PCNA-I1
|
- $75 - $1815
- Product name: PCNA-I1
- CAS: 444930-42-1
- MF: C17H14N2O2S
- MW: 310.37
- EINECS:
- MDL Number:
- Synonyms:N-(3-Methylthiophene-2-carboxylic acid)-N'-[(1-hydroxy-2-naphthalenyl)methylene]hydrazide;2-Thiophenecarboxylic acid, 3-methyl-, 2-[(1-hydroxy-2-naphthalenyl)methylene]hydrazide;PCNA-I1,PCNA-I-1,DNA/RNA Synthesis,inhibit,PCNAI1,Inhibitor,PCNA I1;N'-((1-Hydroxynaphthalen-2-yl)methylene)-3-methylthiophene-2-carbohydrazide;PCNA-I1, 10 mM in DMSO;N'-[(1-hydroxynaphthalen-2-yl) methylidene]-3-methylthiophene-2-carbohydrazide
30 prices
Selected condition：
Brand
- aablocks
- ACHEMBLOCK
- AK Scientific
- Arctom
- Biosynth
- Cayman Chemical
- ChemScene
- DC Chemicals
Package
- 10mM*1mLinDMSO
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- 250mg
- 1g
- Manufactureraablocks
- Product numberAA00DLWW
- Product descriptionPCNA-I1 ≥98%
- Packaging5mg
- Price$75
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00DLWW
- Product descriptionPCNA-I1 95%
- Packaging10mg
- Price$134
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00DLWW
- Product descriptionPCNA-I1 95%
- Packaging25mg
- Price$298
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00DLWW
- Product descriptionPCNA-I1 95%
- Packaging50mg
- Price$523
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00DLWW
- Product descriptionPCNA-I1
- Packaging100mg
- Price$876
- Updated2026-05-28
- Buy
- ManufacturerACHEMBLOCK
- Product numberU127716
- Product description3-Methyl-thiophene-2-carboxylic acid (1-hydroxy-naphthalen-2-ylmethylene)-hydrazide 98%
- Packaging25MG
- Price$560
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberU127716
- Product description3-Methyl-thiophene-2-carboxylic acid (1-hydroxy-naphthalen-2-ylmethylene)-hydrazide 98%
- Packaging100MG
- Price$1815
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberU127716
- Product description3-Methyl-thiophene-2-carboxylic acid (1-hydroxy-naphthalen-2-ylmethylene)-hydrazide 98%
- Packaging5MG
- Price$140
- Updated2026-05-27
- Buy
- ManufacturerAK Scientific
- Product number2656EM
- Product descriptionPcna-I1
- Packaging10mg
- Price$241
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberSYN5080
- Product descriptionPCNA-I1
- Packaging50mg
- Price$500
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberBD-A500109
- Product descriptionPCNA-I1 95%
- Packaging50mg
- Price$536
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberBD-A500109
- Product descriptionPCNA-I1 95%
- Packaging25mg
- Price$306
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberBD-A500109
- Product descriptionPCNA-I1 95%
- Packaging10mg
- Price$137
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberBD-A500109
- Product descriptionPCNA-I1 95%
- Packaging5mg
- Price$77
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberBD-A500109
- Product descriptionPCNA-I1 95%
- Packaging100mg
- Price$774
- Updated2026-05-26
- Buy
- ManufacturerBiosynth
- Product numberUSA93042
- Product descriptionPCNA I1
- Packaging50mg
- Price$1034.5
- Updated2026-06-05
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA00DLWW | PCNA-I1 ≥98% | 5mg | $75 | 2026-05-28 | Buy |
| aablocks | AA00DLWW | PCNA-I1 95% | 10mg | $134 | 2026-05-28 | Buy |
| aablocks | AA00DLWW | PCNA-I1 95% | 25mg | $298 | 2026-05-28 | Buy |
| aablocks | AA00DLWW | PCNA-I1 95% | 50mg | $523 | 2026-05-28 | Buy |
| aablocks | AA00DLWW | PCNA-I1 | 100mg | $876 | 2026-05-28 | Buy |
| ACHEMBLOCK | U127716 | 3-Methyl-thiophene-2-carboxylic acid (1-hydroxy-naphthalen-2-ylmethylene)-hydrazide 98% | 25MG | $560 | 2026-05-27 | Buy |
| ACHEMBLOCK | U127716 | 3-Methyl-thiophene-2-carboxylic acid (1-hydroxy-naphthalen-2-ylmethylene)-hydrazide 98% | 100MG | $1815 | 2026-05-27 | Buy |
| ACHEMBLOCK | U127716 | 3-Methyl-thiophene-2-carboxylic acid (1-hydroxy-naphthalen-2-ylmethylene)-hydrazide 98% | 5MG | $140 | 2026-05-27 | Buy |
| AK Scientific | 2656EM | Pcna-I1 | 10mg | $241 | 2021-12-16 | Buy |
| AK Scientific | SYN5080 | PCNA-I1 | 50mg | $500 | 2021-12-16 | Buy |
| Arctom | BD-A500109 | PCNA-I1 95% | 50mg | $536 | 2026-05-26 | Buy |
| Arctom | BD-A500109 | PCNA-I1 95% | 25mg | $306 | 2026-05-26 | Buy |
| Arctom | BD-A500109 | PCNA-I1 95% | 10mg | $137 | 2026-05-26 | Buy |
| Arctom | BD-A500109 | PCNA-I1 95% | 5mg | $77 | 2026-05-26 | Buy |
| Arctom | BD-A500109 | PCNA-I1 95% | 100mg | $774 | 2026-05-26 | Buy |
| Biosynth | USA93042 | PCNA I1 | 50mg | $1034.5 | 2026-06-05 | Buy |
Properties
Density :1.30±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMF: 10 mg/ml; DMSO: 10 mg/ml; DMSO:PBS (pH 7.2) (1:3): 0.25 mg/ml
form :A crystalline solid
pka :8.31±0.50(Predicted)
color :Light yellow to yellow
storage temp. :Store at -20°C
solubility :DMF: 10 mg/ml; DMSO: 10 mg/ml; DMSO:PBS (pH 7.2) (1:3): 0.25 mg/ml
form :A crystalline solid
pka :8.31±0.50(Predicted)
color :Light yellow to yellow
Safety Information
| Symbol(GHS): | ||||||||
|---|---|---|---|---|---|---|---|---|
| Signal word: | ||||||||
| Hazard statements: |
|
|||||||
| Precautionary statements: |
|
Description
PCNA-I1 is an inhibitor of proliferating cell nuclear antigen (PCNA) that binds to PCNA trimers (Kd = 0.41 μM) and dose-dependently reduces the level of PCNA associated with chromatin in PC3 cells. It preferentially inhibits growth of a variety of human and mouse cancer cell lines (IC50s = 0.05-0.3 μM) over non-transformed cells (IC50s = 0.99-2 μM). PCNA-I1 leads to an accumulation of cells in the G1 phase during the first 24 hours of incubation and halts the cell cycle in the S and G2/M phases by 72 hours following treatment. It also reduces tumor growth in an LNCaP prostate cancer mouse xenograft model when administered at a dose of 10 mg/kg, five days per week, for two weeks.Related product price
-
PCNA-I1
$75-1815 -
Triptonide
$72-3780 -
741713-40-6
$54-3200