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ChemicalBook >> CAS DataBase List >> Rbin-1

Rbin-1

Rbin-1 price.
  • $93 - $2200
  • Product name: Rbin-1
  • CAS: 328023-11-6
  • MF: C13H12N4S
  • MW: 256.33
  • EINECS:-0
  • MDL Number:MFCD02369534
  • Synonyms:Rbin-1;3-(2-methylprop-2-enylsulfanyl)-5H-[1,2,4]triazino[5,6-b]indole;Rbin-1 - Ribozinoindole-1;RBIN 1;RIBOZINOINDOLE 1;RBIN1;RIBOZINOINDOLE-1;RBIN-1;RIBOZINOINDOLE1;Ribozinoindole 1;Ribozinoindole1;Ribozinoindole-1;CS-2565
18 prices
Selected condition:
Brand
  • AK Scientific
  • Axon Medchem
  • Cayman Chemical
  • ChemScene
  • Crysdot
  • DC Chemicals
  • TRC
Package
  • 1mg
  • 5mg
  • 10mg
  • 25mg
  • 50mg
  • 100mg
  • 1g
  • ManufacturerAK Scientific
  • Product number3319CP
  • Product description3-(2-Methylprop-2-enylsulfanyl)-5H-[1,2,4]triazino[5,6-b]indole
  • Packaging1mg
  • Price$201
  • Updated2021-12-16
  • Buy
  • ManufacturerAxon Medchem
  • Product numberAxon2663
  • Product descriptionRbin-1-Ribozinoindole-1 99%
  • Packaging10mg
  • Price$137.5
  • Updated2021-12-16
  • Buy
  • ManufacturerAxon Medchem
  • Product numberAxon2663
  • Product descriptionRbin-1-Ribozinoindole-1 99%
  • Packaging50mg
  • Price$522.5
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number20745
  • Product descriptionRbin-1 ≥98%
  • Packaging1mg
  • Price$93
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number20745
  • Product descriptionRbin-1 ≥98%
  • Packaging5mg
  • Price$388
  • Updated2024-03-01
  • Buy
  • ManufacturerChemScene
  • Product numberCS-6068
  • Product descriptionRbin-1 99.91%
  • Packaging1mg
  • Price$110
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-6068
  • Product descriptionRbin-1 99.91%
  • Packaging5mg
  • Price$330
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-6068
  • Product descriptionRbin-1 99.91%
  • Packaging10mg
  • Price$500
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-6068
  • Product descriptionRbin-1 99.91%
  • Packaging25mg
  • Price$1000
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-6068
  • Product descriptionRbin-1 99.91%
  • Packaging50mg
  • Price$1500
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-6068
  • Product descriptionRbin-1 99.91%
  • Packaging100mg
  • Price$2100
  • Updated2021-12-16
  • Buy
  • ManufacturerCrysdot
  • Product numberCD11144576
  • Product descriptionRbin-1 97%
  • Packaging5mg
  • Price$339
  • Updated2021-12-16
  • Buy
  • ManufacturerCrysdot
  • Product numberCD11144576
  • Product descriptionRbin-1 97%
  • Packaging10mg
  • Price$513
  • Updated2021-12-16
  • Buy
  • ManufacturerCrysdot
  • Product numberCD11144576
  • Product descriptionRbin-1 97%
  • Packaging25mg
  • Price$1026
  • Updated2021-12-16
  • Buy
  • ManufacturerCrysdot
  • Product numberCD11144576
  • Product descriptionRbin-1 97%
  • Packaging50mg
  • Price$1538
  • Updated2021-12-16
  • Buy
  • ManufacturerDC Chemicals
  • Product numberDC11468
  • Product descriptionRbin-1 >98%
  • Packaging100mg
  • Price$650
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 3319CP 3-(2-Methylprop-2-enylsulfanyl)-5H-[1,2,4]triazino[5,6-b]indole 1mg $201 2021-12-16 Buy
Axon Medchem Axon2663 Rbin-1-Ribozinoindole-1 99% 10mg $137.5 2021-12-16 Buy
Axon Medchem Axon2663 Rbin-1-Ribozinoindole-1 99% 50mg $522.5 2021-12-16 Buy
Cayman Chemical 20745 Rbin-1 ≥98% 1mg $93 2024-03-01 Buy
Cayman Chemical 20745 Rbin-1 ≥98% 5mg $388 2024-03-01 Buy
ChemScene CS-6068 Rbin-1 99.91% 1mg $110 2021-12-16 Buy
ChemScene CS-6068 Rbin-1 99.91% 5mg $330 2021-12-16 Buy
ChemScene CS-6068 Rbin-1 99.91% 10mg $500 2021-12-16 Buy
ChemScene CS-6068 Rbin-1 99.91% 25mg $1000 2021-12-16 Buy
ChemScene CS-6068 Rbin-1 99.91% 50mg $1500 2021-12-16 Buy
ChemScene CS-6068 Rbin-1 99.91% 100mg $2100 2021-12-16 Buy
Crysdot CD11144576 Rbin-1 97% 5mg $339 2021-12-16 Buy
Crysdot CD11144576 Rbin-1 97% 10mg $513 2021-12-16 Buy
Crysdot CD11144576 Rbin-1 97% 25mg $1026 2021-12-16 Buy
Crysdot CD11144576 Rbin-1 97% 50mg $1538 2021-12-16 Buy
DC Chemicals DC11468 Rbin-1 >98% 100mg $650 2021-12-16 Buy

Properties

Boiling point :479.6±47.0 °C(Predicted)
Density :1.34±0.1 g/cm3(Predicted)
storage temp. :Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility :Soluble in DMSO (up to at least 25 mg/ml)
pka :10.34±0.50(Predicted)
form :solid
color :Pale yellow
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Rbin-1 is a triazinoindole inhibitor of midasin (mdn1), an essential protein for eukaryotic ribosome biogenesis. It inhibits the growth of fission yeast strains in vitro (GI50 = 136 nM) and inhibits mdn1 ATPase activity by approximately 40% when used at a concentration of 1 μM. Rbin-1 inhibits pre-rRNA processing and nuclear export of the pre-60S ribosome subunit in mdn1-ts, but not mdn1-F1093L mutant, S. pombe cells. It also decreases ribosome assembly protein 4 (Rsa4) levels in Rix1 particles, a ribosome assembly intermediate, Rix1-bound Ytm1 levels, and Rix7 and Ppp1 levels in the nucleolar pre-60S particle Nsa1 in mdn1-ts fission yeast cells.

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