Pifithrin-μ
|
- $30 - $1802
- Product name: Pifithrin-μ
- CAS: 64984-31-2
- MF: C8H7NO2S
- MW: 181.21
- EINECS:
- MDL Number:MFCD00181531
- Synonyms:PHENYLETHYNSULFONIC ACID AMIDE;Pifithrin--;Phenyl-ethynesulfonic Acid Amide;Pifithrin-u;2-Phenylethynesulfonamide, PFTμ;EthynesulfonaMide, 2-phenyl-;NSC 303580;Pftmu
58 prices
Selected condition：
Brand
- aablocks
- ACHEMBLOCK
- AK Scientific
- American Custom Chemicals Corporation
- ApexBio Technology
- Arctom
- AvaChem
- Axon Medchem
- Biorbyt Ltd
- Cayman Chemical
- ChemScene
- Crysdot
- CSNpharm
- DC Chemicals
- Matrix Scientific
- Medical Isotopes, Inc.
- Sigma-Aldrich
- TCI Chemical
- Tocris
- TRC
- Usbiological
Package
- 10.00mg
- 25.00mg
- 10mM*1mLinDMSO
- 10
- 50.00mg
- 250mg
- 5g
- 50
- 1000mg
- 5mg
- 10mM(in1mLDMSO)
- 10mg
- 25mg
- 50mg
- 100mg
- 500MG
- 1g
- 10mM(1mLinDMSO)
- Manufactureraablocks
- Product numberAA00EBJ6
- Product description2-phenylacetylenesulfonamide 98%
- Packaging5mg
- Price$30
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00EBJ6
- Product description2-phenylacetylenesulfonamide 98%
- Packaging10mg
- Price$46
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00EBJ6
- Product description2-phenylacetylenesulfonamide 98
- Packaging25mg
- Price$104
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00EBJ6
- Product description2-phenylacetylenesulfonamide 98
- Packaging50mg
- Price$143
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00EBJ6
- Product description2-phenylacetylenesulfonamide 98
- Packaging100mg
- Price$204
- Updated2026-05-28
- Buy
- ManufacturerACHEMBLOCK
- Product numberY228723
- Product descriptionPIFITHRIN-MU 97.00%
- Packaging100MG
- Price$275
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberY228723
- Product descriptionPIFITHRIN-MU 97.00%
- Packaging500MG
- Price$825
- Updated2026-05-27
- Buy
- ManufacturerAK Scientific
- Product numberX5920
- Product description2-phenylacetylenesulfonamide
- Packaging1g
- Price$619
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberCHM0014835
- Product descriptionPHENYLETHYNSULFONIC ACID AMIDE 95.00%
- Packaging10MG
- Price$721.88
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberCHM0014835
- Product descriptionPHENYLETHYNSULFONIC ACID AMIDE 95.00%
- Packaging100MG
- Price$1732.5
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4482
- Product descriptionPifithrin-μ
- Packaging50mg
- Price$190
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberA4482
- Product descriptionPifithrin-μ
- Packaging10mg
- Price$55
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberA4482
- Product descriptionPifithrin-μ
- Packaging10mM(in1mLDMSO)
- Price$60
- Updated2026-05-06
- Buy
- ManufacturerArctom
- Product numberSLK-S2930
- Product descriptionPifithrin-μ 99.93%
- Packaging10mg
- Price$140
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberSLK-S2930
- Product descriptionPifithrin-μ 99.93%
- Packaging10mM(1mLinDMSO)
- Price$188
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberSLK-S2930
- Product descriptionPifithrin-μ 99.93%
- Packaging50mg
- Price$352
- Updated2026-05-26
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA00EBJ6 | 2-phenylacetylenesulfonamide 98% | 5mg | $30 | 2026-05-28 | Buy |
| aablocks | AA00EBJ6 | 2-phenylacetylenesulfonamide 98% | 10mg | $46 | 2026-05-28 | Buy |
| aablocks | AA00EBJ6 | 2-phenylacetylenesulfonamide 98 | 25mg | $104 | 2026-05-28 | Buy |
| aablocks | AA00EBJ6 | 2-phenylacetylenesulfonamide 98 | 50mg | $143 | 2026-05-28 | Buy |
