RO8994
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- $68 - $1459
- Product name: RO8994
- CAS: 1309684-94-3
- MF: C31H31Cl2FN4O4
- MW: 613.51
- EINECS:-0
- MDL Number:MFCD29472243
- Synonyms:RO8994;(2'S,3R,4'S,5'R)-N-[4-(Aminocarbonyl)-2-methoxyphenyl]-6-chloro-4'-(3-chloro-2-fluorophenyl)-2'-(2,2-dimethylpropyl)-1,2-dihydro-2-oxo-spiro[3H-indole-3,3'-pyrrolidine]-5'-carboxamide;Spiro[3H-indole-3,3'-pyrrolidine]-5'-carboxamide, N-[4-(aminocarbonyl)-2-methoxyphenyl]-6-chloro-4'-(3-chloro-2-fluorophenyl)-2'-(2,2-dimethylpropyl)-1,2-dihydro-2-oxo-, (2'S,3R,4'S,5'R)-;RO-8994;RO 8994;RO8994;RO-8994;RO 8994;CS-2264;E2 conjugating enzyme,MDM-2/p53,Ubiquitin conjugating enzyme,Ubiquitin activating enzyme,E3 ligating enzyme,RO8994,inhibit,Inhibitor,RO 8994,RO-8994,E1/E2/E3 Enzyme,E1 activating enzyme,Ubiquitin ligase;(2'S,3R,4'R,5'R)-N-(4-carbamoyl-2-methoxyphenyl)-6-chloro-4'-(3-chloro-2-fluorophenyl)-2'-neopentyl-2-oxospiro[indoline-3,3'-pyrrolidine]-5'-
14 prices
Selected condition：
Brand
- AK Scientific
- Cayman Chemical
- ChemScene
- Crysdot
- DC Chemicals
- TRC
Package
- 1mg
- 2.5mg
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- 250mg
- ManufacturerAK Scientific
- Product number4309DK
- Product descriptionCID53238217
- Packaging5mg
- Price$415
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number25674
- Product descriptionRO8994
- Packaging1mg
- Price$68
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number25674
- Product descriptionRO8994
- Packaging5mg
- Price$286
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number25674
- Product descriptionRO8994
- Packaging10mg
- Price$535
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number25674
- Product descriptionRO8994
- Packaging25mg
- Price$1169
- Updated2024-03-01
- Buy
- ManufacturerChemScene
- Product numberCS-5002
- Product descriptionRO8994 99.30%
- Packaging5mg
- Price$90
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-5002
- Product descriptionRO8994 99.30%
- Packaging10mg
- Price$150
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-5002
- Product descriptionRO8994 99.30%
- Packaging100mg
- Price$650
- Updated2021-12-16
- Buy
- ManufacturerCrysdot
- Product numberCD31003931
- Product descriptionRO8994 98+%
- Packaging5mg
- Price$243
- Updated2021-12-16
- Buy
- ManufacturerCrysdot
- Product numberCD31003931
- Product descriptionRO8994 98+%
- Packaging10mg
- Price$347
- Updated2021-12-16
- Buy
- ManufacturerCrysdot
- Product numberCD31003931
- Product descriptionRO8994 98+%
- Packaging50mg
- Price$1042
- Updated2021-12-16
- Buy
- ManufacturerCrysdot
- Product numberCD31003931
- Product descriptionRO8994 98+%
- Packaging100mg
- Price$1459
- Updated2021-12-16
- Buy
- ManufacturerDC Chemicals
- Product numberDC8467
- Product descriptionRO8994 >98%
- Packaging250mg
- Price$1300
- Updated2021-12-16
- Buy
- ManufacturerTRC
- Product numberR637390
- Product descriptionRO8994
- Packaging2.5mg
- Price$200
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | 4309DK | CID53238217 | 5mg | $415 | 2021-12-16 | Buy |
| Cayman Chemical | 25674 | RO8994 | 1mg | $68 | 2024-03-01 | Buy |
| Cayman Chemical | 25674 | RO8994 | 5mg | $286 | 2024-03-01 | Buy |
| Cayman Chemical | 25674 | RO8994 | 10mg | $535 | 2024-03-01 | Buy |
| Cayman Chemical | 25674 | RO8994 | 25mg | $1169 | 2024-03-01 | Buy |
| ChemScene | CS-5002 | RO8994 99.30% | 5mg | $90 | 2021-12-16 | Buy |
| ChemScene | CS-5002 | RO8994 99.30% | 10mg | $150 | 2021-12-16 | Buy |
| ChemScene | CS-5002 | RO8994 99.30% | 100mg | $650 | 2021-12-16 | Buy |
| Crysdot | CD31003931 | RO8994 98+% | 5mg | $243 | 2021-12-16 | Buy |
| Crysdot | CD31003931 | RO8994 98+% | 10mg | $347 | 2021-12-16 | Buy |
| Crysdot | CD31003931 | RO8994 98+% | 50mg | $1042 | 2021-12-16 | Buy |
| Crysdot | CD31003931 | RO8994 98+% | 100mg | $1459 | 2021-12-16 | Buy |
| DC Chemicals | DC8467 | RO8994 >98% | 250mg | $1300 | 2021-12-16 | Buy |
| TRC | R637390 | RO8994 | 2.5mg | $200 | 2021-12-16 | Buy |
Properties
Boiling point :753.5±60.0 °C(Predicted)
Density :1.41±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMF:12.5(Max Conc. mg/mL);20.4(Max Conc. mM)
DMSO:14.0(Max Conc. mg/mL);22.8(Max Conc. mM)
Ethanol:5.0(Max Conc. mg/mL);8.1(Max Conc. mM) form :A crystalline solid
pka :12.00±0.70(Predicted)
Density :1.41±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMF:12.5(Max Conc. mg/mL);20.4(Max Conc. mM)
DMSO:14.0(Max Conc. mg/mL);22.8(Max Conc. mM)
Ethanol:5.0(Max Conc. mg/mL);8.1(Max Conc. mM) form :A crystalline solid
pka :12.00±0.70(Predicted)
Safety Information
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Description
RO8994 is an inhibitor of the protein-protein interaction between MDM2 and the tumor suppressor p53 in a homogeneous time-resolved fluorescence (HTRF) binding assay (IC50 = 5 nM). It inhibits the proliferation of SJSA-1, RKO, and HCT116 cells with an average IC50 value of 20 nM and increases apoptosis in SJSA-1 cells in a concentration-dependent manner. RO8994 reduces tumor growth and induces tumor regression in an SJSA-1 osteosarcoma mouse xenograft model when administered at doses of 1.56 and 6.25 mg/kg, respectively.Suppliers and manufacturers
ATK CHEMICAL COMPANY LIMITED
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TargetMol Chemicals Inc.
ShenZhen Trendseen Biological Technology Co.,Ltd.
Jilin Chinese Academy of Sciences-yanshen Technology
Aladdin Scientific
Amadis Chemical Company Limited
Changzhou Chenhong Biotechnology Co., Ltd.
Shanghai Boyle Chemical Co., Ltd.