420 free base
- Packaging50mg
- Price$647
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberB1495
- Product descriptionOSI-420 free base
- Packaging200mg
- Price$2006
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberB1495
- Product descriptionOSI-420 free base
- Packaging10mg
- Price$210
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberB1495
- Product descriptionOSI-420 free base
- Packaging5mg
- Price$120
- Updated2026-05-06
- Buy
- ManufacturerAxon Medchem
- Product numberAxon1632
- Product descriptionOSI 420
- Packaging5mg
- Price$148.5
- Updated2026-05-19
- Buy
- ManufacturerAxon Medchem
- Product numberAxon1632
- Product descriptionOSI 420
- Packaging2mg
- Price$99
- Updated2026-05-19
- Buy
- ManufacturerBiosynth
- Product numberFO26597
- Product descriptionDesmethyl erlotinib
- Packaging5mg
- Price$294
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA0027F3 | 2-((4-((3-Ethynylphenyl)amino)-7-(2-methoxyethoxy)quinazolin-6-yl)oxy)ethanol | 1mg | $59 | 2026-05-28 | Buy |
| aablocks | AA0027F3 | 2-((4-((3-Ethynylphenyl)amino)-7-(2-methoxyethoxy)quinazolin-6-yl)oxy)ethanol | 2mg | $76 | 2026-05-28 | Buy |
| aablocks | AA0027F3 | 2-((4-((3-Ethynylphenyl)amino)-7-(2-methoxyethoxy)quinazolin-6-yl)oxy)ethanol | 5mg | $114 | 2026-05-28 | Buy |
| aablocks | AA0027F3 | 2-((4-((3-Ethynylphenyl)amino)-7-(2-methoxyethoxy)quinazolin-6-yl)oxy)ethanol | 10mg | $179 | 2026-05-28 | Buy |
| aablocks | AA0027F3 | 2-((4-((3-Ethynylphenyl)amino)-7-(2-methoxyethoxy)quinazolin-6-yl)oxy)ethanol | 25mg | $300 | 2026-05-28 | Buy |
| aablocks | AA0027F3 | 2-((4-((3-Ethynylphenyl)amino)-7-(2-methoxyethoxy)quinazolin-6-yl)oxy)ethanol | 50mg | $439 | 2026-05-28 | Buy |
| aablocks | AA0027F3 | 2-((4-((3-Ethynylphenyl)amino)-7-(2-methoxyethoxy)quinazolin-6-yl)oxy)ethanol | 100mg | $626 | 2026-05-28 | Buy |
| American Custom Chemicals Corporation | CHM0152394 | 2-(4-(3-ETHYNYLPHENYLAMINO)-7-(2-METHOXYETHOXY)QUINAZOLIN-6-YLOXY)ETHANOL 95.00% | 1MG | $818.61 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | CHM0152394 | 2-(4-(3-ETHYNYLPHENYLAMINO)-7-(2-METHOXYETHOXY)QUINAZOLIN-6-YLOXY)ETHANOL 95.00% | 10MG | $2728.69 | 2021-12-16 | Buy |
| ApexBio Technology | B1495 | OSI-420 free base | 50mg | $647 | 2026-05-06 | Buy |
| ApexBio Technology | B1495 | OSI-420 free base | 200mg | $2006 | 2026-05-06 | Buy |
| ApexBio Technology | B1495 | OSI-420 free base | 10mg | $210 | 2026-05-06 | Buy |
| ApexBio Technology | B1495 | OSI-420 free base | 5mg | $120 | 2026-05-06 | Buy |
| Axon Medchem | Axon1632 | OSI 420 | 5mg | $148.5 | 2026-05-19 | Buy |
| Axon Medchem | Axon1632 | OSI 420 | 2mg | $99 | 2026-05-19 | Buy |
| Biosynth | FO26597 | Desmethyl erlotinib | 5mg | $294 | 2021-12-16 | Buy |
Properties
Melting point :140-142°C
Density :1.30
storage temp. :-20°C Freezer
solubility :insoluble in H2O; insoluble in EtOH; ≥51 mg/mL in DMSO
form :A crystalline solid
color :White to off-white
InChI :InChI=1S/C21H21N3O4/c1-3-15-5-4-6-16(11-15)24-21-17-12-19(27-8-7-25)20(28-10-9-26-2)13-18(17)22-14-23-21/h1,4-6,11-14,25H,7-10H2,2H3,(H,22,23,24)
InChIKey :KOQIAZNBAWFSQM-UHFFFAOYSA-N
SMILES :C(O)COC1C(OCCOC)=CC2C(C=1)=C(NC1=CC=CC(C#C)=C1)N=CN=2
Density :1.30
storage temp. :-20°C Freezer
solubility :insoluble in H2O; insoluble in EtOH; ≥51 mg/mL in DMSO
form :A crystalline solid
color :White to off-white
InChI :InChI=1S/C21H21N3O4/c1-3-15-5-4-6-16(11-15)24-21-17-12-19(27-8-7-25)20(28-10-9-26-2)13-18(17)22-14-23-21/h1,4-6,11-14,25H,7-10H2,2H3,(H,22,23,24)
InChIKey :KOQIAZNBAWFSQM-UHFFFAOYSA-N
SMILES :C(O)COC1C(OCCOC)=CC2C(C=1)=C(NC1=CC=CC(C#C)=C1)N=CN=2
Safety Information
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| Signal word: | Warning | ||||||||||||||
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Description
OSI-420 is a metabolite of Erlotinib. Erlontinib potently inhibits EGFR autophosphorylation in cultured human head and neck tumor cells, a cell line which exhibits high levels of EGFR. Erlotinib also inhibits the proliferation of PC-9 cell lines, which contain a deletion mutation on exon 19 of the EGFR gene. A combination of Erlotinib and rapamycin produced a synergistic inhibitory effect on cell growth.Related product price
-
OSI-420-d4, Free Base (Desmethyl Erlotinib-d4)
$537-3965 -
Dacomitinib (PF299804)
$10-1703 -
CO-1686
$9-3510
Suppliers and manufacturers
Hebei Mingji Chemical Technology Co., Ltd
Shanghai Boyle Chemical Co., Ltd.
J & K SCIENTIFIC LTD.
Chemsky（shanghai）International Co.,Ltd.
Jinan Trio PharmaTech Co., Ltd.
NCE Biomedical Co.,Ltd.
Shanghai Witofly Chemical Co.,Ltd
Chengdu Aofan Pharmtech Co.,Ltd
Wuxi Zhongkun Biochemical Technology Co., Ltd.
ShangHai KenEn Chemical Technology Co., Ltd.