| aablocks | AA00EBJ6 | 2-phenylacetylenesulfonamide 98 | 100mg | $204 | 2026-05-28 | Buy |
| ACHEMBLOCK | Y228723 | PIFITHRIN-MU 97.00% | 100MG | $275 | 2026-05-27 | Buy |
| ACHEMBLOCK | Y228723 | PIFITHRIN-MU 97.00% | 500MG | $825 | 2026-05-27 | Buy |
| AK Scientific | X5920 | 2-phenylacetylenesulfonamide | 1g | $619 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | CHM0014835 | PHENYLETHYNSULFONIC ACID AMIDE 95.00% | 10MG | $721.88 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | CHM0014835 | PHENYLETHYNSULFONIC ACID AMIDE 95.00% | 100MG | $1732.5 | 2021-12-16 | Buy |
| ApexBio Technology | A4482 | Pifithrin-μ | 50mg | $190 | 2026-05-06 | Buy |
| ApexBio Technology | A4482 | Pifithrin-μ | 10mg | $55 | 2026-05-06 | Buy |
| ApexBio Technology | A4482 | Pifithrin-μ | 10mM(in1mLDMSO) | $60 | 2026-05-06 | Buy |
| Arctom | SLK-S2930 | Pifithrin-μ 99.93% | 10mg | $140 | 2026-05-26 | Buy |
| Arctom | SLK-S2930 | Pifithrin-μ 99.93% | 10mM(1mLinDMSO) | $188 | 2026-05-26 | Buy |
| Arctom | SLK-S2930 | Pifithrin-μ 99.93% | 50mg | $352 | 2026-05-26 | Buy |
Properties
Melting point :135.0 to 139.0 °C
Boiling point :351.7±25.0 °C(Predicted)
Density :1.39±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: soluble >10mg/mL, clear
pka :7.96±0.60(Predicted)
form :solid
color :White or off-white
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
InChI :InChI=1S/C8H7NO2S/c9-12(10,11)7-6-8-4-2-1-3-5-8/h1-5H,(H2,9,10,11)
InChIKey :ZZUZYEMRHCMVTB-UHFFFAOYSA-N
SMILES :C(S(N)(=O)=O)#CC1=CC=CC=C1
Boiling point :351.7±25.0 °C(Predicted)
Density :1.39±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: soluble >10mg/mL, clear
pka :7.96±0.60(Predicted)
form :solid
color :White or off-white
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
InChI :InChI=1S/C8H7NO2S/c9-12(10,11)7-6-8-4-2-1-3-5-8/h1-5H,(H2,9,10,11)
InChIKey :ZZUZYEMRHCMVTB-UHFFFAOYSA-N
SMILES :C(S(N)(=O)=O)#CC1=CC=CC=C1
Safety Information
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| Signal word: | Warning | ||||||||||||||
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Description
In addition to its transactivational functions, p53 mediates apoptosis by binding with the anti-apoptotic proteins Bcl-xL and Bcl-2 at the mitochondrial surface. Pifithrin-μ (PFT-μ) is an inhibitor of p53-mediated apoptosis, preventing p53 binding to Bcl-xL and Bcl-2 at the mitochondria without affecting p53 transactivational activities In vitro, PFT-μ binds both p53 (Kd = 0.82 mM) and Bcl-xL (Kd = 0.80 mM). PFT-μ reduces p53-mediated apoptosis induced by γ-radiation in mouse thymocytes in vitro and protects mice from doses of radiation that cause lethal hematopoietic syndrome. At 25 μM, PFT-μ reduces apoptosis triggered by nutlin-3, which inhibits MDM2/p53 binding and potentiates p53-mediated growth arrest and apoptosis. PFT-μ also interacts selectively with heat shock protein 70 (HSP70), leading to disruption of the association between HSP70 and many of its co-chaperones and substrate proteins.More related product prices
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Suppliers and manufacturers
J & K SCIENTIFIC LTD.
3B Pharmachem (Wuhan) International Co.,Ltd.
TCI (Shanghai) Development Co., Ltd.
Chemsky (shanghai) International Co.,Ltd
Jinan Trio PharmaTech Co., Ltd.
Dalian Meilun Biotech Co., Ltd.
NCE Biomedical Co.,Ltd.
TOKYO CHEMICAL INDUSTRY CO., LTD.
9ding chemical ( Shanghai) Limited
Shanghai Witofly Chemical Co.,Ltd